Editorial Material
Microbiology
Eain A. Murphy
Summary: The necessity for viruses to modulate the innate immune response significantly impacts the outcome of viral infections. Viruses encode factors that undermine antiviral responses, with recent research highlighting the impact of virus-encoded noncoding RNAs on key components of the interferon pathway, particularly focusing on Epstein-Barr virus microRNAs.
Review
Biochemistry & Molecular Biology
Xiaoyang Xu, Pengyu Hong, Zhefu Wang, Zhangui Tang, Kun Li
Summary: Fibrosis, a histopathological manifestation of chronic inflammatory diseases, is regulated by two types of TGF-β signaling pathways. miRNA, a small RNA that can regulate physiological and pathological processes in fibrotic diseases, is crucial in this context. The review introduces TGF-β signaling pathways and miRNA classification, summarizes limitations in fibrosis research, and suggests potential therapeutic options.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2021)
Review
Neurosciences
Bakhya Shree, Vivek Sharma
Summary: This article summarizes the complex regulatory network between non-coding RNAs and the TGF-beta pathway during glioma pathogenesis, and discusses their role as potential therapeutic targets for gliomas.
Review
Endocrinology & Metabolism
John Garcia, Anne M. Delany
Summary: This review highlights the role of miRNAs in regulating bone forming osteoblasts through their effects on the TGF beta and BMP pathways. By targeting ligands, receptors, and SMAD-mediated signaling, miRNAs contribute to the modulation of TGF beta and BMP signaling in the osteoblast lineage, which may have implications for potential therapeutic strategies. Induced during fracture, mechanical unloading, or estrogen deprivation, many of these miRNAs could potentially be used for localized delivery of therapeutics to promote bone formation.
Article
Biochemistry & Molecular Biology
Ali Afrasiabi, Nicole L. Fewings, Stephen D. Schibeci, Jeremy T. Keane, David R. Booth, Grant P. Parnell, Sanjay Swaminathan
Summary: EBV infection may dysregulate the B cell miRNA machinery, including MS risk miRNAs, and interact with MS risk genes to potentially contribute to the pathogenesis of MS.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Anna Manzeger, Gantsetseg Garmaa, Miklos M. Mozes, Georg Hansmann, Gabor Kokeny
Summary: Pioglitazone can inhibit excessive production of renal TGF-beta and dysregulation of fibrosis-related miRNAs, as well as restore autophagy function. Animal experiments showed that pioglitazone significantly improved kidney fibrosis and related autophagy dysfunction, and suppressed the expression of inflammatory genes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Neurosciences
Rie Hosokawa, Yuta Yoshino, Yu Funahashi, Fumie Horiuchi, Jun-ichi Iga, Shu-ichi Ueno
Summary: This study investigates the expression of miRNA and mRNA in peripheral blood to explore a diagnostic biomarker for autism spectrum disorder (ASD). The results suggest that upregulated expression of miR-15b-5p may serve as a useful diagnostic marker for ASD and it may regulate the expression of TGFBR3 mRNA.
Article
Virology
Fizza Nazim, Hammad Afzal Kayani, Apsara Ali Nathwani, Fatima Mir, Syed Hani Abidi
Summary: The study investigated the rate of CMV and EBV co-infection in HIV-positive children in Pakistan and analyzed the differential expression of cytokines in HIV mono- and HIV/CMV/EBV co-infected children. The results showed that CMV and EBV co-infection affected HIV viral loads and the expression of certain cytokines, potentially impacting the dynamics of HIV disease in infected children.
Review
Biochemistry & Molecular Biology
Soudeh Ghafouri-Fard, Bashdar Mahmud Hussen, Hazha Hadayat Jamal, Mohammad Taheri, Guive Sharifi
Summary: Non-coding RNAs, especially lncRNAs and miRNAs, play important roles in regulating viral infections and immune responses. The expression of various host and viral lncRNAs is altered during viral infection, which can either inhibit viral infection, promote viral replication, or suppress antiviral responses.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Reproductive Biology
Qiqi Li, Xing Du, Lingfang Wang, Kerong Shi, Qifa Li
Summary: This study revealed the regulatory mechanism of TGF-beta 1 on porcine granulosa cell states, identified multiple signaling pathways regulating cell states, and potential therapeutic RNA molecules.
Article
Oncology
Zelin Yang, Liang Yang, Zhenkai Sun, Yuxi Rong, Chenglian Bai, Qiaoxiang Dong, Lin Jian
Summary: APOC1 is overexpressed in glioblastoma and is inversely related to patient prognosis. Overexpression of APOC1 promotes cell proliferation, migration, and invasion, while inhibition of APOC1 reduces tumor growth. miRNA-660-3p suppresses tumorigenesis by targeting APOC1. Therefore, the miRNA-660-3p/APOC1 axis can serve as potential intervention targets in managing glioblastoma progression.
CANCER BIOLOGY & THERAPY
(2023)
Article
Neurosciences
Wei-Wei Duan, Li-Ting Yang, Jian Liu, Zi-Yu Dai, Ze-Yu Wang, Hao Zhang, Xun Zhang, Xi-Song Liang, Peng Luo, Jian Zhang, Zao-Qu Liu, Nan Zhang, Hao-Yang Mo, Chun-Run Qu, Zhi-Wei Xia, Quan Cheng
Summary: In this study, a prognostic lncRNA signature related to TGF-beta signaling was established in glioma. The signature was proven to be a reliable prognostic tool and provided insights into immune infiltration characteristics and immunotherapy response prediction. Furthermore, AGAP2-AS1 was identified as an important player in glioma progression.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Review
Cell Biology
Nicole L. Diggins, Meaghan H. Hancock
Summary: Viruses use various mechanisms to overcome barriers to infection in host cells. One such mechanism is the use of virally-encoded microRNAs (miRNAs) to regulate host gene expression for the benefit of the virus. Despite little sequence homology, different viruses target common cellular pathways such as apoptosis, immune evasion, cell growth, and differentiation. This article highlights the importance of viral miRNAs in lytic and latent infections by targeting these common cellular processes and provides insights into their mimicry of host cell miRNAs and regulation of host miRNA expression.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2023)
Article
Physiology
Hongqiang Zhang, Dingqian Liu, Shichao Zhu, Fanshun Wang, Xiaoning Sun, Shouguo Yang, Chunsheng Wang
Summary: This study identified that plasma exosomal miR-423-5p regulates TGF-beta signaling by targeting SMAD2, thus exerting functions in the occurrence and development of BAV disease and its complication bicuspid aortopathy. These miRNAs may be involved in the pathogenesis of BAV disease.
FRONTIERS IN PHYSIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Marta Maruszewska-Cheruiyot, Michael James Stear, Maja Machcinska, Katarzyna Donskow-Lysoniewska
Summary: There has been little interaction between parasitologists and oncologists historically, although some helminth infections may predispose to tumor development. Recent research suggests that both tumors and parasites suppress the immune response to increase their chances of survival. They both exploit the TGF beta signaling pathway to modulate the immune response for their own benefit.
Article
Biochemistry & Molecular Biology
Jiayu Wang, Noemi Nagy, Maria G. Masucci
Correction
Biochemistry & Molecular Biology
Jiayu Wang, Noemi Nagy, Maria G. Masucci
Article
Biochemistry & Molecular Biology
Arvind Venkat Namuduri, Gabriel Heras, Volker M. Lauschke, Maurizio Vitadello, Leonardo Traini, Nicola Cacciani, Luisa Gorza, Stefano Gastaldello
Article
Oncology
Xiuxiu Liu, Gabriel Heras, Volker M. Lauschke, Jia Mi, Geng Tian, Stefano Gastaldello
EXPERIMENTAL CELL RESEARCH
(2020)
Article
Biochemistry & Molecular Biology
Victoria L. Wyckelsma, Tomas Venckunas, Marius Brazaitis, Stefano Gastaldello, Audrius Snieckus, Nerijus Eimantas, Neringa Baranauskiene, Andrejus Subocius, Albertas Skurvydas, Mati Paasuke, Helena Gapeyeva, Priit Kaasik, Reedik Paasuke, Jaak Jurimae, Brigitte A. Graf, Bengt Kayser, Nicolas Place, Daniel C. Andersson, Sigitas Kamandulis, Hakan Westerblad
Article
Cell Biology
Paivi Yla-Anttila, Soham Gupta, Maria G. Masucci
Summary: Macroautophagy plays a critical role in controlling viral infections, with viruses evolving strategies to interfere with this process. The Epstein-Barr virus-encoded BPLF1 protein regulates selective autophagy, promoting infection and viral production by targeting the cellular defense mechanism.
Article
Multidisciplinary Sciences
Galina Yurevna Zheleznyakova, Eliane Piket, Maria Needhamsen, Michael Hagemann-Jensen, Diana Ekman, Yanan Han, Tojo James, Mohsen Khademi, Faiez Al Nimer, Patrick Scicluna, Jesse Huang, Ingrid Kockum, Omid R. Faridani, Tomas Olsson, Fredrik Piehl, Maja Jagodic
Summary: The study found widespread changes in miRNAs and other sncRNAs in patients with multiple sclerosis, especially more pronounced in CSF cells, showing a striking contrast with changes in peripheral blood cells. This suggests that sncRNA-mediated mechanisms play an important role in regulating the transcriptome of pathogenic cells, primarily in the CNS target organ.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Biochemistry & Molecular Biology
Paivi Yla-Anttila, Maria G. Masucci
Summary: Autophagy is a crucial protein degradation and recycling mechanism that plays a significant role in cellular homeostasis and defense against microbial invasion. It can be non-selective or selective, with different autophagy receptors recognizing specific targets for degradation. Some viruses, like EBV, KSHV, and HCMV, interfere with selective autophagy by regulating the activity of autophagy receptors such as SQSTM1/p62.
BIOCHEMICAL JOURNAL
(2021)
Article
Endocrinology & Metabolism
Kasun Godakumara, James Ord, Freddy Lattekivi, Keerthie Dissanayake, Janeli Viil, Nageswara Rao Boggavarapu, Omid R. Faridani, Kersti Jaager, Agne Velthut-Meikas, Ulle Jaakma, Andres Salumets, Alireza Fazeli
Summary: The study demonstrates that trophoblast-derived EVs have the capability to modify the gene expression of endometrial cells, particularly in the aspects of extracellular matrix remodeling and G protein-coupled receptors signaling. These alterations may play a significant role in embryo-maternal communication during implantation.
REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY
(2021)
Article
Cell Biology
Maaike van der Lee, William G. Allard, Rolf H. A. M. Vossen, Renee F. Baak-Pablo, Roberta Menafra, Birgit A. L. M. Deiman, Maarten J. Deenen, Patrick Neven, Inger Johansson, Stefano Gastaldello, Magnus Ingelman-Sundberg, Henk-Jan Guchelaar, Jesse J. Swen, Seyed Yahya Anvar
Summary: The study introduces a proof-of-concept approach using continuous-scale assignments to predict CYP2D6 enzyme activity, showing potential for more accurate prediction of individual drug response compared to conventional *-allele approach. This model, trained with complete CYP2D6 gene sequences and tamoxifen metabolism data, explained a higher percentage of interindividual variability in enzyme activity and demonstrated advantages in predicting known and novel allele combinations.
SCIENCE TRANSLATIONAL MEDICINE
(2021)
Article
Microbiology
Jinlin Li, Noemi Nagy, Jiangnan Liu, Soham Gupta, Teresa Frisan, Thomas Hennig, Donald P. Cameron, Laura Baranello, Maria G. Masucci
Summary: The study reveals that EBV's BPLF1 can alter the structure of TOP2 in cells, preventing DNA damage response and promoting cell survival and virus replication. This protective effect relies heavily on the expression of TDP2, which aids in DNA repair.
Article
Biochemistry & Molecular Biology
Victoria L. Wyckelsma, Ada Trepci, Lilly Schwieler, Tomas Venckunas, Marius Brazaitis, Sigitas Kamandulis, Henrikas Paulauskas, Helena Gapeyeva, Mati Paasuke, Stefano Gastaldello, Sophie Imbeault, Hakan Westerblad, Sophie Erhardt, Daniel C. Andersson
Summary: In elderly men, three weeks of sprint interval training shifted KP metabolism towards neuroprotection, but this shift was blocked by antioxidant treatment.
Article
Obstetrics & Gynecology
Carolina von Grothusen, Caroline Frisendahl, Vijayachitra Modhukur, Parameswaran Grace Lalitkumar, Maire Peters, Omid R. Faridani, Andres Salumets, Nageswara Rao Boggavarapu, Kristina Gemzell-Danielsson
Summary: This study compares the abundance of miRNAs in uterine fluid between healthy fertile women and women with recurrent implantation failure (RIF). The results show that the composition of miRNAs in RIF uterine fluid is different from that of healthy fertile women, and the dysregulated miRNAs are associated with impaired endometrial receptivity and embryo implantation. These findings shed light on the molecular mechanisms behind RIF and may have implications for future biomarker and clinical treatment studies.
HUMAN REPRODUCTION
(2022)
Article
Physiology
Gianluigi Pironti, Stefano Gastaldello, Dilson E. Rassier, Johanna T. Lanner, Mattias Carlstrom, Lars H. Lund, Hakan Westerblad, Takashi Yamada, Daniel C. Andersson
Summary: This study used a mouse model of rheumatoid arthritis (RA) to find evidence of impaired cardiac contractile function associated with reduced Ca2+ sensitivity, increased expression of PAD2, and citrullination of alpha-actin, which was triggered by TNF-alpha. This provides molecular and physiological evidence for acquired cardiomyopathy and a potential mechanism for RA-associated heart failure.
Article
Cell Biology
Silvia Codenotti, Daniela Zizioli, Luca Mignani, Sara Rezzola, Giovanna Tabellini, Silvia Parolini, Arianna Giacomini, Michela Asperti, Maura Poli, Delia Mandracchia, Marika Vezzoli, Simona Bernardi, Domenico Russo, Stefania Mitola, Eugenio Monti, Luca Triggiani, Davide Tomasini, Stefano Gastaldello, Matteo Cassandri, Rossella Rota, Francesco Marampon, Alessandro Fanzani
Summary: In pediatric rhabdomyosarcoma, elevated Akt signaling promotes tumor malignancy by hyperactivating the mTOR/p70S6K pathway and enhancing cell invasion and migration. Inhibiting PI3K and Akt signaling can reverse the aggressive phenotype of tumor cells, while mTOR inhibition fails to block cell dissemination. Additionally, pronounced Akt1 signaling increases the susceptibility of tumor cells to certain treatments, such as 2-DG and lovastatin.
