Article
Hematology
Ming-Yue Fei, Yong Wang, Bin-He Chang, Kai Xue, Fangyi Dong, Dan Huang, Xi-Ya Li, Zi-Juan Li, Cheng-Long Hu, Ping Liu, Ji-Chuan Wu, Peng-Cheng Yu, Ming-Hua Hong, Shu-Bei Chen, Chun-Hui Xu, Bing-Yi Chen, Yi-Lun Jiang, Na Liu, Chong Zhao, Jia-Cheng Jin, Dan Hou, Xin-Chi Chen, Yi-Yi Ren, Chu-Han Deng, Jia-Ying Zhang, Li-juan Zong, Rou-Jia Wang, Fei-Fei Gao, Hui Liu, Qun-Ling Zhang, Ling-Yun Wu, Jinsong Yan, Shuhong Shen, Chun-Kang Chang, Xiao-Jian Sun, Lan Wang
Summary: The high expression of ID1 in the bone marrow microenvironment of AML patients, induced by BMP6 secreted from AML cells, regulates the proliferation of AML cells. Knocking out ID1 in mesenchymal cells can suppress AML cell proliferation and delay AML progression, while the interaction between ID1 and RNF4 can regulate SP1 protein levels, affecting AML cell proliferation.
Article
Genetics & Heredity
Zhengqin Ye, Siyi Wang, Chang Shan, Qi Zhu, Ying Xue, Keqin Zhang
Summary: This study investigated the protein levels of activin A, BMP4, and BMP6 in the serum of FOP patients. The results showed that there were no significant differences in the serum levels of these proteins between FOP patients and healthy control subjects. Therefore, the study suggests that activin A, BMP4, and BMP6 may not be the stimulators for FOP flare-up and may not be suitable as biomarkers for FOP diagnosis.
ORPHANET JOURNAL OF RARE DISEASES
(2023)
Article
Biochemistry & Molecular Biology
Magdalena Wytrwal, Malgorzata Sekula-Stryjewska, Agata Pomorska, Ewa Oclon, Ewa Zuba-Surma, Szczepan Zapotoczny, Krzysztof Szczubialka
Summary: This study investigated the covalent binding of recombinant human bone morphogenetic protein-2 and -7 in stem cells and its effects on cell adhesion, migration, and osteogenesis. The presence of both proteins enhanced cell adhesion but limited cell motility, while the presence of single proteins promoted cell migration activity. Additionally, the coexistence of the proteins significantly increased early osteogenic marker expression.
Article
Polymer Science
Oana Gherasim, Alexandru Mihai Grumezescu, Valentina Grumezescu, Ecaterina Andronescu, Irina Negut, Alexandra Catalina Birca, Bianca Galateanu, Ariana Hudita
Summary: Osteoconductive and osteoinductive coatings are effective strategies for enhancing the integration of metallic implants with bone. Composite materials based on PLA and HAp benefit bone cell development, while the addition of osteogenic proteins contributes to new bone formation. Laser-processed composites show superior ability to promote osteoprogenitor cell adhesion, viability, and proliferation.
Article
Engineering, Biomedical
Sarah A. Schoonraad, Alan A. Jaimes, Arjun J. X. Singh, Kiera J. Croland, Stephanie J. Bryant
Summary: This study investigates the osteogenic effects of tethered BMP-2 and BMP-9 on human MSCs encapsulated in a hydrogel. The results show that tethered BMP-2 and BMP-9 both effectively enhance osteogenesis of MSCs, leading to a mature osteoblast phenotype.
ACTA BIOMATERIALIA
(2023)
Article
Orthopedics
Takahiro Niikura, Takahiro Oda, Naoe Jimbo, Masato Komatsu, Keisuke Oe, Tomoaki Fukui, Tomoyuki Matsumoto, Shinya Hayashi, Takehiko Matsushita, Tomoo Itoh, Ryosuke Kuroda
Summary: This study confirmed the presence of osteoinductive factors BMP-4, 6, 7, and 9 in IM harvested from patients, indicating the effectiveness of the Masquelet technique in healing large bone defects.
JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Malgorzata Wozniak, Anna Borkowska, Marta Jastrzebska, Marcin Sochal, Ewa Malecka-Wojciesko, Renata Talar-Wojnarowska
Summary: In recent years, it has been observed that the concentration of erythroferrone and BMP-6 are significantly higher in patients with inflammatory bowel diseases, especially those with anemia. This finding highlights the importance of further research on this topic.
Article
Chemistry, Applied
Ao Zheng, Xiao Wang, Jie Wang, Xianzhen Xin, Yuanman Yu, Yang Liu, Jing Wang, Kaige Lv, Lingyan Cao
Summary: This study explored the synergistic effect of sulfonated chitosan and BMP-2, with results showing that 26SCS can affect the structure of BMP-2 protein and enhance its biological activity.
CARBOHYDRATE POLYMERS
(2021)
Article
Biochemistry & Molecular Biology
Hyun Seok, Hee-Youl Kim, Dong-Cheol Kang, Jung-Ho Park, Jong Hoon Park
Summary: The study compared the bone regeneration ability of bone scaffolds using particle and block bones with rhBMP-2, showing that rhBMP-2 with block bones resulted in significantly higher bone volume but also led to the formation of adipose tissue and void spaces.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biotechnology & Applied Microbiology
Liwei Zhu, Yuzhe Liu, Ao Wang, Zhengqing Zhu, Youbin Li, Chenyi Zhu, Zhenjia Che, Tengyue Liu, He Liu, Lanfeng Huang
Summary: Bone morphogenetic protein (BMP) plays an important role in promoting bone healing, but its mechanism needs further exploration. By modifying implants to carry BMP and achieve slow and sustained release, effective bone healing can be stimulated.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Multidisciplinary Sciences
Benjamin Tajer, James A. Dutko, Shawn C. Little, Mary C. Mullins
Summary: The study explores the BMP2/7 heterodimer signaling mechanism in zebrafish embryos, revealing that BMP2 homodimers require nonredundant type I receptors Acvr1 and Bmpr1 for signaling, despite not being able to bind Acvr1 in vitro. The kinase activity of Acvr1 is essential for the signaling complex, suggesting that the potency of the heterodimer arises from recruiting both Acvr1 and Bmpr1.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Oncology
Wangyang Meng, Han Xiao, Rong Zhao, Dong Li, Kuo Li, Yunchong Meng, Jiaping Chen, Yangwei Wang, Yongde Liao
Summary: In lung adenocarcinoma, BMP5 was identified as an independent protective prognostic factor, significantly correlated with EGFR expression and mutations, and potentially involved in targeted therapy. By co-expression with hub genes, the re-established risk model showed improved prognostic correlation and value.
FRONTIERS IN ONCOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Gaoli Xu, Chenxi Shen, Haiyan Lin, Jian Zhou, Ting Wang, Ben Wan, Munerah Binshabaib, Tymour Forouzanfar, Guochao Xu, Nawal Alharbi, Gang Wu
Summary: This study synthesized a novel biomimetically-precipitated nanocrystalline calcium phosphate (BpNcCaP) with internally incorporated bone morphogenetic protein-2 (BpNcCaP + BMP-2), demonstrating its potential application in repairing large-volume bone defects.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Gastroenterology & Hepatology
Martijn A. J. Koppens, Hayley Davis, Gabriel N. Valbuena, Eoghan J. Mulholland, Nadia Nasreddin, Mathilde Colombe, Agne Antanaviciute, Sujata Biswas, Matthias Friedrich, Lennard Lee, Lai Mun Wang, Viktor H. Koelzer, James E. East, Alison Simmons, Douglas J. Winton, Simon J. Leedham
Summary: The study reveals that BMP signaling inhibits dedifferentiation of intestinal epithelial cells, and attenuation of the BMP pathway through stromal upregulation of Grem1 is essential for adaptive reprogramming in intestinal regeneration. However, the functional impact of this intervention is submaximal, suggesting potential therapeutic pathway manipulation in inflammatory bowel disease.
