Fluorescence polarization assays in small molecule screening

Fluorescence anisotropy: from single molecules to live cells

(2010) Claudiu C. Gradinaru et al.   ANALYST

Development of a high-throughput fluorescence polarization assay for the discovery of phosphopantetheinyl transferase inhibitors

(2010) Benjamin P. Duckworth et al.   ANALYTICAL BIOCHEMISTRY

A fluorescence polarization-based assay for the identification and evaluation of calmodulin antagonists

(2010) Tomonori Arai et al.   ANALYTICAL BIOCHEMISTRY

A Fluorescence Anisotropy Assay for the Muscarinic M1 G-protein-Coupled Receptor

(2010) Kristin G. Huwiler et al.   ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES

Development and Validation of a Transcreener Assay for Detection of AMP- and GMP-Producing Enzymes

(2010) Matt Staeben et al.   ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES

Novel Alexa Fluor-488 labeled antagonist of the A2A adenosine receptor: Application to a fluorescence polarization-based receptor binding assay

(2010) Miklós Kecskés et al.   BIOCHEMICAL PHARMACOLOGY

Fluorescence Polarization/Anisotropy in Diagnostics and Imaging

(2010) David M. Jameson et al.   CHEMICAL REVIEWS

No Taste for Methyl: Methylation Sensitive Proteolysis in Drug Screening

(2010) Elisabeth-Maria Bissinger et al.   CHEMISTRY & BIOLOGY

Accessing Protein Methyltransferase and Demethylase Enzymology Using Microfluidic Capillary Electrophoresis

(2010) Tim J. Wigle et al.   CHEMISTRY & BIOLOGY

Structure-Based Drug Design and Optimization of Mannoside Bacterial FimH Antagonists

(2010) Zhenfu Han et al.   JOURNAL OF MEDICINAL CHEMISTRY

A chemiluminescence-based method for identification of histone lysine methyltransferase inhibitors

(2010) Amy M. Quinn et al.   Molecular BioSystems

Assay Strategies for the Discovery and Validation of Therapeutics Targeting Brugia pahangi Hsp90

(2010) Tony Taldone et al.   PLoS Neglected Tropical Diseases

Characterization and Optimization of a Red-Shifted Fluorescence Polarization ADP Detection Assay

(2009) Karen M. Kleman-Leyer et al.   ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES

Development and Validation of a High-Density Fluorescence Polarization-Based Assay for the Trypanosoma RNA Triphosphatase TbCet1

(2009) Christophe Antczak et al.   COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING

Developments in fluorescent probes for receptor research

(2009) Marcello Leopoldo et al.   DRUG DISCOVERY TODAY

Discovery of a 2,4-Diamino-7-aminoalkoxyquinazoline as a Potent and Selective Inhibitor of Histone Lysine Methyltransferase G9a

(2009) Feng Liu et al.   JOURNAL OF MEDICINAL CHEMISTRY

A strategy to discover inhibitors of Bacillus subtilis surfactin-type phosphopantetheinyl transferase

(2009) Adam Yasgar et al.   Molecular BioSystems

The Year In G Protein-Coupled Receptor Research

(2009) Robert P. Millar et al.   MOLECULAR ENDOCRINOLOGY

Protein methyltransferases as a target class for drug discovery

(2009) Robert A. Copeland et al.   NATURE REVIEWS DRUG DISCOVERY

From carbohydrate leads to glycomimetic drugs

(2009) Beat Ernst et al.   NATURE REVIEWS DRUG DISCOVERY

IC50-to-Ki: a web-based tool for converting IC50 to Ki values for inhibitors of enzyme activity and ligand binding

(2009) R. Z. Cer et al.   NUCLEIC ACIDS RESEARCH

A Novel Class of Small Molecule Inhibitors of Hsp90

(2008) Fang Yi et al.   ACS Chemical Biology

Bright Ideas for Chemical Biology

(2008) Luke D. Lavis et al.   ACS Chemical Biology

Fluorescence polarization immunoassays and related methods for simple, high-throughput screening of small molecules

(2008) David S. Smith et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

A high-throughput assay based on fluorescence polarization for inhibitors of the polo-box domain of polo-like kinase 1

(2008) Wolfgang Reindl et al.   ANALYTICAL BIOCHEMISTRY

High-affinity bisubstrate probe for fluorescence anisotropy binding/displacement assays with protein kinases PKA and ROCK

(2008) Angela Vaasa et al.   ANALYTICAL BIOCHEMISTRY

Fluorescence Anisotropy Assay for the Traceless Kinetic Analysis of Protein Digestion

(2008) Felix Cleemann et al.   ANALYTICAL CHEMISTRY

Inhibition of Polo-like Kinase 1 by Blocking Polo-Box Domain-Dependent Protein-Protein Interactions

(2008) Wolfgang Reindl et al.   CHEMISTRY & BIOLOGY

A High Throughput Fluorescence Polarization Assay for Inhibitors of the GoLoco Motif/G-alpha Interaction

(2008) Adam Kimple et al.   COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING

Fluorescence Spectroscopic Profiling of Compound Libraries

(2008) Anton Simeonov et al.   JOURNAL OF MEDICINAL CHEMISTRY

Facile Conversion of FP to TR-FRET Assays using Terbium Chelates:Nuclear Receptor Competitive Binding Assays as Examples

(2008) Kurt Vogel et al.   Letters in Drug Design & Discovery

Development, validation and implementation of immobilized metal affinity for phosphochemicals (IMAP)-based high-throughput screening assays for low-molecular-weight compound libraries

(2008) Elizabeth R Sharlow et al.   Nature Protocols

Dual-fluorophore quantitative high-throughput screen for inhibitors of BRCT–phosphoprotein interaction

(2007) Anton Simeonov et al.   ANALYTICAL BIOCHEMISTRY