Lysosomal trapping of a radiolabeled substrate of P-glycoprotein as a mechanism for signal amplification in PET

Synthesis and evaluation of [11C]XR9576 to assess the function of drug efflux transporters using PET

(2010) Kazunori Kawamura et al.   ANNALS OF NUCLEAR MEDICINE

Synthesis and in vivo evaluation of [11C]tariquidar, a positron emission tomography radiotracer based on a third-generation P-glycoprotein inhibitor

(2010) Florian Bauer et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Probing Multidrug Resistance P-glycoprotein Transporter Activity with SPECT Radiopharmaceuticals

(2010) David Piwnica-Worms et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

N-desmethyl-Loperamide Is Selective for P-Glycoprotein among Three ATP-Binding Cassette Transporters at the Blood-Brain Barrier

(2010) P. Kannan et al.   DRUG METABOLISM AND DISPOSITION

P-Glycoprotein Function at the Blood-Brain Barrier in Humans Can Be Quantified with the Substrate Radiotracer 11C-N-Desmethyl-Loperamide

(2010) W. C. Kreisl et al.   JOURNAL OF NUCLEAR MEDICINE

The Role of Lysosomes in Limiting Drug Toxicity in Mice

(2010) R. A. Ndolo et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Imaging the Function of P-Glycoprotein With Radiotracers: Pharmacokinetics and In Vivo Applications

(2009) P Kannan et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Quantitative techniques in 18FDG PET scanning in oncology

(2008) F Castell et al.   BRITISH JOURNAL OF CANCER

Synthesis and Evaluation of [N-methyl-11C]N-Desmethyl-loperamide as a New and Improved PET Radiotracer for Imaging P-gp Function

(2008) Neva Lazarova et al.   JOURNAL OF MEDICINAL CHEMISTRY

P-Glycoprotein Function at the Blood-Brain Barrier Imaged Using 11C-N-Desmethyl-Loperamide in Monkeys

(2008) J.-S. Liow et al.   JOURNAL OF NUCLEAR MEDICINE

11C-Loperamide and Its N-Desmethyl Radiometabolite Are Avid Substrates for Brain Permeability-Glycoprotein Efflux

(2008) S. S. Zoghbi et al.   JOURNAL OF NUCLEAR MEDICINE

Profiling SLCO and SLC22 genes in the NCI-60 cancer cell lines to identify drug uptake transporters

(2008) M. Okabe et al.   MOLECULAR CANCER THERAPEUTICS