Article
Medicine, Research & Experimental
Tingting Lv, Yu Zhang, XingZhao Ji, Shengnan Sun, Li Xu, Weixia Ma, Yi Liu, Qiang Wan
Summary: GCN5L1 regulates the acetylation and intracellular trafficking of TFAM, playing an important role in AKI-associated mitochondrial impairment.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Natalya Kozhukhar, Mikhail F. Alexeyev
Summary: Researchers used the GeneSwap approach to analyze the contributions of the TFAM C-terminal domain to mtDNA transcription and replication. They found that tail-less TFAM supports both mtDNA replication and transcription, and mutations in TFAM impair HSP1 transcription to a greater extent than LSP transcription. These findings suggest the need for further refinement of the current model of mtDNA transcription.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Guglielmina Chimienti, Anna Picca, Flavio Fracasso, Francesco Russo, Antonella Orlando, Giuseppe Riezzo, Christiaan Leeuwenburgh, Vito Pesce, Angela Maria Serena Lezza
Summary: The study indicates that calorie restriction has certain effects in delaying aging, reducing oxidative damage to mitochondrial DNA and increasing the expression of mitochondrial-related proteins in aged rats. However, it also suggests a potential age-related boundary for the efficacy of calorie restriction after 28 months.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Endocrinology & Metabolism
Sing -Young Chen, Martina Beretta, Ellen M. Olzomer, Divya P. Shah, Derek Y. H. Wong, Stephanie J. Alexopoulos, Isabella Aleksovska, Joseph M. Salamoun, Christopher J. Garcia, Blake J. Cochran, Kerry-Anne Rye, Greg C. Smith, Frances L. Byrne, Margaret J. Morris, Webster L. Santos, James Cantley, Kyle L. Hoehn
Summary: This study compares the metabolic effects of calorie restriction and the mitochondrial uncoupler BAM15 in a mouse model with severe hyperglycemia, obesity, hypertriglyceridemia, and fatty liver. The results showed that BAM15 was more effective than calorie restriction in improving glucose control, and its effects were independent of weight loss.
MOLECULAR METABOLISM
(2022)
Article
Biochemistry & Molecular Biology
Sunao Shimizu, Shuya Kasai, Hiromi Yamazaki, Yota Tatara, Junsei Mimura, Mate Janos Engler, Kunikazu Tanji, Yoshikazu Nikaido, Takuro Inoue, Hiroyuki Suganuma, Koichi Wakabayashi, Ken Itoh
Summary: Sulforaphane (SFN) has shown to improve age-related cognitive decline. This study found that broccoli sprout powder containing sulforaphane glucosinolate (SGS) can prevent cognitive decline in senescence-accelerated mice by maintaining mitochondrial function.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Ping Ren, Fangchao Gong, Liang Chang, Xiaodong Hong, Lei Xing, Hong Zhang
Summary: The study demonstrated that zafirlukast enhances mitochondrial function by promoting mitochondrial respiration and biogenesis in human bronchial epithelial cells. This effect is mediated through upregulation of PGC-1 alpha expression and activation of the CREB pathway.
JOURNAL OF MOLECULAR HISTOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Carlos Cardanho-Ramos, Vanessa Alexandra Morais
Summary: Neurons primarily rely on mitochondria for ATP production and Ca2+ homeostasis, with different pools of mitochondria in each sub-compartment. Mitochondria are generated in the cell body and travel to the synapse, but in long cells like motor neurons, biogenesis also occurs at the periphery. Mitochondrial biogenesis in the cell body is triggered by Ca2+ and ATP levels, while mechanisms promoting biogenesis away from the cell body are less understood.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Ying Jiang, Da Li, Zhiqiang Du, Jie Li, Rongrong Lu, Qin Zhou, Qi Wang, Haohao Zhu
Summary: The study investigated the protective effects of Perampanel on mitochondrial biogenesis and bioenergetics in human neuronal cells. Results showed that Perampanel stimulated mitochondrial biogenesis and improved mitochondrial bioenergetics.
ACS CHEMICAL NEUROSCIENCE
(2021)
Article
Physiology
Julian D. C. Serna, Andressa G. Amaral, Camille C. Caldeira da Silva, Ana C. Munhoz, Eloisa A. Vilas-Boas, Sergio L. Menezes-Filho, Alicia J. Kowaltowski
Summary: Caloric restriction (CR) prevents obesity and increases resilience against pathological stimuli, but it may have unexpected deleterious effects in the kidneys, including increased mitochondrial reactive oxygen production and permeability transition.
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY
(2022)
Article
Gastroenterology & Hepatology
Wei Wang, Chun -Fan Jiang, Hai-Sen Yin, Shan Gao, Bao-Ping Yu
Summary: TFAM plays a crucial role in pancreatic cancer by regulating mitochondrial functions, affecting cancer cell growth and survival. Inhibiting TFAM may have therapeutic value in overcoming drug resistance and enhancing drug efficacy.
HEPATOBILIARY & PANCREATIC DISEASES INTERNATIONAL
(2023)
Article
Neurosciences
Shweta Goyal, Saurabh Tiwari, Brashket Seth, Ankit Tandon, Jai Shankar, Meetali Sinha, Sangh Jyoti Singh, Smriti Priya, Rajnish Kumar Chaturvedi
Summary: Mitochondrial biogenesis is influenced by different protein import mechanisms, and exposure to BPA may lead to neurotoxicity, affect mitochondrial dynamics, and protein import, ultimately triggering cell apoptosis.
Article
Cell Biology
Jayanta Kumar Das, Nirad Banskota, Julian Candia, Michael E. Griswold, Melissa Orenduff, Rafael de Cabo, David L. Corcoran, Sai Krupa Das, Supriyo De, Kim Marie Huffman, Virginia B. Kraus, William E. Kraus, Corby K. Martin, Susan B. Racette, Leanne M. Redman, Birgit Schilling, Daniel W. Belsky, Luigi Ferrucci
Summary: Using high-depth RNA-Seq analysis, this study found that caloric restriction (CR) positively affects skeletal muscle quality in humans and alters the gene expression and splicing profiles of biological pathways affected by CR in model organisms.
Article
Biochemistry & Molecular Biology
Xiaojing Wei, Chuanfei Wei, Yutian Tan, Ximing Dong, Zhao Yang, Jianqun Yan, Xiao Luo
Summary: This study aimed to determine the regulation of NAD+-related enzymes in the liver and their relationships with glucose and lipid metabolism. It was found that both high-fat diet feeding and calorie restriction increased hepatic NAD+ levels and the expression of related genes. In addition, high-fat diet feeding and calorie restriction had different effects on hepatic lipogenesis and gluconeogenesis. These findings highlight the importance of hepatic NAD+ metabolism in maintaining metabolic flexibility.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2023)
Article
Endocrinology & Metabolism
Rory P. Cunningham, Mary P. Moore, Ryan J. Dashek, Grace M. Meers, Vivien Jepkemoi, Takamune Takahashi, Victoria J. Vieira-Potter, Jill A. Kanaley, Frank W. Booth, R. Scott Rector
Summary: This study demonstrates for the first time the requirement of eNOS in hepatocytes for the exercise-induced increase in hepatic fatty acid oxidation in male mice. Deletion of eNOS in hepatocytes also appears to impair the energy-sensing ability of the cell and inhibit the activation of the autophagy initiating factor ULK1.
Article
Biochemistry & Molecular Biology
Qi Long, Yanshuang Zhou, Hao Wu, Shiwei Du, Mingli Hu, Juntao Qi, Wei Li, Jingyi Guo, Yi Wu, Liang Yang, Ge Xiang, Liang Wang, Shouhua Ye, Jiayuan Wen, Heng Mao, Junwei Wang, Hui Zhao, Wai-Yee Chan, Jinsong Liu, Yonglong Chen, Pilong Li, Xingguo Liu
Summary: Fluorescence imaging and fluorescence recovery after photobleaching assays reveal that the mitochondrial nucleoid forms a suborganelle via liquid-liquid phase separation interactions between mitochondrial DNA and the mitochondrial transcriptional machinery. Mitochondrial transcription factor A (TFAM) undergoes phase separation with mtDNA to drive nucleoid self-assembly. Moreover, nucleoid droplet formation promotes recruitment of the transcription machinery, concentrating initiation, elongation, and termination factors, and retaining substrates to facilitate mtDNA transcription.
