PPARγ Ameliorates Mycobacterium tuberculosis H37Ra-Induced Foamy Macrophage Formation via the ABCG1-Dependent Cholesterol Efflux Pathway in THP-1 Macrophages

Mycobacterium tuberculosis Infection-Driven Foamy Macrophages and Their Implications in Tuberculosis Control as Targets for Host-Directed Therapy

(2020) Dahee Shim et al.   Frontiers in Immunology

Lipid Uptake by Alveolar Macrophages Drives Fibrotic Responses to Silica Dust

(2019) Xiaomin Hou et al.   Scientific Reports

Mycobacterium tuberculosis and macrophage nuclear receptors: What we do and don't know

(2019) Chrissy M. Leopold Wager et al.   TUBERCULOSIS

Foam Cells: One Size Doesn’t Fit All

(2019) Valentina Guerrini et al.   TRENDS IN IMMUNOLOGY

Lipid metabolism and its implication in mycobacteria–host interaction

(2018) Gabriela Gago et al.   CURRENT OPINION IN MICROBIOLOGY

IL-36/LXR axis modulates cholesterol metabolism and immune defense to Mycobacterium tuberculosis

(2018) Fadhil Ahsan et al.   Scientific Reports

Beyond the Foam Cell: The Role of LXRs in Preventing Atherogenesis

(2018) Adil Rasheed et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Storage lipid studies in tuberculosis reveal that foam cell biogenesis is disease-specific

(2018) Valentina Guerrini et al.   PLoS Pathogens

Allicin induces the upregulation of ABCA1 expression via PPARγ/LXRα signaling in THP-1 macrophage-derived foam cells

(2017) Xiao-Long Lin et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Characterization of a secretory hydrolase fromMycobacterium tuberculosissheds critical insight into host lipid utilization byM. tuberculosis

(2017) Khundrakpam Herojit Singh et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PPAR-γ and Akt regulate GLUT1 and GLUT3 surface localization during Mycobacterium tuberculosis infection

(2017) Shyamashree Dasgupta et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

ROS via BTK-p300-STAT1-PPARγ signaling activation mediates cholesterol crystals-induced CD36 expression and foam cell formation

(2017) Sivareddy Kotla et al.   Redox Biology

Anti-atherosclerotic potential of baicalin mediated by promoting cholesterol efflux from macrophages via the PPARγ-LXRα-ABCA1/ABCG1 pathway

(2016) Xin-Wei He et al.   BIOMEDICINE & PHARMACOTHERAPY

Chewing the fat: lipid metabolism and homeostasis during M. tuberculosis infection

(2016) Rustin R Lovewell et al.   CURRENT OPINION IN MICROBIOLOGY

CD36-Mediated Uptake of Surfactant Lipids by Human Macrophages Promotes Intracellular Growth ofMycobacterium tuberculosis

(2016) Claire E. Dodd et al.   JOURNAL OF IMMUNOLOGY

Macrophage defense mechanisms against intracellular bacteria

(2015) Günter Weiss et al.   IMMUNOLOGICAL REVIEWS

M. tuberculosis Secretory Protein ESAT-6 Induces Metabolic Flux Perturbations to Drive Foamy Macrophage Differentiation

(2015) Varshneya Singh et al.   Scientific Reports

Outcome of Mycobacterium tuberculosis and Toll-like receptor interaction: immune response or immune evasion?

(2014) Iti Saraav et al.   IMMUNOLOGY AND CELL BIOLOGY

Mycobacterium tuberculosis Modulates Macrophage Lipid-Sensing Nuclear Receptors PPAR  and TR4 for Survival

(2012) S. Mahajan et al.   JOURNAL OF IMMUNOLOGY

Restoration of PPARγ reverses lipid accumulation in alveolar macrophages of GM-CSF knockout mice

(2010) Anagha Malur et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Mycobacterium bovis Bacillus Calmette-Guerin Infection Induces TLR2-Dependent Peroxisome Proliferator-Activated Receptor   Expression and Activation: Functions in Inflammation, Lipid Metabolism, and Pathogenesis

(2009) P. E. Almeida et al.   JOURNAL OF IMMUNOLOGY

Foamy macrophages and the progression of the human tuberculosis granuloma

(2009) David G Russell et al.   NATURE IMMUNOLOGY

Foamy Macrophages from Tuberculous Patients' Granulomas Constitute a Nutrient-Rich Reservoir for M. tuberculosis Persistence

(2008) Pascale Peyron et al.   PLoS Pathogens