Design of synthetic materials for intracellular delivery of RNAs: From siRNA-mediated gene silencing to CRISPR/Cas gene editing
出版年份 2018 全文链接
标题
Design of synthetic materials for intracellular delivery of RNAs: From siRNA-mediated gene silencing to CRISPR/Cas gene editing
作者
关键词
nucleic acid therapeutics, nanoparticles, synthetic nanomaterials, RNAi, mRNA, CRISPR/Cas
出版物
Nano Research
Volume -, Issue -, Pages -
出版商
Springer Nature America, Inc
发表日期
2018-08-07
DOI
10.1007/s12274-018-2099-4
参考文献
相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。- Development of Cationic Quaternary Ammonium Sulfonamide Amino Lipids for Nucleic Acid Delivery
- (2018) Jason B. Miller et al. ACS Applied Materials & Interfaces
- Macrophage-Specific in Vivo Gene Editing Using Cationic Lipid-Assisted Polymeric Nanoparticles
- (2018) Ying-Li Luo et al. ACS Nano
- The Polyploid State Plays a Tumor-Suppressive Role in the Liver
- (2018) Shuyuan Zhang et al. DEVELOPMENTAL CELL
- Knockdown of Anillin Actin Binding Protein Blocks Cytokinesis in Hepatocytes and Reduces Liver Tumor Development in Mice Without Affecting Regeneration
- (2018) Shuyuan Zhang et al. GASTROENTEROLOGY
- Incorporation of mRNA in Lamellar Lipid Matrices for Parenteral Administration
- (2018) Antje Ziller et al. MOLECULAR PHARMACEUTICS
- A Direct Comparison of in Vitro and in Vivo Nucleic Acid Delivery Mediated by Hundreds of Nanoparticles Reveals a Weak Correlation
- (2018) Kalina Paunovska et al. NANO LETTERS
- mRNA vaccines — a new era in vaccinology
- (2018) Norbert Pardi et al. NATURE REVIEWS DRUG DISCOVERY
- A Single Administration of CRISPR/Cas9 Lipid Nanoparticles Achieves Robust and Persistent In Vivo Genome Editing
- (2018) Jonathan D. Finn et al. Cell Reports
- Evolved Cas9 variants with broad PAM compatibility and high DNA specificity
- (2018) Johnny H. Hu et al. NATURE
- Nanotechnologies in delivery of mRNA therapeutics using nonviral vector-based delivery systems
- (2017) S Guan et al. GENE THERAPY
- Lipid Nanoparticle Systems for Enabling Gene Therapies
- (2017) Pieter R. Cullis et al. MOLECULAR THERAPY
- The chemical evolution of oligonucleotide therapies of clinical utility
- (2017) Anastasia Khvorova et al. NATURE BIOTECHNOLOGY
- Structure-guided chemical modification of guide RNA enables potent non-viral in vivo genome editing
- (2017) Hao Yin et al. NATURE BIOTECHNOLOGY
- Elimination of large tumors in mice by mRNA-encoded bispecific antibodies
- (2017) Christiane R Stadler et al. NATURE MEDICINE
- Nusinersen, an antisense oligonucleotide drug for spinal muscular atrophy
- (2017) David R Corey NATURE NEUROSCIENCE
- MicroRNA therapeutics: towards a new era for the management of cancer and other diseases
- (2017) Rajesha Rupaimoole et al. NATURE REVIEWS DRUG DISCOVERY
- N1-methyl-pseudouridine in mRNA enhances translation through eIF2α-dependent and independent mechanisms by increasing ribosome density
- (2017) Yuri V. Svitkin et al. NUCLEIC ACIDS RESEARCH
