Review
Hematology
E. D. P. van Bergen, M. Monnikhof, F. P. J. G. Lafeber, R. E. G. Schutgens, S. C. Mastbergen, L. F. D. van Vulpen
Summary: (Non-)selective non-steroidal anti-inflammatory drugs (NSAIDs) are commonly used for musculoskeletal pain. These drugs have potential joint protective effects and could be valuable for hemophilia patients in developing countries and those with a high rate of opioid poisoning. However, concerns about adverse bleeding and cardiovascular events restrict their prescription in this population. A systematic review of studies conducted until March 2021 found that most studies did not show a significant risk of bleeding or cardiovascular events associated with the use of (non-)selective NSAIDs. However, there were limitations in some studies and a lack of research on cardiovascular events. Further studies with long-term follow-up involving larger patient populations, including older patients, are needed to confirm the safety of these drugs.
Article
Chemistry, Analytical
Haifeng Sha, Bing Yan
Summary: Non-steroidal anti-inflammatory drugs (NSAIDs), as a new water pollutant, pose potential hazards to the environment and human health due to their difficult degradation and long-term accumulation. In this study, a water-stable MIL-53(Al) type MOF [Al(OH)(TDC)]center dot 1.5H(2)O center dot 0.7DMF (MIL-53-TDC) was selected as the sensing material, and Eu3+ functionalized MIL-53-TDC hybrid materials (Eu@MIL-53-TDC) were developed as a fluorescence sensor for the detection of two NSAIDs, S-ibuprofen (S-IBP) and diclofenac (DCF).
ANALYTICA CHIMICA ACTA
(2023)
Review
Food Science & Technology
Nagesh Kishan Panchal, Evan Prince Sabina
Summary: Non-steroidal anti-inflammatory drugs (NSAIDs) are widely used medications with analgesic, anti-inflammatory, and antipyretic effects. They may offer protection against diseases like cancer and cardiovascular diseases. However, overdosing on NSAIDs can lead to adverse effects on various systems. Despite existing studies on the clinical risks of NSAIDs, comprehensive reviews on the various toxicities caused by overdosing are lacking. Thus, this review provides a comprehensive overview of NSAIDs and focuses on the toxicities caused by prolonged use or overdosage.
FOOD AND CHEMICAL TOXICOLOGY
(2023)
Review
Environmental Sciences
Ewa Mulkiewicz, Daniel Wolecki, Klaudia Swiacka, Jolanta Kumirska, Piotr Stepnowski, Magda Caban
Summary: This review presents the current state of knowledge on the metabolic pathways of NSAIDs in organisms at various levels of biological organisation. The study found similarities in NSAIDs metabolism to that in mammals, as well as differences such as newly detected metabolites and phase III metabolism in plants. Some metabolites were found to exhibit higher toxicity than their parent forms.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Review
Pharmacology & Pharmacy
Ulrich Kintscher, George L. Bakris, Peter Kolkhof
Summary: This review provides information on the molecular pharmacology and relevant clinical data of a new class of non-steroidal MRAs, discussing their cardiorenal outcomes. These compounds have an improved benefit-risk profile in treating cardiovascular diseases, and finerenone has a novel indication.
BRITISH JOURNAL OF PHARMACOLOGY
(2022)
Article
Public, Environmental & Occupational Health
Abigail R. Cartus, Marian P. Jarlenski, Katherine P. Himes, Alton Everette James, Ashley Naimi, Lisa M. Bodnar
Summary: The study found that severe maternal morbidity (SMM) is associated with an increased risk of adverse cardiovascular events in the 2 years postpartum, particularly heart failure, ischemic heart disease, and stroke/transient ischemic attack. Women who survive SMM may benefit from more comprehensive postpartum care.
AMERICAN JOURNAL OF EPIDEMIOLOGY
(2022)
Article
Public, Environmental & Occupational Health
Kathryn R. K. Benson, Clarissa J. Diamantidis, Clemontina A. Davenport, Robert S. Sandler, L. Ebony Boulware, Dinushika Mohottige
Summary: This study examined racial differences in the use of OTC NSAIDs and HPP-NSAIDs and found that Black individuals had higher usage rates. Further research is necessary to identify potential mechanisms driving this disparity.
