Mechanism of drug extrusion by brain endothelial cells via lysosomal drug trapping and disposal by neutrophils

Autophagy and doxorubicin resistance in cancer

(2018) Chao Chen et al.   ANTI-CANCER DRUGS

P-gp Protein Expression and Transport Activity in Rodent Seizure Models and Human Epilepsy

(2017) Anika M. S. Hartz et al.   MOLECULAR PHARMACEUTICS

Cellular Models and In Vitro Assays for the Screening of modulators of P-gp, MRP1 and BCRP

(2017) Mariline Gameiro et al.   MOLECULES

Crosstalk of cell polarity signaling pathways

(2017) Tomáš Mazel   PROTOPLASMA

Extracellular Vesicles: Novel Mediators of Cell Communication In Metabolic Disease

(2017) Isabel Huang-Doran et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Neutrophil Biology and the Next Generation of Myeloid Growth Factors

(2017) David C. Dale   Journal of the National Comprehensive Cancer Network

Role of autophagy and lysosomal drug sequestration in acquired resistance to doxorubicin in MCF-7 cells

(2016) Baoqing Guo et al.   BMC CANCER

Immortalized endothelial cell lines for in vitro blood–brain barrier models: A systematic review

(2016) Nurul Adhwa Rahman et al.   BRAIN RESEARCH

Neutrophil extracellular trap formation in theStreptococcus suis-infected cerebrospinal fluid compartment

(2016) Nicole de Buhr et al.   CELLULAR MICROBIOLOGY

Lysosomes as mediators of drug resistance in cancer

(2016) Benny Zhitomirsky et al.   DRUG RESISTANCE UPDATES

New experimental models of the blood-brain barrier for CNS drug discovery

(2016) Mohammad A. Kaisar et al.   Expert Opinion on Drug Discovery

Turning the gun on cancer: Utilizing lysosomal P-glycoprotein as a new strategy to overcome multi-drug resistance

(2016) Nicole Seebacher et al.   FREE RADICAL BIOLOGY AND MEDICINE

Focus on Extracellular Vesicles: New Frontiers of Cell-to-Cell Communication in Cancer

(2016) Chiara Ciardiello et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

In vitro models of the blood–brain barrier: An overview of commonly used brain endothelial cell culture models and guidelines for their use

(2016) Hans C Helms et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Molecular mechanisms of LL-37-induced receptor activation: An overview

(2016) Eddy-Tim Verjans et al.   PEPTIDES

Microtubule and Actin Interplay Drive Intracellular c-Src Trafficking

(2016) Christopher Arnette et al.   PLoS One

Intercellular transfer of P-glycoprotein in human blood-brain barrier endothelial cells is increased by histone deacetylase inhibitors

(2016) Andreas Noack et al.   Scientific Reports

Glucose Modulation Induces Lysosome Formation and Increases Lysosomotropic Drug Sequestration via the P-Glycoprotein Drug Transporter

(2015) Nicole A. Seebacher et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Quantitative Determination of Luminal and Abluminal Membrane Distributions of Transporters in Porcine Brain Capillaries by Plasma Membrane Fractionation and Quantitative Targeted Proteomics

(2015) Yoshiyuki Kubo et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Microparticles in cancer: A review of recent developments and the potential for clinical application

(2015) Joyce Gong et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Ectosomes and exosomes: shedding the confusion between extracellular vesicles

(2015) Emanuele Cocucci et al.   TRENDS IN CELL BIOLOGY

The Mechanism of Phagocytosis: Two Stages of Engulfment

(2014) David M. Richards et al.   BIOPHYSICAL JOURNAL

Neutrophils sense microbe size and selectively release neutrophil extracellular traps in response to large pathogens

(2014) Nora Branzk et al.   NATURE IMMUNOLOGY

Drug-Induced Trafficking of P-Glycoprotein in Human Brain Capillary Endothelial Cells as Demonstrated by Exposure to Mitomycin C

