Copper oxide nanoparticle toxicity profiling using untargeted metabolomics

Expert consensus on an in vitro approach to assess pulmonary fibrogenic potential of aerosolized nanomaterials

(2016) Amy J. Clippinger et al.   ARCHIVES OF TOXICOLOGY

Copper status of exposed microorganisms influences susceptibility to metallic nanoparticles

(2016) Vincent C. Reyes et al.   ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY

A combined proteomics and metabolomics approach to assess the effects of gold nanoparticlesin vitro

(2016) Sabrina Gioria et al.   Nanotoxicology

ZnO Nanoparticles Impose a Panmetabolic Toxic Effect Along with Strong Necrosis, Inducing Activation of the Envelope Stress Response in Salmonella enterica Serovar Enteritidis

(2015) Sinisa Vidovic et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Synthesis and Antibacterial Activity of CuO Nanoparticles Suspension Induced by Laser Ablation in Liquid

(2015) Khawla S. Khashan et al.   ARABIAN JOURNAL FOR SCIENCE AND ENGINEERING

Alteration of metabolomic profiles by titanium dioxide nanoparticles in human gingivitis model

(2015) Rene Garcia-Contreras et al.   BIOMATERIALS

LC-MS untargeted metabolomic analysis of drug-induced hepatotoxicity in HepG2 cells

(2015) Juan Carlos García-Cañaveras et al.   ELECTROPHORESIS

Nephron Toxicity Profiling via Untargeted Metabolome Analysis Employing a High Performance Liquid Chromatography-Mass Spectrometry-based Experimental and Computational Pipeline

(2015) Christina Ranninger et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Occupational Exposure to Airborne Nanomaterials: An Assessment of Worker Exposure to Aerosolized Metal Oxide Nanoparticles in Semiconductor Wastewater Treatment

(2015) Sara A. Brenner et al.   JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL HYGIENE

Metabolomics reveals the perturbations in the metabolome ofCaenorhabditis elegansexposed to titanium dioxide nanoparticles

(2015) Ch Ratnasekhar et al.   Nanotoxicology

Acute exposure to silica nanoparticles enhances mortality and increases lung permeability in a mouse model of Pseudomonas aeruginosa pneumonia

(2015) Mathilde Delaval et al.   Particle and Fibre Toxicology

Multi-walled carbon nanotube induced frustrated phagocytosis, cytotoxicity and pro-inflammatory conditions in macrophages are length dependent and greater than that of asbestos

(2015) Matthew S.P. Boyles et al.   TOXICOLOGY IN VITRO

Toxic mechanisms of copper oxide nanoparticles in epithelial kidney cells

(2015) Amalie Thit et al.   TOXICOLOGY IN VITRO

Metabolomics techniques for nanotoxicity investigations

(2015) Mengying Lv et al.   Bioanalysis

Nanotechnology in the real world: Redeveloping the nanomaterial consumer products inventory

(2015) Marina E Vance et al.   Beilstein Journal of Nanotechnology

Comparative Proteomic Analysis of the Molecular Responses of Mouse Macrophages to Titanium Dioxide and Copper Oxide Nanoparticles Unravels Some Toxic Mechanisms for Copper Oxide Nanoparticles in Macrophages

(2015) Sarah Triboulet et al.   PLoS One

Autonomous Metabolomics for Rapid Metabolite Identification in Global Profiling

(2014) H. Paul Benton et al.   ANALYTICAL CHEMISTRY

The potential toxicity of copper nanoparticles and copper sulphate on juvenile Epinephelus coioides

(2014) Tao Wang et al.   AQUATIC TOXICOLOGY

Copper: toxicological relevance and mechanisms

(2014) Lisa M. Gaetke et al.   ARCHIVES OF TOXICOLOGY

Enhanced intracellular translocation and biodistribution of gold nanoparticles functionalized with a cell-penetrating peptide (VG-21) from vesicular stomatitis virus

(2014) Pooja Munnilal Tiwari et al.   BIOMATERIALS

Cytotoxicity and genotoxicity of nano - and microparticulate copper oxide: role of solubility and intracellular bioavailability

(2014) Annetta Semisch et al.   Particle and Fibre Toxicology

Mechanism-based genotoxicity screening of metal oxide nanoparticles using the ToxTracker panel of reporter cell lines

(2014) Hanna L Karlsson et al.   Particle and Fibre Toxicology

Activation of nicotinamide N-methyltrasferase and increased formation of 1-methylnicotinamide (MNA) in atherosclerosis

(2014) Łukasz Mateuszuk et al.   Pharmacological Reports

SILAC-Based Quantitative Proteomic Analysis of Human Lung Cell Response to Copper Oxide Nanoparticles

(2014) Mariola J. Edelmann et al.   PLoS One

Insight into the primary mode of action of TiO2nanoparticles onEscherichia coliin the dark

(2014) Bénédicte Sohm et al.   PROTEOMICS

Measurement of DNA Concentration as a Normalization Strategy for Metabolomic Data from Adherent Cell Lines

(2013) Leslie P. Silva et al.   ANALYTICAL CHEMISTRY

Toxicity of Ag, CuO and ZnO nanoparticles to selected environmentally relevant test organisms and mammalian cells in vitro: a critical review

(2013) Olesja Bondarenko et al.   ARCHIVES OF TOXICOLOGY

Selective metabolic effects of gold nanorods on normal and cancer cells and their application in anticancer drug screening

(2013) Limin Zhang et al.   BIOMATERIALS

Interference of CuO nanoparticles with metal homeostasis in hepatocytes under sub-toxic conditions

(2013) Martine Cuillel et al.   Nanoscale

Understanding the metabolic fate and assessing the biosafety of MnO nanoparticles by metabonomic analysis

(2013) Jinquan Li et al.   NANOTECHNOLOGY

Copper Oxide Nanoparticles Induced Mitochondria Mediated Apoptosis in Human Hepatocarcinoma Cells

(2013) Maqsood A. Siddiqui et al.   PLoS One

Intracellular Uptake and Toxicity of Ag and CuO Nanoparticles: A Comparison Between Nanoparticles and their Corresponding Metal Ions

(2013) Pontus Cronholm et al.   Small

The modality of cell–particle interactions drives the toxicity of nanosized CuO and TiO2 in human alveolar epithelial cells

(2013) Elisa Moschini et al.   TOXICOLOGY LETTERS

Metabolic effects of TiO2 nanoparticles, a common component of sunscreens and cosmetics, on human keratinocytes

(2013) P Tucci et al.   Cell Death & Disease

CuO Nanoparticle Interaction with Human Epithelial Cells: Cellular Uptake, Location, Export, and Genotoxicity

(2012) Zhenyu Wang et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Engineered nanomaterial risk. Lessons learnt from completed nanotoxicology studies: potential solutions to current and future challenges

(2012) Helinor Johnston et al.   CRITICAL REVIEWS IN TOXICOLOGY

Metabolic profiling reveals disorder of carbohydrate metabolism in mouse fibroblast cells induced by titanium dioxide nanoparticles

(2012) Chengyu Jin et al.   JOURNAL OF APPLIED TOXICOLOGY

Application of integrated transcriptomic, proteomic and metabolomic profiling for the delineation of mechanisms of drug induced cell stress

(2012) Anja Wilmes et al.   Journal of Proteomics

A cross-platform toolkit for mass spectrometry and proteomics

(2012) Matthew C Chambers et al.   NATURE BIOTECHNOLOGY

Metabolomics: the apogee of the omics trilogy

(2012) Gary J. Patti et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Critical role of surface chemical modifications induced by length shortening on multi-walled carbon nanotubes-induced toxicity

(2012) Cyrill Bussy et al.   Particle and Fibre Toxicology

Tonicity-independent regulation of the osmosensitive transcription factor TonEBP (NFAT5)

(2011) Julia A. Halterman et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Copper: An essential metal in biology

(2011) Richard A. Festa et al.   CURRENT BIOLOGY

Earthworm Sublethal Responses to Titanium Dioxide Nanomaterial in Soil Detected by 1H NMR Metabolomics

(2011) Melissa L. Whitfield Åslund et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Nitric oxide synthases: regulation and function

