Article
Biochemistry & Molecular Biology
Deeksha Tiwari, Gaurava Srivastava, Omkar Indari, Vijay Tripathi, Mohammad Imran Siddiqi, Hem Chandra Jha
Summary: Recent reports suggest that persistent Epstein-Barr virus infection could lead to the formation of proteinaceous plaques in the brain, a hallmark of Alzheimer's disease. The apolipoprotein E (ApoE), a major genetic risk factor for AD, may also affect the outcome of EBV infection. This study investigates the interactions between ApoE and various EBV proteins, and finds possible stable interactions between the C-terminal domain of ApoE3 and EBV proteins EBNA1 and BZLF1. These interactions may interfere with the clearance of amyloid fragments from the brain, contributing to the development of AD.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Article
Microbiology
Shen Li, Li Yang, Yanling Li, Wenxing Yue, Shuyu Xin, Jing Li, Sijing Long, Wentao Zhang, Pengfei Cao, Jianhong Lu
Summary: EBV switches between latent and lytic phases in hosts, and the mechanism of controlling this viral biphasic life cycle remains largely unknown. This study identified BRD7 as a crucial host protein in EBV latent infection and revealed its role in regulating c-Myc expression.
MICROBIOLOGY SPECTRUM
(2023)
Article
Infectious Diseases
Anna E. Coghill, Jianwen Fang, Zhiwei Liu, Chien-Jen Chen, Ruth F. Jarrett, Henrik Hjalgrim, Carla Proietti, Kelly J. Yu, Wan-Lun Hsu, Pei-Jen Lou, Chen-Ping Wang, Yingdong Zhao, Denise L. Doolan, Allan Hildesheim
Summary: This study examined the IgG antibody responses against 115 EBV peptide sequences in 316 cancer-free adults and identified eight EBV peptide sequences that appear to play a role in immunogenicity. This finding is important for understanding the role of EBV in B-cell immunity in humans.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Immunology
Maria Inmaculada Dominguez-Mozo, Lorena Lopez-Lozano, Silvia Perez-Perez, Angel Garcia-Martinez, Maria Jose Torrejon, Rafael Arroyo, Roberto Alvarez-Lafuente
Summary: The study analyzed the prevalence and levels of EBV antibodies in MS patients in Spain, as well as their interactions with environmental and genetic risk factors. The results showed higher antibody levels in MS patients compared to healthy controls.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Samantha S. Soldan, Emma M. Anderson, Drew M. Frase, Yue Zhang, Lisa B. Caruso, Yin Wang, Julianna S. Deakyne, Benjamin E. Gewurz, Italo Tempera, Paul M. Lieberman, Troy E. Messick
Summary: The study demonstrated that the EBNA1 inhibitor VK-1727 selectively inhibited cell growth in EBV-positive gastric carcinoma and reduced tumor growth in animal models, but not in EBV-negative gastric carcinoma. Short-term treatment tended to activate viral genes, while long-term treatment resulted in significant decrease in viral gene expression.
Article
Oncology
Louise Zanella, Maria Elena Reyes, Ismael Riquelme, Michel Abanto, Daniela Leon, Tamara Viscarra, Carmen Ili, Priscilla Brebi
Summary: EBV, a globally distributed pathogen, is associated with various human cancers originating from B-cells and non-B-cells. The virus is classified into EBV-1 and EBV-2, differing in their transformation abilities, with EBV-1 being more efficient in transforming B-cells into LCL and EBV-2 preferring T-cell lymphocyte infection. The EBNA3A oncoprotein plays an essential role in B-cell transformation and has six nuclear localization signals (NLSs) that regulate nucleocytoplasmic protein trafficking, with variations in genetic patterns associated with EBV types.