(2014) Andreas Noack et al.   PLoS One

Extracellular vesicles: emerging targets for cancer therapy

(2014) Pieter Vader et al.   TRENDS IN MOLECULAR MEDICINE

Lysosomal Adaptation: How the Lysosome Responds to External Cues

(2014) C. Settembre et al.   Cold Spring Harbor Perspectives in Biology

Microparticle drug sequestration provides a parallel pathway in the acquisition of cancer drug resistance

(2013) Joyce Gong et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

P-glycoprotein Mediates Drug Resistance via a Novel Mechanism Involving Lysosomal Sequestration

(2013) Tetsuo Yamagishi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Biogenesis of extracellular vesicles (EV): exosomes, microvesicles, retrovirus-like vesicles, and apoptotic bodies

(2013) Johnny C. Akers et al.   JOURNAL OF NEURO-ONCOLOGY

Extracellular vesicles: communication, coercion, and conditioning

(2013) David A. Shifrin et al.   MOLECULAR BIOLOGY OF THE CELL

Where is it and How Does it Get There – Intracellular Localization and Traffic of P-glycoprotein

(2013) Dong Fu   Frontiers in Oncology

Neutrophil Function: From Mechanisms to Disease

(2012) Borko Amulic et al.   Annual Review of Immunology

Innate immunity in the central nervous system

(2012) Richard M. Ransohoff et al.   JOURNAL OF CLINICAL INVESTIGATION

Transcriptional Profiling of Human Brain Endothelial Cells Reveals Key Properties Crucial for Predictive In Vitro Blood-Brain Barrier Models

(2012) Eduard Urich et al.   PLoS One

Localization Microscopy (SPDM) Reveals Clustered Formations of P-Glycoprotein in a Human Blood-Brain Barrier Model

(2012) Olga Huber et al.   PLoS One

Membrane vesicles, current state-of-the-art: emerging role of extracellular vesicles

(2011) Bence György et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Ectosomes

(2011) Emanuele Cocucci et al.   CURRENT BIOLOGY

Anti-inflammatory effects of kaempferol-3-O-sophoroside in human endothelial cells

(2011) Tae Hoon Kim et al.   INFLAMMATION RESEARCH

Target-specific mechanics of phagocytosis: protrusive neutrophil response to zymosan differs from the uptake of antibody-tagged pathogens

(2011) C.-Y. Lee et al.   JOURNAL OF CELL SCIENCE

Sensitive and Specific Fluorescent Probes for Functional Analysis of the Three Major Types of Mammalian ABC Transporters

(2011) Irina V. Lebedeva et al.   PLoS One

Lysosomal trapping of a radiolabeled substrate of P-glycoprotein as a mechanism for signal amplification in PET

(2011) P. Kannan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neutrophils block permeability increases induced by oxygen glucose deprivation in a culture model of the human blood–brain barrier

(2010) Krystyna M. Cowan et al.   BRAIN RESEARCH

Reversal of ABC Drug Transporter-Mediated Multidrug Resistance in Cancer Cells: Evaluation of Current Strategies

(2010) Chung-Pu Wu et al.   Current Molecular Pharmacology

Regulated Exocytosis and Vesicle Trafficking in Astrocytes

(2009) Marko Kreft et al.   Annals of the New York Academy of Sciences

Modulation of blood–brain barrier permeability by neutrophils: in vitro and in vivo studies

(2009) Shannon L. Joice et al.   BRAIN RESEARCH

Potent and Selective Inhibitors of Breast Cancer Resistance Protein (ABCG2) Derived from thep-Glycoprotein (ABCB1) Modulator Tariquidar

(2009) Matthias Kühnle et al.   JOURNAL OF MEDICINAL CHEMISTRY

Structure and function of the blood–brain barrier

(2009) N. Joan Abbott et al.   NEUROBIOLOGY OF DISEASE

Autophagy and multivesicular bodies: two closely related partners

(2008) C M Fader et al.   CELL DEATH AND DIFFERENTIATION