Article
Microbiology
Xiangyong Zeng, Yunman Zou, Jia Zheng, Shuyi Qiu, Lanlan Liu, Chaoyang Wei
Summary: This review focuses on the microbial community from the perspective of quorum sensing, which plays important roles in substance cycles, product synthesis, and species evolution. It provides a theoretical basis for controlling the microbial community using quorum sensing approaches and summarizes the latest progress in applications of quorum sensing in wastewater treatment, human health, food fermentation, and synthetic biology. The relationships between quorum sensing and microbial interactions are also explored in depth.
MICROBIOLOGICAL RESEARCH
(2023)
Article
Multidisciplinary Sciences
Justin E. Silpe, Olivia P. Duddy, Bonnie L. Bassler
Summary: This study reveals that bacteriophages can manipulate the bacterial cell-to-cell communication process and trigger the death of host bacteria. The activity of a specific phage receptor is modulated by noncognate signaling molecules and synthetic inhibitors. The findings suggest that the density and species composition of bacterial communities can influence the outcome of bacterial-phage interactions.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Biochemistry & Molecular Biology
Megha Shah, Veronique L. Taylor, Diane Bona, Yvonne Tsao, Sabrina Y. Stanley, Sheila M. Pimentel-Elardo, Matthew McCallum, Joseph Bondy-Denomy, P. Lynne Howell, Justin R. Nodwell, Alan R. Davidson, Trevor F. Moraes, Karen L. Maxwell
Summary: The study identified a new phage anti-activator protein, Aqs1, which inhibits phage infection by suppressing the quorum-sensing master regulator LasR. Aqs1 also inhibits the bacterial type IV pilus assembly ATPase protein PilB, preventing phages from superinfecting host cells. This research highlights the potential of small phage proteins to disrupt key biological pathways and offers insights into the evolutionary dynamics between phages and their hosts.
Review
Microbiology
Lachlan Dow
Summary: Quorum sensing is a process where bacteria can sense their own species' cell density, coordinating gene expression and physiological processes on a community-wide scale. QS signals not only mediate intraspecies interactions, but also interactions between prokaryotes and eukaryotes, playing a role in altering microalgae growth, metabolism, and nutrient acquisition.
Article
Engineering, Environmental
Chunxiao Dai, Yuanyuan Qu, Weize Wu, Shuzhen Li, Zhuo Chen, Shengyang Lian, Jiawei Jing
Summary: This study established a QS-related protein database and an automatic annotation pipeline for rapid and accurate annotation and classification of QS-related sequences in aquatic environments. It provides a useful tool for understanding bacterial communication in water environments.
Review
Microbiology
Evgeniya V. Prazdnova, Andrey V. Gorovtsov, Nikita G. Vasilchenko, Maxim P. Kulikov, Varvara N. Statsenko, Anna A. Bogdanova, Alexandr G. Refeld, Yaroslav A. Brislavskiy, Vladimir A. Chistyakov, Michael L. Chikindas
Summary: This review focuses on the mechanisms of quorum-sensing suppression by Gram-positive microorganisms and its practical applications in food fermentation, probiotics, and biotechnology. It also discusses the possible evolutionary role of quorum-quenching mechanisms during the development of interspecies interactions of bacteria.
Article
Immunology
Sathursha Gunaratnam, Mathieu Millette, Lynne McFarland, Herbert L. DuPont, Monique Lacroix
Summary: This paper discusses the potential of opportunistic pathogenic bacteria to cause disease when disrupting the normal microbiome, and current therapeutic strategies for Clostridioides difficile, including disrupting virulence factor production through interfering with quorum sensing systems. Probiotics and other QS inhibitors targeting QS systems may represent important new directions for the treatment and prevention of C. difficile infections.
MICROBIAL PATHOGENESIS
(2021)
Article
Microbiology
Yamin Shen, Shuji Gao, Qingying Fan, Jing Zuo, Yuxin Wang, Li Yi, Yang Wang
Summary: Quorum sensing (QS) is a communication mechanism that coordinates bacterial pathogens' population response by controlling bacterial communication and influencing the transcriptional expression of multiple genes through signaling molecules. Secretion systems (SS) play a crucial role in bacterial information exchange and virulence, involving the secretion or transfer of virulence factors. QS has been found to directly or indirectly regulate many bacterial SS, impacting bacterial virulence and antibiotic resistance. Understanding the relationship between QS and SS provides a theoretical basis for studying bacterial pathogenicity and developing novel antibacterial drugs.
MICROBIOLOGICAL RESEARCH
(2023)
Article
Microbiology
Guanhua Xuan, Hong Lin, Lin Tan, Gang Zhao, Jingxue Wang
Summary: Quorum sensing (QS) regulates phage-bacterium interactions by upregulating phage receptor expression, increasing phage adsorption and infection rates. This QS-mediated phage susceptibility is a dynamic process depending on host cell density.
Review
Microbiology
Josefina Leon-Felix, Claudia Villicana
Summary: Recent research has highlighted the impact of social interactions between bacteriophages and host populations on lysis-lysogeny decisions and phage counterdefensive strategies in bacteria. Social communication may affect the dynamics and evolution of microbial communities, including implications for phage therapy.
JOURNAL OF BACTERIOLOGY
(2021)
Review
Microbiology
Esmeralda Escobar-Mucino, Margarita M. P. Arenas-Hernandez, M. Lorena Luna-Guevara
Summary: Quorum sensing is a cell-cell communication process in bacteria that can be controlled by inhibitor molecules to regulate the expression of virulence genes and combat infectious pathogens. These inhibitors also have negative regulatory activity on genes related to bacterial biofilm formation.
Article
Chemistry, Medicinal
Andrea Muras, Ana Parga, Celia Mayer, Ana Otero
Summary: Interfering with quorum sensing systems of bacteria is a promising strategy to control biofilm formation, and the xCELLigence(R) system is proposed as an efficient method for quantifying biofilm formation.
Review
Microbiology
Xiaojie Zhang, Baobao Liu, Xueyan Ding, Peng Bin, Yang Yang, Guoqiang Zhu
Summary: The QS system plays a central role in the regulation of virulence in Salmonella, and blocking this system may be a new strategy for treating Salmonella infection. Studying the application of QQ technology in Salmonella infection can provide insight into the regulation mechanism of bacterial virulence.
Article
Microbiology
Guanhua Xuan, Hong Lin, Lin Tan, Gang Zhao, Jingxue Wang
Summary: Quorum sensing (QS) plays a crucial role in regulating interactions between bacteria, including phage-bacterium interactions. This study showed that Pseudomonas aeruginosa PAO1 uses las QS to increase phage infection rates by upregulating the expression of galU, which is necessary for synthesizing phage receptor lipopolysaccharides. Inhibition of QS may reduce therapeutic efficacy of phages and affect the balance between antibiotic treatment and phage therapy.
Review
Fisheries
P. Snega Priya, Seenivasan Boopathi, Raghul Murugan, B. Haridevamuthu, Aziz Arshad, Jesu Arockiaraj
Summary: Bacteria produce virulence factors that cause mortality in fish and crustaceans, and these factors require abundant quorum sensing (QS) signals and high cell density. QS signals not only interfere with cellular pathways and induce cell death in mammalian cells, but also impair the immune system, indicating their importance as a major virulence factor. In aquatic organisms, the impact of QS signals is still being explored. However, aquatic organisms produce enzymes that degrade and detoxify these signals, and physical and chemical factors also affect their stability. Understanding the influence of QS signals on aquatic organisms is crucial for controlling disease progression.
REVIEWS IN AQUACULTURE
(2023)
