Cardiotoxicity of kinase inhibitors: the prediction and translation of preclinical models to clinical outcomes

Imatinib in Pulmonary Arterial Hypertension Patients with Inadequate Response to Established Therapy

(2010) Hossein A. Ghofrani et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Treatment-emergent hypertension and outcomes in patients with advanced non-small-cell lung cancer receiving chemotherapy with or without the vascular endothelial growth factor receptor inhibitor cediranib: NCIC Clinical Trials Group Study BR24

(2010) R. Goodwin et al.   ANNALS OF ONCOLOGY

Extracellular signal-regulated kinase 1/2 (ERK1/2) signaling in cardiac hypertrophy

(2010) Izhak Kehat et al.   Annals of the New York Academy of Sciences

PI3K(p110α) Protects Against Myocardial Infarction-Induced Heart Failure

(2010) Ruby C.Y. Lin et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Activation of AMPK is necessary for killing cancer cells and sparing cardiac cells

(2010) Scott A. Shell et al.   CELL CYCLE

Human and Murine Embryonic Stem Cell-Derived Cardiomyocytes Serve Together as a Valuable Model for Drug Safety Screening

(2010) Huamin Liang et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Kinases as targets in the treatment of solid tumors

(2010) Georgios Giamas et al.   CELLULAR SIGNALLING

Juvenile Exposure to Anthracyclines Impairs Cardiac Progenitor Cell Function and Vascularization Resulting in Greater Susceptibility to Stress-Induced Myocardial Injury in Adult Mice

(2010) Chengqun Huang et al.   CIRCULATION

Research Priorities in Hypertrophic Cardiomyopathy

(2010) Thomas Force et al.   CIRCULATION

Molecular Mechanisms of Cardiovascular Toxicity of Targeted Cancer Therapeutics

(2010) Hui Cheng et al.   CIRCULATION RESEARCH

The Vulnerability of the Heart As a Pluricellular Paracrine Organ

(2010) Gilles W. De Keulenaer et al.   CIRCULATION RESEARCH

Glycogen Synthase Kinase-3β Regulates Post–Myocardial Infarction Remodeling and Stress-Induced Cardiomyocyte Proliferation In Vivo

(2010) Kathleen C. Woulfe et al.   CIRCULATION RESEARCH

High-Sensitivity Cardiac Troponin Assays: What Analytical and Clinical Issues Need to Be Addressed before Introduction into Clinical Practice?

(2010) F. S. Apple   CLINICAL CHEMISTRY

The mTOR Pathway: A New Target in Cancer Therapy

(2010) L. Ciuffreda et al.   CURRENT CANCER DRUG TARGETS

Cardiovascular side effects of cancer therapies: a position statement from the Heart Failure Association of the European Society of Cardiology

(2010) Thomas Eschenhagen et al.   EUROPEAN JOURNAL OF HEART FAILURE

Reduction of Sympathetic Activity via Adrenal-targeted GRK2 Gene Deletion Attenuates Heart Failure Progression and Improves Cardiac Function after Myocardial Infarction

(2010) Anastasios Lymperopoulos et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cardiomyocyte PDGFR-β signaling is an essential component of the mouse cardiac response to load-induced stress

(2010) Vishnu Chintalgattu et al.   JOURNAL OF CLINICAL INVESTIGATION

GSK-3α directly regulates β-adrenergic signaling and the response of the heart to hemodynamic stress in mice

(2010) Jibin Zhou et al.   JOURNAL OF CLINICAL INVESTIGATION

Trastuzumab-Induced Cardiotoxicity: Clinical and Prognostic Implications of Troponin I Evaluation

(2010) Daniela Cardinale et al.   JOURNAL OF CLINICAL ONCOLOGY

ROCK1 plays an essential role in the transition from cardiac hypertrophy to failure in mice

(2010) Jianjian Shi et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Zebrafish heart regeneration occurs by cardiomyocyte dedifferentiation and proliferation

(2010) Chris Jopling et al.   NATURE

Metabolic Signatures of Exercise in Human Plasma

(2010) G. D. Lewis et al.   Science Translational Medicine

Differentiation of Human Embryonic Stem Cells to Cardiomyocytes for In Vitro and In Vivo Applications

(2010) Hilmar Vidarsson et al.   Stem Cell Reviews and Reports

The cardiotoxicity and myocyte damage caused by small molecule anticancer tyrosine kinase inhibitors is correlated with lack of target specificity

(2010) Brian B. Hasinoff   TOXICOLOGY AND APPLIED PHARMACOLOGY

Cardiotoxicity induced by tyrosine kinase inhibitors

(2009) George S. Orphanos et al.   ACTA ONCOLOGICA

VEGF kinase inhibitors: how do they cause hypertension?

