Article
Pharmacology & Pharmacy
Xiao Guan, Dan Yu, Mengjie HuangFu, Zhiyi Huang, Tong Dou, Yisa Liu, Luwei Zhou, Xumei Li, Lin Wang, Haiping Liu, Juan Wang, Xu Chen
Summary: The study demonstrated that curcumol inhibits invasion and metastasis of EBV-positive NPC cells by targeting NCL, which further regulates related signaling pathways, providing a new pharmacological basis for clinical treatment.
BIOCHEMICAL PHARMACOLOGY
(2021)
Article
Microbiology
Danijela Miljanovic, Andja Cirkovic, Ivica Jermic, Milica Basaric, Ivana Lazarevic, Milka Grk, Rada Miskovic, Aleksa Despotovic, Ana Banko
Summary: The study aimed to analyze the association between EBV and RA by examining antibody titers, DNA viremia, infection status and EBNA1 variants in RA patients. The results showed a higher prevalence of active/recent EBV infection in RA patients compared to controls, along with elevated levels of specific antibodies. The findings suggest the need for further research to understand the causal relationship between EBV and RA. Evaluation: 8/10.
Article
Immunology
Ana Banko, Andja Cirkovic, Rada Miskovic, Ivica Jeremic, Milka Grk, Milica Basaric, Ivana Lazarevic, Sanvila Raskovic, Aleksa Despotovic, Danijela Miljanovic
Summary: The study found that there is a significant association between EBV infection and SLE development. Anti-EBV-EA(D) IgG antibodies were shown to increase the possibility of having SLE by 24 times in SLE patients. Higher titers of anti-EBV-EA(D) IgG antibodies were associated with lymphopenia and hematological SLE manifestation. Furthermore, novel data on EBV EBNA1 and LMP1 gene polymorphisms in lupus were reported.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Genetics & Heredity
Yue Liang, Wen Liu, Menghe Zhao, Duo Shi, Yan Zhang, Bing Luo
Summary: This study aimed to investigate the association of Epstein-Barr virus (EBV) with nuclear respiratory factor 1 (NRF1) and its biological function in EBV-associated gastric cancer (EBVaGC). It was found that LMP2A upregulated NRF1 expression by activating the NF-kappa B pathway and promoted cell migration and the anti-apoptotic ability of cells. NRF1 also maintained latent infection of EBV by regulating the expression of specific proteins. These findings provide a new theoretical basis for NRF1-based anti-cancer therapy.
Article
Oncology
Catherine S. Forconi, David H. Mulama, Priya Saikumar Lakshmi, Joslyn Foley, Juliana A. Otieno, Jonathan D. Kurtis, Leslie J. Berg, John M. Ong'echa, Christian Muenz, Ann M. Moormann
Summary: Children diagnosed with endemic Burkitt lymphoma (eBL) show deficient IFN-? responses to EBNA1, but the specific contributions of immune-regulatory cytokines and EBNA1-specific T cell phenotypes have not been clearly characterized. Our study compared cytokine expression and T cell memory profiles in response to EBNA1 and a malaria antigen among eBL patients and healthy children with different malaria exposures. Results indicate that eBL children have lower rates of EBNA1-specific IFN-? producing CD4(+) T cells compared to healthy children with high or low malaria exposures.
Article
Immunology
Viktoryia Laurynenka, Lili Ding, Kenneth M. Kaufman, Judith A. James, John B. Harley
Summary: The association between EBV infection and SLE is reconfirmed, and the presence of anti-EBNA1 antibodies in SLE cases is more frequent than in EBV-infected controls, supporting the hypothesis that anti-EBNA1 contributes to SLE.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Surgery
Catherine Gisi, Kelly Wang, Farhaad Khan, Sonya Reicher, Linda Hou, Clark Fuller, James Sattler, Viktor Eysselein
Summary: This study aimed to evaluate the efficacy of single-session laparoscopic hernia repair followed by transoral incisionless fundoplication (HH + TIF) in treating GERD. The results showed significant improvement in GERD symptoms post-procedure, with the majority of patients reporting high satisfaction levels (>75%) and reduced proton pump inhibitor (PPI) use. No serious adverse events were reported.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2021)
Article
Chemistry, Multidisciplinary
Xiao-xuan Yu, Meng-yuan Zhu, Jia-rong Wang, Hui Li, Po Hu, Ying-jie Qing, Xiang-yuan Wang, Hong-zheng Wang, Zhan-yu Wang, Jing-yan Xu, Qing-long Guo, Hui Hui
Summary: The study shows that LW-213 effectively inhibits the growth of CTCL cells and induces apoptosis. The mechanisms involve ROS formation, calcium release, and activation of different signaling pathways.
ACTA PHARMACOLOGICA SINICA
(2021)
Article
Cell Biology
Maria C. Tovar Fernandez, Ewa M. Sroka, Mathilde Lavigne, Aikaterini Thermou, Chrysoula Daskalogianni, Benedicte Manoury, Rodrigo Prado Martins, Robin Fahraeus
Summary: The accumulation of protein aggregates is toxic and its relation to diseases is still unclear. This study reveals that certain antigenic peptides can be presented to the MHC class I pathway via autophagy. The presentation of peptides derived from the viral EBNA1 protein was not affected by autophagy suppression, while the presentation of ovalbumin was suppressed. The study also suggests that the relative levels of protein expression do not affect autophagy-mediated antigen presentation.
CELLULAR IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Jayaraju Dheekollu, Andreas Wiedmer, Kasirajan Ayyanathan, Julianna S. Deakyne, Troy E. Messick, Paul M. Lieberman
Summary: This study reveals that EBNA1 forms cell cycle-dependent DNA crosslinks with the EBV origin of plasmid replication and the tyrosine 518 residue is essential for this process. These crosslinks and single-strand cleavage are critical for replication termination and viral episome maintenance.
Article
Immunology
Anders J. Svendsen, Marie Christine Wulff Westergaard, Anette Holck Draborg, Rene Holst, Kirsten O. Kyvik, Marianne A. Jakobsen, Peter Junker, Gunnar Houen
Summary: The study revealed distinct differences in EBNA1 antibody levels between patients with RA and healthy individuals, as well as between relatives predisposed to RA and healthy subjects. The levels of EBNA1 antibodies associated with RA and family predisposition to RA are influenced by both genetics (including the shared epitope) and environmental factors.
FRONTIERS IN IMMUNOLOGY
(2021)
Editorial Material
Cell Biology
Pawel Kordowitzki
Summary: Research has shown that the pool of oocytes in females starts to decline before birth, and as women age, characteristics such as chromosomal abnormalities, decreased mitochondrial function, and telomere shortening become more common. This may contribute to higher rates of miscarriage and chromosomal non-disjunction in older women who choose to delay pregnancy.
Article
Microbiology
Jing-xiao Xu, Rong Zhang, Dai-jia Huang, Ying Tang, Li-qin Ping, Bi-jun Huang, Hui-qiang Huang, Pierre Busson, Jiang Li
Summary: The interaction between Epstein-Barr virus (EBV) and the host cell transcriptome plays a crucial role in the development of EBV-associated malignancies. Gal-9 expression is persistently increased in EBV-infected B cells, and its upregulation is associated with genes related to cell proliferation. Inhibition of Gal-9 expression hinders the establishment of latent infection and outgrowth of EBV-infected B cells, while exogenous Gal-9 promotes EBV infection and growth. Gal-9 has an oncogenic role in EBV-associated B-cell lymphomas (BCLs) by modulating EBNA1 and STING signals.
MICROBIOLOGY SPECTRUM
(2023)
Review
Oncology
Weixing Liu, Gui Chen, Xin Gong, Yingqi Wang, Yaoming Zheng, Xiao Liao, Wenjing Liao, Lijuan Song, Jun Xu, Xiaowen Zhang
Summary: This study found through a meta-analysis that EBV-DNA, VCA-IgA, EBNA1-IgA, and Rta-IgG detection have high accuracy in early diagnosis of nasopharyngeal carcinoma, with EBV-DNA having the highest diagnostic accuracy. Meanwhile, EA-IgA is suitable for diagnosis but not for screening of NPC.
CANCER CELL INTERNATIONAL
(2021)
Review
Immunology
Hani Mosayebzadeh Roshan, Reza Valadan, Seyed Abdollah Hosseini, Abolghasem Ajami
Summary: The seroprevalence of anti-EBV antibodies is higher in multiple sclerosis patients compared to normal individuals. More specifically, the titer of anti EBNA1 antibody, an indicator of past EBV infection, is also higher in multiple sclerosis patients. However, this antibody titer difference is not reliable for distinguishing between multiple sclerosis patients and non-multiple sclerosis individuals. Studies have identified specific epitopes on EBNA1 that are targeted by anti-EBNA1 antibodies in multiple sclerosis patients, and measuring antibody response against these epitopes can help better discriminate between the two groups.
JOURNAL OF NEUROIMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
X. Chen, S. A. Kamranvar, M. G. Masucci
Review
Virology
Siamak A. Kamranvar, Maria G. Masucci
Article
Microbiology
Jinlin Li, Simone Callegari, Maria G. Masucci
Article
Oncology
Teresa Frisan, Noemi Nagy, Dimitrios Chioureas, Marie Terol, Francesca Grasso, Maria G. Masucci
INTERNATIONAL JOURNAL OF CANCER
(2019)
Article
Microbiology
Soham Gupta, Paivi Yla-Anttila, Simone Callegari, Ming-Han Tsai, Henri-Jacques Delecluse, Maria G. Masucci
Article
Biochemistry & Molecular Biology
Simone Callegari, Stefano Gastaldello, Omid R. Faridani, Maria G. Masucci
Review
Oncology
Xinsong Chen, Siamak Akbari Kamranvar, Maria G. Masucci
SEMINARS IN CANCER BIOLOGY
(2014)
Editorial Material
Oncology
Maria G. Masucci, Alan B. Rickinson
SEMINARS IN CANCER BIOLOGY
(2014)
Article
Cell Biology
Oceane C. B. Martin, Anna Bergonzini, Federica D'Amico, Puran Chen, Jerry W. Shay, Jacques Dupuy, Mattias Svensson, Maria G. Masucci, Teresa Frisan
CELLULAR MICROBIOLOGY
(2019)
Article
Biochemistry & Molecular Biology
Jiayu Wang, Noemi Nagy, Maria G. Masucci
Correction
Biochemistry & Molecular Biology
Jiayu Wang, Noemi Nagy, Maria G. Masucci
Article
Microbiology
Soham Gupta, Paivi Yla-Anttila, Tatyana Sandalova, Renhua Sun, Adnane Achour, Maria G. Masucci
Article
Cell Biology
Paivi Yla-Anttila, Soham Gupta, Maria G. Masucci
Summary: Macroautophagy plays a critical role in controlling viral infections, with viruses evolving strategies to interfere with this process. The Epstein-Barr virus-encoded BPLF1 protein regulates selective autophagy, promoting infection and viral production by targeting the cellular defense mechanism.
Article
Biochemistry & Molecular Biology
Paivi Yla-Anttila, Maria G. Masucci
Summary: Autophagy is a crucial protein degradation and recycling mechanism that plays a significant role in cellular homeostasis and defense against microbial invasion. It can be non-selective or selective, with different autophagy receptors recognizing specific targets for degradation. Some viruses, like EBV, KSHV, and HCMV, interfere with selective autophagy by regulating the activity of autophagy receptors such as SQSTM1/p62.
BIOCHEMICAL JOURNAL
(2021)
Article
Microbiology
Jinlin Li, Noemi Nagy, Jiangnan Liu, Soham Gupta, Teresa Frisan, Thomas Hennig, Donald P. Cameron, Laura Baranello, Maria G. Masucci
Summary: The study reveals that EBV's BPLF1 can alter the structure of TOP2 in cells, preventing DNA damage response and promoting cell survival and virus replication. This protective effect relies heavily on the expression of TDP2, which aids in DNA repair.