Effects of high-fat diet feeding on Znt8-null mice: differences between β-cell and global knockout of Znt8

β-Cell Uncoupling Protein 2 Regulates Reactive Oxygen Species Production, Which Influences Both Insulin and Glucagon Secretion

(2011) Christine A. Robson-Doucette et al.   DIABETES

Glucose Regulates Free Cytosolic Zn2+Concentration, Slc39 (ZiP), and Metallothionein Gene Expression in Primary Pancreatic Islet β-Cells

(2011) Elisa A. Bellomo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Vhl is required for normal pancreatic β cell function and the maintenance of β cell mass with age in mice

(2011) Diana Choi et al.   LABORATORY INVESTIGATION

Human Islet Distribution Program for Basic Research at a Single Center

(2011) T. Kin et al.   TRANSPLANTATION PROCEEDINGS

The longitudinal association of common susceptibility variants for type 2 diabetes and obesity with fasting glucose level and BMI

(2010) Rebecca J Webster et al.   BMC Medical Genetics

Deletion of Pten in Pancreatic  -Cells Protects Against Deficient  -Cell Mass and Function in Mouse Models of Type 2 Diabetes

(2010) L. Wang et al.   DIABETES

Conditional Gene Targeting in Mouse Pancreatic  -Cells: Analysis of Ectopic Cre Transgene Expression in the Brain

(2010) B. Wicksteed et al.   DIABETES

Beta cell-specific Znt8 deletion in mice causes marked defects in insulin processing, crystallisation and secretion

(2010) N. Wijesekara et al.   DIABETOLOGIA

Free zinc ions outside a narrow concentration range are toxic to a variety of cells in vitro

(2010) Rebecca A Bozym et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Association between Type 2 Diabetes Loci and Measures of Fatness

(2010) Slavica Pecioska et al.   PLoS One

Downregulation of ZnT8 expression in pancreatic β-cells of diabetic mice

(2010) Motoyuki Tamaki et al.   Islets

20-Hydroxyecdysone decreases weight and hyperglycemia in a diet-induced obesity mice model

(2009) Pablo Kizelsztein et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Deletion of the mouseSlc30a8gene encoding zinc transporter-8 results in impaired insulin secretion

(2009) Lynley D. Pound et al.   BIOCHEMICAL JOURNAL

Loss of Lkb1 in Adult β Cells Increases β Cell Mass and Enhances Glucose Tolerance in Mice

(2009) Accalia Fu et al.   Cell Metabolism

Confirmation of Multiple Risk Loci and Genetic Impacts by a Genome-Wide Association Study of Type 2 Diabetes in the Japanese Population

(2009) F. Takeuchi et al.   DIABETES

Insulin Storage and Glucose Homeostasis in Mice Null for the Granule Zinc Transporter ZnT8 and Studies of the Type 2 Diabetes-Associated Variants

(2009) T. J. Nicolson et al.   DIABETES

Characterization of Erg K+Channels in α- and β-Cells of Mouse and Human Islets

(2009) Alexandre B. Hardy et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Uncoupling protein 2 regulates reactive oxygen species formation in islets and influences susceptibility to diabetogenic action of streptozotocin

(2009) Simon C Lee et al.   JOURNAL OF ENDOCRINOLOGY

Insulin crystallization depends on zinc transporter ZnT8 expression, but is not required for normal glucose homeostasis in mice

(2009) K. Lemaire et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The genetic susceptibility to type 2 diabetes may be modulated by obesity status: implications for association studies

(2008) Stéphane Cauchi et al.   BMC Medical Genetics

Common Variants in CDKAL1, CDKN2A/B, IGF2BP2, SLC30A8, and HHEX/IDE Genes Are Associated With Type 2 Diabetes and Impaired Fasting Glucose in a Chinese Han Population

(2008) Y. Wu et al.   DIABETES

Implication of Genetic Variants Near TCF7L2, SLC30A8, HHEX, CDKAL1, CDKN2A/B, IGF2BP2, and FTO in Type 2 Diabetes and Obesity in 6,719 Asians

(2008) M. C.Y. Ng et al.   DIABETES

Adiposity-Related Heterogeneity in Patterns of Type 2 Diabetes Susceptibility Observed in Genome-Wide Association Data

(2008) N. J. Timpson et al.   DIABETES

A gene expression network model of type 2 diabetes links cell cycle regulation in islets with diabetes susceptibility

(2008) M. P. Keller et al.   GENOME RESEARCH

Diabetes-linked zinc transporter ZnT8 is a homodimeric protein expressed by distinct rodent endocrine cell types in the pancreas and other glands

(2008) C. Murgia et al.   NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES