The Role of Hepatocyte Hemojuvelin in the Regulation of Bone Morphogenic Protein-6 and Hepcidin Expressionin Vivo

Hepatocyte-targeted HFE and TFR2 control hepcidin expression in mice

(2010) J. Gao et al.   BLOOD

Iron-Induced Expression of Bone Morphogenic Protein 6 in Intestinal Cells Is the Main Regulator of Hepatic Hepcidin Expression In Vivo

(2009) Stephanie Arndt et al.   GASTROENTEROLOGY

Hemojuvelin-Neogenin Interaction Is Required for Bone Morphogenic Protein-4-induced Hepcidin Expression

(2009) An-Sheng Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lack of the bone morphogenetic protein BMP6 induces massive iron overload

(2009) Delphine Meynard et al.   NATURE GENETICS

BMP6 is a key endogenous regulator of hepcidin expression and iron metabolism

(2009) Billy Andriopoulos Jr et al.   NATURE GENETICS

Selective binding of RGMc/hemojuvelin, a key protein in systemic iron metabolism, to BMP-2 and neogenin

(2008) Robin Kuns-Hashimoto et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Hemojuvelin regulates hepcidin expression via a selective subset of BMP ligands and receptors independently of neogenin

(2008) Y. Xia et al.   BLOOD

Iron regulates phosphorylation of Smad1/5/8 and gene expression of Bmp6, Smad7, Id1, and Atoh8 in the mouse liver

(2008) L. Kautz et al.   BLOOD

Iron Homeostasis: Fitting the Puzzle Pieces Together

(2008) Tomas Ganz   Cell Metabolism

Furin-mediated release of soluble hemojuvelin: a new link between hypoxia and iron homeostasis

(2007) L. Silvestri et al.   BLOOD

Regulation of iron acquisition and storage: consequences for iron-linked disorders

(2007) Ivana De Domenico et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY