Pharmacology of the New Treatments for Lower Gastrointestinal Motility Disorders and Irritable Bowel Syndrome

Randomised clinical trial: the clinical effects of a novel neurokinin receptor antagonist, DNK333, in women with diarrhoea-predominant irritable bowel syndrome

(2011) S. Zakko et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Randomised clinical trial: the ileal bile acid transporter inhibitor A3309 vs. placebo in patients with chronic idiopathic constipation - a double-blind study

(2011) M. Simrén et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Mesalazine (5-aminosalicylic acid) alters faecal bacterial profiles, but not mucosal proteolytic activity in diarrhoea-predominant irritable bowel syndrome

(2011) C. N. Andrews et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Systematic review: the effects of fibre in the management of chronic idiopathic constipation

(2011) N. C. Suares et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Opioid-Induced Constipation: Challenges and Therapeutic Opportunities

(2011) Michael Camilleri   AMERICAN JOURNAL OF GASTROENTEROLOGY

A Randomized Placebo-Controlled Phase IIb Trial of A3309, A Bile Acid Transporter Inhibitor, for Chronic Idiopathic Constipation

(2011) William D Chey et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Effect of the α2δ ligand, pregabalin, on colonic sensory and motor functions in healthy adults

(2011) Johanna Iturrino et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Association of TCF7L2 Allelic Variations with Gastric Function, Satiation, and GLP-1 Levels

(2011) Maria I. Vazquez-Roque et al.   CTS-Clinical and Translational Science

Arrows

(2011) Bang Wong   NATURE METHODS

Rifaximin Therapy for Patients with Irritable Bowel Syndrome without Constipation

(2011) Mark Pimentel et al.   NEW ENGLAND JOURNAL OF MEDICINE

The effects of methylnaltrexone alone and in combination with acutely administered codeine on gastrointestinal and colonic transit in health

(2010) B. S. Wong et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Clinical trial: the efficacy and tolerability of velusetrag, a selective 5-HT4 agonist with high intrinsic activity, in chronic idiopathic constipation - a 4-week, randomized, double-blind, placebo-controlled, dose-response study

(2010) M. Goldberg et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Overall Mortality, Incremental Life Expectancy, and Cause of Death at 25 Years in the Program on the Surgical Control of the Hyperlipidemias

(2010) Henry Buchwald et al.   ANNALS OF SURGERY

Efficacy and Safety of Tapentadol Extended Release Compared with Oxycodone Controlled Release for the Management of Moderate to Severe Chronic Pain Related to Osteoarthritis of the Knee

(2010) Marc Afilalo et al.   CLINICAL DRUG INVESTIGATION

Efficacy and Safety of Prucalopride in Patients with Chronic Noncancer Pain Suffering from Opioid-Induced Constipation

(2010) Cornelius E. J. Sloots et al.   DIGESTIVE DISEASES AND SCIENCES

Linaclotide, through activation of guanylate cyclase C, acts locally in the gastrointestinal tract to elicit enhanced intestinal secretion and transit

(2010) Robert W. Busby et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

New-generation 5-HT4 receptor agonists: potential for treatment of gastrointestinal motility disorders

(2010) Noriaki Manabe et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Efficacy and safety of tapentadol extended release for the management of chronic low back pain: results of a prospective, randomized, double-blind, placebo- and active-controlled Phase III study

(2010) Robert Buynak et al.   EXPERT OPINION ON PHARMACOTHERAPY

Chenodeoxycholate in Females With Irritable Bowel Syndrome-Constipation: A Pharmacodynamic and Pharmacogenetic Analysis

(2010) Archana S. Rao et al.   GASTROENTEROLOGY

Linaclotide Improves Abdominal Pain and Bowel Habits in a Phase IIb Study of Patients With Irritable Bowel Syndrome With Constipation

(2010) Jeffrey M. Johnston et al.   GASTROENTEROLOGY

Efficacy of Linaclotide for Patients With Chronic Constipation

(2010) Anthony J. Lembo et al.   GASTROENTEROLOGY

Esophageal Polypoid Mass in a 78-Year-Old Woman

(2010) Sushil K. Ahlawat et al.   GASTROENTEROLOGY

Behavioural and new pharmacological treatments for constipation: getting the balance right

(2010) M. Camilleri et al.   GUT

The mast cell stabiliser ketotifen decreases visceral hypersensitivity and improves intestinal symptoms in patients with irritable bowel syndrome

(2010) T. K. Klooker et al.   GUT

Long-term efficacy and safety of combined prolonged-release oxycodone and naloxone in the management of non-cancer chronic pain

(2010) A. Sandner-Kiesling et al.   INTERNATIONAL JOURNAL OF CLINICAL PRACTICE

Effects of the N-Methyl-D-Aspartate Receptor on Temporal Summation of Second Pain (Wind-up) in Irritable Bowel Syndrome

(2010) QiQi Zhou et al.   JOURNAL OF PAIN

Long-Term Safety and Efficacy of Morphine Sulfate and Naltrexone Hydrochloride Extended Release Capsules, a Novel Formulation Containing Morphine and Sequestered Naltrexone, in Patients with Chronic, Moderate to Severe Pain

(2010) Lynn R. Webster et al.   JOURNAL OF PAIN AND SYMPTOM MANAGEMENT

5-HT4 receptor agonists: similar but not the same

(2010) J. H. De Maeyer et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Identification of subunits of voltage-gated calcium channels and actions of pregabalin on intrinsic primary afferent neurons in the guinea-pig ileum

(2010) K. Needham et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Mu-opioid and noradrenergic α2-adrenoceptor contributions to the effects of tapentadol on spinal electrophysiological measures of nociception in nerve-injured rats

(2010) Lucy A. Bee et al.   PAIN

Bile acids: short and long term effects in the intestine

(2010) Antal Bajor et al.   SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY

Effect of mesalazine on mucosal immune biomarkers in irritable bowel syndrome: a randomized controlled proof-of-concept study

(2009) R. CORINALDESI et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Review article: new receptor targets for medical therapy in irritable bowel syndrome

(2009) M. CAMILLERI   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Do corticotropin releasing factor-1 receptors influence colonic transit and bowel function in women with irritable bowel syndrome?

(2009) Seth Sweetser et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Corticotropin-Releasing Hormone and Mast Cells in the Regulation of Mucosal Barrier Function in the Human Colon

(2009) Conny Wallon et al.   Annals of the New York Academy of Sciences

Substituted 3-(4-(1,3,5-triazin-2-yl)-phenyl)-2-aminopropanoic acids as novel tryptophan hydroxylase inhibitors

(2009) Haihong Jin et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Neurokinin-1 receptor antagonists in the prevention of postoperative nausea and vomiting

(2009) P. Diemunsch et al.   BRITISH JOURNAL OF ANAESTHESIA

Effects of Chenodeoxycholate and a Bile Acid Sequestrant, Colesevelam, on Intestinal Transit and Bowel Function

(2009) Suwebatu T. Odunsi–Shiyanbade et al.   Clinical Gastroenterology and Hepatology

Neuroimaging Placebo Effects: New Tools Generate New Questions

(2009) J M Jarcho et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Effect of Meal Ingestion on Ileocolonic and Colonic Transit in Health and Irritable Bowel Syndrome

(2009) Annemie Deiteren et al.   DIGESTIVE DISEASES AND SCIENCES

Atypical Antipsychotic Quetiapine in the Management of Severe Refractory Functional Gastrointestinal Disorders

(2009) Madhusudan Grover et al.   DIGESTIVE DISEASES AND SCIENCES

W1041 SP-304 to Treat GI Disorders - Effects of a Single, Oral-Dose of SP-304 On Safety, Tolerability, Pharmacokinetics and Pharmacodynamics in Healthy Volunteers

(2009) Kunwar Shailubhai et al.   GASTROENTEROLOGY

Activation of Intestinal Cl− Secretion by Lubiprostone Requires the Cystic Fibrosis Transmembrane Conductance Regulator

(2009) Marcel J.C. Bijvelds et al.   GASTROENTEROLOGY

Developing Irritable Bowel Syndrome Guidelines Through Meta-analyses: Does the Emperor Really Have New Clothes?

(2009) Michael Camilleri et al.   GASTROENTEROLOGY

Postprandial Changes in Small Bowel Water Content in Healthy Subjects and Patients With Irritable Bowel Syndrome

(2009) Luca Marciani et al.   GASTROENTEROLOGY

Risk of venous thromboembolism in hospitalized patients with peripherally inserted central catheters

(2009) Bob L. Lobo et al.   Journal of Hospital Medicine

Efficacy and safety of casopitant mesylate, a neurokinin 1 (NK1)-receptor antagonist, in prevention of chemotherapy-induced nausea and vomiting in patients receiving cisplatin-based highly emetogenic chemotherapy: a randomised, double-blind, placebo-controlled trial

(2009) Steven M Grunberg et al.   LANCET ONCOLOGY

Safety assessment of prucalopride in elderly patients with constipation: a double-blind, placebo-controlled study

(2009) m. camilleri et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Intestinal membrane permeability and hypersensitivity in the irritable bowel syndrome

(2009) QiQi Zhou et al.   PAIN

Update on Abuse-Resistant and Abuse-Deterrent Approaches to Opioid Formulations

(2009) Lynn Webster   PAIN MEDICINE

Clinical trial: asimadoline in the treatment of patients with irritable bowel syndrome

(2008) A. W. MANGEL et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Amitriptyline modifies the visceral hypersensitivity response to acute stress in the irritable bowel syndrome

(2008) N. M. THOUA et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Clinical trial: the glucagon-like peptide-1 analogue ROSE-010 for management of acute pain in patients with irritable bowel syndrome: a randomized, placebo-controlled, double-blind study

(2008) P. M. HELLSTRÖM et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Clinical trial: the efficacy, impact on quality of life, and safety and tolerability of prucalopride in severe chronic constipation - a 12-week, randomized, double-blind, placebo-controlled study

(2008) E. M. M. QUIGLEY et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Response to Dr. Kartsonis

(2008) John F. Johanson   AMERICAN JOURNAL OF GASTROENTEROLOGY

Pilot Study on the Effect of Linaclotide in Patients With Chronic Constipation

(2008) Jeffrey M Johnston et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Dose-response effect of a β3-adrenergic receptor agonist, solabegron, on gastrointestinal transit, bowel function, and somatostatin levels in health

(2008) April B. M. Grudell et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Effect of a chloride channel activator, lubiprostone, on colonic sensory and motor functions in healthy subjects

(2008) Seth Sweetser et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Activation of prostaglandin EP receptors by lubiprostone in rat and human stomach and colon

(2008) A K Bassil et al.   BRITISH JOURNAL OF PHARMACOLOGY

Effects of pregabalin on visceral pain responses and colonic compliance in rats

(2008) A Ravnefjord et al.   BRITISH JOURNAL OF PHARMACOLOGY

A Phase II Trial of the Novel Serotonin Type 3 Receptor Antagonist Ramosetron in Japanese Male and Female Patients with Diarrhea-Predominant Irritable Bowel Syndrome

(2008) K. Matsueda et al.   DIGESTION

A randomised controlled trial with prolonged-release oral oxycodone and naloxone to prevent and reverse opioid-induced constipation

(2008) Winfried Meissner et al.   EUROPEAN JOURNAL OF PAIN

In Vitro Characterization of Viral Fitness of Therapy-Resistant Hepatitis B Variants

(2008) Stéphanie Villet et al.   GASTROENTEROLOGY

Prucalopride (Resolor) in the treatment of severe chronic constipation in patients dissatisfied with laxatives

(2008) J Tack et al.   GUT

Modulation of Peripheral Serotonin Levels by Novel Tryptophan Hydroxylase Inhibitors for the Potential Treatment of Functional Gastrointestinal Disorders

(2008) Zhi-Cai Shi et al.   JOURNAL OF MEDICINAL CHEMISTRY

Analgesic Efficacy and Safety of Oxycodone in Combination With Naloxone as Prolonged Release Tablets in Patients With Moderate to Severe Chronic Pain

(2008) Dana Vondrackova et al.   JOURNAL OF PAIN

The in vitro pharmacological profile of TD-5108, a selective 5-HT4 receptor agonist with high intrinsic activity

(2008) J. A. M. Smith et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

The in vivo gastrointestinal activity of TD-5108, a selective 5-HT4 receptor agonist with high intrinsic activity

(2008) D. T. Beattie et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

GLP-1 suppresses gastrointestinal motility and inhibits the migrating motor complex in healthy subjects and patients with irritable bowel syndrome

(2008) p. m. hellström et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Effects of serotonin 5-HT3receptor antagonists on stress-induced colonic hyperalgesia and diarrhoea in rats: a comparative study with opioid receptor agonists, a muscarinic receptor antagonist and a synthetic polymer

(2008) t. hirata et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Methylnaltrexone for Opioid-Induced Constipation in Advanced Illness

(2008) Jay Thomas et al.   NEW ENGLAND JOURNAL OF MEDICINE

A Placebo-Controlled Trial of Prucalopride for Severe Chronic Constipation

(2008) Michael Camilleri et al.   NEW ENGLAND JOURNAL OF MEDICINE

Alvimopan, a peripherally acting mu-opioid receptor (PAM-OR) antagonist for the treatment of opioid-induced bowel dysfunction: Results from a randomized, double-blind, placebo-controlled, dose-finding study in subjects taking opioids for chronic non-cancer pain

(2008) Lynn Webster et al.   PAIN

Effects of lubiprostone on human uterine smooth muscle cells

(2008) John Cuppoletti et al.   PROSTAGLANDINS & OTHER LIPID MEDIATORS

A randomized, double-blind, placebo-controlled clinical trial of the effectiveness of the novel serotonin type 3 receptor antagonist ramosetron in both male and female Japanese patients with diarrhea-predominant irritable bowel syndrome

(2008) Kei Matsueda et al.   SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY