Article
Chemistry, Multidisciplinary
Christopher Jonkergouw, Pihla Savola, Ekaterina Osmekhina, Joeri van Strien, Piotr Batys, Markus B. Linder
Summary: This study explores the chemical space of QS signaling molecules, defines the performance of different signals and ligands, and discovers a set of orthogonal intercellular QS signaling systems, expanding the toolkit for engineering community-wide behavior.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Microbiology
Yamin Shen, Shuji Gao, Qingying Fan, Jing Zuo, Yuxin Wang, Li Yi, Yang Wang
Summary: Quorum sensing (QS) is a communication mechanism that coordinates bacterial pathogens' population response by controlling bacterial communication and influencing the transcriptional expression of multiple genes through signaling molecules. Secretion systems (SS) play a crucial role in bacterial information exchange and virulence, involving the secretion or transfer of virulence factors. QS has been found to directly or indirectly regulate many bacterial SS, impacting bacterial virulence and antibiotic resistance. Understanding the relationship between QS and SS provides a theoretical basis for studying bacterial pathogenicity and developing novel antibacterial drugs.
MICROBIOLOGICAL RESEARCH
(2023)
Article
Microbiology
Marta Mellini, Morgana Letizia, Lorenzo Caruso, Alessandra Guiducci, Carlo Meneghini, Stephan Heeb, Paul Williams, Miguel Camara, Paolo Visca, Francesco Imperi, Livia Leoni, Giordano Rampioni
Summary: Quorum sensing allows single cells to synchronize gene expression in bacterial populations, but studies have shown significant cell-to-cell variation in this process, resulting in coexisting subpopulations of active and inactive cells. The molecular mechanisms behind this phenomenon, particularly in the las QS system of Pseudomonas aeruginosa, have not been fully defined.
Review
Engineering, Environmental
Zhuqiu Sun, Jinying Xi, Chunping Yang, Wenjie Cong
Summary: Quorum sensing (QS) plays a crucial role in controlling microbial aggregation, and the optimization of biological waste treatment systems by QS regulation has gained significant attention. This review summarizes the methods of enhancing and inhibiting QS in biological waste treatment systems and concludes the specific improvements achieved in different treatment systems. Moreover, it reviews the effects of QS regulation methods on biofilm and analyzes the knowledge gaps in current research, providing suggestions for future studies.
FRONTIERS OF ENVIRONMENTAL SCIENCE & ENGINEERING
(2022)
Article
Biochemical Research Methods
Jonas Kretz, Vera Israel, Matthew McIntosh
Summary: Inducible gene expression is valuable for biotechnological applications and gene regulation studies in bacteria. However, many systems that work well in model organisms like Escherichia coli show poor performance in other biotechnologically relevant bacteria due to weak or leaky expression. To address this, a new invention named ACIT (Alphaproteobacteriahromosomally integrating transcription-control cassette) is described, which allows tight transcription control over any gene or gene cluster of interest through homologous recombination.
ACS SYNTHETIC BIOLOGY
(2023)
Article
Physics, Multidisciplinary
Davide Chiuchiu, Shrabani Mondal, Simone Pigolotti
Summary: Biological processes such as DNA replication, RNA transcription, and protein translation achieve speed and accuracy by dissipating chemical energy in non-equilibrium reactions. These systems involve a trade-off between speed, error, and dissipation. This paper quantifies this trade-off using mathematical optimization theory and characterizes the Pareto optimal front for a generalized kinetic proofreading model. The findings suggest that models with more proofreading steps exhibit better trade-offs and reveal scaling relations between speed, accuracy, and dissipation on the Pareto front.
NEW JOURNAL OF PHYSICS
(2023)
Article
Biochemistry & Molecular Biology
Shivani Nanda, Marc-Antoine Jacques, Wen Wang, Chad L. Myers, L. Safak Yilmaz, Albertha J. M. Walhout
Summary: A new study reveals that three-quarters of metabolic genes in the nematode Caenorhabditis elegans are transcriptionally regulated, and generates a co-regulated subpathway map of metabolism. The researchers also develop a web application to query gene associations with metabolic pathways. This study sheds light on the ubiquity of transcriptional regulation in metabolism and provides a blueprint for similar studies in other organisms.
