Article
Biochemistry & Molecular Biology
Atsushi Kanamori, Fumio Tanaka, Masaki Ominami, Yuji Nadatani, Shusei Fukunaga, Koji Otani, Shuhei Hosomi, Noriko Kamata, Yasuaki Nagami, Koichi Taira, Yasuhiro Fujiwara
Summary: This study found that psychological stress exacerbates ileal inflammation via the CRH-mast cell axis in a mouse model of eosinophilic enteritis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Endocrinology & Metabolism
Christina L. Herrera, Kaushik Maiti, Roger Smith
Summary: Preterm birth is a significant cause of neonatal morbidity and mortality, and its exact mechanisms remain unclear. It is a multifactorial syndrome, making individual predictive measures less effective. Corticotrophin-releasing hormone (CRH) synthesized by the placenta is proposed as a pathway for preterm birth, as it activates the myometrium through the production of estriol and the transcription factor nuclear factor-kappa B.
Review
Endocrinology & Metabolism
Laura M. Stanton, Aidan J. Price, Elizabeth E. Manning
Summary: Stress has a significant impact on mental health globally. Research has focused on understanding the mechanisms by which stress contributes to psychiatric disorders such as depression, particularly the dysfunction of the hypothalamic pituitary adrenal (HPA) axis. Corticotrophin releasing hormone (CRH) neurons in the paraventricular nucleus of the hypothalamus (PVN) play a crucial role in regulating HPA axis activity and stress-related behaviors. This review examines the changes in PVNCRH neural function and its potential implications for the development of maladaptive behaviors in depression, and highlights the need for further research in understanding the role of PVNCRH neurons in chronic stress.
JOURNAL OF NEUROENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Kanako Takahashi, Takeru Shima, Mariko Soya, Jang Soo Yook, Hikaru Koizumi, Subrina Jesmin, Tsuyoshi Saito, Masahiro Okamoto, Hideaki Soya
Summary: Exercise at an intensity above the lactate threshold leads to an increase in plasma adrenocorticotropic hormone (ACTH), indicating a stress response. This study investigated the involvement of arginine vasopressin (AVP) and corticotropin-releasing hormone (CRH) in regulating exercise-induced ACTH response. Using a rat model, the researchers administered AVP and CRH receptor antagonists and observed a suppression of ACTH levels after exercise. Immunohistochemical evaluation confirmed the activation of AVP and CRH neurons in the hypothalamus. These findings suggest that AVP and CRH cooperatively contribute to exercise-induced ACTH response, reflecting the stress response to moderate-intensity exercise in humans.
NEUROENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Satoru Ikenoue, Feizal Waffarn, Masanao Ohashi, Mamoru Tanaka, Daniel L. Gillen, Claudia Buss, Sonja Entringer, Pathik D. Wadhwa
Summary: The study found that placental corticotrophin-releasing hormone in late gestation may influence fetal liver blood flow, which could be significant in clinical investigations of fetal growth and body composition.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Psychiatry
Awirut Oon-arom, Chawisa Suradom, Somdet Srichairatanakool, Suchaya Luewan, Touchwin Petiwathayakorn, Benchalak Maneeton, Narong Maneeton, Suttipong Kawilapat, Manit Srisurapanont
Summary: This study aimed to determine whether serum oxytocin (OT) or corticotrophin-releasing hormone (CRH) levels in the third trimester of pregnancy could predict postpartum depression (PPD) at six weeks after childbirth. The results showed that only high levels of CRH, not OT, in late pregnancy could predict PPD at six weeks postpartum. However, combining CRH levels, late pregnancy stress, and newborn well-being immediately after birth seems to increase the accuracy of PPD prediction.
ASIAN JOURNAL OF PSYCHIATRY
(2023)
Article
Psychiatry
Biswadip Chatterjee, Raka Jain, Nishtha Chawla, Rahul Raghav
Summary: The study found significantly higher levels of serum CRF and perceived stress among opioid-dependent subjects compared to non-using controls, with no significant correlation with craving. The significant difference in serum CRF levels suggests the feasibility of measuring CRF levels in peripheral fluids as a biochemical measure of stress.
ASIAN JOURNAL OF PSYCHIATRY
(2022)
Article
Psychology, Biological
Isabel F. Ramos, Kharah M. Ross, Gabrielle R. Rinne, Jennifer A. Somers, Roberta A. Mancuso, Calvin J. Hobel, Mary Coussons-Read, Christine Dunkel Schetter
Summary: Linear changes in pregnancy anxiety and nonlinear changes in pCRH during pregnancy are independent risk factors for shortened gestational length. This study adds to the growing body of research on biopsychological processes in pregnancy and length of gestation. Modeling changes in psychological and biological processes during pregnancy could provide more insight into understanding risk for adverse pregnancy outcomes.