Article
Biochemistry & Molecular Biology
Divya Singh, Omar Oudit, Sabastian Hajtovic, Dylan Sarbaugh, Rafatu Salis, Temitayo Adebowale, Justin James, Linda A. Spatz
Summary: Pathogens like the Epstein Barr virus have been implicated in the development of systemic lupus erythematosus (SLE), with EBNA-1 potentially playing a role through molecular mimicry. Antibodies generated in response to EBNA-1 have been shown to deposit in the kidney, inducing kidney damage.
MOLECULAR IMMUNOLOGY
(2021)
Article
Microbiology
Makoto Ohashi, Mitchell Hayes, Kyle McChesney, Eric Johannsen
Summary: EBV infection can lead to specific types of lymphoma and some epithelial cancers. In vitro, EBV infection of resting B-lymphocytes drives them to proliferate as lymphoblastoid cell lines, serving as a model for studying EBV lymphomagenesis. This study reveals that interaction between EBNA3C and CtBP results in EBNA3C-mediated upregulation.
Letter
Clinical Neurology
Ingrid Anne Lie, Brit Ellen Rod, Silje Stokke Kvistad, Trygve Holmoy, Kjell-Morten Myhr, Oivind Torkildsen, Stig Wergeland
Summary: This study investigated the effect of IFN beta-1a treatment on serum EBV antibody levels in patients with relapsing-remitting MS and found no significant associations between treatment and EBV antibody levels.
MULTIPLE SCLEROSIS AND RELATED DISORDERS
(2023)
Article
Immunology
Melissa E. Munroe, Jourdan R. Anderson, Timothy F. Gross, Laura L. Stunz, Gail A. Bishop, Judith A. James
Summary: This study explores the impact of the EBV molecular mimic EBNA-1 on disease-specific autoimmunity, finding that mCD40-LMP1 transgenic mice exhibit enhanced cellular and humoral immune responses after EBNA-1 immunization, suggesting an interaction between LMP1 and EBNA-1 that increases immune dysregulation leading to pathogenic, autoantigen-specific lupus inflammation.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Microbiology
Quincy Rosemarie, Elijah Kirschstein, Bill Sugden
Summary: We have discovered how Epstein-Barr virus (EBV) induces the reorganization of cellular chromatin, with viral DNA replication occurring in the chromatin-free regions. Five families of DNA viruses induce similar reorganization, and they infect a variety of hosts. The viral genes and processes required for EBV's chromatin reorganization have been identified, and a two-step model for the process has been proposed. The importance of chromatin reorganization in viral life cycles is emphasized. Overall, a 9 out of 10 score is given for the importance of this research.
Article
Chemistry, Analytical
Yunyun Hu, Ye Tian, Haonan Di, Chengfeng Xue, Yanping Zheng, Bin Hu, Qin Lin, Xiaomei Yan
Summary: This study utilized nanoflow cytometry to examine surface proteins on extracellular vesicles and found that EVSUM5 and EVSUM2 can effectively differentiate NPC patients from NPG patients, providing a more accurate diagnostic method.
ANALYTICAL CHEMISTRY
(2022)
Article
Immunology
Yiran Qu, Bingyang Zhang, Yingli Wang, Shuang Yin, Jordan L. Pederick, John B. Bruning, Yan Sun, Anton Middelberg, Jingxiu Bi
Summary: The study investigated the relationship between insertion sites in ferritin (N-terminus and C-terminus) and immune responses, finding that C-terminus insertion resulted in a stronger cell-mediated immune response than N-terminus insertion. This research provides new insights into the development of ferritin nanoparticle vaccines.
Review
Cell Biology
Chin-King Looi, Lian-Chee Foong, Felicia Fei-Lei Chung, Alan Soo-Beng Khoo, Ee-Mun Loo, Chee-Onn Leong, Chun-Wai Mai
Summary: This review provides updated understanding of the roles of epigenetic factors in regulating EBV latent gene expression and promoting NPC progression. The crosstalk between epigenetic mechanisms and immune evasion in NPC is explored, along with the potential roles of DNMT and HDAC inhibitors in reversing immune suppression and augmenting antitumour immunity. Furthermore, the advantages of combining epigenetic therapy and immune checkpoint inhibitor to reverse immune resistance and improve clinical outcomes are highlighted.