(2011) U. Forstermann et al.   EUROPEAN HEART JOURNAL

Metabonomic Studies of Biochemical Changes in the Serum of Rats by Intratracheally Instilled TiO2 Nanoparticles

(2011) Meng Tang et al.   JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY

Physical−Chemical Aspects of Protein Corona: Relevance toin Vitroandin VivoBiological Impacts of Nanoparticles

(2011) Marco P. Monopoli et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Nanomedicine(s) under the Microscope

(2011) Ruth Duncan et al.   MOLECULAR PHARMACEUTICS

Differential toxicity of copper (II) oxide nanoparticles of similar hydrodynamic diameter on human differentiated intestinal Caco-2 cell monolayers is correlated in part to copper release and shape

(2011) Jean-Pascal Piret et al.   Nanotoxicology

Differential pro-inflammatory effects of metal oxide nanoparticles and their soluble ionsin vitroandin vivo; zinc and copper nanoparticles, but not their ions, recruit eosinophils to the lungs

(2011) Wan-Seob Cho et al.   Nanotoxicology

Coating carbon nanotubes with a polystyrene-based polymer protects against pulmonary toxicity

(2011) Lyes Tabet et al.   Particle and Fibre Toxicology

Nano-copper induces oxidative stress and apoptosis in kidney via both extrinsic and intrinsic pathways

(2011) Abhijit Sarkar et al.   TOXICOLOGY

Adverse outcome pathways: A conceptual framework to support ecotoxicology research and risk assessment

(2010) Gerald T. Ankley et al.   ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY

An insight into the metabolic responses of ultra-small superparamagnetic particles of iron oxide using metabonomic analysis of biofluids

(2010) Jianghua Feng et al.   NANOTECHNOLOGY

NMR-based metabonomic study of the sub-acute toxicity of titanium dioxide nanoparticles in rats after oral administration

(2010) Qian Bu et al.   NANOTECHNOLOGY

Integrated metabonomics analysis of the size-response relationship of silica nanoparticles-induced toxicity in mice

(2010) Xiaoyan Lu et al.   NANOTECHNOLOGY

Global metabolic profiling procedures for urine using UPLC–MS

(2010) Elizabeth J Want et al.   Nature Protocols

Nanoparticle cytotoxicity depends on intracellular solubility: Comparison of stabilized copper metal and degradable copper oxide nanoparticles

(2010) Andreas M. Studer et al.   TOXICOLOGY LETTERS

S-Adenosylmethionine and Methylthioadenosine Inhibit Cellular FLICE Inhibitory Protein Expression and Induce Apoptosis in Colon Cancer Cells

(2009) T. W. H. Li et al.   MOLECULAR PHARMACOLOGY

An investigation into the potential for different surface-coated quantum dots to cause oxidative stress and affect macrophage cell signallingin vitro

(2009) Martin J. D. Clift et al.   Nanotoxicology

Toxicology for the twenty-first century

(2009) Thomas Hartung   NATURE

Expression changes of dopaminergic system-related genes in PC12 cells induced by manganese, silver, or copper nanoparticles

(2009) Jianyong Wang et al.   NEUROTOXICOLOGY

Surface Characteristics, Copper Release, and Toxicity of Nano- and Micrometer-Sized Copper and Copper(II) Oxide Particles: A Cross-Disciplinary Study

(2009) Klara Midander et al.   Small

Copper oxide nanoparticles induce oxidative stress and cytotoxicity in airway epithelial cells

(2009) Baher Fahmy et al.   TOXICOLOGY IN VITRO

OpenMS – An open-source software framework for mass spectrometry

(2008) Marc Sturm et al.   BMC BIOINFORMATICS

Copper Oxide Nanoparticles Are Highly Toxic: A Comparison between Metal Oxide Nanoparticles and Carbon Nanotubes

(2008) Hanna L. Karlsson et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Single-Walled Carbon Nanotubes Can Induce Pulmonary Injury in Mouse Model

(2008) Cheng-Chung Chou et al.   NANO LETTERS

Integrated metabolomic analysis of the nano-sized copper particle-induced hepatotoxicity and nephrotoxicity in rats: A rapid in vivo screening method for nanotoxicity

(2008) Ronghui Lei et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY