Pharmacological agents currently in clinical trials for disorders in neurogastroenterology
出版年份 2013 全文链接
标题
Pharmacological agents currently in clinical trials for disorders in neurogastroenterology
作者
关键词
-
出版物
JOURNAL OF CLINICAL INVESTIGATION
Volume 123, Issue 10, Pages 4111-4120
出版商
American Society for Clinical Investigation
发表日期
2013-09-30
DOI
10.1172/jci70837
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- 848a Lubiprostone Significantly Improves Treatment Response in Non-Methadone Opioid-Induced Bowel Dysfunction Patients with Chronic, Non-Cancer Pain: Results from a Phase 3, Randomized, Double-Blind, Placebo-Controlled Clinical Trial
- (2015) M. Mazen Jamal et al. GASTROENTEROLOGY
- 5 Nortriptyline for Idiopathic Gastroparesis: A Multicenter, Randomized, Double-Masked, Placebo-Controlled Trial (NORIG).
- (2015) Henry P. Parkman et al. GASTROENTEROLOGY
- 902 Randomized Placebo-Controlled Trial of Glutamine for the Treatment of Diarrhea-Predominant IBS
- (2015) Sapreet Basra et al. GASTROENTEROLOGY
- 903 TZP-102-Cl-G003 Phase 2B Study Results: Oral TZP-102 Once Daily for 12 Weeks in Patients With Diabetic Gastroparesis
- (2015) Richard W. McCallum et al. GASTROENTEROLOGY
- 900 Efficacy and Safety of Naloxegol in Patients With Opioid-Induced Constipation: Results From 2 Prospective, Randomized, Controlled Trials
- (2015) William D. Chey et al. GASTROENTEROLOGY
- 901 Effect of the H1-Receptor Antagonist Ebastin on Visceral Perception and Clinical Symptoms in IBS
- (2015) Sander van Wanrooij et al. GASTROENTEROLOGY
- 925g Plecanatide, a Novel Guanylate Cyclase-C (GC-C) Receptor Agonist, is Efficacious and Safe in Patients with Chronic Idiopathic Constipation (CIC): Results from a 951 Patient, 12 Week, Multi-Center Trial
- (2015) Philip B. Miner et al. GASTROENTEROLOGY
- 899 Td-1211 Phase 2B Study Demonstrates Increased Bowel Movement Frequency and Constipation-Related Symptom Improvement in Patients With Opioid Induced Constipation (OIC)
- (2015) Ross G. Vickery et al. GASTROENTEROLOGY
- Randomised clinical trial: macrogol/PEG 3350+electrolytes versus prucalopride in the treatment of chronic constipation - a comparison in a controlled environment
- (2013) R. Cinca et al. ALIMENTARY PHARMACOLOGY & THERAPEUTICS
- ACG Clinical Guideline: Evidenced Based Approach to the Diagnosis and Management of Esophageal Eosinophilia and Eosinophilic Esophagitis (EoE)
- (2013) Evan S Dellon et al. AMERICAN JOURNAL OF GASTROENTEROLOGY
- Current and future pharmacological treatments for diarrhea-predominant irritable bowel syndrome
- (2013) Michael Camilleri EXPERT OPINION ON PHARMACOTHERAPY
- The in vivo pharmacodynamics of the novel opioid receptor antagonist, TD-1211, in models of opioid-induced gastrointestinal and CNS activity
- (2013) Scott R. Armstrong et al. NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
- Effect of hyoscine butylbromide (Buscopan®) on cholinergic pathways in the human intestine
- (2013) D. Krueger et al. NEUROGASTROENTEROLOGY AND MOTILITY
- FDA and EMA end points: which outcome end points should we use in clinical trials in patients with irritable bowel syndrome?
