Oxidative and nitrative alpha-synuclein modifications and proteostatic stress: implications for disease mechanisms and interventions in synucleinopathies
出版年份 2013 全文链接
标题
Oxidative and nitrative alpha-synuclein modifications and proteostatic stress: implications for disease mechanisms and interventions in synucleinopathies
作者
关键词
-
出版物
JOURNAL OF NEUROCHEMISTRY
Volume 125, Issue 4, Pages 491-511
出版商
Wiley
发表日期
2013-03-02
DOI
10.1111/jnc.12226
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注意：仅列出部分参考文献，下载原文获取全部文献信息。- Ubiquitination of α-synuclein and autophagy in Parkinson's disease
- (2014) Simone Engelender Autophagy
- Characterization of mouse cell line IMA 2.1 as a potential model system to study astrocyte functions
- (2014) Stefan Schildknecht ALTEX-Alternatives to Animal Experimentation
- May the Evaluation of Nitrosative Stress Through Selective Increase of 3-Nitrotyrosine Proteins Other Than Nitroalbumin and Dominant Tyrosine-125/136 Nitrosylation of Serum α-Synuclein Serve for Diagnosis of Sporadic Parkinson's Disease?
- (2013) Emilio Fernández et al. ANTIOXIDANTS & REDOX SIGNALING
- Site-Specific Interaction between α-Synuclein and Membranes Probed by NMR-Observed Methionine Oxidation Rates
- (2013) Alexander S. Maltsev et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Autocatalytic Nitration of Prostaglandin Endoperoxide Synthase-2 by Nitrite Inhibits Prostanoid Formation in Rat Alveolar Macrophages
- (2012) Stefan Schildknecht et al. ANTIOXIDANTS & REDOX SIGNALING
- Lipid Peroxidation Product 4-Hydroxy-2-Nonenal Promotes Seeding-Capable Oligomer Formation and Cell-to-Cell Transfer of α-Synuclein
- (2012) Eun-Jin Bae et al. ANTIOXIDANTS & REDOX SIGNALING
- Alpha-synuclein’s degradation in vivo
- (2012) Darius Ebrahimi-Fakhari et al. Autophagy
- Locally Resolved Membrane Binding Affinity of the N-Terminus of α-Synuclein
- (2012) Marta Robotta et al. BIOCHEMISTRY
- Impact of N-Terminal Acetylation of α-Synuclein on Its Random Coil and Lipid Binding Properties
- (2012) Alexander S. Maltsev et al. BIOCHEMISTRY
- Mitochondrial dysfunction in Parkinson's disease: molecular mechanisms and pathophysiological consequences
- (2012) Nicole Exner et al. EMBO JOURNAL
- Toll-like receptor 4 is required for α-synuclein dependent activation of microglia and astroglia
- (2012) Lisa Fellner et al. GLIA
- Remodeling of Lipid Vesicles into Cylindrical Micelles by α-Synuclein in an Extended α-Helical Conformation
- (2012) Naoko Mizuno et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- α-Synuclein in Central Nervous System and from Erythrocytes, Mammalian Cells, andEscherichia coliExists Predominantly as Disordered Monomer
- (2012) Bruno Fauvet et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Characterization of Semisynthetic and NaturallyNα-Acetylated α-Synucleinin Vitroand in Intact Cells
- (2012) Bruno Fauvet et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Intracerebral inoculation of pathological α-synuclein initiates a rapidly progressive neurodegenerative α-synucleinopathy in mice
- (2012) Kelvin C. Luk et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Chemical Strategies for Controlling Protein Folding and Elucidating the Molecular Mechanisms of Amyloid Formation and Toxicity
- (2012) Sara Butterfield et al. JOURNAL OF MOLECULAR BIOLOGY
- Antibody-Aided Clearance of Extracellular -Synuclein Prevents Cell-to-Cell Aggregate Transmission
- (2012) E.-J. Bae et al. JOURNAL OF NEUROSCIENCE
- Elucidating the Role of C-Terminal Post-Translational Modifications Using Protein Semisynthesis Strategies: α-Synuclein Phosphorylation at Tyrosine 125
- (2012) Mirva Hejjaoui et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Mitochondrial dynamics and neuronal fate in Parkinson's disease
- (2012) D. Santos et al. MITOCHONDRION
- α-Synuclein Elevation in Human Neurodegenerative Diseases: Experimental, Pathogenetic, and Therapeutic Implications
- (2012) Ayse Ulusoy et al. MOLECULAR NEUROBIOLOGY
- Progressive degeneration of human neural stem cells caused by pathogenic LRRK2
- (2012) Guang-Hui Liu et al. NATURE
- 100 years of Lewy pathology
- (2012) Michel Goedert et al. Nature Reviews Neurology
- The many faces of α-synuclein: from structure and toxicity to therapeutic target
- (2012) Hilal A. Lashuel et al. NATURE REVIEWS NEUROSCIENCE
