NSAIDs and Cardiovascular Diseases: Role of Reactive Oxygen Species

Risk of Upper and Lower Gastrointestinal Bleeding in Patients Taking Nonsteroidal Anti-inflammatory Drugs, Antiplatelet Agents, or Anticoagulants

(2015) Ángel Lanas et al.   Clinical Gastroenterology and Hepatology

Cellular and molecular studies of the effects of a selective COX-2 inhibitor celecoxib in the cardiac cell line H9c2 and their correlation with death mechanisms

(2014) K.K. Sakane et al.   BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH

Anti-tumor activity of non-steroidal anti-inflammatory drugs: Cyclooxygenase-independent targets

(2014) Jason L. Liggett et al.   CANCER LETTERS

Flavocoxid, a Nutraceutical Approach to Blunt Inflammatory Conditions

(2014) Alessandra Bitto et al.   MEDIATORS OF INFLAMMATION

ROS Regulate Cardiac Function via a Distinct Paracrine Mechanism

(2014) Hui-Ying Lim et al.   Cell Reports

NSAID Use and Association with Cardiovascular Outcomes in Outpatients with Stable Atherothrombotic Disease

(2013) Payal Kohli et al.   AMERICAN JOURNAL OF MEDICINE

Xanthine oxidase inhibition preserves left ventricular systolic but not diastolic function in cardiac volume overload

(2013) James D. Gladden et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Role of mitochondrial oxidative stress in hypertension

(2013) Sergey I. Dikalov et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Non-steroidal anti-inflammatory drugs activate NADPH oxidase in adipocytes and raise the H2O2 pool to prevent cAMP-stimulated protein kinase a activation and inhibit lipolysis

(2013) Héctor Vázquez-Meza et al.   BMC BIOCHEMISTRY

Enhanced apoptotic effects by downregulating Mcl-1: Evidence for the improvement of photodynamic therapy with Celecoxib

(2013) Jiaxing Song et al.   EXPERIMENTAL CELL RESEARCH

Regulation of multiple transcription factors by reactive oxygen species and effects of pro-inflammatory cytokines released during myocardial infarction on cardiac differentiation of embryonic stem cells

(2013) Sau Kwan Law et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Targeting mitochondrial reactive oxygen species as novel therapy for inflammatory diseases and cancers

(2013) Xinyuan Li et al.   Journal of Hematology & Oncology

Vascular and upper gastrointestinal effects of non-steroidal anti-inflammatory drugs: meta-analyses of individual participant data from randomised trials

(2013)   LANCET

Concurrent use of diuretics, angiotensin converting enzyme inhibitors, and angiotensin receptor blockers with non-steroidal anti-inflammatory drugs and risk of acute kidney injury: nested case-control study

(2013) F. Lapi et al.   BMJ-British Medical Journal

Long-Term Cardiovascular Risk of Nonsteroidal Anti-Inflammatory Drug Use According to Time Passed After First-Time Myocardial Infarction

(2012) Anne-Marie Schjerning Olsen et al.   CIRCULATION

Optimization of the Bacterial Cytochrome P450 BM3 System for the Production of Human Drug Metabolites

(2012) Giovanna Di Nardo et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Omega-3 fatty acids cause dramatic changes in TLR4 and purinergic eicosanoid signaling

(2012) P. C. Norris et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Harmful Effects of NSAIDs among Patients with Hypertension and Coronary Artery Disease

(2011) Anthony A. Bavry et al.   AMERICAN JOURNAL OF MEDICINE

Role of nonsteroidal anti-inflammatory drug-activated gene-1 in docetaxel-induced cell death of human colorectal cancer cells with different p53 status

(2011) Il-Yeob Kim et al.   ARCHIVES OF PHARMACAL RESEARCH

Duration of Treatment With Nonsteroidal Anti-Inflammatory Drugs and Impact on Risk of Death and Recurrent Myocardial Infarction in Patients With Prior Myocardial Infarction

