期刊
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 21, 期 3, 页码 1023-1026出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2010.12.028
关键词
Pyridazinone; 1,2,4-Triazole; Antihypertensive activity; Non-invasive method
资金
- University Grant Commission (UGC), New Delhi, India
A number of 6-(substituted phenyl)-2-(4-substituted phenyl-5-thioxo-4,5-dihydro-1H-1,2,4-triazol-3-yl)-4,5-dihydropyridazin-3(2H)-one derivatives were designed and synthesized by a sequence of reactions starting from respective aryl hydrocarbons. The final compounds (4a-4u) were evaluated for antihypertensive activities by non-invasive method using Tail Cuff method. The compounds 4e, 4i and 4k showed appreciable antihypertensive activity comparable with that of standard hydralazine and propranolol. (C) 2010 Elsevier Ltd. All rights reserved.
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