NATURE STRUCTURAL & MOLECULAR BIOLOGY
(2021)
Article
Pharmacology & Pharmacy
Simona Todisco, Biagia Musio, Vito Pesce, Maria Maddalena Cavalluzzi, Giuseppe Petrosillo, Gianluigi La Piana, Maria Noemi Sgobba, Nikola Schlosserova, Lucas Cafferati Beltrame, Rosa Di Lorenzo, Vincenzo Tragni, Domenico Marzulli, Lorenzo Guerra, Anna De Grassi, Vito Gallo, Mariateresa Volpicella, Luigi Leonardo Palese, Giovanni Lentini, Ciro Leonardo Pierri
Summary: Mitochondria and mitochondrial proteins are promising pharmacological target candidates for the prevention of hypertension and cardiovascular diseases. Targeting mitochondrial dysfunction in cardiomyocytes can prevent heart failure. Advances in omics approaches and computational methods allow for detailed investigation of impaired mitochondrial pathways in CVDs and the design of new selective drugs.
BIOCHEMICAL PHARMACOLOGY
(2023)
Article
Cell Biology
Anna Picca, Matthew Triolo, Stephanie E. E. Wohlgemuth, Matthew S. S. Martenson, Robert T. T. Mankowski, Stephen D. D. Anton, Emanuele Marzetti, Christiaan Leeuwenburgh, David A. A. Hood
Summary: Altered mitochondrial quality in muscle may contribute to age-related decline in physical function. This study investigated the relationship between autophagy, mitophagy, lysosomal markers and measures of physical performance and lower extremity tissue composition in young and older adults. The results revealed that older adults had smaller muscle volume, lower tissue composition index, and higher protein content of p62 and BNIP3. The expression levels of p62 and BNIP3 were negatively correlated with the tissue composition index and performance on the 5-time sit-to-stand test. These findings suggest that dysfunction in the autophagy/mitophagy-lysosomal system is associated with deterioration of lower extremity tissue composition and muscle dysfunction.
Editorial Material
Cell Biology
Anna Picca, Emanuele Marzetti, Christiaan Leeuwenburgh
Article
Nutrition & Dietetics
Dongyu Zhang, Kori A. Spiropoulos, Akemi Wijayabahu, Demetra D. Christou, Shama D. Karanth, Stephen D. Anton, Christiaan Leeuwenburgh, Muxuan Liang, Meghann Wheeler, Danting Yang, Aduse-Poku Livingstone, Robert T. Mankowski, Ting -Yuan David Cheng, Hanchao Zhang, Erin M. Siegel, Frank J. Penedo, Jonathan D. Licht, Dejana Braithwaite
Summary: This study aimed to investigate the effects of low muscle mass (LMM) on the risk of all-cause and cardiovascular disease (CVD)-specific mortality in cancer survivors. The results showed that LMM was positively associated with the risk of all-cause and CVD-specific mortality in cancer survivors.
Article
Nutrition & Dietetics
Stefano Cacciatore, Riccardo Calvani, Emanuele Marzetti, Anna Picca, Helio Jose Coelho-Junior, Anna Maria Martone, Claudia Massaro, Matteo Tosato, Francesco Landi
Summary: Muscle strength is associated with aging. While the relationship between adherence to Mediterranean diet and muscle strength in older adults remains inconclusive, this study found that those with higher adherence to Mediterranean diet had a lower risk of probable sarcopenia.
Article
Nutrition & Dietetics
Helio Jose Coelho-Junior, Samuel da Silva Aguiar, Ivan de Oliveira Goncalves, Riccardo Calvani, Matteo Tosato, Francesco Landi, Anna Picca, Emanuele Marzetti
Summary: The present study found that protein intake at lunch was independently and negatively associated with systolic blood pressure in community-dwelling older adults in Brazil. Additionally, participants with higher protein intakes had a lower prevalence of hypertension diagnosed by a physician. These results remained significant after adjusting for several covariates but lost significance when kilocalories and micronutrients were included in the model.
