Article
Biotechnology & Applied Microbiology
Lingchun Kong, Jingjing Li, Yuqin Yang, Huixin Tang, Hong Zou
Summary: This study found that Paeoniflorin (PF) can alleviate the progression of retinal vein occlusion (RVO) by inhibiting the HIF-1 alpha/VEGF/STAT3 pathway. The results of this study may provide theoretical knowledge for exploring novel treatments for RVO patients.
Article
Fisheries
Liulan Zhao, Xiaohong Tang, Rui Huang, Qiao Liu, Lei Liao, Yifan Hu, Kuo He, Xin Zhang, Jiazhong Guo, Shiyi Chen, Song Yang
Summary: This study investigated the effect of acute hypoxia on liver angiogenesis in largemouth bass. The results showed that hypoxia exposure promoted angiogenesis occurrence and increased the concentration of vasodilation factors. Hypoxia exposure also up-regulated the expression of certain genes and proteins related to angiogenesis. The findings suggest that acute hypoxia can stimulate liver angiogenesis in largemouth bass through the HIF-dependent pathway.
FISH & SHELLFISH IMMUNOLOGY
(2022)
Article
Oncology
Ryuta Tagawa, Hiroshi Soda, Yosuke Dotsu, Hiroaki Senju, Satoshi Irifune, Masataka Yoshida, Shota Nakashima, Asuka Umemura, Keisuke Iwasaki, Hirokazu Taniguchi, Shinnosuke Takemoto, Yuichi Fukuda, Hiroshi Mukae
Summary: This article presents the case of a 69-year-old man who developed intractably painful hypertrophic osteoarthropathy (HOA) secondary to lung cancer. Treatment with carboplatin, paclitaxel, and bevacizumab reduced tumor size and plasma vascular endothelial growth factor (VEGF) levels, relieving the patient's leg pain. The immunohistochemical examination showed that lung cancer cells were positive for VEGF, suggesting a potential role of hypoxia-inducible factor-1a in VEGF production. The findings of this study may lead to the development of novel management strategies for painful HOA.
Article
Oncology
Chao Fang, Lei Dai, Cun Wang, Chuanwen Fan, Yongyang Yu, Lie Yang, Hongxin Deng, Zongguang Zhou
Summary: Research showed that SCG2 expression was associated with the survival of CRC patients, and it exhibited anti-tumor and anti-angiogenesis effects by inhibiting HIF-1 alpha/VEGF activity.
MOLECULAR ONCOLOGY
(2021)
Article
Hematology
Tatsuya Akiyama, Taketaro Sadahiro, Yu Yamada, Ryo Fujita, Yuto Abe, Koji Nakano, Seiichiro Honda, Masatsugu Ema, Yoshiaki Kubota, Satoshi Sakai, Nobuyuki Hizawa, Masaki Ieda
Summary: In this study, the differential expression patterns of Flk1 and Flt1 in pulmonary endothelial cells were investigated. Deficiency of Flk1 and hypoxia jointly dysregulated arteriolar endothelial cells, promoting vascular remodeling. Therefore, dysfunctional Flk1+ endothelial cells may contribute to the pathogenesis of vascular remodeling in pulmonary arterioles.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2023)
Review
Engineering, Biomedical
Kelsey G. DeFrates, Daniela Franco, Ellen Heber-Katz, Phillip B. Messersmith
Summary: Traditional approaches in regenerative medicine face limitations in translation and commercialization, prompting the development of therapies that stimulate endogenous processes for regeneration. Recent studies highlight the potential of oxygen-sensing pathways, with upregulation of HIF-1α showing promise in modulating cell metabolism and plasticity for tissue regeneration.
Article
Oncology
Jiajun Li, Xiangen Meng, Fang Li, Jiamin Liu, Mingyang Ma, Wangkun Chen
Summary: The study found that the combination of huperzine A and hyperbaric oxygen therapy can significantly improve cognitive function in elderly patients with vascular dementia, as well as increase the serum HIF-1 alpha level.
AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH
(2021)
Article
Immunology
Gehad M. Menisy, Sherine Zakaria, Ghada M. Suddek
Summary: Nilotinib can alleviate liver damage caused by acetaminophen by decreasing the elevation of biochemical markers, increasing the content of antioxidant substances GSH and SOD, reducing oxidative stress marker MDA, and suppressing the expression of related proteins.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Qiuyue Qin, Yiping Liu, Zhen Yang, Maierhaba Aimaijiang, Rui Ma, Yixin Yang, Yidi Zhang, Yanmin Zhou
Summary: Sufficient oxygen is crucial for normal cellular and physiological function, and both pathological hypoxia and environmental hypoxia can impact bone health. Adaptation to hypoxia is a key event in cellular development and differentiation, and hypoxia-inducible transcription factors (HIFs) are essential for regulating bone development and repair.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Surgery
Yunfei Zhang, Xiao Zhang, Bing Tian, Qin Deng, Chunbao Guo
Summary: This study demonstrates the crucial role of HIF-1 alpha in regulating the intestinal microcirculation during the pathogenesis of NEC. Targeting HIF-1 alpha may be a promising strategy for the treatment of NEC.
JOURNAL OF SURGICAL RESEARCH
(2022)
Article
Neurosciences
Yan Qian, Xin Li, Raofei Fan, Qiaofen Li, Yang Zhang, Xiaona He, Wei Yang, Wei Sun, Shaokun Lv
Summary: This study investigated the role of miR-31 in traumatic brain injury. The results showed that miR-31 inhibits neuronal cell apoptosis by regulating the hypoxia-inducible factor-1A/vascular endothelial growth factor A axis.
Review
Pharmacology & Pharmacy
Baoqi Yu, Xia Wang, Yanting Song, Guomin Xie, Shiyu Jiao, Li Shi, Xuejie Cao, Xinyao Han, Aijuan Qu
Summary: Cardiovascular diseases are the leading cause of death worldwide, and hypoxia-inducible factors (HIFs) play an important role in their pathogenesis. Recent studies have revealed the role of cell-specific HIFs in various cardiovascular diseases, but the potential clinical application of HIF inhibitors in the treatment of cardiovascular diseases is not well understood.
PHARMACOLOGY & THERAPEUTICS
(2022)
Article
Gastroenterology & Hepatology
Pan Cao, Qian Chen, Chun-Xia Shi, Lu-Wen Wang, Zuo-Jiong Gong
Summary: This study suggests that Sirt1 may protect against acute liver failure by inducing the deacetylation of HIF-1 alpha to reduce ROS.
WORLD JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Multidisciplinary Sciences
Ya Guan, Hong Niu, Zhongting Liu, Yu Dang, Jie Shen, Mohamed Zayed, Liang Ma, Jianjun Guan
Summary: The study developed a sustained oxygenation system using oxygen-release microspheres and a reactive oxygen species (ROS)-scavenging hydrogel to promote diabetic wound healing. The sustained release of oxygen enhanced cell survival and migration, angiogenic growth factor expression, angiogenesis, and decreased proinflammatory cytokine expression in diabetic wounds, leading to a significant increase in wound closure rate.
Article
Oncology
Monique B. Nilsson, Jacqulyne Robichaux, Matthew H. Herynk, Tina Cascone, Xiuning Le, Yasir Elamin, Sonia Patel, Fahao Zhang, Li Xu, Limei Hu, Lixia Diao, Li Shen, Junqin He, Xiaoxing Yu, Petros Nikolinakos, Pierre Saintigny, Bingliang Fang, Luc Girard, Jing Wang, John D. Minna, Ignacio I. Wistuba, John V. Heymach
Summary: Research suggests that in EGFR-mutant NSCLC patients, EGFR signaling plays a dominant role in regulating HIF-1 alpha and VEGF in a hypoxia-independent manner, supporting the targeting of VEGF in EGFR-mutant tumors.
