Article
Biochemistry & Molecular Biology
Hairui Han, Nana He, Enzhuang Pan, Xuelian Tan, Zuwang Yang, Xueqing Li, Dahua Shi, Jingquan Dong
Summary: In this study, a 96-hour acute toxicity model was established to investigate the effects of Avermectin (AVM) on the intestinal tract of carp. The results showed that AVM exposure caused intestinal damage, decreased the expression of tight junction protein gene, activated oxidative stress, induced apoptosis, and induced intestinal inflammation in carp. Therefore, it was demonstrated that AVM has complex toxic effects on the fish intestinal tract, providing a new perspective for studying the toxicology of AVM on the fish intestinal tract.
PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Atsushi Kanamori, Fumio Tanaka, Masaki Ominami, Yuji Nadatani, Shusei Fukunaga, Koji Otani, Shuhei Hosomi, Noriko Kamata, Yasuaki Nagami, Koichi Taira, Yasuhiro Fujiwara
Summary: This study found that psychological stress exacerbates ileal inflammation via the CRH-mast cell axis in a mouse model of eosinophilic enteritis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Medicinal
Yueshan Sun, Hong Li, Lei Liu, Xiaoqin Bai, Liping Wu, Jing Shan, Xiaobin Sun, Qiong Wang, Yuanbiao Guo
Summary: The nonfluorinated Lidocaine analog JM25-1 has therapeutic potential on intestinal barrier defects by stabilizing mast cells (MC) and reducing their release of beta-hexosaminidase and cytokines. JM25-1 targets the CRH receptors (CRHR1 and CRHR2) of MC through the PI3K/AKT/mTOR signaling pathway, showing promise for the treatment of irritable bowel syndrome (IBS).
Article
Gastroenterology & Hepatology
Yanrong Wang, Mingbiao Qiao, Xue Yao, Zhonghui Feng, Ruiqi Hu, Jianguo Chen, Lei Liu, Jinbo Liu, Yueshan Sun, Yuanbiao Guo
Summary: Intestinal barrier dysfunction is a prevalent pathogenic factor underlying various disorders, and lidocaine may ameliorate it in IBS by potentially modulating the expression of CRHR2 on intestinal epithelial cells. CRHR2 expression was downregulated in rats under water avoidance stress, leading to decreased tight junction proteins and increased intestinal permeability. Lidocaine improved the severity of IBS rats by modulating intestinal epithelial TJs and protecting intestinal epithelial barrier function.
NEUROGASTROENTEROLOGY AND MOTILITY
(2023)
Article
Neurosciences
Li Zhu, Zhen Ye, Mengting Zhang, Weichen Xu, Ruwen Wang, Shengbing Wu, Heren Gao
Summary: This study aims to demonstrate the protective role of electroacupuncture at PC6 in ameliorating cardiac autonomic imbalance and investigate the underlying mechanisms. The results showed that electroacupuncture at PC6 improved the enhanced LF, reduced HF, and enhanced LF/HF ratio caused by stress. Additionally, it decreased phosphorylated tyrosine hydroxylase expression and increased acetylcholine esterase expression in the heart. Furthermore, it decreased CRH level and CRHR2 expressions in RVLM and NTS of stress rats. These findings suggest that electroacupuncture at PC6 can ameliorate stress-induced cardiac autonomic imbalance by modulating the CRHergic input in the RVLM and NTS.
Review
Physiology
Sergio Esquivel-Ruiz, Paloma Gonzalez-Rodriguez, Jose A. Lorente, Francisco Perez-Vizcaino, Raquel Herrero, Laura Moreno
Summary: Extracellular vesicles play a crucial role in intercellular communication by transferring genetic material, proteins, and organelles between different cell types, particularly in the pathophysiology of lung diseases such as acute respiratory distress syndrome (ARDS). They have the ability to modulate inflammation and alveolar-capillary barrier disruption. Current research is focused on utilizing stem cell-derived EVs for potential therapeutics to attenuate lung injury.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Neurosciences
Angela E. Snyder, Yuval Silberman
Summary: Alcohol Use Disorder and Substance Use Disorder impact millions of individuals in the United States, and stress is a key trigger for relapse in patients. The brain region BNST plays a crucial role in drug-seeking behaviors and stress responses.
Article
Ophthalmology
Jin-Miao Li, Rong Lu, Yun Zhang, Jing Lin, Xia Hua, Stephen C. Pflugfelder, De-Quan Li
Summary: IL-36 cytokines, particularly IL-36 alpha, show differential expression in primary HCECs, with pro-inflammatory effects at hyperosmotic conditions. The antagonists IL-36RA and IL-38 are suppressed under hyperosmotic stress, suggesting a novel mechanism of inflammation induction in dry eye. Further research is needed to explore the therapeutic potential of IL-36RA and IL-38 in dry eye disease.
Article
Multidisciplinary Sciences
Yanru Hou, Lu Wang, Yian Li, Jiajia Ai, Li Tian
Summary: As a specific predictor of ovarian reserve, serum anti-Mullerian hormone (AMH) has been extensively studied in the field of assisted reproductive technology. This study assessed the relationship between AMH levels and pregnancy outcomes in Chinese patients and identified influencing factors for cumulative live birth in patients with high AMH levels. The results showed that patients with high AMH levels had significantly higher cumulative live birth rates and cumulative clinical pregnancy rates compared to those with normal AMH levels. Age over 40, LH/FSH > 2.5, total Gn dose and duration, and serum E2 levels above 4000 ng/ml on HCG day were significantly associated with cumulative live birth rate in the high AMH group.
SCIENTIFIC REPORTS
(2023)
Article
Immunology
Xuejiao Lian, Wenting Zhang, Jingqiu He-Yang, Xiaoying Zhou
Summary: This study explores the role of MC-chymase in IBD and the protective effect of DSLNT on intestinal epithelium. It is found that MC-chymase disrupts intestinal epithelium and DSLNT can protect the epithelium from this damage.
IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY
(2023)
Article
Dermatology
Li Hsin Wang, Sheng-Hsiang Ma, Ying-Hsuan Tai, Ying-Xiu Dai, Yun-Ting Chang, Tzeng-Ji Chen, Mu-Hong Chen
Summary: Patients with alopecia areata (AA) are at a higher risk of experiencing suicidal behaviors, regardless of their concurrent psychiatric illness. It is important for dermatologists to be aware of this increased risk in AA patients.
Article
Gastroenterology & Hepatology
Sumei Liu, Aaron Karo, Sita Agterberg, Howard Hua, Aditi Bhargava
Summary: This study revealed sex differences in colonic secretion and responses to stress-related peptides, with CRF2 receptors playing a more prominent role in colonic secretion in male mice. The greater baseline secretion and responses to UCNs in males may contribute to the higher prevalence of diarrhea-predominant IBS.
NEUROGASTROENTEROLOGY AND MOTILITY
(2021)