BIOLOGICAL PSYCHOLOGY
(2022)
Article
Biology
Alessandra Caruso, Alessandra Gaetano, Sergio Scaccianoce
Summary: CRH plays a role in regulating multiple biological systems, and is also associated with reproduction, neuropsychiatric, gastrointestinal, immune disorders, and tumor development. Further research on the physiological functions of CRH will help determine its role in human diseases and may serve as novel therapeutic targets.
Article
Psychiatry
Dorien Vandael, Keimpe Wierda, Katlijn Vints, Pieter Baatsen, Lies De Groef, Lieve Moons, Vasily Rybakin, Natalia Gounko
Summary: CRF plays a central role in regulating physiological responses to stress by rapidly enhancing synaptic communication in the hippocampus. This process involves changes in both functional and structural aspects of synapses, leading to improvements in synaptic strength and plasticity, which may contribute to enhanced memory consolidation under acute stress.
TRANSLATIONAL PSYCHIATRY
(2021)
Article
Pharmacology & Pharmacy
Pier Giorgio Puzzovio, Hadas Pahima, Tresa George, David Mankuta, Ron Eliashar, Ekaterini Tiligada, Bruce D. Levy, Francesca Levi-Schaffer
Summary: This study investigates the pro-resolution role of mast cells in allergic inflammation. The results show that activated mast cells release a significant amount of resolvin D1 after 30 minutes, which can actively contribute to the resolution of allergic inflammation.
PHARMACOLOGICAL RESEARCH
(2023)
Article
Agriculture, Dairy & Animal Science
Athanasios Samaras, Michail Pavlidis
Summary: This study is the first to demonstrate that fish scales have the ability to produce cortisol, and that cortisol concentration in fish scales can serve as a reliable indicator of chronic stress.
Article
Cardiac & Cardiovascular Systems
Hao-Lin Ren, Ruiping Cai, Ruize Xue, Yaoxia Zhang, Qian Xu, Xianyang Zhang, RenZhi Cai, Wei Sha, Andrew V. V. Schally, Ming-Sheng Zhou
Summary: GHRH-A MR409 has been shown to effectively attenuate vascular calcification and heart valve calcification in diabetic mice, while protecting against endothelial dysfunction and vascular injury. This may be achieved through upregulation of anti-calcifying protein Klotho and reduction in vascular reactive oxygen species (ROS) generation, as well as the expression of redox sensitive osteogenic genes Runx2 and ALP. GHRH-A could represent a new pharmacological strategy for the treatment of vascular calcification and diabetes-associated cardiovascular complications.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Integrative & Complementary Medicine
Yu-Xue Zhao, Chang-Xiang Cui, Jun-Hong Gao, Jun Liu, Qun Liu, Feng-Yan Lu, Juan-Juan Xin, Xiao-Chun Yu, Bing Zhu
Summary: This study demonstrated that electroacupuncture treatment can improve stress-induced jejunal motility disorder, potentially through down-regulation of CRFr2.
ACUPUNCTURE IN MEDICINE
(2021)
Article
Environmental Sciences
Xue Liu, Jiaqian Feng, Zhijing Jiang, Guangbo Zhang, Xiuwen Xu, Jixiu Wang, Jingwen Yang, Tianming Wang
Summary: In the neuroendocrine system, corticotropin-releasing hormone (CRH) activates CRHRs and plays a vital role in the HPA/HPI axis. Two CRHR1 subtypes, LcCRHR1-1 and LcCRHR1-2, were identified in Larimichthys crocea genome and were found to be highly homologous to known teleost CRHRs. These receptors were found to be localized in the cell membrane and respond to LcCRH by increasing cAMP, Ca2+ and mitogen-activated protein kinase phosphorylation. LcCRHR1s were expressed in various tissues, with high expression in the brain and ovaries, and shown to be specifically localized in ovarian follicle cells. This study suggests that the CRH/CRHR1 system may be involved in the neuroendocrine regulation of reproduction in L. crocea.