Article
Dentistry, Oral Surgery & Medicine
Maria del Mar Ferra-Canellas, Marta Munar-Bestard, Laura Garcia-Sureda, Beatrice Lejeune, Joana Maria Ramis, Marta Monjo
Summary: The study demonstrates that low-dose BMP4 MI treatment has anti-inflammatory and regenerative properties on gingival fibroblasts, and improves cell viability in 3D gingiva under inflammatory conditions.
JOURNAL OF PERIODONTOLOGY
(2021)
Article
Clinical Neurology
Francesco Cavallieri, Nicola Fini, Sara Contardi, Massimo Fiorini, Elena Corradini, Franco Valzania
JOURNAL OF SPINAL CORD MEDICINE
(2017)
Article
Medicine, General & Internal
Pierre Brissot, Antonello Pietrangelo, Paul C. Adams, Barbara de Graaff, Christine E. McLaren, Olivier Loreal
NATURE REVIEWS DISEASE PRIMERS
(2018)
Article
Gastroenterology & Hepatology
Elena Buzzetti, Salvatore Petta, Roberta Manuguerra, Tu Vinh Luong, Daniela Cabibi, Elena Corradini, Antonio Craxi, Massimo Pinzani, Emmanuel Tsochatzis, Antonello Pietrangelo
LIVER INTERNATIONAL
(2019)
Meeting Abstract
Hematology
Matthew Wake, Jonathan Papworth, Luke Bayliss, Benjamin Grimshaw, Natalie Rynkiewicz, Jemima Paterson, Alicia Poindron, Erin Spearing, Emily Carter, Robyne Hudson, Verena Petzer, Amelie Largounez, Audrey Belot, Anais Palin, Igor Theurl, Volker Germaschewski, Delphine Meynard
Letter
Hematology
Audrey Belot, Ophelie Gourbeyre, Fay Alexis, Anais Palin, Celine Besson-Fournier, Chloe Latour, Corey R. Hopkins, George F. Tidmarsh, Helene Coppin, Marie-Paule Roth, Matthew R. Ritter, Charles C. Hong, Delphine Meynard
Letter
Hematology
Audrey Belot, Ophelie Gourbeyre, Anais Palin, Aude Rubio, Amelie Largounez, Celine Besson-Fournier, Chloe Latour, Megane Lorgouilloux, Inka Gallitz, Alexandra Montagner, Arnaud Polizzi, Marion Regnier, Sarra Smati, An-Sheng Zhang, Manuel D. Diaz-Munoz, Andrea U. Steinbicker, Herve Guillou, Marie-Paule Roth, Helene Coppin, Delphine Meynard
Article
Gastroenterology & Hepatology
Elena Corradini, Elena Buzzetti, Paola Dongiovanni, Stefania Scarlini, Angela Caleffi, Serena Pelusi, Isabella Bernardis, Paolo Ventura, Raffaela Rametta, Elena Tenedini, Enrico Tagliafico, Anna Ludovica Fracanzani, Silvia Fargion, Antonello Pietrangelo, Luca Vittorio Valenti
Summary: This study identified variants in non-HFE iron genes, particularly ceruloplasmin, that are associated with hyperferritinemia and increased hepatic iron storage in patients with NAFLD. Carriers of these variants are more likely to have severe liver fibrosis, suggesting a genetic predisposition to hepatic iron deposition that may contribute to liver disease progression.
JOURNAL OF HEPATOLOGY
(2021)
Letter
Gastroenterology & Hepatology
Elena Corradini, Luca V. Valenti
JOURNAL OF HEPATOLOGY
(2021)
Article
Medicine, General & Internal
Elena Buzzetti, Paolo Ventura, Elena Corradini
Summary: Iron is a trace element crucial for various vital processes, especially in heme synthesis. The role of iron in porphyrias remains debated due to conflicting results from clinical observations, in vitro studies and animal models. Testing for iron status and its metabolic pathways in patients with porphyrias can provide additional diagnostic and prognostic value for tailored management.
Article
Neurosciences
Jessica Rossi, Francesco Cavallieri, Giada Giovannini, Francesca Benuzzi, Daniela Ballotta, Anna Elisabetta Vaudano, Francesca Ferrara, Sara Contardi, Antonello Pietrangelo, Elena Corradini, Fausta Lui, Stefano Meletti
Summary: This paper describes the MRI findings of a patient with Wilson disease and a seizure disorder resembling juvenile myoclonic epilepsy. The structural MRI revealed a deposition of ferromagnetic materials in the basal ganglia, resulting in marked hypointensities in T2-weighted images of the globus pallidus internus bilaterally. Resting-state fMRI study showed increased functional connectivity in networks involving the primary motor cortex and cortical regions, as well as between the globus pallidus and the thalamo-frontal network. These findings suggest that globus pallidus alterations caused by metal accumulation can disrupt the normal inhibitory function of the globus pallidus on the thalamo-(motor)-cortical pathway, leading to hyperconnectivity in the motor cortex circuitry and the development of myoclonus and tonic-clonic seizures. It is hypothesized that Wilson disease in this patient created a "lesion model" of myoclonic epilepsy.
Review
Biochemistry & Molecular Biology
Andrea Ricci, Giada Di Betto, Elisa Bergamini, Elena Buzzetti, Elena Corradini, Paolo Ventura
Summary: Iron plays a crucial role in cellular functions involving redox reactions. However, uncontrolled interactions between iron and its surroundings can be damaging. Heme, engineered by evolution to exploit iron's properties while minimizing damage, is essential in various metabolic pathways. Impairment in heme biosynthesis can lead to porphyrias and congenital sideroblastic anemias. Understanding the interplay between iron and heme metabolism is important for understanding these inherited conditions.
Article
Virology
Cristina Mussini, Alessandro Cozzi-Lepri, Marianna Meschiari, Erica Franceschini, Giulia Burastero, Matteo Faltoni, Giacomo Franceschi, Vittorio Iadisernia, Sara Volpi, Andrea Dessilani, Licia Gozzi, Jacopo Conti, Martina Del Monte, Jovana Milic, Vanni Borghi, Roberto Tonelli, Lucio Brugioni, Elisa Romagnoli, Antonello Pietrangelo, Elena Corradini, Massimo Girardis, Stefano Busani, Andrea Cossarizza, Enrico Clini, Giovanni Guaraldi
Summary: This observational cohort study evaluated the mortality rate of severe COVID-19 pneumonia patients treated with glucocorticoids + tocilizumab. The study found that the combination therapy was associated with a lower mortality rate, especially in patients with high CRP levels. These results suggest that the CRP level prior to treatment initiation may serve as an important indicator for the use of this treatment regimen.
Article
Hematology
Chloe Latour, Celine Besson-Fournier, Ophelie Gourbeyre, Delphine Meynard, Marie-Paule Roth, Helene Coppin
Meeting Abstract
Hematology
Audrey Belot, Ophelie Gourbeyre, Aude Rubio, Celine Besson-Fournier, Chloe Latour, Inka Gallitz, Alexandra Montagner, Arnaud Polizzi, Marion Regnier, Andrea U. Steinbicker, Herve Guillou, Marie-Paule Roth, Helene Coppin, Delphine Meynard
AMERICAN JOURNAL OF HEMATOLOGY
(2017)
Meeting Abstract
Hematology
Chloe Latour, Celine Besson-Fournier, Ophelie Gourbeyre, Delphine Meynard, Marie-Paule Roth, Helene Coppin
AMERICAN JOURNAL OF HEMATOLOGY
(2017)