Chemical approaches to study metabolic networks

XCMS Online: A Web-Based Platform to Process Untargeted Metabolomic Data

(2012) Ralf Tautenhahn et al.   ANALYTICAL CHEMISTRY

Highly Selective Inhibitors of Monoacylglycerol Lipase Bearing a Reactive Group that Is Bioisosteric with Endocannabinoid Substrates

(2012) Jae Won Chang et al.   CHEMISTRY & BIOLOGY

How Chemoproteomics Can Enable Drug Discovery and Development

(2012) Raymond E. Moellering et al.   CHEMISTRY & BIOLOGY

Metabolite Profiling Identifies Pathways Associated With Metabolic Risk in Humans

(2012) Susan Cheng et al.   CIRCULATION

IDH mutation impairs histone demethylation and results in a block to cell differentiation

(2012) Chao Lu et al.   NATURE

IDH1 mutation is sufficient to establish the glioma hypermethylator phenotype

(2012) Sevin Turcan et al.   NATURE

Metabolomics implicates altered sphingolipids in chronic pain of neuropathic origin

(2012) Gary J. Patti et al.   Nature Chemical Biology

The pharmacological landscape and therapeutic potential of serine hydrolases

(2012) Daniel A. Bachovchin et al.   NATURE REVIEWS DRUG DISCOVERY

Metabolite Profiling Identifies a Key Role for Glycine in Rapid Cancer Cell Proliferation

(2012) M. Jain et al.   SCIENCE

A Dysregulated Endocannabinoid-Eicosanoid Network Supports Pathogenesis in a Mouse Model of Alzheimer's Disease

(2012) Justin R. Piro et al.   Cell Reports

An Activity-Based Imaging Probe for the Integral Membrane Hydrolase KIAA1363

(2011) Jae Won Chang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Pyruvate Kinase M2 Is a PHD3-Stimulated Coactivator for Hypoxia-Inducible Factor 1

(2011) Weibo Luo et al.   CELL

The Metabolic Serine Hydrolases and Their Functions in Mammalian Physiology and Disease

(2011) Jonathan Z. Long et al.   CHEMICAL REVIEWS

A Potent and Selective Inhibitor of KIAA1363/AADACL1 that Impairs Prostate Cancer Pathogenesis

(2011) Jae Won Chang et al.   CHEMISTRY & BIOLOGY

Monoacylglycerol Lipase Exerts Dual Control over Endocannabinoid and Fatty Acid Pathways to Support Prostate Cancer

(2011) Daniel K. Nomura et al.   CHEMISTRY & BIOLOGY

Elucidation of Cellular Metabolism Via Metabolomics and Stable-Isotope Assisted Metabolomics

(2011) Karsten Hiller et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

The oncometabolite 2-hydroxyglutarate inhibits histone lysine demethylases

(2011) Rasheduzzaman Chowdhury et al.   EMBO REPORTS

Comparative Metabolic Flux Profiling of Melanoma Cell Lines

(2011) David A. Scott et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mechanistic and Pharmacological Characterization of PF-04457845: A Highly Potent and Selective Fatty Acid Amide Hydrolase Inhibitor That Reduces Inflammatory and Noninflammatory Pain

(2011) K. Ahn et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

MALDI Mass Spectrometric Imaging of Lipids in Rat Brain Injury Models

(2011) Joseph A. Hankin et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

Selection of tracers for 13C-Metabolic Flux Analysis using Elementary Metabolite Units (EMU) basis vector methodology

(2011) Scott B. Crown et al.   METABOLIC ENGINEERING

Click-generated triazole ureas as ultrapotent in vivo–active serine hydrolase inhibitors

(2011) Alexander Adibekian et al.   Nature Chemical Biology

Phosphoglycerate dehydrogenase diverts glycolytic flux and contributes to oncogenesis

(2011) Jason W Locasale et al.   NATURE GENETICS

Academic cross-fertilization by public screening yields a remarkable class of protein phosphatase methylesterase-1 inhibitors

(2011) D. A. Bachovchin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hypoxia promotes isocitrate dehydrogenase-dependent carboxylation of  -ketoglutarate to citrate to support cell growth and viability

(2011) D. R. Wise et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Endocannabinoid Hydrolysis Generates Brain Prostaglandins That Promote Neuroinflammation

(2011) D. K. Nomura et al.   SCIENCE

Leukemic IDH1 and IDH2 Mutations Result in a Hypermethylation Phenotype, Disrupt TET2 Function, and Impair Hematopoietic Differentiation

(2010) Maria E. Figueroa et al.   CANCER CELL

A fluopol-ABPP HTS assay to identify PAD inhibitors

(2010) Bryan Knuckley et al.   CHEMICAL COMMUNICATIONS

Metabolomics in systems microbiology

(2010) Marshall Louis Reaves et al.   CURRENT OPINION IN BIOTECHNOLOGY

Fluorescence polarization assays in small molecule screening

(2010) Wendy A Lea et al.   Expert Opinion on Drug Discovery

A Mouse Macrophage Lipidome

(2010) Edward A. Dennis et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Activity-based Proteomics of Enzyme Superfamilies: Serine Hydrolases as a Case Study

(2010) Gabriel M. Simon et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Molecular alterations of the IDH1 gene in AML: a Children's Oncology Group and Southwest Oncology Group study

(2010) P A Ho et al.   LEUKEMIA

Cell-Based Assays for High-Throughput Screening

(2010) W. Frank An et al.   MOLECULAR BIOTECHNOLOGY

Quantitative reactivity profiling predicts functional cysteines in proteomes

(2010) Eranthie Weerapana et al.   NATURE

Chronic monoacylglycerol lipase blockade causes functional antagonism of the endocannabinoid system

(2010) Joel E Schlosburg et al.   NATURE NEUROSCIENCE

Inhibition of endocannabinoid catabolic enzymes elicits anxiolytic-like effects in the marble burying assay

(2010) Steven G. Kinsey et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Superfamily-wide portrait of serine hydrolase inhibition achieved by library-versus-library screening

(2010) D. A. Bachovchin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Monoacylglycerol Lipase Regulates a Fatty Acid Network that Promotes Cancer Pathogenesis

(2009) Daniel K. Nomura et al.   CELL

Characterization of Monoacylglycerol Lipase Inhibition Reveals Differences in Central and Peripheral Endocannabinoid Metabolism

(2009) Jonathan Z. Long et al.   CHEMISTRY & BIOLOGY

Discovery and Characterization of a Highly Selective FAAH Inhibitor that Reduces Inflammatory Pain

(2009) Kay Ahn et al.   CHEMISTRY & BIOLOGY

IDH1 Mutations as Molecular Signature and Predictive Factor of Secondary Glioblastomas

(2009) S. Nobusawa et al.   CLINICAL CANCER RESEARCH

Blockade of Endocannabinoid-Degrading Enzymes Attenuates Neuropathic Pain

(2009) S. G. Kinsey et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Cancer-associated IDH1 mutations produce 2-hydroxyglutarate

(2009) Lenny Dang et al.   NATURE

Identification of selective inhibitors of uncharacterized enzymes by high-throughput screening with fluorescent activity-based probes

(2009) Daniel A Bachovchin et al.   NATURE BIOTECHNOLOGY

Noninvasive optical imaging of apoptosis by caspase-targeted activity-based probes

(2009) Laura E Edgington et al.   NATURE MEDICINE

IDH1andIDH2Mutations in Gliomas

(2009) Hai Yan et al.   NEW ENGLAND JOURNAL OF MEDICINE

Dual blockade of FAAH and MAGL identifies behavioral processes regulated by endocannabinoid crosstalk in vivo

(2009) J. Z. Long et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

RBBP9: A tumor-associated serine hydrolase activity required for pancreatic neoplasia

(2009) D. J. Shields et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Imaging of lipid species by MALDI mass spectrometry

(2008) Robert C. Murphy et al.   JOURNAL OF LIPID RESEARCH

Disparate proteome reactivity profiles of carbon electrophiles

(2008) Eranthie Weerapana et al.   Nature Chemical Biology

Selective blockade of 2-arachidonoylglycerol hydrolysis produces cannabinoid behavioral effects

(2008) Jonathan Z Long et al.   Nature Chemical Biology