TGF-β signal transduction pathways and osteoarthritis

Toward regeneration of articular cartilage

(2015) Masahiro Iwamoto et al.   BIRTH DEFECTS RESEARCH PART C-EMBRYO TODAY-REVIEWS

Overexpression of TGF-β1 enhances chondrogenic differentiation and proliferation of human synovium-derived stem cells

(2014) Yong Il Kim et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

TGFβ signaling in cartilage development and maintenance

(2014) Weiguang Wang et al.   BIRTH DEFECTS RESEARCH PART C-EMBRYO TODAY-REVIEWS

CpG methylation regulates allelic expression of GDF5 by modulating binding of SP1 and SP3 repressor proteins to the osteoarthritis susceptibility SNP rs143383

(2014) Louise N. Reynard et al.   HUMAN GENETICS

SMAD3 Is Associated with the Total Burden of Radiographic Osteoarthritis: The Chingford Study

(2014) Erfan Aref-Eshghi et al.   PLoS One

Thoracic Aortic Aneurysm in Infancy in Aneurysms-Osteoarthritis Syndrome Due to a NovelSMAD3Mutation: Further Delineation of the Phenotype

(2013) Anita Wischmeijer et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

Advances in osteoarthritis genetics: Table 1

(2013) Kalliope Panoutsopoulou et al.   JOURNAL OF MEDICAL GENETICS

Inhibition of TGF-β signaling in mesenchymal stem cells of subchondral bone attenuates osteoarthritis

(2013) Gehua Zhen et al.   NATURE MEDICINE

Systems genetics approaches to understand complex traits

(2013) Mete Civelek et al.   NATURE REVIEWS GENETICS

NFAT3 and TGF-β/SMAD3 regulate the expression of miR-140 in osteoarthritis

(2013) Ginette Tardif et al.   ARTHRITIS RESEARCH & THERAPY

Development of the Endochondral Skeleton

(2013) F. Long et al.   Cold Spring Harbor Perspectives in Biology

Chondrocyte-intrinsic Smad3 represses Runx2-inducible matrix metalloproteinase 13 expression to maintain articular cartilage and prevent osteoarthritis

(2012) Carol G. Chen et al.   ARTHRITIS AND RHEUMATISM

Structural studies of the TGF-βs and their receptors - insights into evolution of the TGF-β superfamily

(2012) Andrew P. Hinck   FEBS LETTERS

TGFβ signalling in context

(2012) Joan Massagué   NATURE REVIEWS MOLECULAR CELL BIOLOGY

TGF-Beta Induced Erk Phosphorylation of Smad Linker Region Regulates Smad Signaling

(2012) Chris Hough et al.   PLoS One

Bone morphogenetic protein-2-induced Wnt/beta-catenin signaling pathway activation through enhanced low-density-lipoprotein receptor-related protein 5 catabolic activity contributes to hypertrophy in osteoarthritic chondrocytes

(2012) Ioanna Papathanasiou et al.   ARTHRITIS RESEARCH & THERAPY

Exome Sequencing Identifies SMAD3 Mutations as a Cause of Familial Thoracic Aortic Aneurysm and Dissection With Intracranial and Other Arterial Aneurysms

(2011) Ellen S. Regalado et al.   CIRCULATION RESEARCH

Expression of the osteoarthritis-associated gene GDF5 is modulated epigenetically by DNA methylation

(2011) Louise N. Reynard et al.   HUMAN MOLECULAR GENETICS

Phenotypic spectrum of the SMAD3-related aneurysms–osteoarthritis syndrome

(2011) Ingrid M B H van de Laar et al.   JOURNAL OF MEDICAL GENETICS

Mutations in SMAD3 cause a syndromic form of aortic aneurysms and dissections with early-onset osteoarthritis

(2011) Ingrid M B H van de Laar et al.   NATURE GENETICS

Signaling Pathways in Human Skeletal Dysplasias

(2010) Dustin Baldridge et al.   Annual Review of Genomics and Human Genetics

Genetic variation in the SMAD3 gene is associated with hip and knee osteoarthritis

(2010) Ana M. Valdes et al.   ARTHRITIS AND RHEUMATISM

Smad signaling in skeletal development and regeneration

(2009) Buer Song et al.   CYTOKINE & GROWTH FACTOR REVIEWS

BMP canonical Smad signaling through Smad1 and Smad5 is required for endochondral bone formation

(2009) K. N. Retting et al.   DEVELOPMENT

Critical roles of the TGF-β type I receptor ALK5 in perichondrial formation and function, cartilage integrity, and osteoblast differentiation during growth plate development

(2009) Tomoya Matsunobu et al.   DEVELOPMENTAL BIOLOGY

Increase in ALK1/ALK5 Ratio as a Cause for Elevated MMP-13 Expression in Osteoarthritis in Humans and Mice

(2009) E. N. Blaney Davidson et al.   JOURNAL OF IMMUNOLOGY

Chondrogenic differentiation potential of osteoarthritic chondrocytes and their possible use in matrix-associated autologous chondrocyte transplantation

(2009) Tilo Dehne et al.   ARTHRITIS RESEARCH & THERAPY

Association of the Asporin D14 Allele with Lumbar-Disc Degeneration in Asians

(2008) You-Qiang Song et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Differential upregulation of the three transforming growth factor beta isoforms in human osteoarthritic cartilage

(2008) M Pombo-Suarez et al.   ANNALS OF THE RHEUMATIC DISEASES

Induction of an osteoarthritis-like phenotype and degradation of phosphorylated Smad3 by Smurf2 in transgenic mice

(2008) Qiuqian Wu et al.   ARTHRITIS AND RHEUMATISM

Non-Smad pathways in TGF-β signaling

(2008) Ying E Zhang   CELL RESEARCH

Smad3 activates the Sox9-dependent transcription on chromatin

(2008) Takayuki Furumatsu et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY