KATs in cancer: functions and therapies

Garcinol, an Acetyltransferase Inhibitor, Suppresses Proliferation of Breast Cancer Cell Line MCF-7 Promoted by 17β-Estradiol

(2014) Xia Ye et al.   Asian Pacific Journal of Cancer Prevention

MYC interacts with the human STAGA coactivator complex via multivalent contacts with the GCN5 and TRRAP subunits

(2014) Na Zhang et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Synthesis of a novel series of thiazole-based histone acetyltransferase inhibitors

(2014) Daniela Secci et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Interaction of c-Myb with p300 is required for the induction of acute myeloid leukemia (AML) by human AML oncogenes

(2014) D. R. Pattabiraman et al.   BLOOD

p300 Acetyltransferase Regulates Androgen Receptor Degradation and PTEN-Deficient Prostate Tumorigenesis

(2014) Jian Zhong et al.   CANCER RESEARCH

AF9 YEATS Domain Links Histone Acetylation to DOT1L-Mediated H3K79 Methylation

(2014) Yuanyuan Li et al.   CELL

ATF2: A transcription factor that elicits oncogenic or tumor suppressor activities

(2014) Anindita Bhoumik et al.   CELL CYCLE

Induction of p21Waf1/Cip1 by Garcinol via Downregulation of p38-MAPK Signaling in p53-Independent H1299 Lung Cancer

(2014) Sheng-Yung Yu et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

The Transcription Factor GLI1 Interacts with SMAD Proteins to Modulate Transforming Growth Factor β-Induced Gene Expression in a p300/CREB-binding Protein-associated Factor (PCAF)-dependent Manner

(2014) Monica D. Nye et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inhibition of STAT3 dimerization and acetylation by garcinol suppresses the growth of human hepatocellular carcinoma in vitro and in vivo

(2014) Gautam Sethi et al.   Molecular Cancer

Highly Active Combination of BRD4 Antagonist and Histone Deacetylase Inhibitor against Human Acute Myelogenous Leukemia Cells

(2014) W. Fiskus et al.   MOLECULAR CANCER THERAPEUTICS

Therapeutic targeting of BET bromodomain proteins in castration-resistant prostate cancer

(2014) Irfan A. Asangani et al.   NATURE

Targeting bromodomains: epigenetic readers of lysine acetylation

(2014) Panagis Filippakopoulos et al.   NATURE REVIEWS DRUG DISCOVERY

BET Bromodomain Inhibition Triggers Apoptosis of NF1-Associated Malignant Peripheral Nerve Sheath Tumors through Bim Induction

(2014) Amish J. Patel et al.   Cell Reports

A dual role for Hdac1: oncosuppressor in tumorigenesis, oncogene in tumor maintenance

(2013) F. Santoro et al.   BLOOD

Garcinol, a Polyisoprenylated Benzophenone Modulates Multiple Proinflammatory Signaling Cascades Leading to the Suppression of Growth and Survival of Head and Neck Carcinoma

(2013) F. Li et al.   Cancer Prevention Research

Hbo1 Is a Cyclin E/CDK2 Substrate That Enriches Breast Cancer Stem-like Cells

(2013) M. T. Duong et al.   CANCER RESEARCH

Histone Acetyltransferase PCAF Is Required for Hedgehog-Gli-Dependent Transcription and Cancer Cell Proliferation

(2013) M. Malatesta et al.   CANCER RESEARCH

Selective Inhibition of Tumor Oncogenes by Disruption of Super-Enhancers

(2013) Jakob Lovén et al.   CELL

Transcriptional/epigenetic regulator CBP/p300 in tumorigenesis: structural and functional versatility in target recognition

(2013) Feng Wang et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

BET Bromodomain Inhibition of MYC-Amplified Medulloblastoma

(2013) P. Bandopadhayay et al.   CLINICAL CANCER RESEARCH

Interplay between chromatin-modifying enzymes controls colon cancer progression through Wnt signaling

(2013) Martine Chevillard-Briet et al.   HUMAN MOLECULAR GENETICS

Activating transcription factor 2 in mesenchymal tumors

(2013) Makoto Endo et al.   HUMAN PATHOLOGY

Lysine Acetyltransferase GCN5 Potentiates the Growth of Non-small Cell Lung Cancer via Promotion of E2F1, Cyclin D1, and Cyclin E1 Expression

(2013) Long Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Selective Inhibition of p300 HAT Blocks Cell Cycle Progression, Induces Cellular Senescence, and Inhibits the DNA Damage Response in Melanoma Cells

