Article
Geriatrics & Gerontology
Anoop T. Balachandran, William J. Evans, Peggy M. Cawthon, Yipeng Wang, Mahalakshmi Shankaran, Marc K. Hellerstein, Peihua Qiu, Todd Manini
Summary: The D3Cr dilution method provides a direct measure of skeletal muscle mass and is strongly associated with health-related outcomes in older men. However, its sensitivity to detect changes in muscle mass due to intervention is limited.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2023)
Review
Cell Biology
Giulia Coletta, Stuart M. Phillips
Summary: Consensus on what constitutes sarcopenia is critical to propel research in the field and provide prognostic value and treatment options for patients.
AGEING RESEARCH REVIEWS
(2023)
Review
Physiology
Hugo Falqueto, Marcelo Rodrigues dos Santos, Leandro H. Manfredi
Summary: Sarcopenia is a health concern characterized by reduced physical function and muscle mass. Exercise training can help improve these conditions, but it may not be effective for many elderly individuals. Thus, the use of anabolic-androgenic steroids may be a viable strategy.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Geriatrics & Gerontology
Leatha A. Clark, David W. Russ, Dallin Tavoian, W. David Arnold, Timothy D. Law, Christopher R. France, Brian C. Clark
Summary: The response of muscle strength to resistance exercise in older adults appears to be dependent on the type of contraction, with changes in muscle contractility being positively associated with improvements in isokinetic strength. Changes in lean mass and voluntary activation did not significantly explain the heterogeneity in strength response. More comprehensive assessments of muscle strength adaptations are needed in future investigations.
EXPERIMENTAL GERONTOLOGY
(2021)
Article
Geriatrics & Gerontology
Ana Carolina Silva, Milton Amaral Pereira, Lilian Maria Peixoto, Izinara Cruz Rosse, Joao Batista Ferreira, Emerson Cruz de Oliveira, Lenice Kappes Becker, Daniel Barbosa Coelho
Summary: This study aimed to evaluate the effects of 12 weeks of resistance training with progressive intensity on factors associated with sarcopenia in older individuals. The results showed that resistance training can improve physical performance and muscular strength, but it does not significantly affect muscle mass index and walking speed.
Article
Nutrition & Dietetics
J. Max Michel, Kristy K. Lievense, Sam C. Norton, Juliana V. Costa, Kathryn H. Alphin, Lydia A. Bailey, Gary D. Miller
Summary: This study examined the effects of resistance training (RT) and protein intake on muscle in older adults. The results showed that RT improved muscle quality and function, and the type of protein intake did not have a significant impact on the outcomes.
Article
Geriatrics & Gerontology
Linqian Lu, Xiangfeng He, Lin Ma, Yu Liu, Nan Chen
Summary: Sarcopenia is a chronic and progressive disease associated with aging, which can lead to various health issues. Exercise therapy and nutritional supplement are the main methods for preventing and treating sarcopenia. This study compares the effects of vibration training and resistance training on older adults with sarcopenia.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Nutrition & Dietetics
Natalia Maira da Cruz Alves, Karina Pfrimer, Priscila Carvalho Santos, Ellen Cristini de Freitas, Thiago Neves, Rodrigo Antonio Pessini, Marcia Varella Morandi Junqueira-Franco, Marcello H. Nogueira-Barbosa, Carolyn Anne Greig, Eduardo Ferriolli
Summary: This study found that fish oil supplementation can enhance the response of sarcopenic older women to exercise, increasing muscle strength and physical performance.
Article
Biochemistry & Molecular Biology
Nick Gaulton, Griffen Wakelin, Laura V. Young, Scott Wotherspoon, Michael Kamal, Gianni Parise, Joshua P. Nederveen, Andy Holwerda, Lex B. Verdijk, Luc J. C. van Loon, Tim Snijders, Adam P. Johnston
Summary: Twist2-expressing cells are a population of myogenic progenitors in human skeletal muscle that respond to aging and exercise. They are similar to fibro-adipogenic progenitors (FAPs) and distinct from satellite cells. These cells are more prevalent in aged muscle and increase following resistance exercise training (RET).