MOLECULAR SYSTEMS BIOLOGY
(2023)
Review
Agriculture, Multidisciplinary
Qingying Fan, Haikun Wang, Chenlong Mao, Jinpeng Li, Xiaoling Zhang, Daniel Grenier, Li Yi, Yang Wang
Summary: Quorum sensing is an important signaling mechanism for cell-to-cell communication between bacteria, fungi, and even eukaryotic hosts. The study of interspecies and interkingdom quorum sensing is valuable for understanding bacterial interactions and host interaction mechanisms, and has received considerable attention. Compared to intraspecies quorum sensing, the regulation mechanism of interspecies and interkingdom quorum sensing is often more complex, with a wider distribution of receptors. This review focuses on the latest progress in the distribution, structure, and signal transduction of interspecies and interkingdom quorum sensing receptors and provides guidance for future research on new receptors.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Review
Chemistry, Medicinal
Caterine Henriquez Ruiz, Estefanie Osorio-Llanes, Mayra Hernandez Trespalacios, Evelyn Mendoza-Torres, Wendy Rosales, Carlos Mario Melendez Gomez
Summary: Quorum Sensing (QS) is a cell-to-cell communication mechanism used by some bacterial species. The study of the molecular mechanisms linking signal molecules with bacterial pathogenesis is of growing interest, as it can be used as a therapeutic alternative and to study bacterial resistance phenomena. This study can be approached from different perspectives, such as molecular signals, modulation strategies, regulation strategies of bacterial QS circuits, and the structural evolution of autoinducers. This mini-review highlights the importance of molecular diversity in designing new antimicrobial agents.
MINI-REVIEWS IN MEDICINAL CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Hyo-Jeong Kim, Na-Yeong Kim, Seo-Yeon Ko, Seong-Yong Park, Man-Hwan Oh, Min-Sang Shin, Yoo-Chul Lee, Je-Chul Lee
Summary: This study investigated the regulatory network of the BfmRS two-component and AbaIR quorum sensing systems in the expression of virulence-associated genes in A. baumannii. The findings suggest that BfmR negatively regulates the AbaIR QS system, demonstrating a complex interplay in regulating the pathogenicity of A. baumannii.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biophysics
Jianwei He, Xiaoyan Zhang, Yuanyi Qian, Qiyao Wang, Yunpeng Bai
Summary: In this study, smart whole-cell biosensors were created by combining synthetic biology approaches with the bacterial quorum sensing mechanism. The biosensors demonstrated high sensitivity for phenolic compounds and the capability to degrade methyl parathion, an organophosphate pesticide. The design of these biosensors can be used to develop more efficient sensors for detecting and degrading environmental pollutants.
BIOSENSORS & BIOELECTRONICS
(2022)
Article
Agricultural Engineering
Jun-Hui Yang, Dong-Qi Huang, Yin-Ce Geng, Yi-Rong Ling, Nian-Si Fan, Ren-Cun Jin
Summary: Shortage of anammox sludge limits the application of anammox-based processes. In this study, three reactors were established using different seed sludges. After 27 days, anammox process with the highest nitrogen removal rate of 1.17 kg N m-3 d-1 was achieved using anammox granules and activated sludge. The dominant anammox bacteria shifted from Candidatus Kuenenia to Candidatus Brocadia, and quorum sensing-based regulation contributed to the growth of anammox bacteria.
BIORESOURCE TECHNOLOGY
(2023)
Review
Dentistry, Oral Surgery & Medicine
Andrea Muras, Natalia Mallo, Paz Otero-Casal, Jose M. Pose-Rodriguez, Ana Otero
Summary: This study summarizes the role of bacterial extracellular signaling systems, namely quorum sensing (QS), in oral biofilm formation, and explores the potential of blocking these communication systems as a new approach to prevent and treat oral infectious diseases. Current evidence suggests that QS molecules play an important role in the oral microbial ecosystem. Targeting the mechanisms that regulate gene expression through bacterial communication systems shows promise in controlling oral biofilm formation. However, there is still limited knowledge about microbial interactions and signaling processes within multispecies biofilms in the oral cavity.
Article
Immunology
Sathursha Gunaratnam, Mathieu Millette, Lynne McFarland, Herbert L. DuPont, Monique Lacroix
Summary: This paper discusses the potential of opportunistic pathogenic bacteria to cause disease when disrupting the normal microbiome, and current therapeutic strategies for Clostridioides difficile, including disrupting virulence factor production through interfering with quorum sensing systems. Probiotics and other QS inhibitors targeting QS systems may represent important new directions for the treatment and prevention of C. difficile infections.
MICROBIAL PATHOGENESIS
(2021)
Review
Biotechnology & Applied Microbiology
Yuxin Wang, Jianjun Dai, Xuhang Wang, Yang Wang, Fang Tang
Summary: This review paper summarizes the function of quorum sensing systems in the interaction between bacteriophage and their host bacteria, and its potential application in alternative control strategies for antibiotic-resistant and biofilm-forming pathogens.
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
(2022)
Article
Multidisciplinary Sciences
Cameron Smith, Ximo Pechuan, Raymond S. Puzio, Daniel Biro, Aviv Bergman
JOURNAL OF THE ROYAL SOCIETY INTERFACE
(2015)
Article
Chemistry, Multidisciplinary
Yang-Chun Yong, Yang-Yang Yu, Xinhai Zhang, Hao Song
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2014)
Article
Biotechnology & Applied Microbiology
Huiqing Chong, Hefang Geng, Hongfang Zhang, Hao Song, Lei Huang, Rongrong Jiang
BIOTECHNOLOGY AND BIOENGINEERING
(2014)
Review
Chemistry, Multidisciplinary
Hao Song, Ming-Zhu Ding, Xiao-Qiang Jia, Qian Ma, Ying-Jin Yuan
CHEMICAL SOCIETY REVIEWS
(2014)
Article
Biotechnology & Applied Microbiology
Jian Zha, Minghua Shen, Menglong Hu, Hao Song, Yingjin Yuan
JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY
(2014)
Article
Biotechnology & Applied Microbiology
Jin Du, Wei Bai, Hao Song, Ying-Jin Yuan
METABOLIC ENGINEERING
(2013)
Article
Biochemistry & Molecular Biology
J. M. M. van Oers, Y. Edwards, R. Chahwan, W. Zhang, C. Smith, X. Pechuan, S. Schaetzlein, B. Jin, Y. Wang, A. Bergman, M. D. Scharff, W. Edelmann
Article
Multidisciplinary Sciences
Huiqing Chong, Lei Huang, Jianwei Yeow, Ivy Wang, Hongfang Zhang, Hao Song, Rongrong Jiang
Article
Multidisciplinary Sciences
Victor Bochuan Wang, Song-Lin Chua, Bin Cao, Thomas Seviour, Victor J. Nesatyy, Enrico Marsili, Staffan Kjelleberg, Michael Givskov, Tim Tolker-Nielsen, Hao Song, Joachim Say, Chye Loo, Liang Yang
Article
Multidisciplinary Sciences
Jian Zha, Bing-Zhi Li, Ming-Hua Shen, Meng-Long Hu, Hao Song, Ying-Jin Yuan
Article
Multidisciplinary Sciences
Qian Ma, Yang Zou, Yajin Lv, Hao Song, Ying-Jin Yuan
Article
Multidisciplinary Sciences
Ming-Zhu Ding, Yang Zou, Hao Song, Ying-Jin Yuan
Article
Multidisciplinary Sciences
Robert Smith, Cheemeng Tan, Jaydeep K. Srimani, Anand Pai, Katherine A. Riccione, Hao Song, Lingchong You
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2014)
Article
Biochemistry & Molecular Biology
Yang-Chun Yong, Zhi-Hong Liao, Jian-Zhong Sun, Tao Zheng, Rong-Rong Jiang, Hao Song
PROCESS BIOCHEMISTRY
(2013)
Article
Biochemistry & Molecular Biology
Julia C. Thierauf, Alex A. Farahani, B. Iciar Indave, Adam Z. Bard, Valerie A. White, Cameron R. Smith, Hetal Marble, Martin D. Hyrcza, John K. C. Chan, Justin Bishop, Qiuying Shi, Kim Ely, Abbas Agaimy, Maria Martinez-Lage, Vania Nose, Miguel Rivera, Valentina Nardi, Dora Dias-Santagata, Salil Garg, Peter Sadow, Long P. Le, William Faquin, Lauren L. Ritterhouse, Ian A. Cree, A. John Iafrate, Jochen K. Lennerz
Summary: This study evaluates the diagnostic relevance of MAML2 translocations, finding that they are rare but important in confirming the diagnosis of Mucoepidermoid carcinoma (MEC), especially in head and neck tumors. MAML2 testing is sensitive for MEC and can help distinguish it from other types of tumors, such as adenosquamous carcinoma (ASC).
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Ankita Chadda, Alexander G. Kozlov, Binh Nguyen, Timothy M. Lohman, Eric A. Galburt
Summary: In this study, it was found that the DNA damage response in Mycobacterium tuberculosis differs from well-studied model bacteria. The DNA repair helicase UvrD1 in Mtb is activated through a redox-dependent process and is closely associated with the homo-dimeric Ku protein. Additionally, Ku protein is shown to stimulate the helicase activity of UvrD1.
JOURNAL OF MOLECULAR BIOLOGY
(2024)