Review
Biochemistry & Molecular Biology
Babak Pakbin, Wolfram Manuel Brueck, Thomas B. Brueck
Summary: Shigella species are a major concern in public health as they cause bacillary diarrhea or shigellosis in humans. This study reviewed the molecular mechanisms of pathogenesis in Dysenteriae and non-Dysenteriae clinical groups, including attachment, invasion, intracellular motility, toxin secretion, and host cell interruption mechanisms. Understanding these mechanisms can help in detecting and differentiating Shigella strains and developing strategies to prevent and treat infections caused by these enteric pathogens.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Yongdong Su, Andrew L. Hong
Summary: Renal medullary carcinoma (RMC) is a rare renal malignancy that primarily occurs in adolescents and young adults of African ancestry. This aggressive cancer is driven by the loss of the tumor suppressor SMARCB1, and limited knowledge of RMC biology has hindered treatment options. However, significant advances have been made in understanding the genomics and therapeutic targets of RMC in the past 5 years.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Materials Science, Multidisciplinary
Sai Wang, Cheng Liu, Fei Wang, Xia Yin, Jianyong Yu, Shichao Zhang, Bin Ding
Summary: Extremely cold environments have serious impacts on public health and the economy. Fibrous materials, particularly ultrafine fibers, have been widely recognized as effective heat insulation materials. This review provides an overview of heat transfer mechanisms for single fibers and fiber assemblies, and summarizes the different types of ultrafine fibrous materials for warmth retention. The challenges and prospects of ultrafine fibrous materials for effective warmth retention are also discussed.
ADVANCED FIBER MATERIALS
(2023)
Review
Immunology
Yihao Chen, Shengpan Chen, Jianbo Chang, Junji Wei, Ming Feng, Renzhi Wang
Summary: PHE is considered a promising therapeutic target for ICH, but existing research results are conflicting. Therefore, it is necessary to classify, compare, and summarize existing studies on PHE.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Saeed Aslani, Seyed Mohamad Javad Mirarefin, Habib Zarredar, Milad Asadi, Mohammad Reza Javan, Arezou Khosrojerdi, Thomas P. Johnston, Amirhossein Sahebkar
Summary: Psoriasis is a chronic autoimmune disorder of the skin characterized by abnormal proliferation and differentiation of keratinocytes. The disease is triggered by a complex interplay between environmental and genetic factors, with epigenetic regulation playing a crucial role in the development of psoriasis. Aberrant epigenetic changes, including DNA methylation, histone modifications, and non-coding RNA transcription, have been observed in psoriatic patients. Various compounds and drugs targeting these epigenetic modifications have shown therapeutic potential in clinical trials. This review aims to summarize recent findings on epigenetic irregularities in psoriasis and discuss future challenges.
CURRENT MEDICINAL CHEMISTRY
(2023)
Review
Immunology
Yean Kong Yong, Won Fen Wong, Ramachandran Vignesh, Indranil Chattopadhyay, Vijayakumar Velu, Hong Yien Tan, Ying Zhang, Marie Larsson, Esaki M. Shankar
Summary: This study reviews the latest research progress in understanding the immunopathogenesis of dengue and provides suggestions for targeted strategies against dengue.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Cell Biology
Jan Philipp Bewersdorf, Omar Abdel-Wahab
Summary: This review discusses the development of promising new molecular targeted approaches for AML, as well as progress in immune targeting of AML through various antibodies and cellular therapies. Despite FDA approval of new drugs for AML, it remains a major area of unmet medical need among hematologic malignancies.
GENES & DEVELOPMENT
(2022)
Review
Endocrinology & Metabolism
Congli Chen, Yanmei Sang
Summary: Congenital hyperinsulinemia (CHI) is a clinically diverse disorder that causes persistent and recurrent hypoglycemia in infancy and childhood. There are 16 subtypes of CHI-related genes, with phosphomannomutase 2 hyperinsulinemia (PMM2-HI) being an extremely rare subtype. This review highlights the genetic pathogenesis, and current diagnostic and therapeutic advances of PMM2-HI to raise awareness among clinicians.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Chemistry, Multidisciplinary
Kuan Wang, Haoxiang Zhuo, Jiantao Wang, Fanny Poon, Xueliang Sun, Biwei Xiao
Summary: Sodium-ion batteries, known for their low cost and high safety, have gained significant attention recently as a potential replacement for lithium-ion batteries. This review focuses on the progress of Mn-rich layered materials for sodium-ion batteries, exploring the principles of phase formation, structure transformation, and charge compensation mechanisms, as well as discussing potential challenges in achieving high-performance materials.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Review
Cell Biology
Anna-Lena Mueller, Zahra Payandeh, Niloufar Mohammadkhani, Shaden M. H. Mubarak, Alireza Zakeri, Armina Alagheband Bahrami, Aranka Brockmueller, Mehdi Shakibaei
Summary: Rheumatoid arthritis is a chronic systemic, multifactorial, inflammatory, and progressive autoimmune disease that affects the musculoskeletal system, leading to severe joint damage. Early diagnosis is crucial for preventing joint damage and physical disability. In addition to auto-antibodies, various factors play a role in the progression of rheumatoid arthritis.
Review
Chemistry, Multidisciplinary
Sumon Sarkar, Kelvin Pak Shing Cheung, Vladimir Gevorgyan
Summary: Visible light-induced Pd catalysis is a promising subfield of photocatalysis, enabling radical-based transformations otherwise challenging or unknown in conventional Pd chemistry. Recent discoveries have also shown that photoexcitation can alter oxidative addition and other elementary steps. This Minireview highlights the recent progress in this emerging area.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Review
Nutrition & Dietetics
Flavio Tidona, Miriam Zago, Domenico Carminati, Giorgio Giraffa
Summary: Public awareness about excessive sodium intake necessitates the reevaluation of composition and processing methods for high sodium foods in the food industry. Reducing salt content in cheese poses challenges due to the various functions of sodium chloride in cheese manufacturing and ripening. Salt affects cheese texture, taste, aroma, microbial growth, and shelf-life. Targeted strategies are needed to maintain the quality and safety of different cheese categories when decreasing sodium content.
FRONTIERS IN NUTRITION
(2022)
Review
Immunology
Motoi Yamashita, Kento Inoue, Tsubasa Okano, Tomohiro Morio
Summary: Primary Immunodeficiency (PID) is a genetic disorder affecting the immune system, while Inborn Errors of Immunity (IEI) encompasses a broader range of immune dysfunction disorders. Advances in genetic analysis have aided in identifying disease-causing gene mutations, with treatments for IEI including hematopoietic cell transplantation and gene therapy. Further research on IEI is expected to provide insights into other immune-related disorders.
INFLAMMATION AND REGENERATION
(2021)
Article
Chemistry, Multidisciplinary
Mengdan Yan, Yuchen Qin, Lixia Wang, Meirong Song, Dandan Han, Qiu Jin, Shiju Zhao, Miaomiao Zhao, Zhou Li, Xinyang Wang, Lei Meng, Xiaopeng Wang
Summary: This article provides a systematic summary of recent progress on biomass-derived carbons for sodium-ion energy storage, highlighting the importance of this technology in grid-scale storage. It discusses the principles and challenges of improving sodium-ion storage using biomass-derived carbons, aiming to guide future research in this area.
Article
Food Science & Technology
Xiangcun Wang, Long Chen, David Julian McClements, Zhengyu Jin
Summary: This paper reviews the methods of maintaining the crispness of microwaveable frozen pre-fried foods, summarizes the physicochemical mechanisms of crispness loss, and highlights methods such as optimizing batter ingredients, controlling frying and cooling parameters, as well as using microwave packaging and auxiliary heating methods to protect the crispness of these foods.