Article
Biochemistry & Molecular Biology
Manuela Moriggi, Sara Belloli, Pietro Barbacini, Valentina Murtaj, Enrica Torretta, Linda Chaabane, Tamara Canu, Silvia Penati, Maria Luisa Malosio, Antonio Esposito, Cecilia Gelfi, Rosa Maria Moresco, Daniele Capitanio
Summary: The study revealed gender-specific responses to obesity in mice, with males showing various metabolic alterations while females exhibited activation of compensatory mechanisms. Bioinformatics analysis identified upstream molecules regulating pathways differently in males and females.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Oncology
Maximilian Koeppel, Katlynn Mathis, Kathryn H. Schmitz, Joachim Wiskemann
Summary: Resistance training can effectively counteract muscle loss in cancer patients, with better results in a supervised setting.
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
(2021)
Article
Geriatrics & Gerontology
Samaneh Farsijani, Adam J. Santanasto, Iva Miljkovic, Robert M. Boudreau, Bret H. Goodpaster, Stephen B. Kritchevsky, Anne B. Newman
Summary: The study found that the association between intermuscular fat area and impaired physical function is more significant in individuals with higher muscle area. This suggests that muscle mass plays a moderating role in the relationship between muscle fat deposition and physical performance.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2021)
Article
Medicine, General & Internal
Nobuto Nakanishi, Shigeaki Inoue, Rie Tsutsumi, Yusuke Akimoto, Yuko Ono, Joji Kotani, Hiroshi Sakaue, Jun Oto
Summary: Ultrasound has been widely used for measuring the rectus femoris muscle in critical illness, but its accuracy depends on various factors. A novel phantom model was created to investigate the accuracy of measurements and for training, showing improvements in accuracy through training.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Nutrition & Dietetics
Hamilton Roschel, Ana Paula Hayashi, Alan L. Fernandes, Jose Claudio Jambassi-Filho, Victoria Hevia-Larrain, Mariana de Capitani, Davi A. Santana, Livia S. Goncalves, Ana Lucia De Sa-Pinto, Fernanda R. Lima, Marcelo T. Sapienza, Alberto J. S. Duarte, Rosa M. R. Pereira, Stuart M. Phillips, Bruno Gualano
Summary: The study found that supplementation with whey, soy, leucine, or creatine did not enhance the adaptations to resistance training in pre-frail and frail elderly individuals. However, resistance exercise itself increased muscle mass and function in all participants, with no adverse effects observed.
CLINICAL NUTRITION
(2021)
Article
Geriatrics & Gerontology
Sebastiaan Dalle, Evelien Van Roie, Charlotte Hiroux, Mathias Vanmunster, Walter Coudyzer, Frank Suhr, Stijn Bogaerts, Ruud Van Thienen, Katrien Koppo
Summary: The study found that while Ω-3 fatty acids contribute to increased muscle strength in older adults, they do not improve beneficial catabolic or inflammatory adaptations induced by resistance exercise. Changes in muscle quality, rather than muscle volume, might explain the gains in strength.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2021)
Review
Clinical Neurology
Shilpa Purushotham, Rob S. Stephenson, Andy Sanderson, Deepa Abichandani, Carolyn Greig, Adrian Gardner, Deborah Falla
Summary: This systematic review analyzed the existing evidence of microscopic muscle changes in people with chronic spinal pain. The results showed no difference in fiber type composition and fiber cross-sectional area between people with and without chronic low back pain. The overall quality of evidence is very low, and there is no clear conclusion regarding the differences in microscopic muscle features between people with and without chronic spinal pain.
Article
Nutrition & Dietetics
Sophie L. Mathewson, Adam L. Gordon, Kenneth Smith, Philip J. Atherton, Carolyn A. Greig, Bethan E. Phillips
Summary: This study found that habitual dietary intake did not explain the differences in muscle mass and strength parameters between young and older adults, suggesting that there may be other factors contributing to these differences. Larger sample size studies are needed to further investigate these relationships and potentially inform interventions against sarcopenia development.
Article
Physiology
Jonathan I. Quinlan, Amritpal Dhaliwal, Felicity Williams, Sophie L. Allen, Leigh Breen, Carolyn A. Greig, Janet M. Lord, Matthew J. Armstrong, Ahmed M. Elsharkawy
Summary: This study demonstrated the feasibility and efficacy of percutaneous muscle biopsies in patients with ESLD. The procedure successfully obtained muscle tissue with a high consent rate and yielded sufficient tissue for analysis. The study provides evidence for the safe use of muscle biopsies in this population, even considering disease-specific complications, medications, and comorbidities.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Cell Biology
Amritpal Dhaliwal, Felicity R. Williams, Jonathan Quinlan, Sophie L. Allen, Carolyn Greig, Andrew Filer, Karim Raza, Subrata Ghosh, Gareth G. Lavery, Philip N. Newsome, Surabhi Choudhary, Leigh Breen, Matthew J. Armstrong, Ahmed M. Elsharkawy, Janet M. Lord
Summary: This study aims to identify potential mechanisms driving sarcopenia within chronic inflammatory diseases through a multi-modal approach, in order to define potential interventions for the future. The study will involve multi-modal assessment of sarcopenia in chronic liver disease, inflammatory bowel disease, and rheumatoid arthritis, exploring the impact of chronic inflammation on muscle weakness.
Article
Geriatrics & Gerontology
Carly Welch, Carolyn Greig, Danielle Lewis, Zeinab Majid, Tahir Masud, Hannah Moorey, Thomas Pinkney, Benjamin Stanley, Thomas Jackson
Summary: This study aimed to characterize changes in muscle quantity, quality, strength, and physical function in hospitalized older patients. The Patient-Reported Outcome Measures Information System T-score was found to be a sensitive measure of change in physical function, while changes in muscle quantity, quality, and function were not significant at the study population level.
GERIATRICS & GERONTOLOGY INTERNATIONAL
(2022)
Article
Cell Biology
Sophie L. Allen, Alex P. Seabright, Jonathan Quinlan, Amritpal Dhaliwal, Felicity R. Williams, Nicholas H. F. Fine, David J. Hodson, Matthew J. Armstrong, Ahmed M. Elsharkaway, Carolyn A. Greig, Yu-Chiang Lai, Janet M. Lord, Gareth G. Lavery, Leigh Breen
Summary: This study utilized an in vitro model of liver disease to investigate the effects of serum from liver disease patients on myotube diameter, mitochondrial respiration, and muscle-related protein content. The findings suggest potential mechanisms underlying sarcopenia development in liver disease patients.
Article
Nutrition & Dietetics
Natalia Maira da Cruz Alves, Karina Pfrimer, Priscila Carvalho Santos, Ellen Cristini de Freitas, Thiago Neves, Rodrigo Antonio Pessini, Marcia Varella Morandi Junqueira-Franco, Marcello H. Nogueira-Barbosa, Carolyn Anne Greig, Eduardo Ferriolli
Summary: This study found that fish oil supplementation can enhance the response of sarcopenic older women to exercise, increasing muscle strength and physical performance.
Article
Physiology
Ryan Neil Marshall, James McKendry, Benoit Smeuninx, Alex Peter Seabright, Paul T. Morgan, Carolyn Greig, Leigh Breen
Summary: Ageing is associated with changes in skeletal muscle oxidative metabolism, which may be influenced by physical activity status. The effect of resistance exercise training on skeletal muscle mitochondrial regulation is unclear.
FRONTIERS IN PHYSIOLOGY
(2023)
Article
Gastroenterology & Hepatology
Jennifer Towey, Chiemelie Ngonadi, Neil Rajoriya, Andrew Holt, Carolyn Greig, Matthew J. Armstrong
Summary: This case-control study aims to investigate the impact of HE on nutritional intake and sarcopenia status in patients with ESLD. Through clinical assessment and dietary intake evaluation, the study will explore the effect of HE on nutritional status and muscle health.
