Transcriptomic indices of fast and slow disease progression in two mouse models of amyotrophic lateral sclerosis

S[+] Apomorphine is a CNS penetrating activator of the Nrf2-ARE pathway with activity in mouse and patient fibroblast models of amyotrophic lateral sclerosis

(2013) Richard J. Mead et al.   FREE RADICAL BIOLOGY AND MEDICINE

Axonal transport deficits and neurodegenerative diseases

(2013) Stéphanie Millecamps et al.   NATURE REVIEWS NEUROSCIENCE

The changing scene of amyotrophic lateral sclerosis

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Effect of genetic background on onset and disease progression in the SOD1-G93A model of amyotrophic lateral sclerosis

(2012) Renzo Mancuso et al.   Amyotrophic Lateral Sclerosis

Amyotrophic Lateral Sclerosis: New Insights into Underlying Molecular Mechanisms and Opportunities for Therapeutic Intervention

(2012) Mauro Cozzolino et al.   ANTIOXIDANTS & REDOX SIGNALING

Unraveling the Complexity of Amyotrophic Lateral Sclerosis: Recent Advances from the Transgenic Mutant SOD1 Mice

(2012) M. Peviani et al.   CNS & Neurological Disorders-Drug Targets

Nrf2-dependent Induction of Proteasome and Pa28αβ Regulator Are Required for Adaptation to Oxidative Stress

(2012) Andrew M. Pickering et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Motoneurons Secrete Angiogenin to Induce RNA Cleavage in Astroglia

(2012) A. Skorupa et al.   JOURNAL OF NEUROSCIENCE

Mitochondria, oxidative stress and neurodegeneration

(2012) Antonio Federico et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

EPHA4 is a disease modifier of amyotrophic lateral sclerosis in animal models and in humans

(2012) Annelies Van Hoecke et al.   NATURE MEDICINE

Gene expression profiling in human neurodegenerative disease

(2012) Johnathan Cooper-Knock et al.   Nature Reviews Neurology

Review: Axon pathology in age-related neurodegenerative disorders

(2012) R. Adalbert et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Effect of genetic background on phenotype variability in transgenic mouse models of amyotrophic lateral sclerosis: A window of opportunity in the search for genetic modifiers

(2011) Terry D. Heiman-Patterson et al.   Amyotrophic Lateral Sclerosis

Endogenous regulatory T lymphocytes ameliorate amyotrophic lateral sclerosis in mice and correlate with disease progression in patients with amyotrophic lateral sclerosis

(2011) David R. Beers et al.   BRAIN

PA28 and the proteasome immunosubunits play a central and independent role in the production of MHC class I-binding peptides in vivo

(2011) Natascha de Graaf et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Novel roles of complement in T effector cell regulation

(2011) Peter S. Heeger et al.   IMMUNOBIOLOGY

Complement upregulation and activation on motor neurons and neuromuscular junction in the SOD1 G93A mouse model of familial amyotrophic lateral sclerosis

(2011) Bianca Heurich et al.   JOURNAL OF NEUROIMMUNOLOGY

Complement Protein C1q-Mediated Neuroprotection Is Correlated with Regulation of Neuronal Gene and MicroRNA Expression

(2011) M. E. Benoit et al.   JOURNAL OF NEUROSCIENCE

Molecular pathways of motor neuron injury in amyotrophic lateral sclerosis

(2011) Laura Ferraiuolo et al.   Nature Reviews Neurology

Review: The role of mitochondria in the pathogenesis of amyotrophic lateral sclerosis

(2011) L. M. Duffy et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Amyotrophic Lateral Sclerosis Multiprotein Biomarkers in Peripheral Blood Mononuclear Cells

(2011) Giovanni Nardo et al.   PLoS One

Dysfunction of constitutive and inducible ubiquitin-proteasome system in amyotrophic lateral sclerosis: Implication for protein aggregation and immune response

(2011) Caterina Bendotti et al.   PROGRESS IN NEUROBIOLOGY

The immunoproteasome, the 20S proteasome and the PA28αβ proteasome regulator are oxidative-stress-adaptive proteolytic complexes

(2010) Andrew M. Pickering et al.   BIOCHEMICAL JOURNAL

Mechanisms Underlying Inflammation in Neurodegeneration

(2010) Christopher K. Glass et al.   CELL

The RAD6 DNA Damage Tolerance Pathway Operates Uncoupled from the Replication Fork and Is Functional Beyond S Phase

