Article
Biochemistry & Molecular Biology
Maria Pia Adorni, Marta Biolo, Francesca Zimetti, Marcella Palumbo, Nicoletta Ronda, Paolo Scarinzi, Paolo Simioni, Maria Giovanna Lupo, Nicola Ferri, Lorenzo Previato, Franco Bernini, Alberto Zambon
Summary: Achilles tendon xanthoma formation is related to macrophage cholesterol accumulation and is influenced by lipoprotein dysfunctions. The HDL capacity to promote cholesterol efflux is increased in patients with ATX, while ABCG1-mediated HDL-CEC is decreased and serum CLC is increased. These lipoprotein dysfunctions are correlated with ATX thickness in FH patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cardiac & Cardiovascular Systems
Juan Francisco Aranda, Ana Perez-Garcia, Marta Torrecilla-Parra, Mario Fernandez-de Frutos, Yolanda Martin-Martin, Pedro A. Mateos-Gomez, Virginia Pardo-Marques, Rebeca Busto, Cristina M. Ramirez
Summary: Hypoxia plays a crucial role in the maintenance of atherosclerotic lesions. miR-199a-5p and ABCA1 are inversely regulated by hypoxia and Ac-LDL, and their interaction can control macrophage cholesterol efflux during the onset of atherosclerosis.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Immunology
Haidong Zhao, Mingli Wu, Xiaoqin Tang, Qi Li, Xiaohua Yi, Wanxia Zhao, Xiuzhu Sun
Summary: This study reveals the metabolic mechanism of subcutaneous adipose tissue in chicks, demonstrates the crucial role of FFA-induced Ccl2 (chicken CCL26) secretion in lipid transportation, and identifies the significant involvement of macrophages in this process.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Ann-Kathrin Gaiser, Shanna Bauer, Stephanie Ruez, Karlheinz Holzmann, Marcus Faendrich, Tatiana Syrovets, Thomas Simmet
Summary: AA amyloidosis is a type of amyloid disease that is associated with various chronic inflammatory conditions. The disease is characterized by the deposition of amyloid fibrils formed by serum amyloid A1 (SAA1), leading to organ failure. Research suggests that SAA1 affects macrophage phenotype and function, with potential implications for intervention strategies in AA amyloidosis utilizing M1-polarized macrophages.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Zhexiao Zhang, Yunmei Qiu, Wanzhi Li, Anyang Tang, Hang Huang, Wanyi Yao, Huawen Li, Tangbin Zou
Summary: It is widely believed that the deposition of foam cells in the arterial wall is the main cause of atherosclerosis. However, our experimental results suggest that astaxanthin can promote cholesterol efflux by modulating ATP-binding cassette subfamily A member 1, thereby inhibiting foam cell formation and preventing the occurrence and development of atherosclerosis.
Article
Biochemistry & Molecular Biology
Shiva Ganjali, Susan Hosseini, Manfredi Rizzo, Anatol Kontush, Amirhossein Sahebkar
Summary: This study evaluated the capacity of high-density lipoprotein (HDL) to transport cholesterol from lipid-loaded macrophages and aimed to find a reliable and low-cost biomarker for assessing the risk of premature cardiovascular events in patients with familial hypercholesterolemia (FH). HDL subfractions (HDL2 and HDL3) were isolated and their cholesterol efflux capacity (CEC%) was measured in FH patients and healthy subjects. The results showed that both HDL2 and HDL3 had reduced CEC% in homozygous FH patients compared to heterozygous FH patients and healthy subjects. Logistic regression analysis revealed a strong inverse association between CEC% and the homozygous form of FH. Decreased HDL cholesterol efflux capacity may help identify homozygous FH patients at increased risk for premature cardiovascular diseases. Prospective studies are needed to further evaluate this hypothesis.
