Review of the Structural and Dynamic Mechanisms of PPARγPartial Agonism

On the Metabolically Active Form of Metaglidasen: Improved Synthesis and Investigation of Its Peculiar Activity on Peroxisome Proliferator-Activated Receptors and Skeletal Muscles

(2015) Antonio Laghezza et al.   ChemMedChem

Thiazolidinediones and Edema: Recent Advances in the Pathogenesis of Thiazolidinediones-Induced Renal Sodium Retention

(2015) Shoko Horita et al.   PPAR Research

Transcriptional Coregulators: Fine-Tuning Metabolism

(2014) Laurent Mouchiroud et al.   Cell Metabolism

Can a Selective PPARγ Modulator Improve Glycemic Control in Patients With Type 2 Diabetes With Fewer Side Effects Compared With Pioglitazone?

(2014) Alex M. DePaoli et al.   DIABETES CARE

Pioglitazone has a dubious bladder cancer risk but an undoubted cardiovascular benefit

(2014) R. E. J. Ryder   DIABETIC MEDICINE

An ERK/Cdk5 axis controls the diabetogenic actions of PPARγ

(2014) Alexander S. Banks et al.   NATURE

Design and synthesis of a series of α-benzyl phenylpropanoic acid-type peroxisome proliferator-activated receptor (PPAR) gamma partial agonists with improved aqueous solubility

(2013) Masao Ohashi et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Structural Characterization of Amorfrutins Bound to the Peroxisome Proliferator-Activated Receptor γ

(2013) Jens C. de Groot et al.   JOURNAL OF MEDICINAL CHEMISTRY

Looking at nuclear receptors from a new angle

(2013) Christine Helsen et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Design, synthesis, and evaluation of imidazo[4,5-c]pyridin-4-one derivatives with dual activity at angiotensin II type 1 receptor and peroxisome proliferator-activated receptor-γ

(2012) Agustin Casimiro-Garcia et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis and biological evaluation of novel (−)-cercosporamide derivatives as potent selective PPARγ modulators

(2012) Akihiro Furukawa et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Structural basis for telmisartan-mediated partial activation of PPAR gamma

(2012) Yasushi Amano et al.   HYPERTENSION RESEARCH

GQ-16, a Novel Peroxisome Proliferator-activated Receptor γ (PPARγ) Ligand, Promotes Insulin Sensitization without Weight Gain

(2012) Angélica A. Amato et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Balaglitazone: A Second Generation Peroxisome Proliferator-Activated Receptor (PPAR) Gamma (γ) Agonist

(2012) R. Agrawal et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

Individualized Therapy for Type 2 Diabetes

(2012) Gaia Chiara Mannino et al.   Molecular Diagnosis & Therapy

Medium Chain Fatty Acids Are Selective Peroxisome Proliferator Activated Receptor (PPAR) γ Activators and Pan-PPAR Partial Agonists

(2012) Marcelo Vizoná Liberato et al.   PLoS One

Amorfrutins are potent antidiabetic dietary natural products

(2012) C. Weidner et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pharmacology and in Vitro Profiling of a Novel Peroxisome Proliferator-Activated Receptor γ Ligand, Cerco-A

(2011) Kenji Wakabayashi et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Discovery of GSK1997132B a novel centrally penetrant benzimidazole PPARγ partial agonist

(2011) Mairi Sime et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Substituents at the naphthalene C3 position of (−)-Cercosporamide derivatives significantly affect the maximal efficacy as PPARγ partial agonists

(2011) Akihiro Furukawa et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Thiazolidinediones Enhance Sodium-Coupled Bicarbonate Absorption from Renal Proximal Tubules via PPARγ-Dependent Nongenomic Signaling

(2011) Yoko Endo et al.   Cell Metabolism

Peroxisome Proliferator-Activated Receptor γ Is a Target for Halogenated Analogs of Bisphenol A

(2011) Anne Riu et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Discovery of a Series of Imidazo[4,5-b]pyridines with Dual Activity at Angiotensin II Type 1 Receptor and Peroxisome Proliferator-Activated Receptor-γ

(2011) Agustin Casimiro-Garcia et al.   JOURNAL OF MEDICINAL CHEMISTRY

Antidiabetic actions of a non-agonist PPARγ ligand blocking Cdk5-mediated phosphorylation

(2011) Jang Hyun Choi et al.   NATURE

Discovery of a novel selective PPARγ modulator from (−)-Cercosporamide derivatives

(2010) Akihiro Furukawa et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Drug-Induced Idiosyncratic Hepatotoxicity: Prevention Strategy Developed after the Troglitazone Case

(2010) Toshihiko Ikeda   Drug Metabolism and Pharmacokinetics

The nuclear receptor PPARγ individually responds to serotonin- and fatty acid-metabolites

(2010) Tsuyoshi Waku et al.   EMBO JOURNAL

Endogenous Ligands for Nuclear Receptors: Digging Deeper

(2010) Michael Schupp et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Anti-diabetic drugs inhibit obesity-linked phosphorylation of PPARγ by Cdk5

(2010) Jang Hyun Choi et al.   NATURE

Molecular Mechanisms and Genome-Wide Aspects of PPAR Subtype Specific Transactivation

(2010) Anne Bugge et al.   PPAR Research

INT131: A Selective Modulator of PPARγ

(2009) Alykhan Motani et al.   JOURNAL OF MOLECULAR BIOLOGY

Fat and Beyond: The Diverse Biology of PPARγ

(2008) Peter Tontonoz et al.   Annual Review of Biochemistry

Highly functionalized 7-azaindoles as selective PPARγ modulators

(2008) Sheryl D. Debenham et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

T2384, a Novel Antidiabetic Agent with Unique Peroxisome Proliferator-activated Receptor γ Binding Properties

(2008) Yang Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Crystal Structure of the Peroxisome Proliferator-Activated Receptor γ (PPARγ) Ligand Binding Domain Complexed with a Novel Partial Agonist: A New Region of the Hydrophobic Pocket Could Be Exploited for Drug Design

(2008) Roberta Montanari et al.   JOURNAL OF MEDICINAL CHEMISTRY

Structure of the intact PPAR-γ–RXR-α nuclear receptor complex on DNA

(2008) Vikas Chandra et al.   NATURE

Molecular recognition of nitrated fatty acids by PPARγ

(2008) Yong Li et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The Development of INT131 as a Selective PPAR Modulator: Approach to a Safer Insulin Sensitizer

(2008) Linda S. Higgins et al.   PPAR Research