(2010) Georgios I. Karras et al.   CELL

Nuclear Erythroid Factor 2-mediated Proteasome Activation Delays Senescence in Human Fibroblasts

(2010) Suzanne Kapeta et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Characterization of the Properties of a Novel Mutation in VAPB in Familial Amyotrophic Lateral Sclerosis

(2010) Han-Jou Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The “Dying-Back” Phenomenon of Motor Neurons in ALS

(2010) Michal Dadon-Nachum et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Trimming of Ubiquitin Chains by Proteasome-associated Deubiquitinating Enzymes

(2010) Min Jae Lee et al.   MOLECULAR & CELLULAR PROTEOMICS

The Nrf2 System as a Potential Target for the Development of Indirect Antioxidants

(2010) Kyeong-Ah Jung et al.   MOLECULES

Mutations in CHMP2B in Lower Motor Neuron Predominant Amyotrophic Lateral Sclerosis (ALS)

(2010) Laura E. Cox et al.   PLoS One

Deficits in axonal transport precede ALS symptoms in vivo

(2010) L. G. Bilsland et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Complement in neuroprotection and neurodegeneration

(2010) Vijay Yanamadala et al.   TRENDS IN MOLECULAR MEDICINE

Treatment with lithium carbonate does not improve disease progression in two different strains of SOD1 mutant mice

(2009) Chiara Pizzasegola et al.   Amyotrophic Lateral Sclerosis

Mitochondrial Function, Morphology, and Axonal Transport in Amyotrophic Lateral Sclerosis

(2009) Jordi Magrané et al.   ANTIOXIDANTS & REDOX SIGNALING

Nitroproteomics of Peripheral Blood Mononuclear Cells from Patients and a Rat Model of ALS

(2009) Giovanni Nardo et al.   ANTIOXIDANTS & REDOX SIGNALING

Oncostatin M-induced CCL2 transcription in osteoblastic cells is mediated by multiple levels of STAT-1 and STAT-3 signaling: An implication for the pathogenesis of arthritis

(2009) Sang-Heng Kok et al.   ARTHRITIS AND RHEUMATISM

Mitochondrial dysfunction in amyotrophic lateral sclerosis

(2009) Ping Shi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

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(2009) Richard D Pearson et al.   BMC BIOINFORMATICS

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(2009) A Longatti et al.   CELL DEATH AND DIFFERENTIATION

Angiogenin protects motoneurons against hypoxic injury

(2009) J Sebastià et al.   CELL DEATH AND DIFFERENTIATION

Multiple roles of the vesicular-SNARE TI-VAMP in post-Golgi and endosomal trafficking

(2009) Mathilde Chaineau et al.   FEBS LETTERS

Oxidative stress in ALS: Key role in motor neuron injury and therapeutic target

(2009) Siân C. Barber et al.   FREE RADICAL BIOLOGY AND MEDICINE

Major histocompatability complex class I expression and glial reaction influence spinal motoneuron synaptic plasticity during the course of experimental autoimmune encephalomyelitis

(2009) C.M. Freria et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Classical Major Histocompatibility Complex Class I Molecules in Motoneurons: New Actors at the Neuromuscular Junction

(2009) S. Thams et al.   JOURNAL OF NEUROSCIENCE

Axonal mRNA in Uninjured and Regenerating Cortical Mammalian Axons

(2009) A. M. Taylor et al.   JOURNAL OF NEUROSCIENCE

Specificity of Cytoplasmic Dynein Subunits in Discrete Membrane-trafficking Steps

(2009) Krysten J. Palmer et al.   MOLECULAR BIOLOGY OF THE CELL

A selective inhibitor of the immunoproteasome subunit LMP7 blocks cytokine production and attenuates progression of experimental arthritis

(2009) Tony Muchamuel et al.   NATURE MEDICINE

A role for motoneuron subtype–selective ER stress in disease manifestations of FALS mice

(2009) Smita Saxena et al.   NATURE NEUROSCIENCE

Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources

(2009) Da Wei Huang et al.   Nature Protocols

Inflammation in ALS and SMA: Sorting out the good from the evil

(2009) Dimitra Papadimitriou et al.   NEUROBIOLOGY OF DISEASE

MHC Class I: An Unexpected Role in Neuronal Plasticity

(2009) Carla J. Shatz   NEURON

Characterization of Detergent-Insoluble Proteins in ALS Indicates a Causal Link between Nitrative Stress and Aggregation in Pathogenesis

