期刊
ORGANIC LETTERS
卷 13, 期 12, 页码 3048-3051出版社
AMER CHEMICAL SOC
DOI: 10.1021/ol200922s
关键词
-
资金
- National Institutes of Health [R01GM086258, U54AI057141]
A series of deletion mutants in the recently identified bactobolin biosynthetic pathway defined the roles of several key biosynthetic enzymes and showed how promiscuity in three enzyme systems allows this cluster to produce multiple products. Studies on the deletion mutants also led to four new bactobolin analogs that provide additional structure-activity relationships for this interesting antibiotic family.
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