- Charge-altering releasable transporters (CARTs) for the delivery and release of mRNA in living animals
- (2017) Colin J. McKinlay et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Effects of systemic multiexon skipping with peptide-conjugated morpholinos in the heart of a dog model of Duchenne muscular dystrophy
- (2017) Yusuke Echigoya et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Systemic delivery of factor IX messenger RNA for protein replacement therapy
- (2017) Suvasini Ramaswamy et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- RNAi-based treatment of chronically infected patients and chimpanzees reveals that integrated hepatitis B virus DNA is a source of HBsAg
- (2017) Christine I. Wooddell et al. Science Translational Medicine
- Delivering the right message: Challenges and opportunities in lipid nanoparticles-mediated modified mRNA therapeutics—An innate immune system standpoint
- (2017) Yasmin Granot et al. SEMINARS IN IMMUNOLOGY
- Eteplirsen in the treatment of Duchenne muscular dystrophy
- (2017) Kenji Rowel Lim et al. Drug Design Development and Therapy
- Systemic Messenger RNA Therapy as a Treatment for Methylmalonic Acidemia
- (2017) Ding An et al. Cell Reports
- Systemic Antisense Therapeutics for Dystrophin and Myostatin Exon Splice Modulation Improve Muscle Pathology of Adult mdx Mice
- (2017) Ngoc Lu-Nguyen et al. Molecular Therapy-Nucleic Acids
- Tools for translation: non-viral materials for therapeutic mRNA delivery
- (2017) Khalid A. Hajj et al. Nature Reviews Materials
- Improved base excision repair inhibition and bacteriophage Mu Gam protein yields C:G-to-T:A base editors with higher efficiency and product purity
- (2017) Alexis C. Komor et al. Science Advances
- Current preclinical small interfering RNA (siRNA)-based conjugate systems for RNA therapeutics
- (2016) Soo Hyeon Lee et al. ADVANCED DRUG DELIVERY REVIEWS
- The role of helper lipids in lipid nanoparticles (LNPs) designed for oligonucleotide delivery
- (2016) Xinwei Cheng et al. ADVANCED DRUG DELIVERY REVIEWS
- Recent progress in development of siRNA delivery vehicles for cancer therapy
- (2016) Hyun Jin Kim et al. ADVANCED DRUG DELIVERY REVIEWS
- Bioinspired Alkenyl Amino Alcohol Ionizable Lipid Materials for Highly Potent In Vivo mRNA Delivery
- (2016) Owen S. Fenton et al. ADVANCED MATERIALS
- A Single Methylene Group in Oligoalkylamine-Based Cationic Polymers and Lipids Promotes Enhanced mRNA Delivery
- (2016) Anita Jarzębińska et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Non-Viral CRISPR/Cas Gene Editing In Vitro and In Vivo Enabled by Synthetic Nanoparticle Co-Delivery of Cas9 mRNA and sgRNA
- (2016) Jason B. Miller et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Polymer-Lipid Nanoparticles for Systemic Delivery of mRNA to the Lungs
- (2016) James C. Kaczmarek et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- RNA Interference (RNAi)-Based Therapeutics: Delivering on the Promise?
