Genome-guided discovery of diverse natural products from Burkholderia sp.

Lasso peptides from proteobacteria: Genome mining employing heterologous expression and mass spectrometry

(2013) Julian D. Hegemann et al.   BIOPOLYMERS

Phosphodiesterase 4-targeted treatments for autoimmune diseases

(2013) Neal Kumar et al.   BMC Medicine

Benzoquinones and Terphenyl Compounds As Phosphodiesterase-4B Inhibitors from a Fungus of the Order Chaetothyriales (MSX 47445)

(2013) Tamam El-Elimat et al.   JOURNAL OF NATURAL PRODUCTS

Genomics-Guided Discovery of Thailanstatins A, B, and C As Pre-mRNA Splicing Inhibitors and Antiproliferative Agents from Burkholderia thailandensis MSMB43

(2013) Xiangyang Liu et al.   JOURNAL OF NATURAL PRODUCTS

antiSMASH 2.0—a versatile platform for genome mining of secondary metabolite producers

(2013) Kai Blin et al.   NUCLEIC ACIDS RESEARCH

Phosphodiesterases as Therapeutic Targets for Alzheimer's Disease

(2012) Ana García-Osta et al.   ACS Chemical Neuroscience

Assembly and Absolute Configuration of Short-Lived Polyketides fromBurkholderia thailandensis

(2012) Keishi Ishida et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Genomics-Driven Discovery of Burkholderic Acid, a Noncanonical, Cryptic Polyketide from Human PathogenicBurkholderiaSpecies

(2012) Jakob Franke et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Genome-based bioprospecting of microbes for new therapeutics

(2012) Sergey B Zotchev et al.   CURRENT OPINION IN BIOTECHNOLOGY

Selective PDE inhibitors as novel treatments for respiratory diseases

(2012) Clive P Page et al.   CURRENT OPINION IN PHARMACOLOGY

Malleilactone, a Polyketide Synthase-Derived Virulence Factor Encoded by the Cryptic Secondary Metabolome of Burkholderia pseudomallei Group Pathogens

(2012) John B. Biggins et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Lasso peptides: structure, function, biosynthesis, and engineering

(2012) Mikhail O. Maksimov et al.   NATURAL PRODUCT REPORTS

Discovery and activity profiling of thailandepsins A through F, potent histone deacetylase inhibitors, from Burkholderia thailandensis E264

(2012) Cheng Wang et al.   MedChemComm

PDE4: A Novel Target in the Treatment of Chronic Obstructive Pulmonary Disease

(2011) J M Michalski et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Romidepsin

(2011) Lily P.H. Yang   DRUGS

Romidepsin (Istodax, NSC 630176, FR901228, FK228, depsipeptide): a natural product recently approved for cutaneous T-cell lymphoma

(2011) Karen M VanderMolen et al.   JOURNAL OF ANTIBIOTICS

Thailandepsins: Bacterial Products with Potent Histone Deacetylase Inhibitory Activities and Broad-Spectrum Antiproliferative Activities

(2011) Cheng Wang et al.   JOURNAL OF NATURAL PRODUCTS

Metabolites from the Induced Expression of Cryptic Single Operons Found in the Genome of Burkholderia pseudomallei

(2011) John B. Biggins et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Cloning and Elucidation of the FR901464 Gene Cluster Revealing a Complex Acyltransferase-less Polyketide Synthase Using Glycerate as Starter Units

(2011) Feng Zhang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

antiSMASH: rapid identification, annotation and analysis of secondary metabolite biosynthesis gene clusters in bacterial and fungal genome sequences

(2011) Marnix H. Medema et al.   NUCLEIC ACIDS RESEARCH

Acyldepsipeptide HDAC Inhibitor Production Induced inBurkholderia thailandensis

(2011) John B. Biggins et al.   ORGANIC LETTERS

Sources of Diversity in Bactobolin Biosynthesis byBurkholderia thailandensisE264

(2011) Gavin Carr et al.   ORGANIC LETTERS

Molecular Insights intoBurkholderia pseudomalleiandBurkholderia malleiPathogenesis

(2010) Edouard E. Galyov et al.   Annual Review of Microbiology

New Insights into the Genetic Organization of the FK228 Biosynthetic Gene Cluster inChromobacterium violaceumNo. 968

(2010) Vishwakanth Y. Potharla et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Reconstitution of the FK228 Biosynthetic Pathway Reveals Cross Talk between Modular Polyketide Synthases and Fatty Acid Synthase

(2010) Shane R. Wesener et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Induced Biosynthesis of Cryptic Polyketide Metabolites in a Burkholderia thailandensis Quorum Sensing Mutant

(2010) Keishi Ishida et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Quorum-Sensing-Regulated Bactobolin Production byBurkholderia thailandensisE264

(2010) Mohammad R. Seyedsayamdost et al.   ORGANIC LETTERS

Insights into the Biosynthesis and Stability of the Lasso Peptide Capistruin

(2009) Thomas A. Knappe et al.   CHEMISTRY & BIOLOGY

New natural product biosynthetic chemistry discovered by genome mining

(2009) Christophe Corre et al.   NATURAL PRODUCT REPORTS

Microcin J25 induces the opening of the mitochondrial transition pore and cytochrome c release through superoxide generation

(2008) María Niklison Chirou et al.   FEBS Journal

Glanders

(2008) Glenda D. Dvorak et al.   JAVMA-JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION

Systematic Structure-Activity Analysis of Microcin J25

(2008) Olga Pavlova et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Genome Mining for Novel Natural Product Discovery

(2008) Gregory L. Challis   JOURNAL OF MEDICINAL CHEMISTRY

Exploiting the mosaic structure of trans-acyltransferase polyketide synthases for natural product discovery and pathway dissection

(2008) TuAnh Nguyen et al.   NATURE BIOTECHNOLOGY