Article
Microbiology
Yutao Ye, Jun Liu, Yang Guo, Yujie Gao, Jiayue Rao, Rigu Su, Lu Zhang, Zikun Huang, Qing Luo, Junming Li
Summary: This study investigates the role of PPAR gamma in the formation of foamy macrophages induced by Mtb infection. The results show that the expression of PPAR gamma decreases while lipid body formation increases in response to H37Ra infection. The PPAR gamma antagonist GW9662 enhances lipid body formation and inhibits ABCG1 expression. Additionally, TLR2 plays a greater role in regulating ABCG1 compared to PPAR gamma.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Ilaria Zanotti, Francesco Poti, Marina Cuchel
Summary: HDL plays an antiatherogenic role by accepting cholesterol from cells and promoting reverse cholesterol transport, with cholesterol efflux capacity being associated with cardiovascular risk in various human cohorts. These findings support the protective role of RCT in humans.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
(2022)
Article
Hematology
Svetlana A. Didichenko, Elena Velkoska, Alexei V. Navdaev, Brandon H. Greene, Shuhui Wang Lorkowski, Danielle Duffy, Sojaita J. Mears, Samuel D. Wright, C. Michael Gibson, Jonathan D. Smith, Bronwyn A. Kingwell
Summary: CSL112 infusion enhances HDL functionality in patients with acute myocardial infarction by increasing APOA1 exchange rate and improving cholesterol efflux capacity. The study reveals that specific HDL subpopulations, especially SAA-poor HDL particles, are involved in HDL-APOA1 exchange. This suggests that CSL112 improves the functional status of HDL in post-acute myocardial infarction patients.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2023)
Article
Materials Science, Multidisciplinary
Chao -ping He, Wen-juan Quan, Ya-ling Zeng, Hong-yan Zhou, Pei-dong You, Zhen-xian Li, Ya-mei Li, Li-mei Lin, Bin Liu, Duan-fang Liao, Qin-hui Tuo
Summary: In this study, a compound of curcumin nicotinate (CN) was synthesized and loaded onto biomimetic nanosystem constructed by Prussian blue nanoparticles (PB NPs) to improve its solubility. Hyaluronic acid (HA) modification was adopted to prolong circulation time and improve the accumulation of drugs in the plaque region. The designed nano-platform showed potential for prevention and targeted therapy of atherosclerosis through specific pathways.
MATERIALS & DESIGN
(2023)
Article
Endocrinology & Metabolism
Cristina M. Ramirez, Marta Torrecilla-Parra, Virginia Pardo-Marques, Mario Fernandez de-Frutos, Ana Perez-Garcia, Carlos Tabraue, Juan Vladimir de la Rosa, Patricia Martin-Rodriguez, Mercedes Diaz-Sarmiento, Uxue Nunez, Marta C. Orizaola, Paqui G. Traves, Marta Camps, Lisardo Bosca, Antonio Castrillo
Summary: Macrophages are immune cells crucial for host defense, with the LXR-Cav-1 axis on the cell membrane playing a significant role in cholesterol efflux and inflammatory responses. Modulation of this axis could potentially control exacerbated inflammation and cholesterol overload in macrophages during lipid and immune disorders.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Review
Medicine, General & Internal
Timothy J. Kopper, Xiaoli Yu, Michael W. Graner
Summary: Glioblastomas (GBM) is a devastating disease with poor clinical outcomes. Tumor-derived extracellular vesicles (EVs) impair macrophage function and promote tumor growth. The interaction between macrophages/microglia and gliomas plays a significant role in GBM pathophysiology.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Chemistry, Multidisciplinary
Lang Chen, Chenyan Yu, Wanting Xu, Yuan Xiong, Peng Cheng, Ze Lin, Zhenhe Zhang, Leonard Knoedler, Adriana C. Panayi, Samuel Knoedler, Junqing Wang, Bobin Mi, Guohui Liu
Summary: Ongoing research has shown that the interaction between macrophages and mesenchymal stem cells (MSCs) is significant. Lysine-specific demethylase 6B (KDM6B) has been found to control the osteogenic differentiation of MSCs. However, the role of KDM6B in bone marrow-derived macrophages (BMDMs) is still controversial. This study demonstrates that KDM6B serves as a positive regulator for osteogenic differentiation by decreasing the M1/M2 ratio both in vitro and in vivo.
Article
Biochemistry & Molecular Biology
Maria Pia Adorni, Bianca Papotti, Maria Orietta Borghi, Elena Raschi, Francesca Zimetti, Franco Bernini, Pier Luigi Meroni, Nicoletta Ronda
Summary: This study investigates the direct effects of tofacitinib on macrophage cholesterol metabolism, finding that it can increase cholesterol efflux, decrease cholesterol uptake and synthesis, and have a favorable impact on macrophage cholesterol metabolism. These findings are important for understanding the impact of tofacitinib on cardiovascular risk.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
Sabrina Robichaud, Garrett Fairman, Viyashini Vijithakumar, Esther Mak, David P. Cook, Alexander R. Pelletier, Sylvain Huard, Barbara C. Vanderhyden, Daniel Figeys, Mathieu Lavallee-Adam, Kristin Baetz, Mireille Ouimet
Summary: The study identified multiple lipid droplet-associated proteins involved in lipophagy in macrophages, highlighting their importance in the process. Targeting these proteins to enhance lipophagy for promoting cholesterol efflux in foam cells may represent a novel therapeutic strategy for atherosclerosis.
Review
Medicine, General & Internal
Alice Bellicha, Muriel Coupaye, Helena Mosbah, Maithe Tauber, Jean-Michel Oppert, Christine Poitou
Summary: Patients with PWS have lower habitual PA compared to controls, but PA interventions can increase lean body mass and bone parameters, as well as improve physical function without significant impact on weight and fat mass. Support should be provided to families to facilitate the implementation of supervised PA programs.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Endocrinology & Metabolism
Beatrice Dubern, Helena Mosbah, Marie Pigeyre, Karine Clement, Christine Poitou
Summary: Rare genetic forms of obesity are caused by dysfunction in hypothalamic pathways. The French National Protocol for the Diagnosis and Care of Rare Causes of Obesity provides practical recommendations for assessment and management at all ages. Clinical management is particularly challenging due to the complexity of obesity-related comorbidities and neuropsychological/psychiatric disorders. Strategies for preventing obesity aggravation include limiting access to food, creating a supportive daily eating environment, and engaging in sustained adapted supervised daily physical activity. Genetic diagnosis allows for personalized medicine approaches and improved analysis of the risk/benefit ratio of bariatric surgery.
ANNALES D ENDOCRINOLOGIE
(2022)
Review
Genetics & Heredity
Juliette Coursimault, Anne-Marie Guerrot, Michelle M. Morrow, Catherine Schramm, Francisca Millan Zamora, Anita Shanmugham, Shuxi Liu, Fanggeng Zou, Frederic Bilan, Gwenael Le Guyader, Ange-Line Bruel, Anne-Sophie Denomme-Pichon, Laurence Faivre, Frederic Tran Mau-Them, Marine Tessarech, Estelle Colin, Salima El Chehadeh, Benedicte Gerard, Elise Schaefer, Benjamin Cogne, Bertrand Isidor, Mathilde Nizon, Diane Doummar, Stephanie Valence, Delphine Heron, Boris Keren, Cyril Mignot, Charles Coutton, Francoise Devillard, Anne-Sophie Alaix, Jeanne Amiel, Laurence Colleaux, Arnold Munnich, Karine Poirier, Marlene Rio, Sophie Rondeau, Giulia Barcia, Bert Callewaert, Annelies Dheedene, Candy Kumps, Sarah Vergult, Bjoern Menten, Wendy K. Chung, Rebecca Hernan, Austin Larson, Kelly Nori, Sarah Stewart, James Wheless, Christina Kresge, Beth A. Pletcher, Roseline Caumes, Thomas Smol, Sabine Sigaudy, Christine Coubes, Margaret Helm, Rosemarie Smith, Jennifer Morrison, Patricia G. Wheeler, Amy Kritzer, Guillaume Jouret, Alexandra Afenjar, Jean-Francois Deleuze, Robert Olaso, Anne Boland, Christine Poitou, Thierry Frebourg, Claude Houdayer, Pascale Saugier-Veber, Gael Nicolas, Francois Lecoquierre
Summary: Pathogenic variants of the MYT1L gene cause a syndromic neurodevelopmental disorder characterized by developmental delay, intellectual disability, overweight or obesity, behavioral disorders, and epilepsy. Additional clinical features include learning disabilities, feeding difficulties, and varied dysmorphic features. Highly clustered missense variants do not show significant clinical differences compared to truncating variants. This study provides updated clinical and genetic data for improved diagnosis and management of MYT1L-associated neurodevelopmental disorder patients.