- (2016) Maggie L. Bobbin et al. Annual Review of Pharmacology and Toxicology
- Effects of Chemically Modified Messenger RNA on Protein Expression
- (2016) Bin Li et al. BIOCONJUGATE CHEMISTRY
- Chemically modified RNA induces osteogenesis of stem cells and human tissue explants as well as accelerates bone healing in rats
- (2016) Elizabeth R. Balmayor et al. BIOMATERIALS
- Efficacy and immunogenicity of unmodified and pseudouridine-modified mRNA delivered systemically with lipid nanoparticles in vivo
- (2016) Kevin J. Kauffman et al. BIOMATERIALS
- Therapeutic efficacy in a hemophilia B model using a biosynthetic mRNA liver depot system
- (2016) F DeRosa et al. GENE THERAPY
- Non-viral delivery of genome-editing nucleases for gene therapy
- (2016) M Wang et al. GENE THERAPY
- Lipid nanoparticles for targeted siRNA delivery – going from bench to bedside
- (2016) Victor Kotelianski et al. International Journal of Nanomedicine
- Enhanced intranasal delivery of mRNA vaccine by overcoming the nasal epithelial barrier via intra- and paracellular pathways
- (2016) Man Li et al. JOURNAL OF CONTROLLED RELEASE
- Materials for non-viral intracellular delivery of messenger RNA therapeutics
- (2016) Kevin J. Kauffman et al. JOURNAL OF CONTROLLED RELEASE
- Direct Pharmacological Inhibition of -Catenin by RNA Interference in Tumors of Diverse Origin
- (2016) S. Ganesh et al. MOLECULAR CANCER THERAPEUTICS
- Poly(glycoamidoamine) Brushes Formulated Nanomaterials for Systemic siRNA and mRNA Delivery in Vivo
- (2016) Yizhou Dong et al. NANO LETTERS
- Systemic RNA delivery to dendritic cells exploits antiviral defence for cancer immunotherapy
- (2016) Lena M. Kranz et al. NATURE
- Programmable editing of a target base in genomic DNA without double-stranded DNA cleavage
- (2016) Alexis C. Komor et al. NATURE
- Enhancing homology-directed genome editing by catalytically active and inactive CRISPR-Cas9 using asymmetric donor DNA
- (2016) Christopher D Richardson et al. NATURE BIOTECHNOLOGY
- Therapeutic genome editing by combined viral and non-viral delivery of CRISPR system components in vivo
- (2016) Hao Yin et al. NATURE BIOTECHNOLOGY
- Non-coding RNAs as drug targets
- (2016) Masayuki Matsui et al. NATURE REVIEWS DRUG DISCOVERY
- mRNA capping: biological functions and applications
- (2016) Anand Ramanathan et al. NUCLEIC ACIDS RESEARCH
- Efficient delivery of genome-editing proteins using bioreducible lipid nanoparticles
- (2016) Ming Wang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Functional polyesters enable selective siRNA delivery to lung cancer over matched normal cells
- (2016) Yunfeng Yan et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Modular degradable dendrimers enable small RNAs to extend survival in an aggressive liver cancer model
- (2016) Kejin Zhou et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Progress towards the Synthesis of Amino Polyesters via Ring-Opening Polymerization (ROP) of Functional Lactones
- (2016) Daniel Siegwart et al. SYNLETT
- Self-adjuvanted mRNA vaccines induce local innate immune responses that lead to a potent and boostable adaptive immunity
- (2016) Aleksandra Kowalczyk et al. VACCINE
- Utilising inorganic nanocarriers for gene delivery
- (2016) Xian Jun Loh et al. Biomaterials Science
- Lipid Nanoparticle-mediated siRNA Transfer Against PCTAIRE1/PCTK1/Cdk16 Inhibits In Vivo Cancer Growth
- (2016) Teruki Yanagi et al. Molecular Therapy-Nucleic Acids
- Docosahexaenoic Acid Conjugation Enhances Distribution and Safety of siRNA upon Local Administration in Mouse Brain
