Review
Biochemistry & Molecular Biology
Sasanka Chakrabarti, Marco Bisaglia
Summary: Parkinson's disease is a chronic neurodegenerative condition that affects over 1% of people over the age of 65. It is characterized by the degeneration of specific neurons responsible for motor symptoms. The underlying mechanisms, including redox alterations, mitochondrial dysfunctions, and neuroinflammation, are not fully understood. This review explores the role of dopamine and its oxidation chemistry in the pathogenesis of Parkinson's disease, including the formation of free radicals and toxic metabolites.
Article
Biochemistry & Molecular Biology
Fabio Schifano, Simone Dell'Acqua, Stefania Nicolis, Luigi Casella, Enrico Monzani
Summary: The study explores the interplay between α-Synuclein (aS), dopamine (DA), and iron in Parkinson's disease etiology. At high DA:Fe molar ratios, the formation of the [Fe-III(DA)(2)](-) complex hinders the interaction with aS peptides. However, at lower ratios, the peptide competes with one of the two coordinated DA molecules. Post-translational modifications of the peptide, such as oxidation and phosphorylation, play crucial roles in aS aggregation and affinity for iron(III). Moreover, the presence of a membrane-like environment enhances the peptide's effect on DA oxidation and complex formation and decomposition.
Article
Neurosciences
Samanta Mazzetti, Michela Barichella, Federica Giampietro, Angelica Giana, Alessandra M. Calogero, Alida Amadeo, Nicola Palazzi, Alessandro Comincini, Giorgio Giaccone, Manuela Bramerio, Serena Caronni, Viviana Cereda, Emanuele Cereda, Graziella Cappelletti, Chiara Rolando, Gianni Pezzoli
Summary: This study found a specific subpopulation of astrocytes in the brains of Parkinson's disease (PD) patients, which can protect neurons by sequestering alpha-Synuclein oligomers and are associated with Lewy body negative neurons. These findings suggest the potential neuroprotective role of the vitamin D pathway in neurodegenerative diseases.
CNS NEUROSCIENCE & THERAPEUTICS
(2022)
Review
Biochemistry & Molecular Biology
Parveen Salahuddin, Munazza Tamkeen Fatima, Vladimir N. Uversky, Rizwan Hasan Khan, Zeyaul Islam, Mohammad Furkan
Summary: Neurodegenerative diseases are characterized by the abnormal loss of neurons, with common pathogenic mechanisms involving misfolding and aggregation of proteins. Accumulating evidence suggests that amyloid oligomers, not fibrils, are the most toxic species causing AD and PD.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Review
Clinical Neurology
Paolo Calabresi, Giulia Di Lazzaro, Gioia Marino, Federica Campanelli, Veronica Ghiglieri
Summary: The critical role of alpha-synuclein in Parkinson's disease has been discovered, but current treatments still face challenges. Developing cellular and animal models helps understand the physiological and pathological functions of alpha-synuclein, as well as the pathogenesis of Parkinson's disease.
Article
Biochemistry & Molecular Biology
Alessandra Mingione, Francesca Pivari, Nicoletta Plotegher, Michele Dei Cas, Aida Zulueta, Tommaso Bocci, Marco Trinchera, Elisabetta Albi, Vittorio Maglione, Anna Caretti, Luigi Bubacco, Rita Paroni, Daniele Bottai, Riccardo Ghidoni, Paola Signorelli
Summary: Parkinson's disease is associated with alpha-synuclein aggregation and lipid-protein inclusion formation, leading to impaired autophagy, protein aggregation, and inflammation. Myr treatment may help improve these conditions by reducing intracellular aggregates and inflammation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Neurosciences
Hiroaki Sekiya, Asato Tsuji, Yuki Hashimoto, Mariko Takata, Shunsuke Koga, Katsuya Nishida, Naonobu Futamura, Michi Kawamoto, Nobuo Kohara, Dennis W. Dickson, Hisatomo Kowa, Tatsushi Toda
Summary: The distribution of alpha SYN oligomers differs from Lewy-related pathology (LRP) in Parkinson's disease (PD), with alpha SYN oligomer burden being significantly greater in the neocortex and LRP being greater in vulnerable subcortical regions. In addition, alpha SYN oligomers in the hippocampus are associated with cognitive impairment in PD.
ACTA NEUROPATHOLOGICA COMMUNICATIONS
(2022)
Review
Biochemistry & Molecular Biology
Tapan Behl, Piyush Madaan, Aayush Sehgal, Sukhbir Singh, Md Khalid Anwer, Hafiz A. Makeen, Mohammed Albratty, Syam Mohan, Simona Bungau
Summary: This article discusses the etiology, oxidative stress, autophagy, programmed cell death, and other important roles in the pathogenesis of Parkinson's disease, emphasizing the crucial role of iron and copper in the development of Parkinson's disease. Metal chelators may have the potential to reduce oxidative stress levels by scavenging metal ions, thereby preventing or slowing down the progression of Parkinson's disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Pharmacology & Pharmacy
Yumin Wang, Shuang Wu, Qiang Li, Weihong Lang, Wenjing Li, Xiaodong Jiang, Zhirong Wan, Jichao Chen, Hongquan Wang
Summary: This review summarizes the recent updates and knowledge of the molecular mechanisms underlying the neuroprotective effects of epigallocatechin 3-gallate (EGCG) derived from green tea extract in Parkinson's disease (PD). The review highlights the pleiotropic effects of EGCG, including anti-apoptotic, anti-oxidative stress, anti-inflammatory, modulation of dopamine production, and inhibition of alpha-synuclein aggregation, which make it a promising neuroprotective compound for the treatment of PD.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Yu-Lin Guo, Wen-Jun Duan, Dan-Hua Lu, Xiao-Hui Ma, Xiao-Xiao Li, Zhao Li, Wei Bi, Hiroshi Kurihara, Hai-Zhi Liu, Yi-Fang Li, Rong-Rong He
Summary: GM1 ganglioside has therapeutic effects in experimental models of Parkinson's disease by promoting autophagy to clear harmful protein α-Syn, alleviating symptoms of neurodegenerative diseases like Parkinson's disease.
ACTA PHARMACOLOGICA SINICA
(2021)
Article
Medicine, Research & Experimental
Qingyu Ren, Xin Jiang, Shanshan Zhang, Xin Gao, Yam Nath Paudel, Pengyu Zhang, Rongchun Wang, Kechun Liu, Meng Jin
Summary: In this study, it was found that YIAEDAER peptide extracted from Neptunea arthritica cumingii has potential therapeutic effects on MPTP-induced PD-like condition by modulating multiple genes related to autophagy and oxidative stress.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Clinical Neurology
Thomas Steinkellner, William S. Conrad, Imre Kovacs, Robert A. Rissman, Edward B. Lee, John Q. Trojanowski, Zachary Freyberg, Subhojit Roy, Kelvin C. Luk, Virginia M. Lee, Thomas S. Hnasko
Summary: VGLUT2-expressing dopamine neurons exhibit resilience to degeneration and may be part of a neuroprotective response in Parkinson's disease.
Review
Biochemistry & Molecular Biology
Ritu Soni, Jigna Shah
Summary: Parkinson's disease is a progressive neurodegenerative disorder associated with metabolic syndrome, which may contribute to the development of the disease through various pathological pathways.
ACS CHEMICAL NEUROSCIENCE
(2022)
Review
Biochemistry & Molecular Biology
Engila Khan, Ikramul Hasan, M. Emdadul Haque
Summary: Disease modeling in non-human subjects is crucial for clinical research. Animal models are necessary to replicate the disease process and understand the etiology and pathophysiology. Parkinson's disease, with its progressive nature and various disabilities, has specific pathological hallmarks that involve misfolded protein accumulation and degeneration of neurons. Extensive research has been conducted on Parkinson's disease animal models, including pharmacological and genetic manipulation induction. This review summarizes and discusses commonly used Parkinson's disease animal model systems, as well as their applications and limitations.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Clinical Neurology
P. La Vitola, C. Balducci, M. Baroni, L. Artioli, G. Santamaria, M. Castiglioni, M. Cerovic, L. Colombo, L. Caldinelli, L. Pollegioni, G. Forloni
Summary: The study demonstrates that peripherally induced neuroinflammation can potentiate the detrimental effects of alpha-synuclein oligomers and worsen cognitive deficits in A53T mice. Fine management of neuroinflammation may offer a promising therapeutic approach to prevent or slow down some behavioral aspects in alpha-synucleinopathies.
NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Francesca Munari, Carlo G. Barracchia, Cinzia Franchin, Francesca Parolini, Stefano Capaldi, Alessandro Romeo, Luigi Bubacco, Michael Assfalg, Giorgio Arrigoni, Mariapina D'Onofrio
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2020)
Article
Neurosciences
Alice Filippini, Veronica Mutti, Gaia Faustini, Francesca Longhena, Ileana Ramazzina, Federica Rizzi, Alice Kaganovich, Dorien A. Roosen, Natalie Landeck, Megan Duffy, Isabella Tessari, Federica Bono, Chiara Fiorentini, Elisa Greggio, Luigi Bubacco, Arianna Bellucci, Mariacristina Missale, Mark R. Cookson, Massimo Gennarelli, Isabella Russo
Summary: The progressive neuropathological damage in Parkinson's disease is believed to be related to the spread of aggregated forms of alpha-synuclein. Clearance of extracellular alpha-synuclein by neurons may be a key mechanism to control its concentration. Clusterin, a glycoprotein associated with Alzheimer's disease, interacts with alpha-synuclein aggregates and limits their uptake by astrocytes, which may contribute to the spreading of Parkinson's pathology.
Article
Chemistry, Multidisciplinary
Giulia Marafon, Marco Crisma, Anna Masato, Nicoletta Plotegher, Luigi Bubacco, Alessandro Moretto
Summary: Proteins undergo changes in their 3D structure and function through specific molecular interactions, which is crucial for sensing, processing, and transmitting information from the surrounding environment. The study of early aggregation steps of alpha-synuclein associated with Parkinson's disease showed that light-mediated binding with a photoactive foldamer can promote the process by generating supramolecular fibrillar seeds that act as molecular templates for inducing fast beta-sheet transitions in monomers. This proposed method provides a powerful tool for studying protein aggregation in misfolding diseases in a controlled and inducible system.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Chemistry, Multidisciplinary
Elina Buitrago, Clarisse Faure, Lylia Challali, Elisabetta Bergantino, Ahcene Boumendjel, Luigi Bubacco, Marcello Carotti, Renaud Hardre, Marc Maresca, Christian Philouze, Helene Jamet, Marius Reglier, Catherine Belle
Summary: In this study, a combination of known inhibitors targeting the binuclear copper active site on tyrosinases was investigated, revealing significant enhancement of inhibitory effects, particularly for the HOPNO-TSC compound. The interaction mode with the dicopper(II) active site was elucidated through binding studies with a tyrosinase bio-inspired model, showing that binding to the dicopper center can occur with both chelating sites. Computational and docking studies identified the kojic acid and HOPNO moieties as interacting groups with the dicopper active site.
CHEMISTRY-A EUROPEAN JOURNAL
(2021)
Article
Neurosciences
Linn Streubel-Gallasch, Veronica Giusti, Michele Sandre, Isabella Tessari, Nicoletta Plotegher, Elena Giusto, Anna Masato, Ludovica Iovino, Ilaria Battisti, Giorgio Arrigoni, Derya Shimshek, Elisa Greggio, Marie-Eve Tremblay, Luigi Bubacco, Anna Erlandsson, Laura Civiero
Summary: This study compared the ability of astrocytes carrying PD-linked gene mutations with normal astrocytes in handling α-synuclein, finding a decreased clearance capacity in mutant cells linked to a loss of function in AnxA2.
MOLECULAR NEUROBIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Francesco Agostini, Anna Masato, Luigi Bubacco, Marco Bisaglia
Summary: This article reviews the potential mechanisms and clinical applications of metformin in the treatment of Parkinson's disease. Studies have shown that metformin may exert neuroprotective effects by regulating cellular pathways such as autophagy, degradation of pathological proteins, and mitochondrial function. Epidemiological studies on the correlation between long-term metformin use and the risk of developing Parkinson's disease are also discussed. However, there is controversy regarding the results obtained from experimental models and clinical studies, and further research is needed to clarify the mechanisms and efficacy of metformin in the treatment of Parkinson's disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Neurosciences
Susanna Cogo, Franz Y. Ho, Elena Tosoni, James E. Tomkins, Isabella Tessari, Lucia Iannotta, Thomas J. Montine, Claudia Manzoni, Patrick A. Lewis, Luigi Bubacco, Marie-Christine Chartier Harlin, Jean-Marc Taymans, Arjan Kortholt, Jeremy Nichols, Laura Cendron, Laura Civiero, Elisa Greggio
Summary: This article discusses the importance of Leucine-rich repeat kinase 2 (LRRK2) in Parkinson's disease (PD) research and its relationship with GTPase/Roc and kinase catalytic functions. The study found that Roc mutations can affect the activity of LRRK2 and discusses the molecular interactions between Roc and the regulation of cytoskeletal dynamics and intracellular trafficking pathways.
Review
Neurosciences
Adrianne F. Pike, Ildiko Szabo, Robert Veerhuis, Luigi Bubacco
Summary: This review suggests a hypothesis that Kv1.3 activity-induced NLRP3 inflammasome activation in microglia may be counteracted by the utilization of dopamine from adjacent dopaminergic neurons, preventing microglial activation. However, as dopamine supply decreases, NLRP3 inflammasome activation and Kv1.3 activity would intensify, leading to the development of the major pathological features of Parkinson's disease.
NPJ PARKINSONS DISEASE
(2022)
Article
Chemistry, Multidisciplinary
Andrea Capucciati, Enrico Monzani, Michela Sturini, Stefania Nicolis, Fabio A. Zucca, Luigi Bubacco, Marco Bortolus, Luigi Zecca, Luigi Casella
Summary: The study uses water-soluble melanin-protein-Fe/Cu conjugates derived from norepinephrine and fibrillar beta-lactoglobulin as reliable models for human brain locus coeruleus neuromelanin (NM). Iron and copper promote catecholamine oxidation and tend to remain coupled in oligonuclear aggregates. The Fe-Cu clusters are EPR silent and affect the H-1 NMR spectra of the conjugates.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Biochemistry & Molecular Biology
Federica De Lazzari, Francesco Agostini, Davide Doni, Sandro Malacrida, Mauro A. Zordan, Paola Costantini, Luigi Bubacco, Federica Sandrelli, Marco Bisaglia
Summary: Redox homeostasis plays a vital role in various pathological processes, including neurodegenerative disorders. SOD1 and DJ-1 are key enzymes involved in the antioxidant response, and they play important roles in the maturation process of proteins. Our study demonstrates that the protective activity of DJ-1 in fruit flies is independent of SOD1, suggesting different mechanisms of action.
Article
Neurosciences
Susanna Cogo, James E. Tomkins, Nikoleta Vavouraki, Veronica Giusti, Federica Forcellato, Cinzia Franchin, Isabella Tessari, Giorgio Arrigoni, Laura Cendron, Claudia Manzoni, Laura Civiero, Patrick A. Lewis, Elisa Greggio
Summary: Mutations in SPG11 gene are the major cause of hereditary spastic paraplegia and thinning of the corpus callosum. Previous studies have shown that loss of function of spatacsin results in lysosomal and axonal transport impairments. This study identified 14-3-3 proteins as physiological interactors of spatacsin and revealed that the interaction is regulated by protein kinase A-dependent phosphorylation.
