Review
Biochemistry & Molecular Biology
Raul R. Rodriguez-Berrios, Stephen R. Isbel, Alejandro Bugarin
Summary: Polypropionate units, found in many natural products, have antimicrobial and therapeutic potential. This review includes all epoxide-based methodologies developed by research groups such as Kishi, Katsuki, Marashall, Miyashita, Prieto, Sarabia, Jung, McDonald, etc. for the synthesis of polypropionates. The review also includes the isolation and biological activities of synthetized polypropionates and related natural products.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Endocrinology & Metabolism
Xi-Ding Yang, Xing-Cheng Ge, Si-Yi Jiang, Yong-Yu Yang
Summary: Epidemic obesity is a significant public health problem associated with an increase in obesity-related metabolic diseases. Adipose tissue plays a vital role in regulating whole-body energy metabolism, and lipolysis, the degradation of triglycerides in adipocytes, is closely linked to obesity and its metabolic disorders. Natural products, including flavonoids, alkaloids, and terpenoids, can regulate lipolysis and potentially contribute to weight loss and improved metabolic conditions associated with obesity. Identifying specific secondary metabolites that are effective in reducing weight and mitigating the health risks associated with obesity and lipolysis regulation is crucial.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Chemistry, Organic
Mohamed F. F. Elmansy, Rita M. M. Borik, Rizk E. E. Khidre
Summary: Nature is a valuable source for drug discovery, providing complex chemical structures of natural products that present attractive challenges for organic chemists. Taxol, a unique natural product with impressive biological properties and a tempting chemical structure, has motivated organic chemists worldwide to synthesize it. This review article covers the retrosynthetic analysis and synthetic routes of Taxol, highlighting key steps in each synthesis. It also critically evaluates the advantages and disadvantages of different synthetic routes based on the number of steps, yields, and synthetic challenges.
CURRENT ORGANIC CHEMISTRY
(2023)
Review
Chemistry, Multidisciplinary
Lucas L. Baldassari, Diogo S. Ludtke
Summary: Selenoesters are important compounds for synthetic purposes due to their ability to participate in various chemical transformations, particularly in the formation of acyl radicals. Scientists have developed multiple methods for synthesizing these compounds from different starting materials.
CHEMISTRY-A EUROPEAN JOURNAL
(2021)
Review
Chemistry, Multidisciplinary
Andrey V. Smolobochkin, Almir S. Gazizov, Alexander R. Burilov, Michail A. Pudovik
Summary: This review focuses on the advances in synthesizing norhygrine and its derivatives in the past decade, particularly emphasizing the stereoselective methods used in their preparation. It also provides information on the biological activity of certain derivatives of 1-(pyrrolidin-2-yl)propan-2-one, and highlights the potential for using pyrrolidines containing a terminal carbonyl group in synthesizing various alkaloids with beneficial properties.
HELVETICA CHIMICA ACTA
(2022)
Review
Food Science & Technology
Nahidun Nesa Chowdhury, Mohammad Nazmul Islam, Rifat Jafrin, Abdur Rauf, Anees Ahmed Khalil, Talha Bin Emran, Abdullah S. M. Aljohani, Fahad A. Alhumaydhi, Jose M. Lorenzo, Mohammad Ali Shariati, Jesus Simal-Gandara
Summary: Fruits are a rich source of vitamins and other essential nutrients for the human body. However, the use of synthetic chemicals for ripening and storing fruits has led to postharvest deterioration. This study suggests using natural plant products instead of synthetic chemicals to control postharvest decay. The investigation of various information sources shows that natural chemicals can effectively eliminate postharvest diseases and prolong the shelf life of fruits.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2022)
Article
Chemistry, Multidisciplinary
Harsh Jain, Dipankar Sutradhar, Sourav Roy, Gautam R. Desiraju
Summary: Higher cocrystal synthesis relies heavily on understanding supramolecular synthons, taking into account the electrophilicity/nucleophilicity differences between alternative sites of halogen bond formation, and ensuring that the two halogen bonds in a ternary halogen bonded cocrystal have different strengths. Mimicking hydrogen bond interactions with halogen bonds is a feasible approach for ternary structures, as shown with the pyrene example. Crystal engineers should be able to predict halogen bonds that are stronger than hydrogen bonds.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Chemistry, Multidisciplinary
Julian M. Feilner, Immanuel Plangger, Klaus Wurst, Thomas Magauer
Summary: This study utilized highly functionalized bifunctional alkenes to achieve a polyene tetracyclization, leading to the total synthesis of the tricyclic diterpenoid pimara-15-en-3 alpha-8 alpha-diol. The versatile route also allowed for the preparation of a diverse library of cyclization precursors for the total synthesis of the tetracyclic nor-diterpenoid norflickinflimiod C, providing insights into complex pentacyclic products.
CHEMISTRY-A EUROPEAN JOURNAL
(2021)
Review
Chemistry, Organic
Krishnaji Tadiparthi, Swathy Venkatesh
Summary: This review outlines the total synthesis of natural products based on the butenolide core unit. It highlights the synthetic methods involved in the preparation of butenolide-containing molecules and aims to increase the profile of such scaffolds to the synthetic community.
JOURNAL OF HETEROCYCLIC CHEMISTRY
(2022)
Review
Chemistry, Organic
Michael P. Badart, Bill C. Hawkins
Summary: The spirocyclic motif is common in natural products, serving as an ideal three-dimensional template for interacting with biological targets. Different reaction strategies are used to construct these spirocyclic centers, creating a series of effective medicinal compounds.
SYNTHESIS-STUTTGART
(2021)
Review
Biochemistry & Molecular Biology
Yeqin Yuan, Huizhi Long, Ziwei Zhou, Yuting Fu, Binyuan Jiang
Summary: Breast cancer is the most common cancer in women, with a rising incidence that poses significant challenges for treatment. The PI3K-AKT pathway and its targets play crucial roles in breast cancer development, and natural products and drugs targeting this pathway show potential for treatment. This review discusses the role of the PI3K-AKT signaling pathway in breast cancer and highlights the use of natural products and drugs targeting this pathway in clinical trials.
Review
Medicine, Research & Experimental
M. Vijaykrishnaraj, Kuiwu Wang
Summary: Natural products found in various natural foods have potential biological activities, including plants, fruits, vegetables, and marine life. The biochemical reaction known as advanced glycation end products (AGEs) in the human body contributes to the pathogenesis of diabetic complications. Researchers are exploring the use of food-derived natural products to control AGEs-related disease complications.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Review
Pharmacology & Pharmacy
Changsheng Wu, Yizhen Yin, Lele Zhu, Youming Zhang, Yue-Zhong Li
Summary: Metagenomics offers the advantage of accessing the biosynthetic potential of uncultivable microbes compared to culture-based natural product discovery. DNA sequencing allows the straightforward resolution of the genomes of (in)cultivable bugs from environmental samples, enabling the prediction of biosynthetic gene clusters. The predicted chemical diversities can be realized through various methods.
DRUG DISCOVERY TODAY
(2022)
Review
Biotechnology & Applied Microbiology
Mihris Ibnu Saleem Naduthodi, Nico J. Claassens, Sarah 'Adamo, John van der Oost, Maria J. Barbosa
Summary: The high cost of phototrophic cultivation is the main obstacle in commercializing biofuels and other products produced by microalgae, and improving microalgal productivity is seen as a potential solution. While synthetic biology methods have been used to engineer downstream production pathways in some microalgal strains, exploration of enhancing upstream photosynthetic and carbon fixation metabolism for growth and yield improvement in microalgae is limited. Strategies to increase reducing power generation from light and enhance CO2 assimilation through the Calvin cycle or synthetic alternatives are described as key areas for improvement. Optimism is expressed for breakthroughs in microalgal research with recent technological advancements.
TRENDS IN BIOTECHNOLOGY
(2021)
Article
Chemistry, Organic
Sambasivarao Kotha, Ramakrishna Reddy Keesari
Summary: This study investigates the synthetic approaches to tetraquinanes in crinipellin type natural products using ring-rearrangement metathesis and ring-closing metathesis as key steps. Different alkylation sequences are employed to prepare the desired RRM/RCM precursors, resulting in various tetraquinane derivatives that may be useful for designing medicinally important drug-like molecules. Additionally, spiro-quinanes rearrange to fused-quinanes under certain conditions, expanding the understanding of polycyclic systems in natural products.
ASIAN JOURNAL OF ORGANIC CHEMISTRY
(2021)
Review
Chemistry, Multidisciplinary
Adel M. ElSohly, Matthew B. Francis
ACCOUNTS OF CHEMICAL RESEARCH
(2015)
Article
Chemistry, Multidisciplinary
James M. Eagan, Masahiro Hori, Jianbin Wu, Kyalo Stephen Kanyiva, Scott A. Snyder
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2015)
Article
Biochemical Research Methods
Adel M. ElSohly, Chawita Netirojjanakul, Ioana L. Aanei, Astraea Jager, Sean C. Bendall, Michelle E. Farkas, Garry P. Nolan, Matthew B. Francis
BIOCONJUGATE CHEMISTRY
(2015)
Article
Chemistry, Organic
Adam M. Levinson, Phillip J. Milner, Scott A. Snyder
TETRAHEDRON LETTERS
(2015)
Article
Medicine, Research & Experimental
Ioana L. Aanei, Adel M. ElSohly, Michelle E. Farkas, Chawita Netirojjanakul, Melanie Regan, Stephanie Taylor Murphy, James P. O'Neil, Youngho Seo, Matthew B. Francis
MOLECULAR PHARMACEUTICS
(2016)
Article
Chemistry, Multidisciplinary
Adel M. ELSohly, James I. MacDonald, Nina B. Hentzen, Ioana L. Aanei, Kareem M. El Muslemany, Matthew B. Francis
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2017)
Article
Chemistry, Applied
Shixian Deng, Zhenzhuang Cheng, Charles Ingalls, Ferenc Kontes, Jiaming Yan, Sandro Belvedere
ORGANIC PROCESS RESEARCH & DEVELOPMENT
(2017)
Article
Chemistry, Multidisciplinary
Adel M. ElSohly, Daniel A. Wespe, Tyler J. Poore, Scott A. Snyder
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2013)
Article
Chemistry, Multidisciplinary
Tue H. Jepsen, Stephen B. Thomas, Yunqing Lin, Christos I. Stathakis, Irene de Miguel, Scott A. Snyder
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2014)
Article
Biochemical Research Methods
Stacy L. Capehart, Adel M. ElSohly, Allie C. Obermeyer, Matthew B. Francis
BIOCONJUGATE CHEMISTRY
(2014)
Article
Chemistry, Medicinal
Daniel S. Treitler, Zhufang Li, Mark Krystal, Nicholas A. Meanwell, Scott A. Snyder
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2013)
Article
Chemistry, Multidisciplinary
Kareem M. El Muslemany, Amy A. Twite, Adel M. ElSohly, Allie C. Obermeyer, Richard A. Mathies, Matthew B. Francis
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2014)
Article
Chemistry, Organic
Nathan E. Wright, Adel M. ElSohly, Scott A. Snyder
Article
Chemistry, Multidisciplinary
Johnathan C. Maza, Daniel L. V. Bader, Lifeng Xiao, Alan M. Marmelstein, Daniel D. Brauer, Adel M. ElSohly, Matthew J. smith, Shane W. Krska, Craig A. Parish, Matthew B. Francis
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2019)