JOURNAL OF THORACIC ONCOLOGY
(2021)
Article
Gastroenterology & Hepatology
Huaqiang Zhu, Xian Jiang, Xu Zhou, Xuesong Dong, Kai Xie, Chuncheng Yang, Hongchi Jiang, Xueying Sun, Jun Lu
LIVER INTERNATIONAL
(2018)
Review
Gastroenterology & Hepatology
Ping Wang, Gang Tan, Mingxin Zhu, Weidong Li, Bo Zhai, Xueying Sun
EXPERT REVIEW OF GASTROENTEROLOGY & HEPATOLOGY
(2018)
Article
Cell Biology
Zheng Wei, Wenjing Jiang, Hengzhen Wang, Hali Li, Bo Tang, Bing Liu, Hongchi Jiang, Xueying Sun
CELLULAR SIGNALLING
(2018)
Article
Cell Biology
Dan Li, Chaoqun Wang, Panfei Mal, Qingan Yu, Mingqi Gu, Liqian Dong, Wenjing Jiang, Shangha Pan, Changming Xie, Jihua Han, Yaliang Lan, Jing Sun, Ping Sheng, Kunpeng Liu, Yaohua Wu, Lianxin Liu, Yong Ma, Hongchi Jiang
CELL DEATH & DISEASE
(2018)
Article
Multidisciplinary Sciences
Wenjing Jiang, Guangxin Li, Weidong Li, Ping Wang, Peng Xiu, Xian Jiang, Bing Liu, Xueying Sun, Hongchi Jiang
SCIENTIFIC REPORTS
(2018)
Article
Oncology
Xian Jiang, Changlu Zhang, Weidong Li, Dalei Jiang, Zheng Wei, Mei Lv, Xiangjun Xie, Xueying Sun
Article
Biotechnology & Applied Microbiology
QingAn Yu, KunPeng Liu, DaKun Ma, ChangMing Xie, YaoHua Wu, WenJie Dai, HongChi Jiang
BIOMED RESEARCH INTERNATIONAL
(2019)
Article
Oncology
Lixin Ma, Bo Zhai, Huaqiang Zhu, Weidong Li, Wenjing Jiang, Liwang Lei, Shujun Zhang, Haiquan Qiao, Xian Jiang, Xueying Sun
CANCER CELL INTERNATIONAL
(2019)
Article
Surgery
QingAn Yu, KunPeng Liu, Shuang Zhang, Hao Li, ChangMing Xie, YaoHua Wu, HongChi Jiang, WenJie Dai
JOURNAL OF SURGICAL RESEARCH
(2019)
Article
Cell Biology
Ping Wang, Chunlong Zhang, Weidong Li, Bo Zhai, Xian Jiang, Shiva Reddy, Hongchi Jiang, Xueying Sun
CELL COMMUNICATION AND SIGNALING
(2020)
Article
Biochemistry & Molecular Biology
Ping Wang, Weidong Li, Bo Zhai, Xian Jiang, Hongchi Jiang, Chunlong Zhang, Xueying Sun
JOURNAL OF CELLULAR BIOCHEMISTRY
(2020)
Article
Cell Biology
Huaqiang Zhu, Bo Zhai, Changjun He, Ziyi Li, Hengjun Gao, Zheyu Niu, Xian Jiang, Jun Lu, Xueying Sun
CELL DEATH & DISEASE
(2020)
Article
Oncology
Xin Xu, Wenjing Jiang, Peng Han, Jingyan Zhang, Liquan Tong, Xueying Sun
Summary: The study identifies the potential therapeutic targets of the miR-128-3p/c-Met axis for overcoming Lenvatinib resistance in HCC. It demonstrates that miR-128-3p mimics can enhance the anti-tumor effects of Lenvatinib. These findings are significant for further understanding the mechanisms of Lenvatinib resistance and developing novel therapeutic strategies.
JOURNAL OF HEPATOCELLULAR CARCINOMA
(2022)