Article
Nutrition & Dietetics
Hanna K. von Siebenthal, Valeria Galetti, Michael B. Zimmermann, Nicole U. Stoffel
Summary: This study found that the regulatory pathways of iron absorption are intact in infancy, and iron absorption in infants begins to increase at threshold ferritin and hepcidin values similar to adult values. These findings are important for the management of iron nutrition in infants and young children.
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2023)
Article
Pediatrics
Fredrik Baeckstroem, Anna Chmielewska, Magnus Domelloef, Staffan K. Berglund
Summary: This study aimed to assess the ERFE serum concentrations and its predictors in infants, and found that ERFE concentrations increase gradually during the first year of life in infants, but lack correlation to iron status and markers of erythropoiesis.
PEDIATRIC RESEARCH
(2023)
Review
Biochemistry & Molecular Biology
Anne-Cathrine S. Vogt, Tasneem Arsiwala, Mona Mohsen, Monique Vogel, Vania Manolova, Martin F. Bachmann
Summary: Iron is crucial for biological processes and is mainly bound to hemoglobin in red blood cells. It is recycled from senescent cells by macrophages and regulated by hormones like hepcidin. Key proteins like DMT1 and FPN play crucial roles in iron uptake and transport.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Physiology
Yihang Li, Ian Miller, Princy Prasad, Nisha Ajit George, Nermi L. Parrow, Robert E. Fleming
Summary: This study investigates the role of transferrin in the erythropoietic response to iron deficiency and iron deficiency anemia. The results demonstrate that transferrin not only plays a role in iron delivery but also affects iron homeostasis and erythropoiesis. Administration of exogenous iron-loaded transferrin restores iron levels and influences the expression of regulatory proteins involved in erythropoiesis. In iron deficiency anemia, transferrin treatment increases erythropoietin sensitivity, highlighting its importance in the recovery from iron deficiency anemia.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Medicine, Research & Experimental
Sung Yeon Ham, Ji Hae Jun, Hye-Bin Kim, Jae-Kwang Shim, Gisong Lee, Young-Lan Kwak
Summary: This study investigated the activities of key regulators affecting erythropoiesis in a rat model of iron deficiency anemia with inflammation. The results showed that IV iron therapy exacerbated inflammation and oxidative stress and did not resolve anemia.
Review
Food Science & Technology
Mauricio Restrepo-Gallego, Luis E. Diaz, Patricia H. C. Rondo
Summary: Iron deficiency is the leading cause of anemia, and assessing iron nutritional status requires consideration of various laboratory tests and indicators. Using multiple indicators in combination may be the best practice due to the influence of different factors on these indicators. Constant validation, improvement of assessment methods, and identification of new indicators are key to refining the assessment of iron nutritional status and selecting appropriate treatment for improvement.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2021)
Correction
Biology
Gonzalo Villapalos-Garcia, Pablo Zubiaur, Rebeca Rivas-Duran, Pilar Campos-Norte, Cristina Arevalo-Roman, Marta Fernnandez-rico, Lucio Garcia-Fraile Fraile, Paula Fernandez-Campos, Paula Soria-Chacartegui, Sara Fernandez de Cordoba-Onate, Pablo Delgado-Wicke, Elena Fernandez-Ruiz, Isidoro Gonzalez-Alvaro, Jesus Sanz, Francisco Abad-Santos, Ignacio de los Santos
Summary: This study aimed to evaluate predictors of COVID-19 severity. The results showed that the TMPRSS2 genotype, dyslipidemia, sex, and the Charlson Comorbidity Index were identified as the main predictors of disease severity.
LIFE SCIENCE ALLIANCE
(2022)
Article
Biochemistry & Molecular Biology
Peng Ju Liu, Aimin Yao, Xiao Yan Chen, Yanping Liu, Liangkun Ma, Yi Xuan Hou
Summary: Two TMPRSS6 SNPs (rs855791 and rs4820268) were significantly associated with serum iron and transferrin saturation, and the rs4820268 C allele was nominally and significantly associated with an increased risk of GDM. The effects of TMPRSS6 SNPs on GDM risk may not be completely explained by body iron status, suggesting further studies are needed.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2021)
Article
Multidisciplinary Sciences
Francis Xavier Kasujja, Roy William Mayega, Meena Daivadanam, Elizabeth Ekirapa Kiracho, Ronald Kusolo, Fred Nuwaha
Summary: This study compared the performance of HBA(1c) and FPG tests in screening for diabetes and abnormal glucose regulation. The results showed that they had comparable sensitivity and specificity, but their utility in screening for prediabetes in outpatient populations was limited.
Article
Nutrition & Dietetics
Thibaud Lefebvre, Muriel Coupaye, Marina Esposito-Farese, Nathalie Gault, Neila Talbi, Caroline Quintin, Caroline Schmitt, Soumeya Bekri, Andre Bado, Herve Puy, Simon Msika, Carole Brasse-Lagnel, Zoubida Karim
Summary: After sleeve gastrectomy, levels of iron-related markers such as sTfR and PPIX decreased while serum hepcidin levels increased. DMT1 abundance was negatively correlated with serum hepcidin levels, and ferroportin abundance remained unchanged. These results suggest effective iron recovery pathways post-operatively involving suppression of inflammation and improvement in iron absorption and erythropoiesis.
Article
Nutrition & Dietetics
Laura Tarancon-Diez, Miguel Genebat, Manuela Roman-Enry, Elena Vazquez-Alejo, Maria de la Sierra Espinar-Buitrago, Manuel Leal, Ma Angeles Munoz-Fernandez
Summary: This study aimed to determine a clinically relevant ferritin threshold to define absolute iron deficiency. The findings suggest that serum ferritin levels below 50 ng/mL are indicative of early iron deficiency.
Article
Nutrition & Dietetics
Aya Ishibashi, Naho Maeda, Chihiro Kojima, Kazushige Goto
Summary: This study aimed to investigate the influence of twice a day endurance exercise on iron metabolism in female long-distance runners. The results showed that twice a day endurance exercise resulted in a significant elevation of serum hepcidin level 24 hours after completion of the exercise.
Article
Nutrition & Dietetics
Peng Sun, Yueqin Zhou, Suhua Xu, Xiaotong Wang, Xiuxiu Li, Hailin Li, Zongyu Lin, Fenglian Huang, Lewei Zhu, Yanna Zhu
Summary: This study aimed to investigate the association between first-trimester maternal serum hepcidin and third-trimester iron deficiency anemia (IDA). The study found that higher levels of first-trimester hepcidin were negatively associated with the risk of third-trimester IDA, suggesting that elevated hepcidin may predict a reduced risk for developing IDA.
FRONTIERS IN NUTRITION
(2023)
Article
Biochemistry & Molecular Biology
Hilde van der Staaij, Albertine E. Donker, Dirk L. Bakkeren, Jan M. J. I. Salemans, Lisette A. A. Mignot-Evers, Marlies Y. Bongers, Jeanne P. Dieleman, Tessel E. Galesloot, Coby M. Laarakkers, Siem M. Klaver, Dorine W. Swinkels
Summary: In this study, the TSAT/hepcidin ratio was found to be a useful tool for distinguishing IRIDA from IDA, with excellent performance in early diagnosis. This method helps identify IRIDA related to gene mutations, while recent iron therapy and moderate-to-severe inflammation should be excluded.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Nutrition & Dietetics
Andrew D. Jones, Zhen Shi, Nathalie J. Lambrecht, Yaping Jiang, Jingmin Wang, Margit Burmeister, Ming Li, Betsy Lozoff
Summary: This study found that both pregnant women and neonates' hepcidin levels were responsive to iron status. Maternal prepregnancy overweight status was associated with lower cord blood hepcidin concentrations, likely due to lower iron status among the infants born to these mothers.
JOURNAL OF NUTRITION
(2021)