BMJ OPEN GASTROENTEROLOGY
(2022)
Article
Physiology
Jonathan I. Quinlan, Amritpal Dhaliwal, Felicity R. Williams, Sophie L. Allen, Surabhi Choudhary, Alex Rowlands, Leigh Breen, Gareth G. Lavery, Janet M. Lord, Ahmed M. Elsharkawy, Matthew J. Armstrong, Carolyn A. Greig
Summary: The central question of this study is to determine to what extent musculoskeletal impairment occurs in patients with end stage liver disease (ESLD) compared to a healthy control group. The main finding is that muscle mass, quality, and function are impaired in patients with ESLD, particularly in the lower limb muscle groups. This highlights the importance of considering muscle health in the lower limbs, as sarcopenia is associated with reduced quality of life and increased mortality in ESLD patients.
EXPERIMENTAL PHYSIOLOGY
(2023)
Article
Medicine, Research & Experimental
Matthew Willett, Alison Rushton, Gareth Stephens, Sally Fenton, Sarah Rich, Carolyn Greig, Joan Duda
Summary: This study aims to assess the feasibility and acceptability of a complex multicomponent physiotherapy behavior change intervention for patients with lower-limb osteoarthritis (OA). The intervention is based on self-determination theory and other motivational frameworks, and aims to help patients adopt and maintain optimal levels of physical activity. Thirty-five participants will receive a six-session physiotherapy intervention, and feasibility and acceptability will be assessed through interviews and focus groups, among other methods.
PILOT AND FEASIBILITY STUDIES
(2023)
Article
Geriatrics & Gerontology
Benjamin Stanley, Carolyn Greig, Thomas Jackson, Danielle Lewis, Hannah Moorey, Zainab Majid, Tahir Masud, Thomas Pinkney, Carly Welch
Summary: The study aimed to determine the impact of fluid status on ultrasound muscle assessment in diagnosing sarcopenia. The results showed a significant correlation between fluid status and muscle quantity and quality. These findings highlight the importance of considering fluid balance in the diagnosis of sarcopenia.
Article
Nutrition & Dietetics
Anneka E. Welford, Andrea L. Darling, Sarah J. Allison, Susan A. Lanham-New, Carolyn A. Greig
Summary: The aim of this study was to assess the seasonal relationship between serum 25(OH)D concentration, lean mass and muscle strength. The study found no significant association between vitamin D status and functional indicators of musculoskeletal health, which were additionally not affected by season.
JOURNAL OF NUTRITIONAL SCIENCE
(2022)
Article
Rehabilitation
Jonathan I. Quinlan, Clare Jones, Emma Bissonnette, Amritpal Dhaliwal, Felicity Williams, Surabhi Choudhary, Leigh Breen, Gareth G. Lavery, Matthew J. Armstrong, Ahmed M. Elsharkawy, Janet M. Lord, Carolyn A. Greig
Summary: End stage liver disease patients with muscle mass loss are at increased risk of complications, hospitalization, and mortality. This study investigated the impact of reducing the number of slices required for muscle volume estimation and compared two equations for estimating muscle volume. The use of the truncated equation with a 4 cm slice interval on MRI was found to be an efficient and accurate method for estimating quadricep muscle volume in ESLD patients.
FRONTIERS IN REHABILITATION SCIENCES
(2022)
Article
Geriatrics & Gerontology
Carly Welch, Carolyn Greig, Zeinab Majid, Tahir Masud, Hannah Moorey, Thomas Pinkney, Thomas Jackson
Summary: The study aimed to assess the feasibility of conducting acute sarcopenia research in complex populations of hospitalised older adults. Findings showed higher recruitment rates in elective surgery patients and higher completion rates for ultrasound quadriceps. Protocol adaptations are important for ensuring feasibility, and early-stage clinical research should include assessment of muscle quantity and quality.
EUROPEAN GERIATRIC MEDICINE
(2022)