Article
Biochemistry & Molecular Biology
Peter K. Windsor, Stephen P. Plassmeyer, Dominic S. Mattock, Jonathan C. Bradfield, Erika Y. Choi, Bill R. Miller, Byung Hee Han
Summary: The study found that a class of biflavonoids can promote the disaggregation of Aβ fibrils, with varying potency due to structural differences. Computational analysis provided the first atomistic details for the mechanism of Aβ disaggregation by biflavonoids. Molecular docking analysis showed that biflavonoids preferably bind to the aromatic-rich, partially ordered N-termini of Aβ fibrils via pi-pi interactions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Angela Ianniciello, Martha M. Zarou, Kevin M. Rattigan, Mary Scott, Amy Dawson, Karen Dunn, Zuzana Brabcova, Eric R. Kalkman, Colin Nixon, Alison M. Michie, Mhairi Copland, David Vetrie, Martin Ambler, Barbara Saxty, G. Vignir Helgason
Summary: Inhibition of autophagy has shown to reduce growth of CML cells and induce differentiation of CML LSCs by enhancing mitochondrial respiration and loss of quiescence. This suggests a potential alternative strategy for treating patients with CML by combining autophagy inhibition with TKI treatment.
SCIENCE TRANSLATIONAL MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Wang Yin, Cuong Pham, Tao Wang, Hadi Al Shamaileh, Rocky Chowdhury, Shweta Patel, Yong Li, Lingxue Kong, Yingchu Hou, Yimin Zhu, Sunrui Chen, Huo Xu, Lee Jia, Wei Duan, Dongxi Xiang
Summary: This study aimed to overcome drug resistance in liver cancer caused by cancer stem cells by using a CD133 aptamer for targeted delivery of Doxorubicin and enhancing the treatment efficacy through autophagy inhibition. The results showed that CD133 aptamer-guided delivery of Doxorubicin resulted in a higher concentration of Doxorubicin in liver cancer stem cells. The combinatorial treatment strategy of CD133 aptamer-Doxorubicin conjugates and an autophagy inhibitor showed a significantly higher elimination of liver cancer stem cells in vitro.
Article
Oncology
Ahmed A. Abd-Rabou, Hanaa H. Ahmed, Mohamed S. Kishta
Summary: In this study, aptamer nanoparticles loaded with viramidine (VRM) were used to interfere with hepatocellular carcinoma (HCC) cells through NO-mediated extrinsic and intrinsic apoptosis.
Article
Microbiology
Suzanne Pickering, Jonathan Sumner, Claire Kerridge, Marianne Perera, Stuart Neil
Summary: The HIV-1 Vpu protein inhibits NF-κB signaling by binding and inhibiting β-TrCP, and it simultaneously exploits the different paralogues of β-TrCP to degrade its cellular targets, resulting in potent inhibition of both the canonical and non-canonical NF-κB pathways.
Review
Biochemistry & Molecular Biology
Moo-Kon Song, Byeong-Bae Park, Ji-Eun Uhm
Summary: Acute myeloid leukemia (AML) is a heterogeneous hematopoietic neoplasm characterized by genetic abnormalities that have significant prognostic implications. Understanding the molecular abnormalities of the disease may lead to the development of novel targeted therapies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Physiology
Xietian Pan, Chengxiang Li, Haokao Gao
Summary: The study identified that in high glucose conditions, beta-arrestin resistance leads to increased vulnerability of cardiomyocytes, partly due to disruption of the beta-arrestin signaling pathway.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Oncology
Julius Semenas, Tianyan Wang, Azharuddin Sajid Syed Khaja, A. K. M. Firoj Mahmud, Athanasios Simoulis, Thomas Grundstrom, Maria Fallman, Jenny L. Persson
Summary: Tamoxifen shows good tolerance in heavily pretreated castration-resistant prostate cancer patients. It exerts inhibitory effects by targeting cyclin D1 and PIP5K1 alpha/AKT network in prostate cancer cells, and can achieve superior inhibition when used in combination with other inhibitors such as ISA-2011B.
MOLECULAR ONCOLOGY
(2021)
Article
Pharmacology & Pharmacy
Xiao-guo Suo, Fang Wang, Chuan-hui Xu, Xiao-yan He, Jia-nan Wang, Yao Zhang, Wei-jian Ni, Hao Lu, Ming-lu Ji, Yuan He, Shuai-shuai Xie, Ya-ru Yang, Jia-gen Wen, Juan Jin, Qian Gong, Jun Li, Ming-ming Liu, Xiao-ming Meng
Summary: This study found that the expression levels of TGF-beta 1 and its receptor 1 were increased in obstructive fibrosis kidneys. The results showed that AZ12601011 could ameliorate renal injuries and fibrosis by blocking the TGF-beta/Smad3 signaling pathway.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Oncology
Thoria Donia, Mohamed Abouda, Mohamed Kelany, Mohamed Hessien
Summary: The study demonstrates the dual autophagic and apoptotic effects of inhibiting beta-arrestins in triple-negative breast cancer cells. These findings suggest beta-arrestins as selective targets in breast cancer treatment.
Article
Pharmacology & Pharmacy
Yi Ning, Xiaoqi Wang, Pingan Chen, Shiwu Liu, Jue Hu, Rong Xiao, Ling Li, Fangguo Lu
Summary: In this study, a specific aptamer targeting MRSA was obtained using SELEX method, and a bifunctional complex with anti-biofilm activity was prepared by combining the aptamer with berberine. The complex inhibits MRSA biofilm formation by blocking PBP2a function and reducing agr system level, and it has potential for the treatment of chronic MRSA infections and multitarget treatment of bacterial biofilms.
Article
Chemistry, Analytical
Xueli Wang, Chengke Wang, Hei-Nga Chan, Iyaswamy Ashok, Senthil Kumar Krishnamoorthi, Min Li, Hung-Wing Li, Man Shing Wong
Summary: Novel near infrared emissive fluorophores exhibit strong selectivity towards Aβ oligomers and monomers, good biocompatibility and stability, and significant inhibitory effects on Aβ aggregation.
Article
Biochemistry & Molecular Biology
Reiko Iida, Misuzu Ueki, Toshihiro Yasuda
Summary: M-LP/Mpv17L is a unique PDE protein that plays a role in beta-cell hyperplasia and improved glucose tolerance. Its deficiency leads to activation of the Wnt and TGF-β signaling pathways, affecting the development and maintenance of beta-cells.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2022)
Article
Biochemistry & Molecular Biology
Jung-Il Kang, Youn Kyung Choi, Sang-Chul Han, Hyunwoo Nam, Gilwoo Lee, Ji-Hoon Kang, Young Sang Koh, Jin Won Hyun, Eun-Sook Yoo, Hee-Kyoung Kang
Summary: This study found that BDB promotes hair growth in rat models by activating the Wnt/β-catenin and autophagy pathways, while inhibiting the TGF-β pathway, thus regulating the hair cycle.
Article
Pharmacology & Pharmacy
Lianxia Guo, Tianpeng Zhang, Fei Wang, Xun Chen, Haiman Xu, Cui Zhou, Min Chen, Fangjun Yu, Shuai Wang, Deguang Yang, Baojian Wu
Summary: The study showed that Rev-erb-alpha and Rev-erb-beta play crucial roles in regulating AKI and ferroptosis, and targeted inhibition of these molecules can alleviate AKI. Misregulation of circadian clock components may contribute to the occurrence of ferroptosis, exacerbating the severity of AKI.
BRITISH JOURNAL OF PHARMACOLOGY
(2021)