(2009) Pankaj Bhargava   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

A cell-based sensor system for toxicity testing using multiwavelength fluorescence spectroscopy

(2009) Michael Fritzsche et al.   ANALYTICAL BIOCHEMISTRY

Hypertension and clinical benefit of bevacizumab in the treatment of advanced renal cell carcinoma

(2009) P. Bono et al.   ANNALS OF ONCOLOGY

Cardiac Progenitor Cells and Biotinylated Insulin-Like Growth Factor-1 Nanofibers Improve Endogenous and Exogenous Myocardial Regeneration After Infarction

(2009) M. Elena Padin-Iruegas et al.   CIRCULATION

Anthracycline Cardiomyopathy Is Mediated by Depletion of the Cardiac Stem Cell Pool and Is Rescued by Restoration of Progenitor Cell Function

(2009) Antonella De Angelis et al.   CIRCULATION

Protein Kinase Cα, but Not PKCβ or PKCγ, Regulates Contractility and Heart Failure Susceptibility

(2009) Qinghang Liu et al.   CIRCULATION RESEARCH

Functional Cardiomyocytes Derived From Human Induced Pluripotent Stem Cells

(2009) Jianhua Zhang et al.   CIRCULATION RESEARCH

Phospholamban Ablation Rescues Sarcoplasmic Reticulum Ca 2+ Handling but Exacerbates Cardiac Dysfunction in CaMKIIδ C Transgenic Mice

(2009) Tong Zhang et al.   CIRCULATION RESEARCH

Calcium/Calmodulin-Dependent Protein Kinase II Contributes to Cardiac Arrhythmogenesis in Heart Failure

(2009) Can M. Sag et al.   Circulation-Heart Failure

Aurora kinase inhibitors: a new class of drugs targeting the regulatory mitotic system

(2009) José Alejandro Pérez Fidalgo et al.   Clinical & Translational Oncology

A New Season for Cardiac Troponin Assays: It's Time to Keep a Scorecard

(2009) F. S. Apple   CLINICAL CHEMISTRY

Sunitinib-Induced Cardiotoxicity Is Mediated by Off-Target Inhibition of AMP-Activated Protein Kinase

(2009) Risto Kerkela et al.   CTS-Clinical and Translational Science

Determination of Human Serum α1-Acid Glycoprotein and Albumin Binding of Various Marketed and Preclinical Kinase Inhibitors

(2009) Ferenc Zsila et al.   CURRENT MEDICINAL CHEMISTRY

New Developments in Anthracycline-Induced Cardiotoxicity

(2009) A. Mordente et al.   CURRENT MEDICINAL CHEMISTRY

The use ofin vivozebrafish assays in drug toxicity screening

(2009) Peter M Eimon et al.   Expert Opinion on Drug Metabolism & Toxicology

Polo-like kinase inhibitors: an emerging opportunity for cancer therapeutics

(2009) Puneet Chopra et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Controllable Expansion of Primary Cardiomyocytes by Reversible Immortalization

(2009) Yue Zhang et al.   HUMAN GENE THERAPY

Cardiac-specific Deletion of LKB1 Leads to Hypertrophy and Dysfunction

(2009) Yasumasa Ikeda et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Requirement for Ca2+/calmodulin–dependent kinase II in the transition from pressure overload–induced cardiac hypertrophy to heart failure in mice

(2009) Haiyun Ling et al.   JOURNAL OF CLINICAL INVESTIGATION

Selectively Nonselective Kinase Inhibition: Striking the Right Balance

(2009) Richard Morphy   JOURNAL OF MEDICINAL CHEMISTRY

Cardiac anti-remodelling effect of aerobic training is associated with a reduction in the calcineurin/NFAT signalling pathway in heart failure mice

(2009) R. S. F. Oliveira et al.   JOURNAL OF PHYSIOLOGY-LONDON

Imatinib does not substantially modify the glycemic profile in patients with chronic myeloid leukaemia

(2009) Stefania Mariani et al.   LEUKEMIA RESEARCH

Cardiac Safety of Lapatinib: Pooled Analysis of 3689 Patients Enrolled in Clinical Trials

(2009) Edith A. Perez et al.   MAYO CLINIC PROCEEDINGS

Selectivity and therapeutic inhibition of kinases: to be or not to be?

(2009) Kamran Ghoreschi et al.   NATURE IMMUNOLOGY

The most transparent research

(2009) Melinda Wenner   NATURE MEDICINE

Targeting the phosphoinositide 3-kinase pathway in cancer

(2009) Pixu Liu et al.   NATURE REVIEWS DRUG DISCOVERY

Cell cycle kinases as therapeutic targets for cancer

(2009) Silvia Lapenna et al.   NATURE REVIEWS DRUG DISCOVERY

Calcium Pumps in Health and Disease

(2009) Marisa Brini et al.   PHYSIOLOGICAL REVIEWS

Evidence for Cardiomyocyte Renewal in Humans

(2009) Olaf Bergmann et al.   SCIENCE

Prediction of drug-induced cardiotoxicity using human embryonic stem cell-derived cardiomyocytes