- Control of Aβ release from human neurons by differentiation status and RET signaling
- (2012) Diana Scholz et al. NEUROBIOLOGY OF AGING
- A model of nitric oxide induced α-synuclein misfolding in Parkinson's disease
- (2012) David K. Stone et al. NEUROSCIENCE LETTERS
- α-Synuclein phosphorylation as a therapeutic target in Parkinson’s disease
- (2012) Steven P. Braithwaite et al. REVIEWS IN THE NEUROSCIENCES
- Pathological -Synuclein Transmission Initiates Parkinson-like Neurodegeneration in Nontransgenic Mice
- (2012) K. C. Luk et al. SCIENCE
- Mitochondrial Fission, Fusion, and Stress
- (2012) R. J. Youle et al. SCIENCE
- Beyond α-synuclein transfer: pathology propagation in Parkinson's disease
- (2012) Christian Hansen et al. TRENDS IN MOLECULAR MEDICINE
- Increased α-synuclein phosphorylation and nitration in the aging primate substantia nigra
- (2012) A L McCormack et al. Cell Death & Disease
- Environmental toxins trigger PD-like progression via increased alpha-synuclein release from enteric neurons in mice
- (2012) Francisco Pan-Montojo et al. Scientific Reports
- Transmission of Synucleinopathies in the Enteric Nervous System of A53T Alpha-Synuclein Transgenic Mice
- (2012) He-Jin Lee et al. Experimental Neurobiology
- Toll-Like Receptor 4 Promotes α-Synuclein Clearance and Survival of Nigral Dopaminergic Neurons
- (2011) Nadia Stefanova et al. AMERICAN JOURNAL OF PATHOLOGY
- α-Synuclein misfolding and Parkinson's disease
- (2011) Leonid Breydo et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
- Direct Membrane Association Drives Mitochondrial Fission by the Parkinson Disease-associated Protein α-Synuclein
- (2011) Ken Nakamura et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Rapid, complete and large-scale generation of post-mitotic neurons from the human LUHMES cell line
- (2011) Diana Scholz et al. JOURNAL OF NEUROCHEMISTRY
- Functional Alterations to the Nigrostriatal System in Mice Lacking All Three Members of the Synuclein Family
- (2011) S. Anwar et al. JOURNAL OF NEUROSCIENCE
- Distinct Roles In Vivo for the Ubiquitin-Proteasome System and the Autophagy-Lysosomal Pathway in the Degradation of -Synuclein
- (2011) D. Ebrahimi-Fakhari et al. JOURNAL OF NEUROSCIENCE
- Allostery in a Disordered Protein: Oxidative Modifications to α-Synuclein Act Distally To Regulate Membrane Binding
- (2011) Eva Sevcsik et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Kinetic measurements give new insights into lipid membrane permeabilization by α-synuclein oligomers
- (2011) Martin Stöckl et al. Molecular BioSystems
- Exogenous α-Synuclein Fibrils Induce Lewy Body Pathology Leading to Synaptic Dysfunction and Neuron Death
- (2011) Laura A. Volpicelli-Daley et al. NEURON
- Antibodies against Alpha-Synuclein Reduce Oligomerization in Living Cells
- (2011) Thomas Näsström et al. PLoS One
- In vivo demonstration that -synuclein oligomers are toxic
- (2011) B. Winner et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- A novel molecular mechanism for nitrated α-synuclein-induced cell death
- (2011) Yanying Liu et al. Journal of Molecular Cell Biology
- Towards Elucidation of the Role of Ubiquitination in the Pathogenesis of Parkinson’s Disease with Semisynthetic Ubiquitinated α-Synuclein
- (2010) Mirva Hejjaoui et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Dopamine quinones interact with α-synuclein to form unstructured adducts
- (2010) Marco Bisaglia et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- SNARE protein redistribution and synaptic failure in a transgenic mouse model of Parkinson’s disease
- (2010) Pablo Garcia-Reitböck et al. BRAIN
- Direct Evidence of Coexisting Horseshoe and Extended Helix Conformations of Membrane-Bound Alpha-Synuclein
- (2010) Marta Robotta et al. CHEMPHYSCHEM
- Inhibition of mitochondrial fusion by α-synuclein is rescued by PINK1, Parkin and DJ-1
- (2010) Frits Kamp et al. EMBO JOURNAL
- Co-expression of C-terminal truncated alpha-synuclein enhances full-length alpha-synuclein-induced pathology
- (2010) Ayse Ulusoy et al. EUROPEAN JOURNAL OF NEUROSCIENCE
- The lipid peroxidation products 4-oxo-2-nonenal and 4-hydroxy-2-nonenal promote the formation of α-synuclein oligomers with distinct biochemical, morphological, and functional properties
- (2010) Thomas Näsström et al. FREE RADICAL BIOLOGY AND MEDICINE
