期刊
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 18, 期 17, 页码 4798-4801出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2008.07.103
关键词
PPAR; azaindole; indole; selective PPAR modulator; SPPARM
资金
- PPAR team
A series of highly functionalized 3-aroyl and 3-phenoxy-2-methyl-7-azaindoles have been identified, which are potent selective PPAR gamma modulators (SPPAR gamma Ms). Addition of substituents at the 6-position of the 7-azaindoles improves in vitro potency and pharmacokinetics. 7-Azaindoles have significantly improved off-target profiles compared to the parent indole series. (C) 2008 Elsevier Ltd. All rights reserved.
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