(2009) Stefan R. Braam et al.   Stem Cell Research

Cardiomyocytes from human pluripotent stem cells in regenerative medicine and drug discovery

(2009) Stefan R. Braam et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Identification of a Kinase Profile that Predicts Chromosome Damage Induced by Small Molecule Kinase Inhibitors

(2009) Andrew J. Olaharski et al.   PLoS Computational Biology

Distinct organization of energy metabolism in HL-1 cardiac cell line and cardiomyocytes

(2008) Margus Eimre et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Combined Tyrosine and Serine/Threonine Kinase Inhibition by Sorafenib Prevents Progression of Experimental Pulmonary Hypertension and Myocardial Remodeling

(2008) Martina Klein et al.   CIRCULATION

Apoptosis Signal-Regulating Kinase 1/p38 Signaling Pathway Negatively Regulates Physiological Hypertrophy

(2008) Masayuki Taniike et al.   CIRCULATION

c-kit Is Required for Cardiomyocyte Terminal Differentiation

(2008) Ming Li et al.   CIRCULATION RESEARCH

Phospholamban phosphorylation by CaMKII under pathophysiological conditions

(2008) Leticia Vittone   Frontiers in Bioscience-Landmark

Cardiac-specific ablation of Cypher leads to a severe form of dilated cardiomyopathy with premature death

(2008) M. Zheng et al.   HUMAN MOLECULAR GENETICS

The RAS/MAPK syndromes: novel roles of the RAS pathway in human genetic disorders

(2008) Yoko Aoki et al.   HUMAN MUTATION

AMP Activated Protein Kinase-α2 Deficiency Exacerbates Pressure-Overload–Induced Left Ventricular Hypertrophy and Dysfunction in Mice

(2008) Ping Zhang et al.   HYPERTENSION

Molecular regulation of cardiac hypertrophy

(2008) Sean P. Barry et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Long-term primary cultures of human adult atrial cardiac myocytes: Cell viability, structural properties and BNP secretion in vitro

(2008) Vasiliki Bistola et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Heterozygous disruption of Flk-1 receptor leads to myocardial ischaemia reperfusion injury in mice: application of affymetrix gene chip analysis

(2008) M. Thirunavukkarasu et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Deletion of GSK-3β in mice leads to hypertrophic cardiomyopathy secondary to cardiomyoblast hyperproliferation

(2008) Risto Kerkela et al.   JOURNAL OF CLINICAL INVESTIGATION

Antitumor Activity and Biomarker Analysis of Sunitinib in Patients With Bevacizumab-Refractory Metastatic Renal Cell Carcinoma

(2008) Brian I. Rini et al.   JOURNAL OF CLINICAL ONCOLOGY

Cardiac stem cells and myocardial disease

(2008) Jan Kajstura et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Genetic approaches for changing the heart and dissecting complex syndromes

(2008) Michael-Alice Moga et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Cyclin-dependent kinase 2 signaling regulates myocardial ischemia/reperfusion injury

(2008) David A. Liem et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

With great power comes great responsibility: Using mouse genetics to study cardiac hypertrophy and failure

(2008) Jeffery D. Molkentin et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Application of Metabolomics to Cardiovascular Biomarker and Pathway Discovery

(2008) Gregory D. Lewis et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Mechanisms of Myocyte Cytotoxicity Induced by the Multiple Receptor Tyrosine Kinase Inhibitor Sunitinib

(2008) B. B. Hasinoff et al.   MOLECULAR PHARMACOLOGY

A quantitative analysis of kinase inhibitor selectivity

(2008) Mazen W Karaman et al.   NATURE BIOTECHNOLOGY

A new type of ERK1/2 autophosphorylation causes cardiac hypertrophy

(2008) Kristina Lorenz et al.   NATURE MEDICINE

Tyrosine kinase inhibitors reverse type 1 diabetes in nonobese diabetic mice

(2008) C. Louvet et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Distinct roles of GSK-3  and GSK-3  phosphorylation in the heart under pressure overload

(2008) T. Matsuda et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Calcium Handling in Human Embryonic Stem Cell-Derived Cardiomyocytes

(2008) Jonathan Satin et al.   STEM CELLS

Imatinib Mesilate Inhibits Neointimal Hyperplasia via Growth Inhibition of Vascular Smooth Muscle Cells in a Rat Model of Balloon Injury

(2008) Yashiro Makiyama et al.   TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE

Time-Dependent Block of Ultrarapid-Delayed Rectifier K+ Currents by Aconitine, a Potent Cardiotoxin, in Heart-Derived H9c2 Myoblasts and in Neonatal Rat Ventricular Myocytes

(2008) Ya-Jean Wang et al.   TOXICOLOGICAL SCIENCES

Effect of the Multitargeted Tyrosine Kinase Inhibitors Imatinib, Dasatinib, Sunitinib, and Sorafenib on Mitochondrial Function in Isolated Rat Heart Mitochondria and H9c2 Cells

(2008) Yvonne Will et al.   TOXICOLOGICAL SCIENCES