Article
Endocrinology & Metabolism
Pierre Bel Lassen, Nicole Nori, Pierre Bedossa, Laurent Genser, Judith Aron-Wisnewsky, Christine Poitou, Rambabu Surabattula, Mette Juul Nielsen, Morten Asser Karsdal, Diana Julie Leeming, Detlef Schuppan, Karine Clement
Summary: The study found that PRO-C3 is associated with advanced liver fibrosis in patients with severe obesity and decreased after bariatric surgery, without being affected by adipose tissue fibrosis. These data suggest that bariatric surgery prominently eliminates drivers of hepatic fibrogenesis in nonalcoholic fatty liver disease.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Surgery
Mellody Cooiman, Suzanne I. M. Alsters, Maeva Duquesnoy, Eric J. Hazebroek, Hanne J. Meijers-Heijboer, Harvinder Chahal, Johanne Le Beyec-Le Bihan, Karine Clement, Hedi Soula, Alex Blakemore, Christine Poitou, Mieke M. van Haelst
Summary: This multicenter study compares the weight loss and regain outcomes in bariatric surgery patients with MC4R variants to matched controls. The study reveals that cases with MC4R variants show inferior weight outcomes after SG compared to RYGB, highlighting the need for lifelong management to prevent relapse.
Article
Genetics & Heredity
Peter Kuehnen, Martin Wabitsch, Julia von Schnurbein, Costel Chirila, Usha G. Mallya, Patrick Callahan, Ari Gnanasakthy, Christine Poitou, Philipp M. Krabusch, Murray Stewart, Karine Clement
Summary: Individuals with POMC or LEPR deficiency have impaired quality of life before setmelanotide treatment, but setmelanotide can improve their quality of life in the short term, reducing hunger and body weight.
ORPHANET JOURNAL OF RARE DISEASES
(2022)
Article
Endocrinology & Metabolism
Helena Mosbah, Marie-Christine Vantyghem, Estelle Nobecourt, Fabrizio Andreelli, Francoise Archambeaud, Elise Bismuth, Claire Briet, Maryse Cartigny, Benjamin Chevalier, Bruno Donadille, Anne Daguenel, Mathilde Fichet, Jean-Francois Gautier, Sonja Janmaat, Isabelle Jeru, Carole Legagneur, Lysiane Leguier, Julie Maitre, Elise Mongeois, Christine Poitou, Eric Renard, Yves Reznik, Anne Spiteri, Florence Travert, Bruno Verges, Jamila Zammouri, Corinne Vigouroux, Camille Vatier
Summary: Metreleptin therapy improved metabolic outcomes in patients with generalized lipodystrophy (GLD), while the therapeutic indication for metreleptin needs clarification in patients with partial lipodystrophy (PLD).
DIABETES OBESITY & METABOLISM
(2022)
Article
Surgery
Alice Bellicha, Pierre Bel Lassen, Christine Poitou, Laurent Genser, Florence Marchelli, Judith Aron-Wisnewsky, Cecile Ciangura, Flavien Jacques, Pauline Moreau, Karine Clement, Jean-Michel Oppert
Summary: This study aimed to analyze the relationship between changes in physical activity (PA) during COVID-19 lockdowns and changes in lifestyle and psychological outcomes in post-bariatric surgery patients. The study found that patients who reported decreased PA during the lockdown were more likely to experience weight gain, increased fatigue, worsening eating behavior, and depressive symptoms. Follow-up measures are needed to assess the long-term effects of lockdown.
Article
Surgery
Pauline Faucher, Claire Carette, Anne-Sophie Jannot, Blandine Gatta-Cherifi, Alexis Van Straaten, Marie-Astrid Piquet, Gerald Raverot, Maud Alligier, Thibault Batisse, Olivier Ziegler, Delphine Drui, Marion Bretault, Nicolas Farigon, Karem Slim, Laurent Genser, Tigran Poghosyan, Karina Vychnevskaia, Claire Blanchard, Maud Robert, Caroline Gronnier, Christine Poitou, Sebastien Czernichow
Summary: This study aims to investigate the long-term efficacy and safety of bariatric surgery in patients with craniopharyngioma. The results show that bariatric surgery can lead to significant weight loss in craniopharyngioma patients, although the effect is less compared to patients with common obesity. Sleeve gastrectomy may be more effective than Roux-en-Y gastric bypass.
