Morphinan biosynthesis in opium poppy requires a P450-oxidoreductase fusion protein

Epoxy alcohol synthase of the rice blast fungus represents a novel subfamily of dioxygenase-cytochrome P450 fusion enzymes

(2014) Inga Hoffmann et al.   JOURNAL OF LIPID RESEARCH

A microbial biomanufacturing platform for natural and semisynthetic opioids

(2014) Kate Thodey et al.   Nature Chemical Biology

(R,S)-Tetrahydropapaveroline production by stepwise fermentation using engineered Escherichia coli

(2014) Akira Nakagawa et al.   Scientific Reports

Dioxygenases CatalyzeO-Demethylation andO,O-Demethylenation with Widespread Roles in Benzylisoquinoline Alkaloid Metabolism in Opium Poppy

(2013) Scott C. Farrow et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Unusual Cytochrome P450 Enzymes and Reactions

(2013) F. Peter Guengerich et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Involvement of a Natural Fusion of a Cytochrome P450 and a Hydrolase in Mycophenolic Acid Biosynthesis

(2012) Bjarne Gram Hansen et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

A Papaver somniferum 10-Gene Cluster for Synthesis of the Anticancer Alkaloid Noscapine

(2012) T. Winzer et al.   SCIENCE

A bacterial platform for fermentative production of plant alkaloids

(2011) Akira Nakagawa et al.   Nature Communications

Dioxygenases catalyze the O-demethylation steps of morphine biosynthesis in opium poppy

(2010) Jillian M Hagel et al.   Nature Chemical Biology

CYP719B1 Is Salutaridine Synthase, the C-C Phenol-coupling Enzyme of Morphine Biosynthesis in Opium Poppy

(2009) Andreas Gesell et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification of PpoA fromAspergillus nidulansas a Fusion Protein of a Fatty Acid Heme Dioxygenase/Peroxidase and a Cytochrome P450

(2009) Florian Brodhun et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Enantiomeric separation of racemic 1-benzyl-N-methyltetrahydroisoquinolines on chiral columns and chiral purity determinations of the O-methylated metabolites in plant cell cultures by HPLC-CD on-line coupling in combination with HPLC-MS

(2009) Kinuko Iwasa et al.   PHYTOCHEMISTRY

Production of benzylisoquinoline alkaloids in Saccharomyces cerevisiae

(2008) Kristy M Hawkins et al.   Nature Chemical Biology