(2013) Gai Yan et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Two Independent Regions of Simian Virus 40 T Antigen Increase CBP/p300 Levels, Alter Patterns of Cellular Histone Acetylation, and Immortalize Primary Cells

(2013) M. T. Saenz Robles et al.   JOURNAL OF VIROLOGY

Small-Molecule Inhibitors of Acetyltransferase p300 Identified by High-Throughput Screening Are Potent Anticancer Agents

(2013) H. Yang et al.   MOLECULAR CANCER THERAPEUTICS

Acetylation Stabilizes ATP-Citrate Lyase to Promote Lipid Biosynthesis and Tumor Growth

(2013) Ruiting Lin et al.   MOLECULAR CELL

Inhibition of p300 impairs Foxp3+ T regulatory cell function and promotes antitumor immunity

(2013) Yujie Liu et al.   NATURE MEDICINE

Small-molecule inhibition of CBP/catenin interactions eliminates drug-resistant clones in acute lymphoblastic leukemia

(2013) E J Gang et al.   ONCOGENE

MYC, a downstream target of BRD-NUT, is necessary and sufficient for the blockade of differentiation in NUT midline carcinoma

(2013) A R Grayson et al.   ONCOGENE

Brd4 maintains constitutively active NF-κB in cancer cells by binding to acetylated RelA

(2013) Z Zou et al.   ONCOGENE

Targeting HPV16 E6-p300 interaction reactivates p53 and inhibits the tumorigenicity of HPV-positive head and neck squamous cell carcinoma

(2013) X Xie et al.   ONCOGENE

A Histone Acetyltransferase p300 Inhibitor C646 Induces Cell Cycle Arrest and Apoptosis Selectively in AML1-ETO-Positive AML Cells

(2013) Xiao-ning Gao et al.   PLoS One

Androgen Receptor Promotes Ligand-Independent Prostate Cancer Progression through c-Myc Upregulation

(2013) Lina Gao et al.   PLoS One

Decreased Expression of Nuclear p300 Is Associated with Disease Progression and Worse Prognosis of Melanoma Patients

(2013) Anand Rotte et al.   PLoS One

Protein domain mimetics as in vivo modulators of hypoxia-inducible factor signaling

(2013) S. Kushal et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An acetylome peptide microarray reveals specificities and deacetylation substrates for all human sirtuin isoforms

(2013) David Rauh et al.   Nature Communications

Selective Small Molecule Targeting β-Catenin Function Discovered by In Vivo Chemical Genetic Screen

(2013) Jijun Hao et al.   Cell Reports

miR-17-5p targets the p300/CBP-associated factor and modulates androgen receptor transcriptional activity in cultured prostate cancer cells

(2012) Ai-Yu Gong et al.   BMC CANCER

Targeting Pioneering Factor and Hormone Receptor Cooperative Pathways to Suppress Tumor Progression

(2012) S. Shah et al.   CANCER RESEARCH

Acetylation-Dependent Regulation of Skp2 Function

(2012) Hiroyuki Inuzuka et al.   CELL

Histone Recognition and Large-Scale Structural Analysis of the Human Bromodomain Family

(2012) Panagis Filippakopoulos et al.   CELL

Arylsulfonamide KCN1 Inhibits In Vivo Glioma Growth and Interferes with HIF Signaling by Disrupting HIF-1  Interaction with Cofactors p300/CBP

(2012) S. Yin et al.   CLINICAL CANCER RESEARCH

The Acetylase/Deacetylase Couple CREB-binding Protein/Sirtuin 1 Controls Hypoxia-inducible Factor 2 Signaling

(2012) Rui Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Role of Tip60 in Human Melanoma Cell Migration, Metastasis, and Patient Survival

(2012) Guangdi Chen et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Discovery and Characterization of NK13650s, Naturally Occurring p300-Selective Histone Acetyltransferase Inhibitors

(2012) Shigehiro Tohyama et al.   JOURNAL OF ORGANIC CHEMISTRY

High expression of p300 is linked to aggressive features and poor prognosis of Nasopharyngeal Carcinoma

(2012) Zhi-Wei Liao et al.   Journal of Translational Medicine

GCN5 acetylates and regulates the stability of the oncoprotein E2A-PBX1 in acute lymphoblastic leukemia

(2012) T Holmlund et al.   LEUKEMIA

Garcinol Regulates EMT and Wnt Signaling Pathways In Vitro and In Vivo, Leading to Anticancer Activity against Breast Cancer Cells

(2012) A. Ahmad et al.   MOLECULAR CANCER THERAPEUTICS

Characterisation of a Tip60 Specific Inhibitor, NU9056, in Prostate Cancer

(2012) Kelly Coffey et al.   PLoS One

Place your BETs: the therapeutic potential of bromodomains

(2012) R.K. Prinjha et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Histone-modifying enzymes: regulators of developmental decisions and drivers of human disease

(2012) Jill S Butler et al.   Epigenomics

Potential Role of Garcinol as an Anticancer Agent

(2012) Nadia Saadat et al.   Journal of Oncology

HDAC inhibitors and decitabine are highly synergistic and associated with unique gene-expression and epigenetic profiles in models of DLBCL

(2011) M. Kalac et al.   BLOOD

MLL-Rearranged Leukemia Is Dependent on Aberrant H3K79 Methylation by DOT1L

(2011) Kathrin M. Bernt et al.   CANCER CELL

Activation of a Tip60/E2F1/ERCC1 network in human lung adenocarcinoma cells exposed to cisplatin

(2011) Arnaud Van Den Broeck et al.   CARCINOGENESIS

BET Bromodomain Inhibition as a Therapeutic Strategy to Target c-Myc

(2011) Jake E. Delmore et al.   CELL

Tip60: Connecting chromatin to DNA damage signaling

(2011) Yingli Sun et al.   CELL CYCLE

Regulation of the histone acetyltransferase activity of hMOF via autoacetylation of Lys274

(2011) Bingfa Sun et al.   CELL RESEARCH

CPTH6, a Thiazole Derivative, Induces Histone Hypoacetylation and Apoptosis in Human Leukemia Cells

(2011) D. Trisciuoglio et al.   CLINICAL CANCER RESEARCH

6-alkylsalicylates are selective Tip60 inhibitors and target the acetyl-CoA binding site

(2011) Massimo Ghizzoni et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Mice heterozygous for CREB binding protein are hypersensitive to γ-radiation and invariably develop myelodysplastic/myeloproliferative neoplasm

(2011) Stephanie N. Zimmer et al.   EXPERIMENTAL HEMATOLOGY

HDAC inhibitors in cancer biology: emerging mechanisms and clinical applications

(2011) Omar Khan et al.   IMMUNOLOGY AND CELL BIOLOGY

Selective Roles for cAMP Response Element-binding Protein Binding Protein and p300 Protein as Coregulators for Androgen-regulated Gene Expression in Advanced Prostate Cancer Cells

(2011) Irina Ianculescu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of Glycolytic Enzyme Phosphoglycerate Mutase-1 by Sirt1 Protein-mediated Deacetylation

(2011) William C. Hallows et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Histone Acetyltransferase TIP60 Interacts with c-Myb and Inactivates Its Transcriptional Activity in Human Leukemia

(2011) Huiwu Zhao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tip60-mediated acetylation activates transcription independent apoptotic activity of Abl

(2011) Zhihua Jiang et al.   Molecular Cancer

Inhibition of the Acetyltransferases p300 and CBP Reveals a Targetable Function for p300 in the Survival and Invasion Pathways of Prostate Cancer Cell Lines

(2011) F. R. Santer et al.   MOLECULAR CANCER THERAPEUTICS

SAGA and ATAC Histone Acetyl Transferase Complexes Regulate Distinct Sets of Genes and ATAC Defines a Class of p300-Independent Enhancers

(2011) Arnaud R. Krebs et al.   MOLECULAR CELL

CREBBP mutations in relapsed acute lymphoblastic leukaemia

(2011) Charles G. Mullighan et al.   NATURE

Inactivating mutations of acetyltransferase genes in B-cell lymphoma

(2011) Laura Pasqualucci et al.   NATURE

Frequent mutations of chromatin remodeling genes in transitional cell carcinoma of the bladder

(2011) Yaoting Gui et al.   NATURE GENETICS

Recognition of enhancer element–specific histone methylation by TIP60 in transcriptional activation

(2011) Kwang Won Jeong et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Targeting MYC dependence in cancer by inhibiting BET bromodomains

(2011) J. A. Mertz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Improved inhibition of the histone acetyltransferase PCAF by an anacardic acid derivative

(2010) Massimo Ghizzoni et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Virtual Ligand Screening of the p300/CBP Histone Acetyltransferase: Identification of a Selective Small Molecule Inhibitor

(2010) Erin M. Bowers et al.   CHEMISTRY & BIOLOGY

Distinct roles of GCN5/PCAF-mediated H3K9ac and CBP/p300-mediated H3K18/27ac in nuclear receptor transactivation

(2010) Qihuang Jin et al.   EMBO JOURNAL

Target gene context influences the transcriptional requirement for the KAT3 family of CBP and p300 histone acetyltransferases

(2010) David C. Bedford et al.   Epigenetics

Pygo2 Associates with MLL2 Histone Methyltransferase and GCN5 Histone Acetyltransferase Complexes To Augment Wnt Target Gene Expression and Breast Cancer Stem-Like Cell Expansion

(2010) J. Chen et al.   MOLECULAR AND CELLULAR BIOLOGY

Bisbenzamidine derivative, pentamidine represses DNA damage response through inhibition of histone H2A acetylation

(2010) Junya Kobayashi et al.   Molecular Cancer

Mechanism and regulation of acetylated histone binding by the tandem PHD finger of DPF3b

(2010) Lei Zeng et al.   NATURE

Regulation of Cellular Metabolism by Protein Lysine Acetylation

(2010) S. Zhao et al.   SCIENCE

A Role for ATF2 in Regulating MITF and Melanoma Development

(2010) Meera Shah et al.   PLoS Genetics

The metazoan ATAC and SAGA coactivator HAT complexes regulate different sets of inducible target genes

(2009) Zita Nagy et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Hypoxia-inducible factor-1α blocks differentiation of malignant gliomas

(2009) Huimin Lu et al.   FEBS Journal

Inhibition of Lysine Acetyltransferase KAT3B/p300 Activity by a Naturally Occurring Hydroxynaphthoquinone, Plumbagin

(2009) Kodihalli C. Ravindra et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mutations in Multiple Domains of c-Myb Disrupt Interaction with CBP/p300 and Abrogate Myeloid Transforming Ability

(2009) D. R. Pattabiraman et al.   MOLECULAR CANCER RESEARCH

Histone H3 methylation links DNA damage detection to activation of the tumour suppressor Tip60

(2009) Yingli Sun et al.   NATURE CELL BIOLOGY

The p400/Tip60 ratio is critical for colorectal cancer cell proliferation through DNA damage response pathways

(2009) L Mattera et al.   ONCOGENE

CBP and p300 are cytoplasmic E4 polyubiquitin ligases for p53

(2009) D. Shi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lysine Acetylation Targets Protein Complexes and Co-Regulates Major Cellular Functions

(2009) C. Choudhary et al.   SCIENCE

Anacardic acid (6-nonadecyl salicylic acid), an inhibitor of histone acetyltransferase, suppresses expression of nuclear factor- B-regulated gene products involved in cell survival, proliferation, invasion, and inflammation through inhibition of the inhibitory subunit of nuclear factor- B  kinase, leading to potentiation of apoptosis

(2008) B. Sung et al.   BLOOD

Regulation of muscle development by DPF3, a novel histone acetylation and methylation reader of the BAF chromatin remodeling complex

(2008) M. Lange et al.   GENES & DEVELOPMENT

Tip60 Is Regulated by Circadian Transcription Factor Clock and Is Involved in Cisplatin Resistance

(2008) Naoya Miyamoto et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

BRD7, a Novel PBAF-specific SWI/SNF Subunit, Is Required for Target Gene Activation and Repression in Embryonic Stem Cells

(2008) Matthias D. Kaeser et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Human ATAC Is a GCN5/PCAF-containing Acetylase Complex with a Novel NC2-like Histone Fold Module That Interacts with the TATA-binding Protein

(2008) Yuan-Liang Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Novel Histone Acetyltransferase Inhibitor Modulating Gcn5 Network: Cyclopentylidene-[4-(4′-chlorophenyl)thiazol-2-yl)hydrazone

(2008) Franco Chimenti et al.   JOURNAL OF MEDICINAL CHEMISTRY

Mechanism of p300 Specific Histone Acetyltransferase Inhibition by Small Molecules

(2008) M. Arif et al.   JOURNAL OF MEDICINAL CHEMISTRY

PCAF Acetylates β-Catenin and Improves Its Stability

(2008) Xinjian Ge et al.   MOLECULAR BIOLOGY OF THE CELL

The many roles of histone deacetylases in development and physiology: implications for disease and therapy

(2008) Michael Haberland et al.   NATURE REVIEWS GENETICS

Interleukin-4 activates androgen receptor through CBP/p300

(2008) Soo Ok Lee et al.   PROSTATE

Epigenetic Reprogramming by Adenovirus e1a

(2008) R. Ferrari et al.   SCIENCE