NEUROBIOLOGY OF DISEASE
(2022)
Article
Biochemistry & Molecular Biology
Chiara Bacchella, Francesca Camponeschi, Paulina Kolkowska, Arian Kola, Isabella Tessari, Maria Camilla Baratto, Marco Bisaglia, Enrico Monzani, Luigi Bubacco, Stefano Mangani, Luigi Casella, Simone Dell'Acqua, Daniela Valensin
Summary: Alpha-synuclein (α Syn) is the main component of Lewy bodies in Parkinson's disease and its conformation can be modulated by its interaction with lipid membrane and metal ions. The ternary interaction between α Syn, copper, and membranes needs to be investigated in detail. This study analyzed the structural properties of copper-α Syn binding and found that in a membrane-like environment, a Cu:α Syn = 1:2 complex was formed where Cu+ was bound to the Met1 and Met5 residues, which was stable and unreactive in the presence of O-2.
Article
Chemistry, Multidisciplinary
Giovanna Viola, Fulvio Floriani, Carlo Giorgio Barracchia, Francesca Munari, Mariapina D'Onofrio, Michael Assfalg
Summary: Liquid-liquid phase separation (LLPS) of biopolymers to form condensates is a common phenomenon in cells. Ultrasmall gold nanoparticles (usGNPs) can interact with and illuminate protein condensates. They can concentrate into condensed liquid droplets, promoting LLPS of protein domains and potentially controlling the formation and dissolution of condensates. These findings suggest that nanoparticles have broad applications in studying phase separation and controlling condensate formation.
CHEMISTRY-A EUROPEAN JOURNAL
(2023)
Meeting Abstract
Neurosciences
V. Giusti, L. Streubel-Gallasch, M. Sandre, I. Tessari, N. Plotegher, E. Giusto, A. Masato, L. Iovino, I. Battisti, G. Arrigoni, D. Shimshek, E. Greggio, M. -E. Tremblay, L. Bubacco, A. Erlandsson, L. Civiero
Article
Biochemistry & Molecular Biology
Soojung Hahn, Gyuri Kim, Sang-Man Jin, Jae Hyeon Kim
Summary: This study utilized three-dimensional intestinal organoids to investigate the effects of metformin on inflammatory bowel disease (IBD) and found that metformin can enhance intestinal barrier function and reduce levels of inflammatory cytokines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
V. V. Sudarev, M. S. Gette, S. V. Bazhenov, O. M. Tilinova, E. V. Zinovev, I. V. Manukhov, A. I. Kuklin, Yu. L. Ryzhykau, A. V. Vlasov
Summary: This study investigated the self-assembly processes of ferritin-based protein complexes and obtained structurally characterized oligomeric states. These results provide new potential and opportunities for the application of ferritin in various fields.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Yalda Sabaghi, Farnaz Pourfarzad, Leila Zolghadr, Azita Bahrami, Tahereh Shojazadeh, Alireza Farasat, Nematollah Gheibi
Summary: p-Coumaric acid (p-CA) is a plant compound with anti-cancer activities. This study designed a nano-liposomal carrier containing p-CA to enhance its effectiveness against melanoma cells. The findings showed that the liposomal form of p-CA had a greater impact on the cells. Kinetic modeling indicated that the best fitting model was zero-order.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
M. D. Nazmul Hasan, Md Mahfuzur Rahman, Al Asmaul Husna, Nobuhiro Nozaki, Osamu Yamato, Naoki Miura
Summary: This study investigated the expression of ncRNAs other than miRNAs in different histologic subtypes of canine mammary gland tumors (MGT). Three aberrantly expressed ncRNAs were identified as potential biomarkers for differentiating MGT subtypes. YRNA and tRFs expression levels were found to be decreased in metastatic compared to primary MGT cell lines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Seine A. Shintani
Summary: In this study, the researchers used signal analysis to study the instantaneous amplitude and phase of sarcomeric oscillations in skeletal muscle. They identified two types of oscillations, sarcomeric oscillations and sarcosynced oscillations, and visualized their behavior during propagating waves. The researchers discovered the presence of sarcomeric defect holes and sarcomeric collision holes, which are important indicators for understanding the oscillation properties of sarcomeres. This finding has important implications for improving our understanding of muscle function and its regulatory mechanisms.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Shuanglin Zhang, Yuzhong Jia, Guolan Ma, Yanyan Yang, Zhenzhen Cao, Antao Luo, Zefu Zhang, Shihan Li, Jie Wen, Hanfeng Liu, Jihua Ma
Summary: Bupleurum is an antiarrhythmic agent that may exert its effects by inhibiting L-type calcium channels.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Tomotaka Ohkubo, Yasuhiko Matsumoto, Hiroaki Sasaki, Kaoru Kinoshita, Yuki Ogasawara, Takashi Sugita
Summary: This study found that Citrobacter koseri inhibits the growth of Staphylococcus epidermidis, disrupting the balance between S. epidermidis and Staphylococcus aureus, and exacerbating inflammation in atopic dermatitis.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Toshifumi Asano, Philipp Sasse, Takao Nakata
Summary: A Cre recombination-based fluorescent reporter system was developed to monitor cell-cell fusion. The system successfully detected the formation of multinuclear myotubes and placental syncytiotrophoblast. This tool could facilitate the study of cell-to-cell fusion.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Ke Shi, Yunlong Shan, Xiao Sun, Kuida Chen, Qiong Luo, Qiang Xu
Summary: This study found that low expression of TP53INP2 is associated with poor survival in colorectal cancer (CRC) patients. As the malignancy of CRC progresses, TP53INP2 expression gradually decreases. Knockdown of TP53INP2 promotes CRC cell proliferation and tumor growth. Mechanistically, TP53INP2 deficiency decreases phosphorylation of beta-catenin, leading to increased accumulation and enhanced nuclear translocation and transcriptional activity. Additionally, TP53INP2 sequesters TIM50, inhibiting its activation of beta-catenin. In conclusion, downregulation of TP53INP2 promotes CRC progression by activating beta-catenin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Martina Rossi, Fabio Tomaselli, Alejandro Hochkoeppler
Summary: Oligomeric enzymes are known for their higher catalytic rates compared to monomeric enzymes, but the extent of additivity in their activity is still not well understood. This study used tetrameric rabbit lactate dehydrogenase as a model to examine the kinetics of its catalytic action. Surprisingly, when the concentration of the limiting reactant exceeded that of a single subunit, there was a significant slowdown in the enzyme's conformational rearrangements.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Amin Sahraei, Mohammad Javad Shamsoddini, Fakhrossadat Mohammadi, Leila Hassani
Summary: This study explored the inhibitory effects of gallium curcumin, indium curcumin, and vanadyl curcumin on the amyloid fibrillation of hen egg white lysozyme, as well as the binding interactions of these metal complexes with the enzyme. The results showed that indium curcumin and vanadyl curcumin exhibited higher binding affinities and stronger inhibitory effects on amyloid fibrillation compared to gallium curcumin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Takahiro Sasaki, Yoshiki Kuse, Shinsuke Nakamura, Masamitsu Shimazawa
Summary: PGRN deficiency plays a significant role in cardiac remodeling and arrhythmias post-myocardial infarction (MI), potentially by promoting metabolic abnormalities in macrophages.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Hongwei Zhao, Yiqiang Li, Yibo Zhang, Chi Zhang
Summary: Electrical brain stimulation technology is commonly used to treat brain neurological disorders, but it can cause side effects. This study investigated the impact of electric fields on nerve fibers and revealed the possible origin of side effects. The findings provide guidance for selecting electrical parameters in clinical stimulation therapy.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Julia S. Scott, Lake-Ee Quek, Andrew J. Hoy, Johannes V. Swinnen, Zeyad D. Nassar, Lisa M. Butler
Summary: The fatty acid elongation enzyme ELOVL5 plays a critical role in promoting metastasis in prostate cancer. Knocking down ELOVL5 leads to the accumulation of malonyl-CoA, which inhibits fatty acid oxidation in mitochondria. This study highlights the importance of fatty acid elongation in regulating cell viability and provides a potential target for prostate cancer treatment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Zan Zhou, Wen-jun Jiang, Li Li, Jun-qiang Si
Summary: This study investigates the effect of noise exposure on cognitive function in mice and explores the underlying molecular mechanisms. The findings suggest that noise exposure leads to increased inflammation, increased phosphorylation of Tau protein, and decreased levels of postsynaptic density protein, resulting in cognitive impairment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
