The joint power of sex and stress to modulate brain-gut-microbiota axis and intestinal barrier homeostasis: implications for irritable bowel syndrome

Gut Microbiota: The Conductor in the Orchestra of Immune–Neuroendocrine Communication

(2015) Sahar El Aidy et al.   CLINICAL THERAPEUTICS

Psychological comorbidity increases the risk for postinfectious IBS partly by enhanced susceptibility to develop infectious gastroenteritis

(2015) Mira M Wouters et al.   GUT

The role of mast cells in functional GI disorders

(2015) Mira M Wouters et al.   GUT

Gut chemosensing mechanisms

(2015) Arianna Psichas et al.   JOURNAL OF CLINICAL INVESTIGATION

Sexual dimorphism in autoimmunity

(2015) Kira Rubtsova et al.   JOURNAL OF CLINICAL INVESTIGATION

60 YEARS OF NEUROENDOCRINOLOGY: Redefining neuroendocrinology: stress, sex and cognitive and emotional regulation

(2015) Bruce S McEwen et al.   JOURNAL OF ENDOCRINOLOGY

Estrogen modulates intestinal mucus physiochemical properties and protects against oxidant injury

(2015) Mark E. Diebel et al.   Journal of Trauma and Acute Care Surgery

Regulatory immune cells in regulation of intestinal inflammatory response to microbiota

(2015) M Sun et al.   Mucosal Immunology

Gender differences in irritable bowel syndrome: the interpersonal connection

(2015) E. R. Thakur et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Inflammation-induced pain sensitization in men and women

(2015) Alexander Wegner et al.   PAIN

The Olfactory Receptor OR51E1 Is Present along the Gastrointestinal Tract of Pigs, Co-Localizes with Enteroendocrine Cells and Is Modulated by Intestinal Microbiota

(2015) Davide Priori et al.   PLoS One

Rhythmicity of the intestinal microbiota is regulated by gender and the host circadian clock

(2015) Xue Liang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sex-based differences in immune function and responses to vaccination

(2015) S. L. Klein et al.   TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE

Estrogen modulates intestinal mucus physiochemical properties and protects against oxidant injury

(2015) Mark E. Diebel et al.   Journal of Trauma and Acute Care Surgery

Sex differences in gut fermentation and immune parameters in rats fed an oligofructose-supplemented diet

(2015) Padmaja Shastri et al.   Biology of Sex Differences

Stress disrupts intestinal mucus barrier in rats via mucin O-glycosylation shift: prevention by a probiotic treatment

(2014) Stéphanie Da Silva et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Exposure to a social stressor disrupts the community structure of the colonic mucosa-associated microbiota

(2014) Jeffrey D Galley et al.   BMC MICROBIOLOGY

Gut response induced by weaning in piglet features marked changes in immune and inflammatory response

(2014) Lorenzo Bomba et al.   FUNCTIONAL & INTEGRATIVE GENOMICS

Epigenetic upregulation of metabotropic glutamate receptor 2 in the spinal cord attenuates oestrogen-induced visceral hypersensitivity

(2014) Dong-Yuan Cao et al.   GUT

Glutamine Enhances Tight Junction Protein Expression and Modulates Corticotropin-Releasing Factor Signaling in the Jejunum of Weanling Piglets

(2014) Hao Wang et al.   JOURNAL OF NUTRITION

Modulation of enteric neurons by interleukin-6 and corticotropin-releasing factor contributes to visceral hypersensitivity and altered colonic motility in a rat model of irritable bowel syndrome

(2014) Maria M. Buckley et al.   JOURNAL OF PHYSIOLOGY-LONDON

Policy: NIH to balance sex in cell and animal studies

(2014) Janine A. Clayton et al.   NATURE

A role for the gut microbiota in IBS

(2014) Stephen M. Collins   Nature Reviews Gastroenterology & Hepatology

Are there sex differences in placebo analgesia during visceral pain processing? A fMRI study in healthy subjects

(2014) N. Theysohn et al.   NEUROGASTROENTEROLOGY AND MOTILITY

A sustained hypothalamic–pituitary–adrenal axis response to acute psychosocial stress in irritable bowel syndrome

(2014) P. J. Kennedy et al.   PSYCHOLOGICAL MEDICINE

Sex hormones in the modulation of irritable bowel syndrome

(2014) Agata Mulak   WORLD JOURNAL OF GASTROENTEROLOGY

Gender-related differences in irritable bowel syndrome: Potential mechanisms of sex hormones

