Complete biosynthesis of opioids in yeast

The Quest for a Practical Synthesis of Morphine Alkaloids and Their Derivatives by Chemoenzymatic Methods

(2015) Josephine W. Reed et al.   ACCOUNTS OF CHEMICAL RESEARCH

National Institutes of Health Pathways to Prevention Workshop: The Role of Opioids in the Treatment of Chronic Pain

(2015) David B. Reuben et al.   ANNALS OF INTERNAL MEDICINE

De novo production of the key branch point benzylisoquinoline alkaloid reticuline in yeast

(2015) Isis J. Trenchard et al.   METABOLIC ENGINEERING

Engineering strategies for the fermentative production of plant alkaloids in yeast

(2015) Isis J. Trenchard et al.   METABOLIC ENGINEERING

Drugs: Regulate 'home-brew' opiates

(2015) Kenneth A. Oye et al.   NATURE

An enzyme-coupled biosensor enables (S)-reticuline production in yeast from glucose

(2015) William C DeLoache et al.   Nature Chemical Biology

Morphinan biosynthesis in opium poppy requires a P450-oxidoreductase fusion protein

(2015) T. Winzer et al.   SCIENCE

Synthesis of Morphinan Alkaloids in Saccharomyces cerevisiae

(2015) Elena Fossati et al.   PLoS One

The burden of premature opioid-related mortality

(2014) Tara Gomes et al.   ADDICTION

A microbial biomanufacturing platform for natural and semisynthetic opioids

(2014) Kate Thodey et al.   Nature Chemical Biology

Semi-synthetic artemisinin: a model for the use of synthetic biology in pharmaceutical development

(2014) Chris J. Paddon et al.   NATURE REVIEWS MICROBIOLOGY

Benzylisoquinoline alkaloid biosynthesis in opium poppy

(2014) Guillaume A. W. Beaudoin et al.   PLANTA

(R,S)-Tetrahydropapaveroline production by stepwise fermentation using engineered Escherichia coli

(2014) Akira Nakagawa et al.   Scientific Reports

Data access for the 1,000 Plants (1KP) project

(2014) Naim Matasci et al.   GigaScience

Transcriptome analysis based on next-generation sequencing of non-model plants producing specialized metabolites of biotechnological interest

(2013) Mei Xiao et al.   JOURNAL OF BIOTECHNOLOGY

Advancing secondary metabolite biosynthesis in yeast with synthetic biology tools

(2011) Michael S. Siddiqui et al.   FEMS YEAST RESEARCH

Systematic knockdown of morphine pathway enzymes in opium poppy using virus-induced gene silencing

(2011) Champa P. Wijekoon et al.   PLANT JOURNAL

Multiparameter RNA and Codon Optimization: A Standardized Tool to Assess and Enhance Autologous Mammalian Gene Expression

(2011) Stephan Fath et al.   PLoS One

Synthetic biosystems for the production of high-value plant metabolites

(2011) Peter J. Facchini et al.   TRENDS IN BIOTECHNOLOGY

A bacterial platform for fermentative production of plant alkaloids

(2011) Akira Nakagawa et al.   Nature Communications

Atomic Structure of Salutaridine Reductase from the Opium Poppy (Papaver somniferum)

(2010) Yasuhiro Higashi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dioxygenases catalyze the O-demethylation steps of morphine biosynthesis in opium poppy

(2010) Jillian M Hagel et al.   Nature Chemical Biology

CYP719B1 Is Salutaridine Synthase, the C-C Phenol-coupling Enzyme of Morphine Biosynthesis in Opium Poppy

(2009) Andreas Gesell et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Removal of Substrate Inhibition and Increase in Maximal Velocity in the Short Chain Dehydrogenase/Reductase Salutaridine Reductase Involved in Morphine Biosynthesis

(2009) Jörg Ziegler et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Enzymatic assembly of DNA molecules up to several hundred kilobases

(2009) Daniel G Gibson et al.   NATURE METHODS

pEAQ: versatile expression vectors for easy and quick transient expression of heterologous proteins in plants

(2009) Frank Sainsbury et al.   PLANT BIOTECHNOLOGY JOURNAL

Characterization of chromosomal integration sites for heterologous gene expression inSaccharomyces cerevisiae

(2009) Dongmei Bai Flagfeldt et al.   YEAST

The Ehrlich Pathway for Fusel Alcohol Production: a Century of Research on Saccharomyces cerevisiae Metabolism

(2008) L. A. Hazelwood et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Production of benzylisoquinoline alkaloids in Saccharomyces cerevisiae

(2008) Kristy M Hawkins et al.   Nature Chemical Biology

DNA assembler, an in vivo genetic method for rapid construction of biochemical pathways

(2008) Zengyi Shao et al.   NUCLEIC ACIDS RESEARCH

Microbial production of plant benzylisoquinoline alkaloids

(2008) H. Minami et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pervasive and Persistent Redundancy among Duplicated Genes in Yeast

(2008) E. Jedediah Dean et al.   PLoS Genetics