TRENDS IN FOOD SCIENCE & TECHNOLOGY
(2023)
Article
Multidisciplinary Sciences
Katsuhiro Kawaai, Hideaki Ando, Nobuhiko Satoh, Hideomi Yamada, Naoko Ogawa, Matsumi Hirose, Akihiro Mizutani, Benjamin Bonneau, George Seki, Katsuhiko Mikoshiba
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2017)
Review
Biotechnology & Applied Microbiology
Nobuhiko Satoh, Motonobu Nakamura, Atsushi Suzuki, Hiroyuki Tsukada, Shoko Horita, Masashi Suzuki, Kyoji Moriya, George Seki
BIOMED RESEARCH INTERNATIONAL
(2017)
Article
Genetics & Heredity
Shoko Horita, Enver Simsek, Tulay Simsek, Nilgun Yildirim, Hiroyuki Ishiura, Motonobu Nakamura, Nobuhiko Satoh, Atsushi Suzuki, Hiroyuki Tsukada, Tomohito Mizuno, George Seki, Shoji Tsuji, Masaomi Nangaku
BMC MEDICAL GENETICS
(2018)
Article
Urology & Nephrology
Motonobu Nakamura, Hiroyuki Tsukada, George Seki, Nobuhiko Satoh, Tomohito Mizuno, Wataru Fujii, Shoko Horita, Kyoji Moriya, Yusuke Sato, Haruki Kume, Masaomi Nangaku, Masashi Suzuki
KIDNEY INTERNATIONAL
(2020)
Article
Physiology
M. Nakamura, N. Satoh, H. Tsukada, T. Mizuno, W. Fujii, A. Suzuki, S. Horita, M. Nangaku, M. Suzuki
PHYSIOLOGY INTERNATIONAL
(2020)
Article
Education & Educational Research
Shoko Horita, Yoon-Soo Park, Daisuke Son, Masato Eto
Summary: The study found that there were correlations between the results of Japan Residency Matching Program (JRMP) and certain factors/stations of pre-clinical clerkship (OSCE), while no correlation was found between the JRMP results and Computer-Based Test (CBT) results. It was also discovered that scores from the pre-clinical clerkship OSCE and CBT could predict important outcomes like JRMP and National Board Examination (NBE).
BMC MEDICAL EDUCATION
(2021)
Article
Biochemistry & Molecular Biology
Tomohito Mizuno, Nobuhiko Satoh, Shoko Horita, Hiroyuki Tsukada, Mayuko Takagi, Yusuke Sato, Haruki Kume, Masaomi Nangaku, Motonobu Nakamura
Summary: Oxidized phospholipid azPC stimulates renal proximal tubule sodium-coupled bicarbonate transport via the CD36/PPAR gamma/mitogen-activated protein/ERK kinase/ERK pathway.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2022)
Article
Medicine, General & Internal
Junki Mizumoto, Daisuke Son, Masashi Izumiya, Shoko Horita, Masato Eto
Summary: By learning about the social determinants of health and assessment tools, residents acquired knowledge and skills, reflected on their previous practice, and changed their views. They learned when and how to ask about patients' social conditions and coordinate medical care appropriately. Medical education about the social determinants of health can trigger changes in residents' views.
JOURNAL OF GENERAL AND FAMILY MEDICINE
(2022)
Article
Education, Scientific Disciplines
Junki Mizumoto, Toshichika Mitsuyama, Satoshi Kondo, Masashi Izumiya, Shoko Horita, Masato Eto
Summary: This study describes the process of patient care related to social determinants of health (SDH) in primary care settings, using a modified Delphi technique to generate expert consensus. The process was divided into four components: communication, practice, maintenance, and advocacy, with an emphasis on ongoing patient-physician relationships and collaboration with professionals and stakeholders. Further research is needed to explore the impact of this framework on medical education, quality of patient care, and patient outcomes.
Article
Medicine, General & Internal
Junki Mizumoto, Toshichika Mitsuyama, Shinichiro Kumagaya, Masato Eto, Masashi Izumiya, Shoko Horita
Summary: This study explored the psychological and social effects of the COVID-19 disaster on nurses working in primary care, and how they overcame the difficulties. The findings showed that nurses faced various challenges during the pandemic, but also discovered strength and professionalism, and achieved personal growth through the Tojisha-Kenkyu framework.
JOURNAL OF GENERAL AND FAMILY MEDICINE
(2022)
Review
Pharmacology & Pharmacy
Motonobu Nakamura, Nobuhiko Satoh, Shoko Horita, Masaomi Nangaku
Summary: This review provides an overview of the relationship between mTOR and renal gluconeogenesis, emphasizing the importance of mTOR in regulating glucose metabolism, while also suggesting that mTOR signaling defects may lead to various pathological conditions.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Education & Educational Research
Hirohisa Fujikawa, Daisuke Son, Hiroko Mori, Satoshi Kondo, Shoko Horita, Masashi Izumiya, Masato Eto
Summary: This study aimed to develop a vaccination training course for medical students and assessed its educational effectiveness. The results showed that the course significantly improved students' vaccination techniques and confidence, and received positive evaluations.
BMC MEDICAL EDUCATION
(2023)
Review
Urology & Nephrology
Shoko Horita, Motonobu Nakamura, Masashi Suzuki, Nobuhiko Satoh, Atsushi Suzuki, Yukio Homma, Masaomi Nangaku
KIDNEY RESEARCH AND CLINICAL PRACTICE
(2017)