Review
Medicine, General & Internal
Pauline Dodet, Federica Sanapo, Smaranda Leu-Semenescu, Muriel Coupaye, Alice Bellicha, Isabelle Arnulf, Christine Poitou, Stefania Redolfi
Summary: Prader-Willi syndrome is a rare genetic disease associated with sleep alterations, particularly excessive daytime sleepiness. Patients with PWS have impaired ventilatory control and respiratory abnormalities, which are severe during sleep. Sleep studies and objective measurements of excessive daytime sleepiness are recommended. The use of wake-enhancing drugs should be carefully considered due to potential psychological and cardiovascular side effects.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Gastroenterology & Hepatology
Jean Debedat, Tiphaine Le Roy, Lise Voland, Eugeni Belda, Rohia Alili, Solia Adriouch, Pierre Bel Lassen, Kazuyuki Kasahara, Evan Hutchison, Laurent Genser, Licia Torres, Camille Gamblin, Christine Rouault, Jean-Daniel Zucker, Nathalie Kapel, Christine Poitou, Genevieve Marcelin, Federico E. Rey, Judith Aron-Wisnewsky, Karine Clement
Summary: Our study suggests a causal relationship between changes in gut microbiota and weight loss and T2D improvements after RYGB surgery. An increase in gut bacteria in severe cases may lead to metabolic abnormalities, while unresolved T2D cases are not associated with this enrichment.
Review
Endocrinology & Metabolism
Christine Poitou, Anthony Holland, Charlotte Hoybye, Laura C. G. de Graaff, Sandrine Bottius, Berit Otterlei, Maithe Tauber
Summary: Prader-Willi syndrome (PWS) is a common neurodevelopmental genetic disorder characterized by obesity, endocrine disorders, and psychiatric issues. The transition from adolescence to adulthood in individuals with PWS can be challenging due to multiple comorbidities and complex disabilities. Medical care for PWS individuals may be inadequate due to a lack of understanding of the syndrome and a lack of specialized skills.
ENDOCRINE CONNECTIONS
(2023)
Article
Endocrinology & Metabolism
Blandine Gatta-Cherifi, Alexandre Laboye, Caroline Gronnier, Maud Monsaingeon-Henry, Sarah Meulebrouck, Morgane Baron, Francoise Bertin, Emilie Pupier, Sophie Cambos, Christine Poitou, Johanne Le Beyec-Le Bihan, Amelie Bonnefond
Summary: A new pathogenic mutation in the MRAP2 gene was identified in a patient with severe multifactorial obesity, confirming the metabolic phenotype in this monogenic form of obesity.
EUROPEAN JOURNAL OF ENDOCRINOLOGY
(2023)
Meeting Abstract
Biochemistry & Molecular Biology
Juliette Coursimault, Anne-Marie Guerrot, Michelle Morrow, Bert Callewaert, Sarah Vergult, Laurence Faivre, Frederic Tran Mau-Them, Ange-Line Bruel, Estelle Colin, Marine Tessarech, Mathilde Nizon, Benjamin Cogne, Bertrand Isidor, Cyril Mignot, Diane Doummar, Boris Keren, Stephanie Valence, Delphine Heron, Francoise Devillard, Charles Coutton, Marlene Rio, Karine Poirier, Elise Schaefer, Benedicte Gerard, Gwenael Le Guyader, Frederic Bilan, Wendy Chung, Rebecca Hernan, Austin Larson, Kelly Nori, Sarah Stewart, James Wheless, Salima El Chehadeh, Beth Pletcher, Christina Kresge, Margaret Helm, Laurence Colleaux, Anne-Sophie Alaix, Jeanne Amiel, Sophie Rondeau, Roseline Caumes, Thomas Smol, Sabine Sigaudy, Alexandra Afenjar, Christine Coubes, Christine Poitou, Thierry Frebourg, Pascale Saugier-Veber, Gael Nicolas, Francois Lecoquierre
EUROPEAN JOURNAL OF HUMAN GENETICS
(2022)
Article
Clinical Neurology
Liane Schmidt, Evelyn Medawar, Judith Aron-Wisnewsky, Laurent Genser, Christine Poitou, Karine Clement, Hilke Plassmann
Summary: This study examined the differences in ventromedial prefrontal cortex resting-state connectivity between obese and lean participants, finding that this connectivity could predict weight changes over time. Specifically, the ventromedial prefrontal cortex-ventral striatum resting-state connectivity played a key role in predicting weight changes in the study.
BRAIN COMMUNICATIONS
(2021)