JOURNAL OF RACIAL AND ETHNIC HEALTH DISPARITIES
(2023)
Article
Medicine, General & Internal
Foong Way David Tai, Mark E. McAlindon
Summary: NSAIDs are commonly used for treatment, but can cause a variety of gastrointestinal symptoms, which can be reduced by limiting their use or co-administering with proton pump inhibitors (PPIs) to reduce associated complications.
Review
Biochemistry & Molecular Biology
Gustavo Marinho Miranda, Vitoria Ohana Ramos e Santos, Jonatas Reis Bessa, Yanna C. F. Teles, Setondji Cocou Modeste Alexandre Yahouedehou, Marilda Souza Goncalves, Jaime Ribeiro-Filho
Summary: The incorporation of drugs into cyclodextrins has shown promising results in improving the pharmacological and biopharmaceutical properties of non-steroidal anti-inflammatory drugs. This systematic review identified 24 different NSAIDs, 12 types of CDs, and 60 distinct inclusion complexes, with meloxicam and beta-CD being the most studied combination.
Review
Biochemistry & Molecular Biology
Asadur Rahman, Nourin Jahan, Md Tanvir Rahman, Akira Nishiyama
Summary: Inappropriate mineralocorticoid receptor (MR) activation in cardiovascular cells has negative effects on cardiac remodeling and function. MR inhibition is an important strategy to overcome cardiovascular dysfunction, but the clinical application of steroidal MR antagonists is limited due to adverse effects. Newer non-steroidal MR antagonists show promise for clinical use, particularly in patients with type 2 diabetes and chronic kidney disease. Pre-clinical and clinical evidence supports the use of non-steroidal MR antagonists in treating cardiovascular disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Medicinal
I Antal, Zh Kormosh, I Kotsan, N. Kormosh, T. Savchuk, S. Korolchuk, O. Yurchenko, S. Golub, S. Suprunovich, Yu Panchenko, V Tkach
Summary: The study focused on the possibility of extracting ion associates of some non-steroidal anti-inflammatory drugs with a polymethine dye, Astrafloxin. Factors such as medium pH, electrolyte concentration, and nature of the extractant were found to influence the extraction efficiency. Selective determination of these ion associates in combined preparations was achievable by regulating the extraction conditions. The main analytical and metrological characteristics of the developed methods were calculated.
PHARMACEUTICAL CHEMISTRY JOURNAL
(2021)
Review
Pharmacology & Pharmacy
Hongjin Lai, Yi Liu, Juan Wu, Jie Cai, Hui Jie, Yuyang Xu, Senyi Deng
Summary: Inflammatory processes play a crucial role in innate immunity and tumor development in various malignancies. Targeting inflammation with pharmacotherapies, such as non-steroidal anti-inflammatory drugs (NSAIDs), has the potential to reduce the risk of carcinogenesis and enhance the effectiveness of anti-cancer treatments. However, the pharmacogenomic variability of NSAIDs can greatly impact their pharmacokinetics and therapeutic outcomes in cancer patients. Thus, a comprehensive understanding of the pharmacogenomic characteristics of NSAIDs and cancer-related inflammation is important for developing new strategies in cancer treatment.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Soumita Ghosh
Summary: Metabolomics is a valuable tool in understanding the side effects of NSAIDs and has the potential to identify drug targets for side effects mitigation. Researchers focus on metabolomics techniques, bio sample handling, and review of metabolomics studies in different biofluids and tissues related to NSAIDs. The altered pathways highlighted in the analysis, such as TCA cycle and amino acid metabolism, provide insights into the disease progression and pathogenesis influenced by NSAIDs.
Article
Psychiatry
Kyounghoon Park, Seonji Kim, Young-Jin Ko, Byung-Joo Park
Summary: The study revealed that there was no significant difference in CVD-related adverse events risk between SNRI and SSRI, but subgroup analysis showed a higher risk of hemorrhagic stroke among SNRI users with hypertension or diabetes mellitus.
PSYCHIATRY RESEARCH
(2021)
Article
Neurosciences
Craig D. Workman, Alexandra C. Fietsam, Jacob Sosnoff, Thorsten Rudroff
Summary: This study examined the impact of cannabis use on fall risk, cognitive function, and motor function in older adults, finding that chronic cannabis users had higher fall risk, worse balance performance, and slower gait speed compared to non-users.