- (2013) M. Corsetti et al. NEUROGASTROENTEROLOGY AND MOTILITY
- Randomized clinical trial: inhibition of the TRPV1 system in patients with nonerosive gastroesophageal reflux disease and a partial response to PPI treatment is not associated with analgesia to esophageal experimental pain
- (2013) Anne Lund Krarup et al. SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY
- The effects of a novel metabotropic glutamate receptor 5 antagonist (AZD2066) on transient lower oesophageal sphincter relaxations and reflux episodes in healthy volunteers
- (2012) W. O. Rohof et al. ALIMENTARY PHARMACOLOGY & THERAPEUTICS
- Mechanisms of Reflux Perception in Gastroesophageal Reflux Disease: A Review
- (2012) Albert J Bredenoord AMERICAN JOURNAL OF GASTROENTEROLOGY
- Clinical Guideline: Management of Gastroparesis
- (2012) Michael Camilleri et al. AMERICAN JOURNAL OF GASTROENTEROLOGY
- Irritable Bowel Syndrome: Methods, Mechanisms, and Pathophysiology. The confluence of increased permeability, inflammation, and pain in irritable bowel syndrome
- (2012) Michael Camilleri et al. AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
- Effect of a glucagon-like peptide 1 analog, ROSE-010, on GI motor functions in female patients with constipation-predominant irritable bowel syndrome
- (2012) Michael Camilleri et al. AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
- Regional- and agonist-dependent facilitation of human neurogastrointestinal functions by motilin receptor agonists
- (2012) J Broad et al. BRITISH JOURNAL OF PHARMACOLOGY
- Motilin: towards a new understanding of the gastrointestinal neuropharmacology and therapeutic use of motilin receptor agonists
- (2012) G J Sanger et al. BRITISH JOURNAL OF PHARMACOLOGY
- Methadone but not Morphine Inhibits Lubiprostone-Stimulated Cl− Currents in T84 Intestinal Cells and Recombinant Human ClC-2, but not CFTR Cl− Currents
- (2012) John Cuppoletti et al. CELL BIOCHEMISTRY AND BIOPHYSICS
- Efficacy of Buspirone, a Fundus-Relaxing Drug, in Patients With Functional Dyspepsia
- (2012) Jan Tack et al. Clinical Gastroenterology and Hepatology
- Increased Bile Acid Biosynthesis Is Associated With Irritable Bowel Syndrome With Diarrhea
- (2012) Banny S. Wong et al. Clinical Gastroenterology and Hepatology
- Evolving Molecular Targets in the Treatment of Nonmalignant Gastrointestinal Diseases
- (2012) D A Katzka et al. CLINICAL PHARMACOLOGY & THERAPEUTICS
- Randomized Controlled Phase Ib Study of Ghrelin Agonist, RM-131, in Type 2 Diabetic Women With Delayed Gastric Emptying: Pharmacokinetics and pharmacodynamics
- (2012) A. Shin et al. DIABETES CARE
- Effect of Mosapride Combined with Esomeprazole Improves Esophageal Peristaltic Function in Patients with Gastroesophageal Reflux Disease: A Study Using High Resolution Manometry
- (2012) Yu Kyung Cho et al. DIGESTIVE DISEASES AND SCIENCES
- Activation of Colonic Mucosal 5-HT4 Receptors Accelerates Propulsive Motility and Inhibits Visceral Hypersensitivity
- (2012) Jill M. Hoffman et al. GASTROENTEROLOGY
- Measurement of Spleen Stiffness by Acoustic Radiation Force Impulse Imaging Identifies Cirrhotic Patients With Esophageal Varices
- (2012) Yoshitaka Takuma et al. GASTROENTEROLOGY
- A phase 2a, randomized, double-blind 28-day study of TZP-102 a ghrelin receptor agonist for diabetic gastroparesis
- (2012) N. Ejskjaer et al. NEUROGASTROENTEROLOGY AND MOTILITY
- Therapeutic efficacy of acotiamide in patients with functional dyspepsia based on enhanced postprandial gastric accommodation and emptying: randomized controlled study evaluation by real-time ultrasonography
- (2012) H. Kusunoki et al. NEUROGASTROENTEROLOGY AND MOTILITY
- Increase in fecal primary bile acids and dysbiosis in patients with diarrhea-predominant irritable bowel syndrome
- (2012) H. Duboc et al. NEUROGASTROENTEROLOGY AND MOTILITY
- Double-blind placebo-controlled study of mesalamine in post-infective irritable bowel syndrome – a pilot study
- (2012) Ashok K. Tuteja et al. SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY
- Efficacy of Solifenacin on Irritable Bowel Syndrome With Diarrhea: Open-label Prospective Pilot Trial
- (2012) Yasushi Fukushima et al. Journal of Neurogastroenterology and Motility
- Randomised clinical trial: ghrelin agonist TZP-101 relieves gastroparesis associated with severe nausea and vomiting - randomised clinical study subset data
- (2011) J. M. Wo et al. ALIMENTARY PHARMACOLOGY & THERAPEUTICS
- Randomised clinical trial: the safety and efficacy of AST-120 in non-constipating irritable bowel syndrome - a double-blind, placebo-controlled study
- (2011) J. F. Tack et al. ALIMENTARY PHARMACOLOGY & THERAPEUTICS
- Systematic review: the treatment of noncardiac chest pain
- (2011) T. Hershcovici et al. ALIMENTARY PHARMACOLOGY & THERAPEUTICS
- Randomised clinical trial: otilonium bromide improves frequency of abdominal pain, severity of distention and time to relapse in patients with irritable bowel syndrome
- (2011) P. Clavé et al. ALIMENTARY PHARMACOLOGY & THERAPEUTICS
- Mesalazine (5-aminosalicylic acid) alters faecal bacterial profiles, but not mucosal proteolytic activity in diarrhoea-predominant irritable bowel syndrome
- (2011) C. N. Andrews et al. ALIMENTARY PHARMACOLOGY & THERAPEUTICS
- Opioid-Induced Constipation: Challenges and Therapeutic Opportunities
- (2011) Michael Camilleri AMERICAN JOURNAL OF GASTROENTEROLOGY
- Effects of A3309, an Ileal Bile Acid Transporter Inhibitor, on Colonic Transit and Symptoms in Females With Functional Constipation
- (2011) Banny S Wong et al. AMERICAN JOURNAL OF GASTROENTEROLOGY
- The Efficacy and Safety of Rifaximin for the Irritable Bowel Syndrome: A Systematic Review and Meta-Analysis
- (2011) Stacy B Menees et al. AMERICAN JOURNAL OF GASTROENTEROLOGY
- A Randomized Placebo-Controlled Phase IIb Trial of A3309, A Bile Acid Transporter Inhibitor, for Chronic Idiopathic Constipation
- (2011) William D Chey et al. AMERICAN JOURNAL OF GASTROENTEROLOGY
- Pharmacology of the New Treatments for Lower Gastrointestinal Motility Disorders and Irritable Bowel Syndrome
- (2011) M Camilleri CLINICAL PHARMACOLOGY & THERAPEUTICS
- The Tryptophan Hydroxylase Inhibitor LX1031 Shows Clinical Benefit in Patients With Nonconstipating Irritable Bowel Syndrome
- (2011) Philip M. Brown et al. GASTROENTEROLOGY
- Regional colon transit in patients with dys-synergic defaecation or slow transit in patients with constipation
- (2011) Sara Nullens et al. GUT
- A placebo-controlled trial of acotiamide for meal-related symptoms of functional dyspepsia
- (2011) Kei Matsueda et al. GUT
- A Randomized, Placebo-Controlled Phase 3 Trial (Study SB-767905/012) of Alvimopan for Opioid-Induced Bowel Dysfunction in Patients With Non-Cancer Pain
- (2011) Jan-Peter Jansen et al. JOURNAL OF PAIN
- A Randomized, Placebo-Controlled Phase 3 Trial (Study SB-767905/013) of Alvimopan for Opioid-Induced Bowel Dysfunction in Patients With Non-Cancer Pain
- (2011) Gordon Irving et al. JOURNAL OF PAIN
- GSK962040: a small molecule motilin receptor agonist which increases gastrointestinal motility in conscious dogs
- (2011) S. Leming et al. NEUROGASTROENTEROLOGY AND MOTILITY
- Efficacy of ramosetron in the treatment of male patients with irritable bowel syndrome with diarrhea: a multicenter, randomized clinical trial, compared with mebeverine
- (2011) K. J. Lee et al. NEUROGASTROENTEROLOGY AND MOTILITY
- Rifaximin Therapy for Patients with Irritable Bowel Syndrome without Constipation
- (2011) Mark Pimentel et al. NEW ENGLAND JOURNAL OF MEDICINE
- The Evaluation of Otilonium Bromide Treatment in Asian Patients With Irritable Bowel Syndrome
- (2011) Full-Young Chang et al. Journal of Neurogastroenterology and Motility
- Clinical trial: the efficacy and tolerability of velusetrag, a selective 5-HT4 agonist with high intrinsic activity, in chronic idiopathic constipation - a 4-week, randomized, double-blind, placebo-controlled, dose-response study
- (2010) M. Goldberg et al. ALIMENTARY PHARMACOLOGY & THERAPEUTICS
- Comparison of selective M3 and nonselective muscarinic receptor antagonists on gastrointestinal transit and bowel habits in humans
- (2010) Adil E. Bharucha et al. AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
- Overall Mortality, Incremental Life Expectancy, and Cause of Death at 25 Years in the Program on the Surgical Control of the Hyperlipidemias
- (2010) Henry Buchwald et al. ANNALS OF SURGERY
- Efficacy and Safety of Tapentadol Extended Release Compared with Oxycodone Controlled Release for the Management of Moderate to Severe Chronic Pain Related to Osteoarthritis of the Knee
- (2010) Marc Afilalo et al. CLINICAL DRUG INVESTIGATION
- Review of the effect of opioid-related side effects on the undertreatment of moderate to severe chronic non-cancer pain: tapentadol, a step toward a solution?
- (2010) Keith A. Candiotti et al. CURRENT MEDICAL RESEARCH AND OPINION
- Efficacy and Safety of Prucalopride in Patients with Chronic Noncancer Pain Suffering from Opioid-Induced Constipation
- (2010) Cornelius E. J. Sloots et al. DIGESTIVE DISEASES AND SCIENCES
- Efficacy and safety of tapentadol extended release for the management of chronic low back pain: results of a prospective, randomized, double-blind, placebo- and active-controlled Phase III study
- (2010) Robert Buynak et al. EXPERT OPINION ON PHARMACOTHERAPY
- The mast cell stabiliser ketotifen decreases visceral hypersensitivity and improves intestinal symptoms in patients with irritable bowel syndrome
- (2010) T. K. Klooker et al. GUT
- Long-term efficacy and safety of combined prolonged-release oxycodone and naloxone in the management of non-cancer chronic pain
- (2010) A. Sandner-Kiesling et al. INTERNATIONAL JOURNAL OF CLINICAL PRACTICE
- 5-HT4 receptor agonists: similar but not the same
- (2010) J. H. De Maeyer et al. NEUROGASTROENTEROLOGY AND MOTILITY
- Safety and efficacy of ghrelin agonist TZP-101 in relieving symptoms in patients with diabetic gastroparesis: a randomized, placebo-controlled study
- (2010) N. Ejskjaer et al. NEUROGASTROENTEROLOGY AND MOTILITY
- Ghrelin receptor agonist (TZP-101) accelerates gastric emptying in adults with diabetes and symptomatic gastroparesis
- (2009) N. EJSKJAER et al. ALIMENTARY PHARMACOLOGY & THERAPEUTICS
- Effect of mesalazine on mucosal immune biomarkers in irritable bowel syndrome: a randomized controlled proof-of-concept study
- (2009) R. CORINALDESI et al. ALIMENTARY PHARMACOLOGY & THERAPEUTICS
- Systematic review: the prevalence of idiopathic bile acid malabsorption as diagnosed by SeHCAT scanning in patients with diarrhoea-predominant irritable bowel syndrome
- (2009) L. WEDLAKE et al. ALIMENTARY PHARMACOLOGY & THERAPEUTICS
- Efficacy of the 5-HT1A Agonist Tandospirone Citrate in Improving Symptoms of Patients With Functional Dyspepsia: A Randomized Controlled Trial
- (2009) Hiroto Miwa et al. AMERICAN JOURNAL OF GASTROENTEROLOGY
- Epidemiology of Eosinophilic Esophagitis Over Three Decades in Olmsted County, Minnesota
- (2009) Ganapathy A. Prasad et al. Clinical Gastroenterology and Hepatology
- 156 Clinical Benefit in IBS After Disodium Cromoglycate Involves Mast Cell-Mediated Recovery of Healthy-Like Innate Immunity Genes Expression Profile in the Jejunal Mucosa
- (2009) Beatriz Lobo et al. GASTROENTEROLOGY
- Reducing the Gastrointestinal Risks of Low-Dose Aspirin
- (2009) Byron Cryer GASTROENTEROLOGY
- Influence of ghrelin on the gastric accommodation reflex and on meal-induced satiety in man
- (2009) d. ang et al. NEUROGASTROENTEROLOGY AND MOTILITY
- A dose-ranging, placebo-controlled, pilot trial of Acotiamide in patients with functional dyspepsia
- (2009) j. tack et al. NEUROGASTROENTEROLOGY AND MOTILITY
- Differential effects of transient receptor vanilloid one (TRPV1) antagonists in acid-induced excitation of esophageal vagal afferent fibers of rats
- (2009) S. Peles et al. NEUROSCIENCE
- Asimadoline, a kappa-opioid agonist, and satiation in functional dyspepsia
- (2008) N. J. TALLEY et al. ALIMENTARY PHARMACOLOGY & THERAPEUTICS
- Clinical trial: asimadoline in the treatment of patients with irritable bowel syndrome
- (2008) A. W. MANGEL et al. ALIMENTARY PHARMACOLOGY & THERAPEUTICS
- Clinical trial: the glucagon-like peptide-1 analogue ROSE-010 for management of acute pain in patients with irritable bowel syndrome: a randomized, placebo-controlled, double-blind study
- (2008) P. M. HELLSTRÖM et al. ALIMENTARY PHARMACOLOGY & THERAPEUTICS
- A Phase II Trial of the Novel Serotonin Type 3 Receptor Antagonist Ramosetron in Japanese Male and Female Patients with Diarrhea-Predominant Irritable Bowel Syndrome
- (2008) K. Matsueda et al. DIGESTION
- A randomised controlled trial with prolonged-release oral oxycodone and naloxone to prevent and reverse opioid-induced constipation
- (2008) Winfried Meissner et al. EUROPEAN JOURNAL OF PAIN
- Analgesic Efficacy and Safety of Oxycodone in Combination With Naloxone as Prolonged Release Tablets in Patients With Moderate to Severe Chronic Pain
- (2008) Dana Vondrackova et al. JOURNAL OF PAIN
- Effects of serotonin 5-HT3receptor antagonists on stress-induced colonic hyperalgesia and diarrhoea in rats: a comparative study with opioid receptor agonists, a muscarinic receptor antagonist and a synthetic polymer
- (2008) t. hirata et al. NEUROGASTROENTEROLOGY AND MOTILITY
- A Placebo-Controlled Trial of Prucalopride for Severe Chronic Constipation
- (2008) Michael Camilleri et al. NEW ENGLAND JOURNAL OF MEDICINE
- Alvimopan, a peripherally acting mu-opioid receptor (PAM-OR) antagonist for the treatment of opioid-induced bowel dysfunction: Results from a randomized, double-blind, placebo-controlled, dose-finding study in subjects taking opioids for chronic non-cancer pain
- (2008) Lynn Webster et al. PAIN
- A randomized, double-blind, placebo-controlled clinical trial of the effectiveness of the novel serotonin type 3 receptor antagonist ramosetron in both male and female Japanese patients with diarrhea-predominant irritable bowel syndrome
- (2008) Kei Matsueda et al. SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreBecome a Peeref-certified reviewer
The Peeref Institute provides free reviewer training that teaches the core competencies of the academic peer review process.
Get Started