- (2016) Mehran Nikan et al. Molecular Therapy-Nucleic Acids
- Production and clinical development of nanoparticles for gene delivery
- (2016) Jie Chen et al. Molecular Therapy-Methods & Clinical Development
- Effects of local structural transformation of lipid-like compounds on delivery of messenger RNA
- (2016) Bin Li et al. Scientific Reports
- Self-Assembled DNA Nanoclews for the Efficient Delivery of CRISPR-Cas9 for Genome Editing
- (2015) Wujin Sun et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Genome-wide CRISPR Screen in a Mouse Model of Tumor Growth and Metastasis
- (2015) Sidi Chen et al. CELL
- Cpf1 Is a Single RNA-Guided Endonuclease of a Class 2 CRISPR-Cas System
- (2015) Bernd Zetsche et al. CELL
- Technologies for controlled, local delivery of siRNA
- (2015) Samantha M. Sarett et al. JOURNAL OF CONTROLLED RELEASE
- Theranostic applications of carbon nanomaterials in cancer: Focus on imaging and cargo delivery
- (2015) Daiqin Chen et al. JOURNAL OF CONTROLLED RELEASE
- Going beyond the liver: Progress and challenges of targeted delivery of siRNA therapeutics
- (2015) Cornelia Lorenzer et al. JOURNAL OF CONTROLLED RELEASE
- Microfluidic Mixing: A General Method for Encapsulating Macromolecules in Lipid Nanoparticle Systems
- (2015) Alex K. K. Leung et al. JOURNAL OF PHYSICAL CHEMISTRY B
- Rapid Synthesis of a Lipocationic Polyester Library via Ring-Opening Polymerization of Functional Valerolactones for Efficacious siRNA Delivery
- (2015) Jing Hao et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Sequence-engineered mRNA Without Chemical Nucleoside Modifications Enables an Effective Protein Therapy in Large Animals
- (2015) Andreas Thess et al. MOLECULAR THERAPY
- An Orthogonal Array Optimization of Lipid-like Nanoparticles for mRNA Delivery in Vivo
- (2015) Bin Li et al. NANO LETTERS
- Optimization of Lipid Nanoparticle Formulations for mRNA Delivery in Vivo with Fractional Factorial and Definitive Screening Designs
- (2015) Kevin J. Kauffman et al. NANO LETTERS
- Visualizing lipid-formulated siRNA release from endosomes and target gene knockdown
- (2015) Anders Wittrup et al. NATURE BIOTECHNOLOGY
- Clinical experiences with systemically administered siRNA-based therapeutics in cancer
- (2015) Jonathan E. Zuckerman et al. NATURE REVIEWS DRUG DISCOVERY
- One-pot synthesis of functional poly(amino ester sulfide)s and utility in delivering pDNA and siRNA
- (2015) Yunfeng Yan et al. POLYMER
- Postnatal genome editing partially restores dystrophin expression in a mouse model of muscular dystrophy
- (2015) C. Long et al. SCIENCE
- In vivo gene editing in dystrophic mouse muscle and muscle stem cells
- (2015) M. Tabebordbar et al. SCIENCE
- In vivo genome editing improves muscle function in a mouse model of Duchenne muscular dystrophy
- (2015) C. E. Nelson et al. SCIENCE
- Hydrophobically Modified siRNAs Silence Huntingtin mRNA in Primary Neurons and Mouse Brain
- (2015) Julia F Alterman et al. Molecular Therapy-Nucleic Acids
- CRISPR-Cas9 delivery to hard-to-transfect cells via membrane deformation
- (2015) X. Han et al. Science Advances
- Self-adjuvanted mRNA vaccination in advanced prostate cancer patients: a first-in-man phase I/IIa study
- (2015) Hubert Kübler et al. Journal for ImmunoTherapy of Cancer
- Bioreducible Cationic Polymer-Based Nanoparticles for Efficient and Environmentally Triggered Cytoplasmic siRNA Delivery to Primary Human Brain Cancer Cells
- (2014) Kristen L. Kozielski et al. ACS Nano
- Molecular Understanding and Design of Zwitterionic Materials
- (2014) Qing Shao et al. ADVANCED MATERIALS
- Novel Endosomolytic Poly(amido amine) Polymer Conjugates for Systemic Delivery of siRNA to Hepatocytes in Rodents and Nonhuman Primates
- (2014) Rubina Giare Parmar et al. BIOCONJUGATE CHEMISTRY
- CRISPR-Cas9 Knockin Mice for Genome Editing and Cancer Modeling
- (2014) Randall J. Platt et al. CELL
- Crystal Structure of Cas9 in Complex with Guide RNA and Target DNA
- (2014) Hiroshi Nishimasu et al. CELL
- Sulfated quaternary amine lipids: a new class of inverse charge zwitterlipids
- (2014) Vincent J. Venditto et al. CHEMICAL COMMUNICATIONS
- First-in-Human Phase I Study of the Liposomal RNA Interference Therapeutic Atu027 in Patients With Advanced Solid Tumors
- (2014) Beate Schultheis et al. JOURNAL OF CLINICAL ONCOLOGY
- Designer lipids for drug delivery: From heads to tails
- (2014) Aditya G. Kohli et al. JOURNAL OF CONTROLLED RELEASE
- Multivalent N-Acetylgalactosamine-Conjugated siRNA Localizes in Hepatocytes and Elicits Robust RNAi-Mediated Gene Silencing
- (2014) Jayaprakash K. Nair et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Systemic Delivery of a miR34a Mimic as a Potential Therapeutic for Liver Cancer
- (2014) C. L. Daige et al. MOLECULAR CANCER THERAPEUTICS
- Delivery of Therapeutic siRNA to the Lung Endothelium via Novel Lipoplex Formulation DACC
- (2014) V Fehring et al. MOLECULAR THERAPY
- Drug development: Try and try again
- (2014) Megan Scudellari NATURE
- Rapid modelling of cooperating genetic events in cancer through somatic genome editing
- (2014) Francisco J. Sánchez-Rivera et al. NATURE
- CRISPR-mediated direct mutation of cancer genes in the mouse liver
- (2014) Wen Xue et al. NATURE
- DNA interrogation by the CRISPR RNA-guided endonuclease Cas9
- (2014) Samuel H. Sternberg et al. NATURE
- Efficient delivery of RNAi prodrugs containing reversible charge-neutralizing phosphotriester backbone modifications
- (2014) Bryan R Meade et al. NATURE BIOTECHNOLOGY
- Cationic lipid-mediated delivery of proteins enables efficient protein-based genome editing in vitro and in vivo
- (2014) John A Zuris et al. NATURE BIOTECHNOLOGY
- CRISPR-Cas systems for editing, regulating and targeting genomes
- (2014) Jeffry D Sander et al. NATURE BIOTECHNOLOGY
- Genome editing with Cas9 in adult mice corrects a disease mutation and phenotype
- (2014) Hao Yin et al. NATURE BIOTECHNOLOGY
- In vivo endothelial siRNA delivery using polymeric nanoparticles with low molecular weight
- (2014) James E. Dahlman et al. Nature Nanotechnology
- mRNA-based therapeutics — developing a new class of drugs
- (2014) Ugur Sahin et al. NATURE REVIEWS DRUG DISCOVERY
- Drugging the undruggable RAS: Mission Possible?
- (2014) Adrienne D. Cox et al. NATURE REVIEWS DRUG DISCOVERY
- A guide to genome engineering with programmable nucleases
- (2014) Hyongbum Kim et al. NATURE REVIEWS GENETICS
- Cystic fibrosis genetics: from molecular understanding to clinical application
- (2014) Garry R. Cutting NATURE REVIEWS GENETICS
- Synthesis, properties, and biological activity of boranophosphate analogs of the mRNA cap: versatile tools for manipulation of therapeutically relevant cap-dependent processes
- (2014) Joanna Kowalska et al. NUCLEIC ACIDS RESEARCH
- Correlating animal and human phase Ia/Ib clinical data with CALAA-01, a targeted, polymer-based nanoparticle containing siRNA
- (2014) J. E. Zuckerman et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Lipopeptide nanoparticles for potent and selective siRNA delivery in rodents and nonhuman primates