(2009) Manuela Basso et al.   PLoS One

Activation of innate and humoral immunity in the peripheral nervous system of ALS transgenic mice

(2009) I. M. Chiu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Complement-Derived Anaphylatoxin C3a Regulates In Vitro Differentiation and Migration of Neural Progenitor Cells

(2009) Noriko Shinjyo et al.   STEM CELLS

Roles of endosomal trafficking in neurite outgrowth and guidance

(2009) Sharon Sann et al.   TRENDS IN CELL BIOLOGY

SOCS1 and SOCS3 in the control of CNS immunity

(2009) Brandi J. Baker et al.   TRENDS IN IMMUNOLOGY

T cell-microglial dialogue in Parkinson's disease and amyotrophic lateral sclerosis: are we listening?

(2009) Stanley H. Appel et al.   TRENDS IN IMMUNOLOGY

Role of Axonal Transport in Neurodegenerative Diseases

(2008) Kurt J. De Vos et al.   Annual Review of Neuroscience

Activating Transcription Factor 3 Is a Novel Repressor of the Nuclear Factor Erythroid-Derived 2 Related Factor 2 (Nrf2) Regulated Stress Pathway

(2008) S. L. Brown et al.   CANCER RESEARCH

Targeting angiogenin in therapy of amyotropic lateral sclerosis

(2008) Hiroko Kishikawa et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Uncoupling protein-2 (UCP2) induces mitochondrial proton leak and increases susceptibility of non-alcoholic steatohepatitis (NASH) liver to ischaemia-reperfusion injury

(2008) G Serviddio et al.   GUT

Functional alterations of the ubiquitin-proteasome system in motor neurons of a mouse model of familial amyotrophic lateral sclerosis†

(2008) Cristina Cheroni et al.   HUMAN MOLECULAR GENETICS

Complement anaphylatoxin C5a neuroprotects through regulation of glutamate receptor subunit 2 in vitro and in vivo

(2008) Piali Mukherjee et al.   Journal of Neuroinflammation

Nuclear Erythroid 2-Related Factor 2-Antioxidative Response Element Signaling Pathway in Motor Cortex and Spinal Cord in Amyotrophic Lateral Sclerosis

(2008) Alexander Sarlette et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Expression of Nonclassical Class I Major Histocompatibility Genes Defines a Tripartite Organization of the Mouse Vomeronasal System

(2008) T. Ishii et al.   JOURNAL OF NEUROSCIENCE

Neuron-Specific Expression of Mutant Superoxide Dismutase Is Sufficient to Induce Amyotrophic Lateral Sclerosis in Transgenic Mice

(2008) D. Jaarsma et al.   JOURNAL OF NEUROSCIENCE

Complement C3 Deficiency Leads to Accelerated Amyloid   Plaque Deposition and Neurodegeneration and Modulation of the Microglia/Macrophage Phenotype in Amyloid Precursor Protein Transgenic Mice

(2008) M. Maier et al.   JOURNAL OF NEUROSCIENCE

Control of Motoneuron Survival by Angiogenin

(2008) D. Kieran et al.   JOURNAL OF NEUROSCIENCE

Nrf2 Activation in Astrocytes Protects against Neurodegeneration in Mouse Models of Familial Amyotrophic Lateral Sclerosis

(2008) M. R. Vargas et al.   JOURNAL OF NEUROSCIENCE

ALS-causing SOD1 mutants generate vascular changes prior to motor neuron degeneration

(2008) Zhihui Zhong et al.   NATURE NEUROSCIENCE

Astrocytes as determinants of disease progression in inherited amyotrophic lateral sclerosis

(2008) Koji Yamanaka et al.   NATURE NEUROSCIENCE

Neurovascular signalling defects in neurodegeneration

(2008) Serena Zacchigna et al.   NATURE REVIEWS NEUROSCIENCE

Synaptic vesicle protein trafficking at the glutamate synapse

(2008) M.S. Santos et al.   NEUROSCIENCE

CD4+ T cells support glial neuroprotection, slow disease progression, and modify glial morphology in an animal model of inherited ALS

(2008) D. R. Beers et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

T lymphocytes potentiate endogenous neuroprotective inflammation in a mouse model of ALS

(2008) I. M. Chiu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Transgenics, toxicity and therapeutics in rodent models of mutant SOD1-mediated familial ALS

(2008) B TURNER et al.   PROGRESS IN NEUROBIOLOGY