FRONTIERS IN MARINE SCIENCE
(2023)
Article
Immunology
Huang Huang, Jiang-Qi Liu, Yong Yu, Li-Hua Mo, Rong-Ti Ge, Huan-Ping Zhang, Zhi-Gang Liu, Peng-Yuan Zheng, Ping-Chang Yang
CELLULAR & MOLECULAR IMMUNOLOGY
(2016)
Article
Oncology
Lan Cui, Ruifeng Zheng, Wentao Liu, Peihong Shen, Youcai Tang, Junbo Luo, Wei Zhang, Guocong Jia, Yongfeng Wang, Shuaihua Zhao, Qiaoting Xie, Yanwei Li
MOLECULAR MEDICINE REPORTS
(2018)
Article
Electrochemistry
Fangfang Yao, Pengyuan Zheng, Huang Huang, Yong Yu, Lu Me, Runping Jia
INTERNATIONAL JOURNAL OF ELECTROCHEMICAL SCIENCE
(2018)
Article
Immunology
Mao-Gang Li, Xiao-Yu Liu, Zhi-Qiang Liu, Jing-Yi Hong, Jiang-Qi Liu, Cai-Jie Zhou, Tian-Yong Hu, Xiao-Jun Xiao, Pi-Xin Ran, Peng-Yuan Zheng, Zhi-Gang Liu, Ping-Chang Yang
JOURNAL OF IMMUNOLOGY
(2018)
Article
Microbiology
Y. Deng, M. Li, L. Mei, L. M. Cong, Y. Liu, B. B. Zhang, C. Y. He, P. Y. Zheng, J. L. Yuan
BENEFICIAL MICROBES
(2018)
Article
Biochemistry & Molecular Biology
Bai-Sui Feng, Yong-Jin Wu, Xian-Hai Zeng, Dian Yu, Zhi-Qiang Liu, Cai-Jie Zhou, Zhi-Gang Liu, Peng-Yuan Zheng, Ping-Chang Yang
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2018)
Article
Immunology
H. Huang, J. -Y. Hong, Y. -J. Wu, E. -Y. Wang, Z. -Q. Liu, B. -H. Cheng, L. Mei, Z. -G. Liu, P. -C. Yang, P. -Y. Zheng
CLINICAL AND EXPERIMENTAL IMMUNOLOGY
(2018)
Article
Immunology
Bai-Sui Feng, Yong-Jin Wu, Jing-Yi Hong, Xiao-Rui Geng, Jiang-Qi Liu, Zhi-Gang Liu, Peng-Yuan Zheng, Ping-Chang Yang
IMMUNOLOGY LETTERS
(2018)
Article
Multidisciplinary Sciences
Youcai Tang, Keith S. Blomenkamp, Peter Fickert, Michael Trauner, Jeffrey H. Teckman
Article
Multidisciplinary Sciences
Simeng Liu, Enyao Li, Zhenyu Sun, Dongjun Fu, Guiqin Duan, Miaomiao Jiang, Yong Yu, Lu Mei, Pingchang Yang, Youcai Tang, Pengyuan Zheng
SCIENTIFIC REPORTS
(2019)
Article
Cell Biology
Fumin Xue, Chao An, Lixiang Chen, Gang Liu, Feifei Ren, Xinhua Guo, Haibin Su, Lu Mei, Xiangdong Sun, Jinpeng Li, Youcai Tang, Xiuli An, Pengyuan Zheng
CELL COMMUNICATION AND SIGNALING
(2019)
Article
Cell Biology
Feifei Ren, Qitai Zhao, Bin Liu, Xiangdong Sun, Youcai Tang, Huang Huang, Lu Mei, Yong Yu, Hui Mo, Haibin Dong, Pengyuan Zheng, Yang Mi
JOURNAL OF CELLULAR PHYSIOLOGY
(2020)
Article
Medicine, Research & Experimental
Peng-Yuan Zheng, Xiao-Rui Geng, Jing-Yi Hong, Gui Yang, Jiang-Qi Liu, Li-Hua Mo, Yan Feng, Yuan-Yi Zhang, Tao Liu, Pixin Ran, Zhi-Gang Liu, Ping-Chang Yang
Article
Medicine, Research & Experimental
Liu Chao, Pengyuan Zheng, Liu Xia, Yu Yong, Gaofeng Lu, Fuai Tang, Zhiguo Zhao
IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES
(2017)
Article
Allergy
Z. -Q. Liu, X. -X. Li, S. -Q. Qiu, Y. Yu, M. -G. Li, L. -T. Yang, L. -J. Li, S. Wang, P. -Y. Zheng, Z. -G. Liu, P. -C. Yang