- (2014) Y. Dong et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The new frontier of genome engineering with CRISPR-Cas9
- (2014) J. A. Doudna et al. SCIENCE
- A critical analysis of codon optimization in human therapeutics
- (2014) Vincent P. Mauro et al. TRENDS IN MOLECULAR MEDICINE
- Degradable lipid nanoparticles with predictable in vivo siRNA delivery activity
- (2014) Kathryn A. Whitehead et al. Nature Communications
- Lipid-Like Nanomaterials for Simultaneous Gene Expression and Silencing In Vivo
- (2014) Yizhou Dong et al. Advanced Healthcare Materials
- The Role of Surface Functionality in Determining Nanoparticle Cytotoxicity
- (2013) Sung Tae Kim et al. ACCOUNTS OF CHEMICAL RESEARCH
- The Headgroup Evolution of Cationic Lipids for Gene Delivery
- (2013) Defu Zhi et al. BIOCONJUGATE CHEMISTRY
- Endosomolytic Bioreducible Poly(amido amine disulfide) Polymer Conjugates for the in Vivo Systemic Delivery of siRNA Therapeutics
- (2013) Rubina Giare Parmar et al. BIOCONJUGATE CHEMISTRY
- A bioreducible linear poly(β-amino ester) for siRNA delivery
- (2013) Kristen L. Kozielski et al. CHEMICAL COMMUNICATIONS
- Nanoparticles encapsulating hepatitis B virus cytosine-phosphate-guanosine induce therapeutic immunity against HBV infection
- (2013) Shujuan Lv et al. HEPATOLOGY
- Biodegradable Lipids Enabling Rapidly Eliminated Lipid Nanoparticles for Systemic Delivery of RNAi Therapeutics
- (2013) Martin A Maier et al. MOLECULAR THERAPY
- Knockdown of β-catenin with Dicer-Substrate siRNAs Reduces Liver Tumor Burden In vivo
- (2013) Henryk Dudek et al. MOLECULAR THERAPY
- Image-based analysis of lipid nanoparticle–mediated siRNA delivery, intracellular trafficking and endosomal escape
- (2013) Jerome Gilleron et al. NATURE BIOTECHNOLOGY
- Modified mRNA directs the fate of heart progenitor cells and induces vascular regeneration after myocardial infarction
- (2013) Lior Zangi et al. NATURE BIOTECHNOLOGY
- Efficiency of siRNA delivery by lipid nanoparticles is limited by endocytic recycling
- (2013) Gaurav Sahay et al. NATURE BIOTECHNOLOGY
- Delivery materials for siRNA therapeutics
- (2013) Rosemary Kanasty et al. NATURE MATERIALS
- Genome engineering using the CRISPR-Cas9 system
- (2013) F Ann Ran et al. Nature Protocols
- MicroRNAs and other non-coding RNAs as targets for anticancer drug development
- (2013) Hui Ling et al. NATURE REVIEWS DRUG DISCOVERY
- Safety and Efficacy of RNAi Therapy for Transthyretin Amyloidosis
- (2013) Teresa Coelho et al. NEW ENGLAND JOURNAL OF MEDICINE
- Role of Phospholipids in Endocytosis, Phagocytosis, and Macropinocytosis
- (2013) Michal Bohdanowicz et al. PHYSIOLOGICAL REVIEWS
- Scalable synthesis and derivation of functional polyesters bearing ene and epoxide side chains
- (2013) Yunfeng Yan et al. Polymer Chemistry
- Mutant KRAS is a druggable target for pancreatic cancer
- (2013) E. Zorde Khvalevsky et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Multiparametric approach for the evaluation of lipid nanoparticles for siRNA delivery
- (2013) C. A. Alabi et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Enhancing tumor cell response to chemotherapy through nanoparticle-mediated codelivery of siRNA and cisplatin prodrug
- (2013) X. Xu et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- RNA-Guided Human Genome Engineering via Cas9
- (2013) P. Mali et al. SCIENCE
- Multiplex Genome Engineering Using CRISPR/Cas Systems
- (2013) L. Cong et al. SCIENCE
- Single-Step Assembly of Cationic Lipid–Polymer Hybrid Nanoparticles for Systemic Delivery of siRNA
- (2012) Xian-Zhu Yang et al. ACS Nano
- In Vitro–In Vivo Translation of Lipid Nanoparticles for Hepatocellular siRNA Delivery
- (2012) Kathryn A. Whitehead et al. ACS Nano
- 2′-Fluoro RNA Shows Increased Watson-Crick H-Bonding Strength and Stacking Relative to RNA: Evidence from NMR and Thermodynamic Data
- (2012) Amritraj Patra et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Maximizing the Potency of siRNA Lipid Nanoparticles for Hepatic Gene Silencing In Vivo
- (2012) Muthusamy Jayaraman et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Synthesis and characterization of novel zwitterionic lipids with pH-responsive biophysical properties
- (2012) Colin L. Walsh et al. CHEMICAL COMMUNICATIONS
- How cationic lipids transfer nucleic acids into cells and across cellular membranes: Recent advances
- (2012) Zia ur Rehman et al. JOURNAL OF CONTROLLED RELEASE
- Correction to “Lipid Nanoparticles Containing siRNA Synthesized by Microfluidic Mixing Exhibit an Electron-Dense Nanostructured Core”
- (2012) Alex K. K. Leung et al. Journal of Physical Chemistry C
- RGD-Based Strategies To Target Alpha(v) Beta(3) Integrin in Cancer Therapy and Diagnosis
- (2012) Fabienne Danhier et al. MOLECULAR PHARMACEUTICS
- Increased Erythropoiesis in Mice Injected With Submicrogram Quantities of Pseudouridine-containing mRNA Encoding Erythropoietin
- (2012) Katalin Karikó et al. MOLECULAR THERAPY
- Protective efficacy of in vitro synthesized, specific mRNA vaccines against influenza A virus infection
- (2012) Benjamin Petsch et al. NATURE BIOTECHNOLOGY
- RNA therapeutics: beyond RNA interference and antisense oligonucleotides
- (2012) Ryszard Kole et al. NATURE REVIEWS DRUG DISCOVERY
- Nonviral delivery of self-amplifying RNA vaccines
- (2012) A. J. Geall et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- A Programmable Dual-RNA-Guided DNA Endonuclease in Adaptive Bacterial Immunity
- (2012) M. Jinek et al. SCIENCE
- Defined Folate-PEG-siRNA Conjugates for Receptor-specific Gene Silencing
- (2012) Christian Dohmen et al. Molecular Therapy-Nucleic Acids
- The Business of RNAi Therapeutics in 2012
- (2012) Dirk Haussecker Molecular Therapy-Nucleic Acids
- Microfluidic Synthesis of Highly Potent Limit-size Lipid Nanoparticles for In Vivo Delivery of siRNA
- (2012) Nathan M Belliveau et al. Molecular Therapy-Nucleic Acids
- miR-34 – a microRNA replacement therapy is headed to the clinic
- (2012) Andreas G. Bader Frontiers in Genetics
- Differentially Charged Hollow Core/Shell Lipid-Polymer-Lipid Hybrid Nanoparticles for Small Interfering RNA Delivery
- (2011) Jinjun Shi et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Multivalent Cyclic RGD Conjugates for Targeted Delivery of Small Interfering RNA
- (2011) Md. Rowshon Alam et al. BIOCONJUGATE CHEMISTRY
- Systemic delivery of siRNA with cationic lipid assisted PEG-PLA nanoparticles for cancer therapy
- (2011) Xian-Zhu Yang et al. JOURNAL OF CONTROLLED RELEASE
- In Vitroandin VivomRNA Delivery Using Lipid-Enveloped pH-Responsive Polymer Nanoparticles
- (2011) Xingfang Su et al. MOLECULAR PHARMACEUTICS
- An Amino Acid-based Amphoteric Liposomal Delivery System for Systemic Administration of siRNA
- (2011) Roger C Adami et al. MOLECULAR THERAPY
- MicroRNA history: Discovery, recent applications, and next frontiers
- (2011) Maria I. Almeida et al. MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS
- Expression of therapeutic proteins after delivery of chemically modified mRNA in mice
- (2011) Michael S D Kormann et al. NATURE BIOTECHNOLOGY
- Transfection Efficiency of Cationic Lipids with Different Hydrophobic Domains in Gene Delivery
- (2010) DeFu Zhi et al. BIOCONJUGATE CHEMISTRY
- Atu027 Prevents Pulmonary Metastasis in Experimental and Spontaneous Mouse Metastasis Models
- (2010) A. Santel et al. CLINICAL CANCER RESEARCH
- Endocytosis of nanomedicines
- (2010) Gaurav Sahay et al. JOURNAL OF CONTROLLED RELEASE
- Targeted Delivery of RNAi Therapeutics With Endogenous and Exogenous Ligand-Based Mechanisms
- (2010) Akin Akinc et al. MOLECULAR THERAPY
- Evidence of RNAi in humans from systemically administered siRNA via targeted nanoparticles
- (2010) Mark E. Davis et al. NATURE
- Rapid translocation of nanoparticles from the lung airspaces to the body
- (2010) Hak Soo Choi et al. NATURE BIOTECHNOLOGY
- Rational design of cationic lipids for siRNA delivery
- (2010) Sean C Semple et al. NATURE BIOTECHNOLOGY
- Improved specificity of gene silencing by siRNAs containing unlocked nucleobase analogs
- (2010) Narendra Vaish et al. NUCLEIC ACIDS RESEARCH
- Incorporation of pseudouridine into mRNA enhances translation by diminishing PKR activation
- (2010) Bart R. Anderson et al. NUCLEIC ACIDS RESEARCH
- Lipid-like materials for low-dose, in vivo gene silencing
- (2010) K. T. Love et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Novel Brush Polymers with Phosphorylcholine Bristle Ends: Synthesis, Structure, Properties, and Biocompatibility
- (2009) Gahee Kim et al. ADVANCED FUNCTIONAL MATERIALS
- Knocking down barriers: advances in siRNA delivery
- (2009) Kathryn A. Whitehead et al. NATURE REVIEWS DRUG DISCOVERY
- A Combinatorial Polymer Library Approach Yields Insight into Nonviral Gene Delivery
- (2008) Jordan J. Green et al. ACCOUNTS OF CHEMICAL RESEARCH
- Efficient Gene Delivery Vectors by Tuning the Surface Charge Density of Amino Acid-Functionalized Gold Nanoparticles
- (2008) Partha S. Ghosh et al. ACS Nano
- Atu027, a Liposomal Small Interfering RNA Formulation Targeting Protein Kinase N3, Inhibits Cancer Progression
- (2008) M. Aleku et al. CANCER RESEARCH
- The Business of RNAi Therapeutics
- (2008) Dirk Haussecker HUMAN GENE THERAPY
- Incorporation of Pseudouridine Into mRNA Yields Superior Nonimmunogenic Vector With Increased Translational Capacity and Biological Stability
- (2008) Katalin Karikó et al. MOLECULAR THERAPY
- Resolution of liver cirrhosis using vitamin A–coupled liposomes to deliver siRNA against a collagen-specific chaperone
- (2008) Yasushi Sato et al. NATURE BIOTECHNOLOGY
- A combinatorial library of lipid-like materials for delivery of RNAi therapeutics
- (2008) Akin Akinc et al. NATURE BIOTECHNOLOGY
- Membrane lipids: where they are and how they behave
- (2008) Gerrit van Meer et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Sorafenib in Liver Cancer — Just the Beginning
- (2008) Lewis R. Roberts NEW ENGLAND JOURNAL OF MEDICINE
- Chemical Modification of siRNAs for In Vivo Use
- (2008) Mark A. Behlke OLIGONUCLEOTIDES
- Synthesis and characterization of mRNA cap analogs containing phosphorothioate substitutions that bind tightly to eIF4E and are resistant to the decapping pyrophosphatase DcpS
- (2008) J. Kowalska et al. RNA
- Functionalized Carbon Nanotubes in Drug Design and Discovery
- (2007) Maurizio Prato et al. ACCOUNTS OF CHEMICAL RESEARCH
- Inorganic Nanoparticles as Carriers of Nucleic Acids into Cells
- (2007) Viktoriya Sokolova et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Discover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversationAdd your recorded webinar
Do you already have a recorded webinar? Grow your audience and get more views by easily listing your recording on Peeref.
Upload Now