(2014) Mathieu Meleine   WORLD JOURNAL OF GASTROENTEROLOGY

Individual diet has sex-dependent effects on vertebrate gut microbiota

(2014) Daniel I. Bolnick et al.   Nature Communications

Circulating testosterone and estradiol, autonomic balance and baroreflex sensitivity in middle-aged and elderly men with heart failure

(2013) Agnieszka Rydlewska et al.   Aging Male

Diet Complexity and Estrogen Receptor β Status Affect the Composition of the Murine Intestinal Microbiota

(2013) Rani Menon et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Altered gut microbiota and activity in a murine model of autism spectrum disorders

(2013) Caroline G.M. de Theije et al.   BRAIN BEHAVIOR AND IMMUNITY

The adoptive transfer of behavioral phenotype via the intestinal microbiota: experimental evidence and clinical implications

(2013) Stephen M Collins et al.   CURRENT OPINION IN MICROBIOLOGY

Consumption of Fermented Milk Product With Probiotic Modulates Brain Activity

(2013) Kirsten Tillisch et al.   GASTROENTEROLOGY

Rifaximin Alters Intestinal Bacteria and Prevents Stress-Induced Gut Inflammation and Visceral Hyperalgesia in Rats

(2013) Dabo Xu et al.   GASTROENTEROLOGY

Taste receptors of the gut: emerging roles in health and disease

(2013) Inge Depoortere   GUT

Impaired duodenal mucosal integrity and low-grade inflammation in functional dyspepsia

(2013) Hanne Vanheel et al.   GUT

Psychological stress and corticotropin-releasing hormone increase intestinal permeability in humans by a mast cell-dependent mechanism

(2013) Tim Vanuytsel et al.   GUT

Gender Bias in Autoimmunity Is Influenced by Microbiota

(2013) Leonid Yurkovetskiy et al.   IMMUNITY

Sexually Dimorphic Effects of Unpredictable Early Life Adversity on Visceral Pain Behavior in a Rodent Model

(2013) Aaron Chaloner et al.   JOURNAL OF PAIN

The microbiome: stress, health and disease

(2013) Rachel D. Moloney et al.   MAMMALIAN GENOME

Microbiota is essential for social development in the mouse

(2013) L Desbonnet et al.   MOLECULAR PSYCHIATRY

Diet rapidly and reproducibly alters the human gut microbiome

(2013) Lawrence A. David et al.   NATURE

The gastrointestinal mucus system in health and disease

(2013) Malin E. V. Johansson et al.   Nature Reviews Gastroenterology & Hepatology

Corticosterone mediates stress-related increased intestinal permeability in a region-specific manner

(2013) G. Zheng et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Visceral hypersensitivity in female but not in male serotonin transporter knockout rats

(2013) J. J. Galligan et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Altered colonic function and microbiota profile in a mouse model of chronic depression

(2013) A. J. Park et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Sex differences in emotion-related cognitive processes in irritable bowel syndrome and healthy control subjects

(2013) Jennifer S. Labus et al.   PAIN

Welcome to the Microgenderome

(2013) M. B. Flak et al.   SCIENCE

Mucus Enhances Gut Homeostasis and Oral Tolerance by Delivering Immunoregulatory Signals

(2013) M. Shan et al.   SCIENCE

Sex Differences in the Gut Microbiome Drive Hormone-Dependent Regulation of Autoimmunity

(2013) J. G. M. Markle et al.   SCIENCE

Sex differences matter in the gut: effect on mucosal immune activation and inflammation

(2013) Sumathi Sankaran-Walters et al.   Biology of Sex Differences

Regulation of Intestinal Homeostasis by Innate Immune Cells

(2013) Hisako Kayama et al.   Immune Network

Effect of Gender on Prevalence of Irritable Bowel Syndrome in the Community: Systematic Review and Meta-Analysis

(2012) Rebecca M Lovell et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

The hypothalamic-pituitary-adrenal axis and sex hormones in chronic stress and obesity: pathophysiological and clinical aspects

(2012) Renato Pasquali   Annals of the New York Academy of Sciences

Microbial steroid transformations: current state and prospects

(2012) Marina V. Donova et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Estrogen effects on the brain: Actions beyond the hypothalamus via novel mechanisms.

(2012) Bruce S. McEwen et al.   BEHAVIORAL NEUROSCIENCE

Carbachol ameliorates lipopolysaccharide-induced intestinal epithelial tight junction damage by down-regulating NF-κβ and myosin light-chain kinase pathways

(2012) Ying Zhang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Repeated exposure to water immersion stress reduces the Muc2 gene level in the rat colon via two distinct mechanisms

(2012) Mizuki Shigeshiro et al.   BRAIN BEHAVIOR AND IMMUNITY

Intestinal Permeability and Its Regulation by Zonulin: Diagnostic and Therapeutic Implications

(2012) Alessio Fasano   Clinical Gastroenterology and Hepatology

A new soy germ fermented ingredient displays estrogenic and protease inhibitor activities able to prevent irritable bowel syndrome-like symptoms in stressed female rats

(2012) Lara Moussa et al.   CLINICAL NUTRITION

Innate immune signalling at the intestinal epithelium in homeostasis and disease

(2012) Johanna Pott et al.   EMBO REPORTS

Brain-Gut Interactions in Inflammatory Bowel Disease

(2012) Bruno L. Bonaz et al.   GASTROENTEROLOGY

Diarrhoea-predominant irritable bowel syndrome: an organic disorder with structural abnormalities in the jejunal epithelial barrier

(2012) Cristina Martínez et al.   GUT

The brain–gut pathway in functional gastrointestinal disorders is bidirectional: a 12-year prospective population-based study

(2012) N A Koloski et al.   GUT

The microbiome-gut-brain axis during early life regulates the hippocampal serotonergic system in a sex-dependent manner

(2012) G Clarke et al.   MOLECULAR PSYCHIATRY

Novel insights in the role of peripheral corticotropin-releasing factor and mast cells in stress-induced visceral hypersensitivity

(2012) M. Larauche   NEUROGASTROENTEROLOGY AND MOTILITY

Acute experimental stress evokes a differential gender-determined increase in human intestinal macromolecular permeability

(2012) C. Alonso et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Peripheral Mechanisms in Irritable Bowel Syndrome

(2012) Michael Camilleri   NEW ENGLAND JOURNAL OF MEDICINE

Expression of corticotropin releasing factor receptor type 1 (CRF1) in the human gastrointestinal tract and upregulation in the colonic mucosa in patients with ulcerative colitis

(2012) Pu-Qing Yuan et al.   PEPTIDES

CRF Induces Intestinal Epithelial Barrier Injury via the Release of Mast Cell Proteases and TNF-α

(2012) Elizabeth L. Overman et al.   PLoS One

Prevention of gut leakiness by a probiotic treatment leads to attenuated HPA response to an acute psychological stress in rats

(2012) Afifa Ait-Belgnaoui et al.   PSYCHONEUROENDOCRINOLOGY

Host-Gut Microbiota Metabolic Interactions

(2012) J. K. Nicholson et al.   SCIENCE

Natural History of Irritable Bowel Syndrome in Women and Dysmenorrhea: A 10-Year Follow-Up Study

(2012) Linda Bjork Olafsdottir et al.   Gastroenterology Research and Practice

Role of female sex hormones, estradiol and progesterone, in mast cell behavior

(2012) Oliver Zierau et al.   Frontiers in Immunology

Amygdala activation by corticosterone alters visceral and somatic pain in cycling female rats

(2011) Jenny K. Gustafsson et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Estrogen receptor-β signaling modulates epithelial barrier function

(2011) Mirjam Looijer-van Langen et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

The influence of sex and gender on the immune response

(2011) Sabine Oertelt-Prigione   AUTOIMMUNITY REVIEWS

The role of gender and organ specific autoimmunity

(2011) Udi Nussinovitch et al.   AUTOIMMUNITY REVIEWS

Eosinophils Express Muscarinic Receptors and Corticotropin-Releasing Factor to Disrupt the Mucosal Barrier in Ulcerative Colitis

(2011) Conny Wallon et al.   GASTROENTEROLOGY

Centrally Acting Therapies for Irritable Bowel Syndrome

(2011) Madhusudan Grover et al.   GASTROENTEROLOGY CLINICS OF NORTH AMERICA

Evaluation of the effects of gender and estradiol treatment on the intestinal microcirculation during experimental sepsis

(2011) Nivin Sharawy et al.   MICROVASCULAR RESEARCH

Peripheral α-helical CRF (9-41) does not reverse stress-induced mast cell dependent visceral hypersensitivity in maternally separated rats

(2011) R. M. van den Wijngaard et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve

(2011) J. A. Bravo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Corticotropin-releasing factor secretion from dendritic cells stimulated by commensal bacteria

(2011) Mariko Hojo   WORLD JOURNAL OF GASTROENTEROLOGY

Gender Dimorphism in the Gut: Mucosal Protection by Estrogen Stimulation of IgA Transcytosis

(2011) Mark E. Diebel et al.   JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE

Neurosteroids and GABA-A Receptor Function

(2011) Mingde Wang   Frontiers in Endocrinology

Meta-analysis: do irritable bowel syndrome symptoms vary between men and women?

(2010) M. A. Adeyemo et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Chronological assessment of mast cell-mediated gut dysfunction and mucosal inflammation in a rat model of chronic psychosocial stress

(2010) María Vicario et al.   BRAIN BEHAVIOR AND IMMUNITY

Estrogen Receptors in Immunity and Autoimmunity

(2010) Melissa Cunningham et al.   CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY

5-HTTLPR and STin2 polymorphisms in the serotonin transporter gene and irritable bowel syndrome: effect of bowel habit and sex

(2010) Beate Niesler et al.   EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY

Quantitative Meta-analysis Identifies Brain Regions Activated During Rectal Distension in Irritable Bowel Syndrome

(2010) Kirsten Tillisch et al.   GASTROENTEROLOGY

Sex Differences in Stress Response Circuitry Activation Dependent on Female Hormonal Cycle

(2010) J. M. Goldstein et al.   JOURNAL OF NEUROSCIENCE

Sex Steroids Localized to the Amygdala Increase Pain Responses to Visceral Stimulation in Rats

(2010) Brent Myers et al.   JOURNAL OF PAIN

Bowels control brain: gut hormones and obesity

(2010) Benjamin C. T. Field et al.   Nature Reviews Endocrinology

Stress-induced barrier disruption of rat follicle-associated epithelium involves corticotropin-releasing hormone, acetylcholine, substance P, and mast cells

(2010) å. v. Keita et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Reduced anxiety-like behavior and central neurochemical change in germ-free mice

(2010) K. M. Neufeld et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Distinct alterations in colonic morphology and physiology in two rat models of enhanced stress-induced anxiety and depression-like behaviour

(2010) Dervla O'Malley et al.   STRESS-THE INTERNATIONAL JOURNAL ON THE BIOLOGY OF STRESS

5-hydroxytryptamine signalling in irritable bowel syndrome with diarrhoea: effects of gender and menstrual status

(2009) L. A. HOUGHTON et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Exposure to Severe Wartime Conditions in Early Life Is Associated With an Increased Risk of Irritable Bowel Syndrome: A Population-Based Cohort Study

(2009) Tamira K Klooker et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Mucosal Immune Activation in Irritable Bowel Syndrome: Gender-Dependence and Association With Digestive Symptoms

(2009) Cesare Cremon et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Cortagine, a CRF1 agonist, induces stresslike alterations of colonic function and visceral hypersensitivity in rodents primarily through peripheral pathways

(2009) Muriel Larauche et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Early weaning stress impairs development of mucosal barrier function in the porcine intestine

(2009) Feli Smith et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Roles of ZO-1 and ZO-2 in Establishment of the Belt-like Adherens and Tight Junctions with Paracellular Permselective Barrier Function

(2009) Sachiko Tsukita et al.   Annals of the New York Academy of Sciences

Repeated restraint stress increases IgA concentration in rat small intestine

(2009) Humberto Reyna-Garfias et al.   BRAIN BEHAVIOR AND IMMUNITY

Stress-induced dendritic remodeling in the medial prefrontal cortex: Effects of circuit, hormones and rest

(2009) Rebecca M. Shansky et al.   BRAIN RESEARCH

Estradiol and testosterone differently affect visceral pain-related behavioural responses in male and female rats

(2009) Anna Maria Aloisi et al.   EUROPEAN JOURNAL OF PAIN

Human mast cells express androgen receptors but treatment with testosterone exerts no influence on IgE-independent mast cell degranulation elicited by neuromuscular blocking agents

(2009) WenChieh Chen et al.   EXPERIMENTAL DERMATOLOGY

Childhood Trauma Is Associated With Hypothalamic-Pituitary-Adrenal Axis Responsiveness in Irritable Bowel Syndrome

(2009) Elizabeth J. Videlock et al.   GASTROENTEROLOGY

The Relationship Between Intestinal Microbiota and the Central Nervous System in Normal Gastrointestinal Function and Disease

(2009) Stephen M. Collins et al.   GASTROENTEROLOGY

Postinfectious Irritable Bowel Syndrome

(2009) Robin Spiller et al.   GASTROENTEROLOGY

Do fluctuations in ovarian hormones affect gastrointestinal symptoms in women with irritable bowel syndrome?