(2011) Anne-Marie Schjerning Olsen et al.   CIRCULATION

The Progression of Hypertensive Heart Disease

(2011) Mark H. Drazner   CIRCULATION

Apple Peel Polyphenol Extract Protects against Indomethacin-Induced Damage in Caco-2 Cells by Preventing Mitochondrial Complex I Inhibition

(2011) Catalina Carrasco-Pozo et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Membrane Position of Ibuprofen Agrees with Suggested Access Path Entrance to Cytochrome P450 2C9 Active Site

(2011) Karel Berka et al.   JOURNAL OF PHYSICAL CHEMISTRY A

Bioactive lipoxygenase metabolites stimulation of NADPH oxidases and reactive oxygen species

(2011) Kyung-Jin Cho et al.   MOLECULES AND CELLS

Hydrogen peroxide controls Akt activity via ubiquitination/degradation pathways

(2011) Sungkwan An   ONCOLOGY REPORTS

The cellular and molecular origin of reactive oxygen species generation during myocardial ischemia and reperfusion

(2011) Koen Raedschelders et al.   PHARMACOLOGY & THERAPEUTICS

Differential involvement of mitochondrial dysfunction, cytochrome P450 activity, and active transport in the toxicity of structurally related NSAIDs

(2011) Jolanda S. van Leeuwen et al.   TOXICOLOGY IN VITRO

Cardiovascular Risk with Non-Steroidal Anti-Inflammatory Drugs: Systematic Review of Population-Based Controlled Observational Studies

(2011) Patricia McGettigan et al.   PLOS MEDICINE

Plasma and cerebrospinal fluid pharmacokinetics of flurbiprofen in children

(2010) Elina Kumpulainen et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Use of Nonsteroidal Anti-Inflammatory Drugs in Patients With Cardiovascular Disease

(2010) Muhammad Amer et al.   Cardiology in Review

Mitochondrial proton and electron leaks

(2010) Martin Jastroch et al.   Essays in Biochemistry

5-Lipoxygenase plays an essential role in 4-HNE-enhanced ROS production in murine macrophages via activation of NADPH oxidase

(2010) Mi R. Yun et al.   FREE RADICAL RESEARCH

Effect of short-term NSAID use on echocardiographic parameters in elderly people: a population-based cohort study

(2010) K. E. van den Hondel et al.   HEART

Genetic deletion of mPGES-1 abolishes PGE2 production in murine dendritic cells and alters the cytokine profile, but does not affect maturation or migration

(2010) S.U. Monrad et al.   PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS

Metabolism related toxicity of diclofenac in yeast as model system

(2010) Jolanda S. van Leeuwen et al.   TOXICOLOGY LETTERS

Rationale, design, and governance of Prospective Randomized Evaluation of Celecoxib Integrated Safety versus Ibuprofen Or Naproxen (PRECISION), a cardiovascular end point trial of nonsteroidal antiinflammatory agents in patients with arthritis

(2009) Matthew C. Becker et al.   AMERICAN HEART JOURNAL

An Evidence-Based Review of the Cardiovascular Risks of Nonsteroidal Anti-Inflammatory Drugs

(2009) Michael E. Farkouh et al.   AMERICAN JOURNAL OF CARDIOLOGY

Guidelines for Prevention of NSAID-Related Ulcer Complications

(2009) Frank L Lanza et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Increased Mortality and Cardiovascular Morbidity Associated With Use of Nonsteroidal Anti-inflammatory Drugs in Chronic Heart Failure

(2009) Gunnar H. Gislason et al.   ARCHIVES OF INTERNAL MEDICINE

Cardiovascular Risks of Nonsteroidal Antiinflammatory Drugs in Patients After Hospitalization for Serious Coronary Heart Disease

(2009) Wayne A. Ray et al.  

Genetically based impairment in CYP2C8- and CYP2C9-dependent NSAID metabolism as a risk factor for gastrointestinal bleeding: Is a combination of pharmacogenomics and metabolomics required to improve personalized medicine?

(2009) José AG Agúndez et al.   Expert Opinion on Drug Metabolism & Toxicology

The NF-κB activation pathways, emerging molecular targets for cancer prevention and therapy

(2009) Yong Lin et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Hydrogen peroxide is the major oxidant product of xanthine oxidase

(2009) Eric E. Kelley et al.   FREE RADICAL BIOLOGY AND MEDICINE

Chronic doxorubicin cardiotoxicity is mediated by oxidative DNA damage-ATM-p53-apoptosis pathway and attenuated by pitavastatin through the inhibition of Rac1 activity

(2009) Masashi Yoshida et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

RAGE-Induced Cytosolic ROS Promote Mitochondrial Superoxide Generation in Diabetes

(2009) M. T. Coughlan et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Prothrombotic effects of diclofenac on arteriolar platelet activation and thrombosisin vivo

(2009) L. STRUTHMANN et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Aspirin and non-steroidal anti-inflammatory drugs for cancer prevention: an international consensus statement

(2009) Jack Cuzick et al.   LANCET ONCOLOGY

Non-aspirin NSAIDs, cyclooxygenase-2 inhibitors and risk for cardiovascular events-stroke, acute myocardial infarction, and death from coronary heart disease

(2009) Christianne L. Roumie et al.   PHARMACOEPIDEMIOLOGY AND DRUG SAFETY

Cardiovascular safety and gastrointestinal tolerability of etoricoxib vs diclofenac in a randomized controlled clinical trial (The MEDAL study)

(2009) B. Combe et al.   RHEUMATOLOGY

Canadian consensus guidelines on long-term nonsteroidal anti-inflammatory drug therapy and the need for gastroprotection: benefits versus risks

(2008) A. ROSTOM et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

The balance between severe cardiovascular and gastrointestinal events among users of selective and non-selective non-steroidal anti-inflammatory drugs

(2008) M W van der Linden et al.   ANNALS OF THE RHEUMATIC DISEASES

AKT and Oxidative Stress Team Up to Kill Cancer Cells

(2008) Ignacio Dolado et al.   CANCER CELL

Susceptibility for NSAIDs-Induced Apoptosis Correlates to p53 Gene Status in Gastric Cancer Cells

(2008) Yan-Jie Zhang et al.   CANCER INVESTIGATION

Can Patients With Cardiovascular Disease Take Nonsteroidal Antiinflammatory Drugs?

(2008) Kathryn A. Taubert   CIRCULATION

Cardiovascular Risk of Celecoxib in 6 Randomized Placebo-Controlled Trials

(2008) Scott D. Solomon et al.   CIRCULATION

Risk of Myocardial Infarction and Death Associated With the Use of Nonsteroidal Anti-Inflammatory Drugs (NSAIDs) Among Healthy Individuals: A Nationwide Cohort Study

(2008) EL Fosbøl et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Sustained oxidative stress inhibits NF-κB activation partially via inactivating the proteasome

(2008) M WU et al.   FREE RADICAL BIOLOGY AND MEDICINE

Cyclooxygenase in normal human tissues - is COX-1 really a constitutive isoform, and COX-2 an inducible isoform?

(2008) Nina Zidar et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Does the varied use of NSAIDs explain the differences in the risk of myocardial infarction?

(2008) T.-P. van Staa et al.   JOURNAL OF INTERNAL MEDICINE

Cyclooxygenase 2-Selective and Nonselective Nonsteroidal Anti-Inflammatory Drugs Induce Oxidative Stress by Up-Regulating Vascular NADPH Oxidases

(2008) H. Li et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

COX-2 selectivity alone does not define the cardiovascular risks associated with non-steroidal anti-inflammatory drugs

(2008) Timothy D Warner et al.   LANCET

Nonsteroidal Anti-Inflammatory Drugs Induced Endothelial Apoptosis by Perturbing Peroxisome Proliferator-Activated Receptor-  Transcriptional Pathway

(2008) J.-Y. Liou et al.   MOLECULAR PHARMACOLOGY

NSAIDs Downregulate Bcl-XLand Dissociate BAX and Bcl-XLto Induce Apoptosis in Colon Cancer Cells

(2008) Alexander Bank et al.   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL

New anti-inflammatory steroids from the Formosan soft coral Clavularia viridis

(2008) Chin-Hsiang Chang et al.   STEROIDS