PI3K-AKT-Targeting Breast Cancer Treatments: Natural Products and Synthetic Compounds

Breast cancer is the most commonly diagnosed cancer in women. The high incidence of breast cancer, which is continuing to rise, makes treatment a significant challenge. The PI3K-AKT pathway and its downstream targets influence various cellular processes. In recent years, mounting evidence has shown that natural products and synthetic drugs targeting PI3K-AKT signaling have the potential to treat breast cancer. In this review, we discuss the role of the PI3K-AKT signaling pathway in the occurrence and development of breast cancer and highlight PI3K-AKT-targeting natural products and drugs in clinical trials for the treatment of breast cancer.

Automated summary

Breast cancer is the most common cancer in women, with a rising incidence that poses significant challenges for treatment. The PI3K-AKT pathway and its targets play crucial roles in breast cancer development, and natural products and drugs targeting this pathway show potential for treatment. This review discusses the role of the PI3K-AKT signaling pathway in breast cancer and highlights the use of natural products and drugs targeting this pathway in clinical trials.