Article
Medicine, General & Internal
Vincenzo Galluzzo, Maria Beatrice Zazzara, Francesca Ciciarello, Matteo Tosato, Anna Maria Martone, Cristina Pais, Giulia Savera, Riccardo Calvani, Anna Picca, Emanuele Marzetti, Francesco Landi
Summary: This study aimed to evaluate the association between physical activity levels and parameters of physical function in COVID-19 survivors with post-acute symptoms. The results showed that stopping physical activity after COVID-19 results in comparable physical performance to those who were never active. However, older adults who continue to engage in physical activity perform better in the six-minute walking test than sedentary peers.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Robert T. Mankowski, Stephanie E. Wohlgemuth, Guilherme Bresciani, A. Daniel Martin, George Arnaoutakis, Tomas Martin, Eric Jeng, Leonardo Ferreira, Tiago Machuca, Mindaugas Rackauskas, Ashley J. Smuder, Thomas Beaver, Christiaan Leeuwenburgh, Barbara K. Smith
Summary: Mechanical ventilation during cardiothoracic surgery can lead to ventilator-induced diaphragm dysfunction (VIDD) and delay recovery. In this study, intraoperative phrenic nerve stimulation was performed to offset VIDD and investigate changes in mitochondrial function.
Article
Biochemistry & Molecular Biology
Helio Jose Coelho-Junior, Riccardo Calvani, Anna Picca, Matteo Tosato, Giulia Savera, Francesco Landi, Emanuele Marzetti
Summary: The study aimed to investigate the relationship between protein intake and blood pressure, glucose levels, and blood cholesterol in a large sample of Italian older adults. The findings showed that high protein intake was negatively associated with diastolic blood pressure and positively associated with total blood cholesterol levels in a large cohort of Italian older adults.
Article
Health Care Sciences & Services
Helio Jose Coelho-Junior, Riccardo Calvani, Anna Picca, Matteo Tosato, Francesco Landi, Emanuele Marzetti
Summary: The study aimed to examine the relationship between adherence to specific exercise modalities and the severity of sarcopenia in older adults in Italy. The data was collected as part of the Longevity Check-Up 7+ (Lookup 7+) project. The results showed that engagement in running and/or swimming and strength training with or without stretching had a positive impact on reducing the severity of sarcopenia in older adults.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Anna Picca, Flora Guerra, Riccardo Calvani, Helio Jose Coelho, Francesco Landi, Cecilia Bucci, Emanuele Marzetti
Summary: Mitophagy plays a crucial role in maintaining mitochondrial quality, and extracellular vesicles (EVs) containing mitochondrial components are released through the endosomal-lysosomal system. This process occurs in response to mild mitochondrial damage and lysosomal dysfunction, with mitochondrial-derived vesicles (MDVs) helping to limit the release of proinflammatory mitochondrial damage-associated molecular patterns.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Nutrition & Dietetics
Helio Jose Coelho-Junior, Riccardo Calvani, Anna Picca, Stefano Cacciatore, Matteo Tosato, Francesco Landi, Emanuele Marzetti
Summary: Previous studies have shown that regular aerobic training and adherence to a Mediterranean diet can lower the prevalence of sarcopenia in older adults. However, the effect of their combination on sarcopenia indices is unknown.
Article
Nutrition & Dietetics
Stefano Cacciatore, Giordana Gava, Riccardo Calvani, Emanuele Marzetti, Helio Jose Coelho-Junior, Anna Picca, Ilaria Esposito, Francesca Ciciarello, Sara Salini, Andrea Russo, Matteo Tosato, Francesco Landi
Summary: This study investigated the prevalence of high adiposity and its relationship with Mediterranean diet adherence in older adults. The results showed that low and moderate adherence to the Mediterranean diet was associated with a higher risk of high adiposity, while high adherence was associated with a lower risk. Other factors associated with high adiposity risk were age, gender, and physical inactivity.