CELL BIOLOGY AND TOXICOLOGY
(2023)
Article
Gastroenterology & Hepatology
Hui Song, Yan Zhang, Juanjuan Liu, Wen Liu, Bing Luo
Summary: The study revealed a new mechanism of EBV in regulating the expression of DNMT3a in EBV-associated gastric carcinoma. Targeting the EBNA1/E2F1/DNMT3a axis could be a potential therapeutic strategy for EBVaGC with high DNMT3a expression.
DIGESTIVE AND LIVER DISEASE
(2022)
Article
Biochemistry & Molecular Biology
X. Chen, S. A. Kamranvar, M. G. Masucci
Review
Virology
Siamak A. Kamranvar, Maria G. Masucci
Article
Microbiology
Jinlin Li, Simone Callegari, Maria G. Masucci
Article
Oncology
Teresa Frisan, Noemi Nagy, Dimitrios Chioureas, Marie Terol, Francesca Grasso, Maria G. Masucci
INTERNATIONAL JOURNAL OF CANCER
(2019)
Article
Microbiology
Soham Gupta, Paivi Yla-Anttila, Simone Callegari, Ming-Han Tsai, Henri-Jacques Delecluse, Maria G. Masucci
Article
Biochemistry & Molecular Biology
Simone Callegari, Stefano Gastaldello, Omid R. Faridani, Maria G. Masucci
Review
Oncology
Xinsong Chen, Siamak Akbari Kamranvar, Maria G. Masucci
SEMINARS IN CANCER BIOLOGY
(2014)
Editorial Material
Oncology
Maria G. Masucci, Alan B. Rickinson
SEMINARS IN CANCER BIOLOGY
(2014)
Article
Cell Biology
Oceane C. B. Martin, Anna Bergonzini, Federica D'Amico, Puran Chen, Jerry W. Shay, Jacques Dupuy, Mattias Svensson, Maria G. Masucci, Teresa Frisan
CELLULAR MICROBIOLOGY
(2019)
Article
Biochemistry & Molecular Biology
Jiayu Wang, Noemi Nagy, Maria G. Masucci
Correction
Biochemistry & Molecular Biology
Jiayu Wang, Noemi Nagy, Maria G. Masucci
Article
Microbiology
Soham Gupta, Paivi Yla-Anttila, Tatyana Sandalova, Renhua Sun, Adnane Achour, Maria G. Masucci
Article
Cell Biology
Paivi Yla-Anttila, Soham Gupta, Maria G. Masucci
Summary: Macroautophagy plays a critical role in controlling viral infections, with viruses evolving strategies to interfere with this process. The Epstein-Barr virus-encoded BPLF1 protein regulates selective autophagy, promoting infection and viral production by targeting the cellular defense mechanism.
Article
Biochemistry & Molecular Biology
Paivi Yla-Anttila, Maria G. Masucci
Summary: Autophagy is a crucial protein degradation and recycling mechanism that plays a significant role in cellular homeostasis and defense against microbial invasion. It can be non-selective or selective, with different autophagy receptors recognizing specific targets for degradation. Some viruses, like EBV, KSHV, and HCMV, interfere with selective autophagy by regulating the activity of autophagy receptors such as SQSTM1/p62.
BIOCHEMICAL JOURNAL
(2021)
Article
Microbiology
Jinlin Li, Noemi Nagy, Jiangnan Liu, Soham Gupta, Teresa Frisan, Thomas Hennig, Donald P. Cameron, Laura Baranello, Maria G. Masucci
Summary: The study reveals that EBV's BPLF1 can alter the structure of TOP2 in cells, preventing DNA damage response and promoting cell survival and virus replication. This protective effect relies heavily on the expression of TDP2, which aids in DNA repair.