Mechanism of Metformin-dependent Inhibition of Mammalian Target of Rapamycin (mTOR) and Ras Activity in Pancreatic Cancer
出版年份 2014 全文链接
标题
Mechanism of Metformin-dependent Inhibition of Mammalian Target of Rapamycin (mTOR) and Ras Activity in Pancreatic Cancer
作者
关键词
-
出版物
JOURNAL OF BIOLOGICAL CHEMISTRY
Volume 289, Issue 40, