Recovery of Indicators of Mitochondrial Biogenesis, Oxidative Stress, and Aging With (−)-Epicatechin in Senile Mice

Validation of anti-aging drugs by treating age-related diseases

(2016) Mikhail V. Blagosklonny   Aging-US

Sirt1 Extends Life Span and Delays Aging in Mice through the Regulation of Nk2 Homeobox 1 in the DMH and LH

(2013) Akiko Satoh et al.   Cell Metabolism

(–)-Epicatechin is associated with increased angiogenic and mitochondrial signalling in the hindlimb of rats selectively bred for innate low running capacity

(2013) Maik Hüttemann et al.   CLINICAL SCIENCE

Consumption of Polyphenol Plants May Slow Aging and Associated Diseases

(2013) Utku Uysal et al.   CURRENT PHARMACEUTICAL DESIGN

(−)-Epicatechin rich cocoa mediated modulation of oxidative stress regulators in skeletal muscle of heart failure and type 2 diabetes patients

(2013) Israel Ramirez-Sanchez et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Effects of (−)-epicatechin on molecular modulators of skeletal muscle growth and differentiation

(2013) Gabriela Gutierrez-Salmean et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Antioxidants Improve the Phenotypes of Dilated Cardiomyopathy and Muscle Fatigue in Mitochondrial Superoxide Dismutase-Deficient Mice

(2013) Hirofumi Koyama et al.   MOLECULES

Aging and Calorie Restriction Oppositely Affect Mitochondrial Biogenesis through TFAM Binding at Both Origins of Mitochondrial DNA Replication in Rat Liver

(2013) Anna Picca et al.   PLoS One

Efficacy of vitamin and antioxidant supplements in prevention of cardiovascular disease: systematic review and meta-analysis of randomised controlled trials

(2013) S.-K. Myung et al.   BMJ-British Medical Journal

Effects of chocolate, cocoa, and flavan-3-ols on cardiovascular health: a systematic review and meta-analysis of randomized trials

(2012) Lee Hooper et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Dietary (Poly)phenolics in Human Health: Structures, Bioavailability, and Evidence of Protective Effects Against Chronic Diseases

(2012) Daniele Del Rio et al.   ANTIOXIDANTS & REDOX SIGNALING

SIRT1 Is Required for AMPK Activation and the Beneficial Effects of Resveratrol on Mitochondrial Function

(2012) Nathan L. Price et al.   Cell Metabolism

Mitochondria and Cardiovascular Aging

(2012) Dao-Fu Dai et al.   CIRCULATION RESEARCH

Senescent Cells: A Novel Therapeutic Target for Aging and Age-Related Diseases

(2012) R M Naylor et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Impaired SIRT1 nucleocytoplasmic shuttling in the senescent heart during ischemic stress

(2012) Chao Tong et al.   FASEB JOURNAL

The role of PGC-1 coactivators in aging skeletal muscle and heart

(2012) Lloye M. Dillon et al.   IUBMB LIFE

Quantitative digital in situ senescence-associated β-galactosidase assay

(2011) Liran I Shlush et al.   BMC CELL BIOLOGY

Alterations in Skeletal Muscle Indicators of Mitochondrial Structure and Biogenesis in Patients with Type 2 Diabetes and Heart Failure: Effects of Epicatechin Rich Cocoa

(2011) Pam R. Taub et al.   CTS-Clinical and Translational Science

Dual Role of Mitofilin in Mitochondrial Membrane Organization and Protein Biogenesis

(2011) Karina von der Malsburg et al.   DEVELOPMENTAL CELL

(-)-Epicatechin enhances fatigue resistance and oxidative capacity in mouse muscle

(2011) Leonardo Nogueira et al.   JOURNAL OF PHYSIOLOGY-LONDON

Telomere dysfunction induces metabolic and mitochondrial compromise

(2011) Ergün Sahin et al.   NATURE

Polyphenols and Human Health: Prevention of Disease and Mechanisms of Action

(2011) David Vauzour et al.   Nutrients

Senescence-associated beta-galactosidase activity expression in aging hippocampal neurons

(2010) Yi-Qun Geng et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Chronic green tea catechins administration prevents oxidative stress-related brain aging in C57BL/6J mice

(2010) Qiong Li et al.   BRAIN RESEARCH

Calorie Restriction Reduces Oxidative Stress by SIRT3-Mediated SOD2 Activation

(2010) Xiaolei Qiu et al.   Cell Metabolism

Peroxisome Proliferator-activated Receptor γ Co-activator 1α (PGC-1α) and Sirtuin 1 (SIRT1) Reside in Mitochondria

(2010) Katia Aquilano et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cell Senescence in the Aging Kidney

(2010) H. Yang et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Age-associated loss of Sirt1-mediated enhancement of glucose-stimulated insulin secretion in beta cell-specific Sirt1-overexpressing (BESTO) mice

(2009) Kathryn Moynihan Ramsey et al.   AGING CELL

Transcriptional Control of Mitochondrial Biogenesis and Function

(2009) M. Benjamin Hock et al.   Annual Review of Physiology

Grapes, Wines, Resveratrol, and Heart Health

(2009) Alberto A A Bertelli et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

Flavanols, the Kuna, cocoa consumption, and nitric oxide

(2009) Norman K. Hollenberg et al.   Journal of the American Society of Hypertension

Protocols to detect senescence-associated beta-galactosidase (SA-βgal) activity, a biomarker of senescent cells in culture and in vivo

(2009) Florence Debacq-Chainiaux et al.   Nature Protocols

Increased muscle PGC-1  expression protects from sarcopenia and metabolic disease during aging

(2009) T. Wenz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Proteomic DIGE analysis of the mitochondria-enriched fraction from aged rat skeletal muscle

(2009) Kathleen O'Connell et al.   PROTEOMICS

Mitochondrial biogenesis and healthy aging

(2008) Guillermo López-Lluch et al.   EXPERIMENTAL GERONTOLOGY