(2009) Margaret M. Heitkemper et al.   Gender Medicine

Psychological stress induces eosinophils to produce corticotrophin releasing hormone in the intestine

(2009) P-Y Zheng et al.   GUT

Progesterone inhibits Toll-like receptor 4-mediated innate immune response in macrophages by suppressing NF-κB activation and enhancing SOCS1 expression

(2009) Li Su et al.   IMMUNOLOGY LETTERS

Serotonin transporter activity and serotonin concentration in platelets of patients with irritable bowel syndrome: effect of gender

(2009) Leonora Franke et al.   JOURNAL OF GASTROENTEROLOGY

Sex, Gender, and Pain: A Review of Recent Clinical and Experimental Findings

(2009) Roger B. Fillingim et al.   JOURNAL OF PAIN

Oestradiol decreases colonic permeability through oestrogen receptor β-mediated up-regulation of occludin and junctional adhesion molecule-A in epithelial cells

(2009) Viorica Braniste et al.   JOURNAL OF PHYSIOLOGY-LONDON

Metabotyping of Biofluids Reveals Stress-Based Differences in Gut Permeability in Healthy Individuals

(2009) Serge Rezzi et al.   JOURNAL OF PROTEOME RESEARCH

Sex, trauma, stress hormones and depression

(2009) E Young et al.   MOLECULAR PSYCHIATRY

Chronic stress effects on dendritic morphology in medial prefrontal cortex: sex differences and estrogen dependence

(2009) J.E. Garrett et al.   NEUROSCIENCE

Intestinal membrane permeability and hypersensitivity in the irritable bowel syndrome

(2009) QiQi Zhou et al.   PAIN

Sex differences in stress responses: Focus on ovarian hormones

(2009) Gert J. Ter Horst et al.   PHYSIOLOGY & BEHAVIOR

Impact of oral bisphenol A at reference doses on intestinal barrier function and sex differences after perinatal exposure in rats

(2009) V. Braniste et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Chronic peripheral administration of corticotropin-releasing factor causes colonic barrier dysfunction similar to psychological stress

(2008) Aaron A. Teitelbaum et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Early Life Stress Alters Behavior, Immunity, and Microbiota in Rats: Implications for Irritable Bowel Syndrome and Psychiatric Illnesses

(2008) Siobhain M. O'Mahony et al.   BIOLOGICAL PSYCHIATRY

Estrogen receptor-α and -β regulate the human corticotropin-releasing hormone gene through similar pathways

(2008) Xiao-Ning Chen et al.   BRAIN RESEARCH

Male Sex Hormones May Influence the Symptoms of Irritable Bowel Syndrome in Young Men

(2008) Beom Jin Kim et al.   DIGESTION

Gender Differences in Gastrointestinal, Psychological, and Somatic Symptoms in Irritable Bowel Syndrome

(2008) Kevin C. Cain et al.   DIGESTIVE DISEASES AND SCIENCES

Maladaptive Intestinal Epithelial Responses to Life Stress May Predispose Healthy Women to Gut Mucosal Inflammation

(2008) Carmen Alonso et al.   GASTROENTEROLOGY

Unique Role of Junctional Adhesion Molecule-A in Maintaining Mucosal Homeostasis in Inflammatory Bowel Disease

(2008) Stefania Vetrano et al.   GASTROENTEROLOGY

Targeted Epithelial Tight Junction Dysfunction Causes Immune Activation and Contributes to Development of Experimental Colitis

(2008) Liping Su et al.   GASTROENTEROLOGY

Impaired intestinal barrier integrity in the colon of patients with irritable bowel syndrome: involvement of soluble mediators

(2008) T Piche et al.   GUT

Dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis in irritable bowel syndrome

(2008) l. chang et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Stress neuropeptides evoke epithelial responses via mast cell activation in the rat colon

(2008) Javier Santos et al.   PSYCHONEUROENDOCRINOLOGY

Testosterone Reduces Macrophage Expression in the Mouse of Toll-Like Receptor 4, a Trigger for Inflammation and Innate Immunity

(2007) Jennifer A. Rettew et al.   BIOLOGY OF REPRODUCTION

Campylobacter jejuni infection increases anxiety-like behavior in the holeboard: Possible anatomical substrates for viscerosensory modulation of exploratory behavior

(2007) Lisa E. Goehler et al.   BRAIN BEHAVIOR AND IMMUNITY