Phospho-selective mechanisms of arrestin conformations and functions revealed by unnatural amino acid incorporation and 19F-NMR

Dual agonist occupancy of AT1-R–α2C-AR heterodimers results in atypical Gs-PKA signaling

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Ghrelin receptor conformational dynamics regulate the transition from a preassembled to an active receptor:Gq complex

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The catalytic region and PEST domain of PTPN18 distinctly regulate the HER2 phosphorylation and ubiquitination barcodes

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A stress response pathway in mice upregulates somatostatin level and transcription in pancreatic delta cells through Gs and β-arrestin 1

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Concomitant Action of Structural Elements and Receptor Phosphorylation Determines Arrestin-3 Interaction with the Free Fatty Acid Receptor FFA4

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Divergent Transducer-specific Molecular Efficacies Generate Biased Agonism at a G Protein-coupled Receptor (GPCR)

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Mutation of Putative GRK Phosphorylation Sites in the Cannabinoid Receptor 1 (CB1R) Confers Resistance to Cannabinoid Tolerance and Hypersensitivity to Cannabinoids in Mice

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Visualization of arrestin recruitment by a G-protein-coupled receptor

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Major ligand-induced rearrangement of the heptahelical domain interface in a GPCR dimer

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Targeted Disruption of β-Arrestin 2-Mediated Signaling Pathways by Aptamer Chimeras Leads to Inhibition of Leukemic Cell Growth

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Crystal structure of a common GPCR-binding interface for G protein and arrestin

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A Genetically Encoded19F NMR Probe for Tyrosine Phosphorylation

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The Dynamic Process of β2-Adrenergic Receptor Activation

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Crystal structure of pre-activated arrestin p44

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Structure of active β-arrestin-1 bound to a G-protein-coupled receptor phosphopeptide

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Involvement of distinct arrestin-1 elements in binding to different functional forms of rhodopsin

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β-Arrestin1-mediated recruitment of c-Src underlies the proliferative action of glucagon-like peptide-1 in pancreatic β INS832/13 cells

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Competing G protein-coupled receptor kinases balance G protein and β-arrestin signaling

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Structural insights into biased G protein-coupled receptor signaling revealed by fluorescence spectroscopy

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Biased Signaling Pathways in  2-Adrenergic Receptor Characterized by 19F-NMR

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Molecular Mechanism of β-Arrestin-Biased Agonism at Seven-Transmembrane Receptors

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A stress response pathway regulates DNA damage through β2-adrenoreceptors and β-arrestin-1

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Multiple ligand-specific conformations of the β2-adrenergic receptor

(2011) Alem W Kahsai et al.   Nature Chemical Biology

Distinct Phosphorylation Sites on the  2-Adrenergic Receptor Establish a Barcode That Encodes Differential Functions of  -Arrestin

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Adding New Chemistries to the Genetic Code

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Meningococcus Hijacks a β2-Adrenoceptor/β-Arrestin Pathway to Cross Brain Microvasculature Endothelium

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Site-specific Phosphorylation of CXCR4 Is Dynamically Regulated by Multiple Kinases and Results in Differential Modulation of CXCR4 Signaling

(2010) John M. Busillo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Differential G-protein-coupled Receptor Phosphorylation Provides Evidence for a Signaling Bar Code

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Global phosphorylation analysis of  -arrestin-mediated signaling downstream of a seven transmembrane receptor (7TMR)

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Structure of an Arrestin2-Clathrin Complex Reveals a Novel Clathrin Binding Domain That Modulates Receptor Trafficking

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Structural Basis for the Recognition of c-Src by Its Inactivator Csk

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Distinct conformational changes in  -arrestin report biased agonism at seven-transmembrane receptors

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