Effects of subclass change on the structural stability of chimeric, humanized, and human antibodies under thermal stress

Marketed therapeutic antibodies compendium

(2012) Janice M. Reichert   mAbs

Elucidation of Acid-induced Unfolding and Aggregation of Human Immunoglobulin IgG1 and IgG2 Fc

(2011) Ramil F. Latypov et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Advances in the assessment and control of the effector functions of therapeutic antibodies

(2011) Xu-Rong Jiang et al.   NATURE REVIEWS DRUG DISCOVERY

High-throughput measurement, correlation analysis, and machine-learning predictions for pH and thermal stabilities of Pfizer-generated antibodies

(2011) Amy C. King et al.   PROTEIN SCIENCE

Acid-Induced Aggregation of Human Monoclonal IgG1 and IgG2: Molecular Mechanism and the Effect of Solution Composition

(2010) Sanjay B. Hari et al.   BIOCHEMISTRY

Influence of pH on Heat-Induced Aggregation and Degradation of Therapeutic Monoclonal Antibodies

(2010) Tomoyoshi Ishikawa et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Formulation Development of Therapeutic Monoclonal Antibodies Using High-Throughput Fluorescence and Static Light Scattering Techniques: Role of Conformational and Colloidal Stability

(2010) Deborah S. Goldberg et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

IgG2m4, an engineered antibody isotype with reduced Fc function

(2010) Zhiqiang An et al.   mAbs

Increased aggregation propensity of IgG2 subclass over IgG1: Role of conformational changes and covalent character in isolated aggregates

(2010) Heather Franey et al.   PROTEIN SCIENCE

Immunogenicity of aggregates of recombinant human growth hormone in mouse models

(2009) Amber Haynes Fradkin et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

High throughput thermostability screening of monoclonal antibody formulations

(2009) Feng He et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Aggregation of a multidomain protein: A coagulation mechanism governs aggregation of a model IgG1 antibody under weak thermal stress

(2009) Christian Beyschau Andersen et al.   PROTEIN SCIENCE

Disulfide Connectivity of Human Immunoglobulin G2 Structural Isoforms

(2008) Theresa Martinez et al.   BIOCHEMISTRY

When binding is enough: nonactivating antibody formats

(2008) Aran F Labrijn et al.   CURRENT OPINION IN IMMUNOLOGY

Human IgG2 Antibodies Display Disulfide-mediated Structural Isoforms

(2008) Jette Wypych et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural and Functional Characterization of Disulfide Isoforms of the Human IgG2 Subclass

(2008) Thomas M. Dillon et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Human IgG2 Antibody Disulfide Rearrangementin Vivo

(2008) Y. Diana Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Fragmentation of a Recombinant Monoclonal Antibody at Various pH

(2008) Georgeen Gaza-Bulseco et al.   PHARMACEUTICAL RESEARCH

Contribution of Variable Domains to the Stability of Humanized IgG1 Monoclonal Antibodies

(2007) Roxana M. Ionescu et al.   JOURNAL OF PHARMACEUTICAL SCIENCES