- Lysosomal Degradation of α-Synucleinin Vivo
- (2010) Sally K. Mak et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Entacapone and Tolcapone, Two CatecholO-Methyltransferase Inhibitors, Block Fibril Formation of α-Synuclein and β-Amyloid and Protect against Amyloid-induced Toxicity
- (2010) Saviana Di Giovanni et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Neuroprotection by Minocycline Caused by Direct and Specific Scavenging of Peroxynitrite
- (2010) Stefan Schildknecht et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- The Transgenic Overexpression of α-Synuclein and Not Its Related Pathology Associates with Complex I Inhibition
- (2010) Virginie Loeb et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- -Synuclein Activates Microglia by Inducing the Expressions of Matrix Metalloproteinases and the Subsequent Activation of Protease-Activated Receptor-1
- (2010) E.-J. Lee et al. JOURNAL OF IMMUNOLOGY
- Regulatory T Cells Attenuate Th17 Cell-Mediated Nigrostriatal Dopaminergic Neurodegeneration in a Model of Parkinson’s Disease
- (2010) Ashley D. Reynolds et al. JOURNAL OF IMMUNOLOGY
- A Pathologic Cascade Leading to Synaptic Dysfunction in -Synuclein-Induced Neurodegeneration
- (2010) D. A. Scott et al. JOURNAL OF NEUROSCIENCE
- Phosphorylation at S87 Is Enhanced in Synucleinopathies, Inhibits -Synuclein Oligomerization, and Influences Synuclein-Membrane Interactions
- (2010) K. E. Paleologou et al. JOURNAL OF NEUROSCIENCE
- Characterization of Lewy body pathology in 12- and 16-year-old intrastriatal mesencephalic grafts surviving in a patient with Parkinson's disease
- (2010) Jia-Yi Li et al. MOVEMENT DISORDERS
- Detection of elevated levels of -synuclein oligomers in CSF from patients with Parkinson disease
- (2010) T. Tokuda et al. NEUROLOGY
- Increased Expression of α-Synuclein Reduces Neurotransmitter Release by Inhibiting Synaptic Vesicle Reclustering after Endocytosis
- (2010) Venu M. Nemani et al. NEURON
- α-Synuclein Suppression by Targeted Small Interfering RNA in the Primate Substantia Nigra
- (2010) Alison L. McCormack et al. PLoS One
- Preferentially Increased Nitration of α-Synuclein at Tyrosine-39 in a Cellular Oxidative Model of Parkinson’s Disease
- (2009) Steven R. Danielson et al. ANALYTICAL CHEMISTRY
- Methionine oxidation stabilizes non-toxic oligomers of α-synuclein through strengthening the auto-inhibitory intra-molecular long-range interactions
- (2009) Wenbo Zhou et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
- Biophysics of Parkinsons Disease: Structure and Aggregation of α- Synuclein
- (2009) Vladimir Uversky et al. CURRENT PROTEIN & PEPTIDE SCIENCE
- Chemical model systems for cellular nitros(yl)ation reactions
- (2009) Andreas Daiber et al. FREE RADICAL BIOLOGY AND MEDICINE
- Formation of dopamine-mediated α-synuclein-soluble oligomers requires methionine oxidation
- (2009) Su Ling Leong et al. FREE RADICAL BIOLOGY AND MEDICINE
- Loss of Parkin or PINK1 Function Increases Drp1-dependent Mitochondrial Fragmentation
- (2009) A. Kathrin Lutz et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Nitrated -Synuclein-Induced Alterations in Microglial Immunity Are Regulated by CD4+ T Cell Subsets
- (2009) A. D. Reynolds et al. JOURNAL OF IMMUNOLOGY
- At Low Concentrations, 3,4-Dihydroxyphenylacetic Acid (DOPAC) Binds Non-Covalently to α-Synuclein and Prevents Its Fibrillation
- (2009) Wenbo Zhou et al. JOURNAL OF MOLECULAR BIOLOGY
- The First N-terminal Amino Acids of α-Synuclein Are Essential for α-Helical Structure Formation In Vitro and Membrane Binding in Yeast
- (2009) Katherina Vamvaca et al. JOURNAL OF MOLECULAR BIOLOGY
- Seeding induced by α-synuclein oligomers provides evidence for spreading of α-synuclein pathology
- (2009) Karin M. Danzer et al. JOURNAL OF NEUROCHEMISTRY
- Pathologic Modifications of α-Synuclein in 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine (MPTP)-Treated Squirrel Monkeys
- (2009) Alison L. McCormack et al. JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY
- The sour side of neurodegenerative disorders: the effects of protein glycation
- (2009) Hugo Vicente Miranda et al. JOURNAL OF PATHOLOGY
- Modulation of α-synuclein expression in transgenic animals for modelling synucleinopathies — is the juice worth the squeeze?
- (2009) Vladimir L. Buchman et al. NEUROTOXICITY RESEARCH
- Abberant α-Synuclein Confers Toxicity to Neurons in Part through Inhibition of Chaperone-Mediated Autophagy
- (2009) Maria Xilouri et al. PLoS One
- Inclusion formation and neuronal cell death through neuron-to-neuron transmission of -synuclein
- (2009) P. Desplats et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Exogenous -synuclein fibrils seed the formation of Lewy body-like intracellular inclusions in cultured cells
- (2009) K. C. Luk et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Regulation of Neuronal Survival Factor MEF2D by Chaperone-Mediated Autophagy
- (2009) Q. Yang et al. SCIENCE
- Peroxynitrite as regulator of vascular prostanoid synthesis
- (2008) Stefan Schildknecht et al. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
- Protein tyrosine nitration—An update
- (2008) Harry Ischiropoulos ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
- Mitochondrial association of alpha-synuclein causes oxidative stress
- (2008) M. S. Parihar et al. CELLULAR AND MOLECULAR LIFE SCIENCES
- Methionine sulfoxide reductase A protects dopaminergic cells from Parkinson's disease-related insults
- (2008) Fang Liu et al. FREE RADICAL BIOLOGY AND MEDICINE
- Wild Type α-Synuclein Is Degraded by Chaperone-mediated Autophagy and Macroautophagy in Neuronal Cells
- (2008) Tereza Vogiatzi et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Mitochondrial Import and Accumulation of α-Synuclein Impair Complex I in Human Dopaminergic Neuronal Cultures and Parkinson Disease Brain
- (2008) Latha Devi et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Phosphorylation at Ser-129 but Not the Phosphomimics S129E/D Inhibits the Fibrillation of α-Synuclein
- (2008) Katerina E. Paleologou et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Controlling the mass action of α-synuclein in Parkinson’s disease
- (2008) Changyoun Kim et al. JOURNAL OF NEUROCHEMISTRY
- Targeted Overexpression of Human α-Synuclein Triggers Microglial Activation and an Adaptive Immune Response in a Mouse Model of Parkinson Disease
- (2008) Shaji Theodore et al. JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY
- Neurotoxic Activation of Microglia Is Promoted by a Nox1-Dependent NADPH Oxidase
- (2008) C. Cheret et al. JOURNAL OF NEUROSCIENCE
- Neuroinflammation and Oxidation/Nitration of -Synuclein Linked to Dopaminergic Neurodegeneration
- (2008) H.-M. Gao et al. JOURNAL OF NEUROSCIENCE
- Lewy bodies in grafted neurons in subjects with Parkinson's disease suggest host-to-graft disease propagation
- (2008) Jia-Yi Li et al. NATURE MEDICINE
- Lewy body–like pathology in long-term embryonic nigral transplants in Parkinson's disease
- (2008) Jeffrey H Kordower et al. NATURE MEDICINE
- Nitrated α–Synuclein Immunity Accelerates Degeneration of Nigral Dopaminergic Neurons
- (2008) Eric J. Benner et al. PLoS One
- Inhibition of α-Synuclein Fibrillization by Dopamine Is Mediated by Interactions with Five C-Terminal Residues and with E83 in the NAC Region
- (2008) Fernando E. Herrera et al. PLoS One
- Structure of membrane-bound -synuclein from site-directed spin labeling and computational refinement
- (2008) C. C. Jao et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
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