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The ‘overly-sensitive’ heart: sodium channel block and QRS interval prolongation

(2011) Gary A Gintant et al.   BRITISH JOURNAL OF PHARMACOLOGY

Guide to Receptors and Channels (GRAC), 5th edition

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Cardiotoxicity testing using pluripotent stem cell-derived human cardiomyocytes and state-of-the-art bioanalytics: a review

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Somatic coding mutations in human induced pluripotent stem cells

(2011) Athurva Gore et al.   NATURE

Cardiotoxicity of kinase inhibitors: the prediction and translation of preclinical models to clinical outcomes

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A novel secretagogue increases cardiac contractility by enhancement of L-type Ca2+ current

(2010) Zhi Su et al.   BIOCHEMICAL PHARMACOLOGY

Reducing QT liability and proarrhythmic risk in drug discovery and development

(2010) Jean-Pierre Valentin   BRITISH JOURNAL OF PHARMACOLOGY

Dealing with hERG liabilities early: diverse approaches to an important goal in drug development

(2010) BD Guth et al.   BRITISH JOURNAL OF PHARMACOLOGY

An introduction to QT interval prolongation and non-clinical approaches to assessing and reducing risk

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An evaluation of hERG current assay performance: Translating preclinical safety studies to clinical QT prolongation

(2010) Gary Gintant   PHARMACOLOGY & THERAPEUTICS

The action potential and comparative pharmacology of stem cell-derived human cardiomyocytes

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Kinetic Cell-Based Morphological Screening: Prediction of Mechanism of Compound Action and Off-Target Effects

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On the Road to iPS Cell Cardiovascular Applications

(2009) Timothy J. Kamp et al.   CIRCULATION RESEARCH

Prospects for pluripotent stem cell-derived cardiomyocytes in cardiac cell therapy and as disease models

(2009) Christian Freund et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Optimization of Cav1.2 screening with an automated planar patch clamp platform

(2009) Bharathi Balasubramanian et al.   JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS

The application of cell-based label-free technology in drug discovery

(2008) Biao Xi et al.   Biotechnology Journal

Preclinical assessment of cardiac toxicity

(2008) Ralf Kettenhofen et al.   DRUG DISCOVERY TODAY

Excitation–Contraction Coupling of the Mouse Embryonic Cardiomyocyte

(2008) Risto Rapila et al.   JOURNAL OF GENERAL PHYSIOLOGY

Tetrodotoxin

(2008) Toshio NARAHASHI   PROCEEDINGS OF THE JAPAN ACADEMY SERIES B-PHYSICAL AND BIOLOGICAL SCIENCES

Drugs and trafficking of ion channels: a new pro-arrhythmic threat on the horizon?

(2007) M A G Heyden et al.   BRITISH JOURNAL OF PHARMACOLOGY