Article
Oncology
Sarah Ouahoud, Rutger J. Jacobs, Ludmilla L. Kodach, Philip W. Voorneveld, Lukas J. A. C. Hawinkels, Nikki L. Weil, Britt van Vliet, Ron M. Herings, Lennart R. A. Van der Burg, Tom van Wezel, Hans Morreau, Marije Slingerland, Esther Bastiaannet, Hein Putter, James C. H. Hardwick
Summary: This study found that long-term use of statins is associated with a reduced risk of developing colorectal cancer, particularly for SMAD4-positive colorectal cancer.
BRITISH JOURNAL OF CANCER
(2022)
Article
Pharmacology & Pharmacy
Jetty A. Overbeek, Josephina G. Kuiper, Marina Bakker, B. J. F. ( Bart) Bemt, Ron M. C. Herings
Summary: The study aimed to provide an overview of the utilization of originator and biosimilar infliximab in the Netherlands. It found that while there was an increase in the use of biosimilars, the proportion of patients switching remained relatively low as nonmedical switch is not encouraged in the Netherlands.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2022)
Article
Behavioral Sciences
Eline Houben, Rachael J. Benson, Eric A. P. Steegers, Ron M. C. Herings
Summary: The study observed an increase in the use of known safest ASMs and ASMs with uncertain risk among pregnant women in the Netherlands over the past two decades, while the use of ASMs with higher risk of congenital malformations decreased. Only a small proportion of women switched to a safer alternative before or during pregnancy, with most either discontinuing treatment or switching within the same category.
EPILEPSY & BEHAVIOR
(2022)
Article
Gastroenterology & Hepatology
Joseph J. Y. Sung, Sulleman Moreea, Harinder Dhaliwal, Dana C. Moffatt, Krish Ragunath, Terry Ponich, Alan N. Barkun, Ernst J. Kuipers, Robert Bailey, Fergal Donnellan, David Wagner, Keith Sanborn, James Lau
Summary: The study evaluated the safety and effectiveness of Hemospray as a monotherapy for active peptic ulcer bleeding. Results showed that Hemospray was successfully administered in nearly all patients, with a high rate of hemostasis achieved. Recurrent bleeding was observed in a small percentage of patients, but no adverse events were attributed to the use of Hemospray.
GASTROINTESTINAL ENDOSCOPY
(2022)
Article
Multidisciplinary Sciences
Miriam P. van der Meulen, Esther Toes-Zoutendijk, Manon C. W. Spaander, Evelien Dekker, Johannes M. G. Bonfrer, Anneke J. van Vuuren, Ernst J. Kuipers, Folkert J. van Kemenade, M. F. van Velthuysen, Maarten G. J. Thomeer, Harriet van Veldhuizen, Harry J. de Koning, Iris Lansdorp-Vogelaar, Monique E. van Leerdam
Summary: The participation rate in FIT screening is lower for individuals with a lower socioeconomic status (SES), but they have a higher detection rate for advanced neoplasia. Screening has the potential to reduce health inequalities in CRC mortality.
Article
Endocrinology & Metabolism
Josephina G. Kuiper, Aline C. Fenneman, Anne H. van der Spek, Elena Rampanelli, Max Nieuwdorp, Myrthe P. P. Van Herk-Sukel, Valery E. P. P. Lemmens, Ernst J. Kuipers, Ron M. C. Herings, Eric Fliers
Summary: This study did not find a reduced risk of colorectal cancer in levothyroxine users. When stratified by tumour subsite, a borderline significant risk reduction of rectal cancer was found, indicating a need for further research.
ENDOCRINE CONNECTIONS
(2022)
Article
Gastroenterology & Hepatology
M. C. Mommersteeg, I Simovic, B. Yu, S. A. van Nieuwenburg, I. M. J. Bruno, M. Doukas, E. J. Kuipers, M. C. W. Spaander, M. P. Peppelenbosch, N. Castano-Rodriguez, G. M. Fuhler
Summary: The SNP in the ATG16L1 gene is associated with increased intestinal endoplasmic reticulum stress and progression of gastric cancer induced by H. pylori. Individuals with the G-allele are more prone to developing gastric cancer.
Article
Medicine, General & Internal
Edith M. Heintjes, Anastassia Anastassopoulou, Josephina Kuiper, Aikaterini Bilitou, Fernie J. A. Penning-van Beest, Ron M. C. Herings, Maarten J. Postma, J. Wouter Jukema
Summary: This study aimed to investigate the treatment patterns, LDL-C levels and healthcare resource utilization of patients with hypercholesterolaemia or mixed dyslipidaemia at high or very high cardiovascular risk in the Netherlands in 2018. The findings revealed suboptimal treatment with the majority of patients receiving statin monotherapy and only a small percentage receiving combination therapy. Alternative treatment strategies are required to further lower cardiovascular risk.
CURRENT MEDICAL RESEARCH AND OPINION
(2023)
Article
Primary Health Care
Eline Houben, Karin M. A. Swart, Eric AP Steegers, Petra J. M. Elders, Ron MC Herings
Summary: This study examined GPs' awareness of pregnancy and its association with prescribing medication with potential safety risks to women. Results indicated that although GPs' awareness of pregnancy improved over time, inadequate use of available information systems for appropriate drug surveillance still exists.
BRITISH JOURNAL OF GENERAL PRACTICE
(2023)
Article
Public, Environmental & Occupational Health
Linda C. C. Hendriksen, Paul D. D. van Der Linden, Ron M. C. Herings, Bruno H. H. Stricker, Loes E. E. Visser
Summary: Recent studies indicate that women using diuretics have a higher risk of hospital admission due to diuretic-induced hyponatremia compared to men. This study aimed to determine whether these sex differences persist after adjusting for confounding variables.
PHARMACOEPIDEMIOLOGY AND DRUG SAFETY
(2023)
Article
Public, Environmental & Occupational Health
Jetty A. Overbeek, Karin M. A. Swart, Eline Houben, Fernie J. A. Penning-van Beest, Ron M. C. Herings
Summary: This study aimed to assess the completeness and representativeness of the PHARMO GP data for the Dutch population. The findings showed that the PHARMO GP data were representative of the Dutch population in terms of demographic characteristics and diagnoses, but differences were observed in non-urbanized areas and medication use. Therefore, caution should be exercised when using this data for research purposes.
CLINICAL EPIDEMIOLOGY
(2023)
Review
Immunology
Jesse M. van den Berg, Sharon Remmelzwaal, Marieke T. Blom, Beryl A. C. E. Hoek, Karin M. A. Swart, Jetty A. Overbeek, George L. Burchell, Ron M. C. Herings, Petra J. M. Elders
Summary: Persons with diabetes have a higher risk of severe illness or death from COVID-19. The effectiveness of COVID-19 vaccines may be lower in individuals with diabetes. More research is needed to compare vaccine effectiveness between those with and without diabetes.
Article
Pharmacology & Pharmacy
Annemarie Voss, Elisabeth Smits, Karin M. A. Swart, Yanina Balabanova, Gunnar Brobert, Kiliana Suzart-Woischnik, Ron M. C. Herings, Tania Schink, Ulrike Haug
Summary: Since its market approval in 2011, the use of rivaroxaban, a direct oral anticoagulant, has significantly increased in Europe. The baseline characteristics of new rivaroxaban users with non-valvular atrial fibrillation in Germany and the Netherlands have changed over time, with an increasing proportion of patients in Germany not using oral anticoagulants prior to starting rivaroxaban and an increasing proportion of patients in the Netherlands having heart failure at baseline.
DRUGS-REAL WORLD OUTCOMES
(2023)
Article
Primary Health Care
Karin M. A. Swart, Amber A. W. A. van der Heijden, Marieke T. Blom, Jetty A. Overbeek, Giel Nijpels, Hein P. J. van Hout, Petra J. M. Elders, Ron M. C. Herings
Summary: This study aimed to estimate the ability of using electronic medical record data to identify frailty in older patients. The Charlson Comorbidity Index (CCI) was found to be the only measure with acceptable performance, while the other measures showed poorer performance in older age groups.
BRITISH JOURNAL OF GENERAL PRACTICE
(2023)
Article
Pharmacology & Pharmacy
Luis Alberto Garcia Rodriguez, Ana Ruigomez, Tania Schink, Annemarie Voss, Elisabeth Smits, Karin M. A. Swart, Yanina Balabanova, Kiliana Suzart-Woischnik, Gunnar Brobert, Ron M. C. Herings
Summary: This study evaluated the safety and effectiveness of rivaroxaban versus vitamin K antagonists in stroke prevention for patients with nonvalvular atrial fibrillation in Europe. The results showed that the incidence of intracranial bleeding was generally lower with rivaroxaban, while gastrointestinal and urogenital bleeding were higher.
EXPERT OPINION ON DRUG SAFETY
(2023)
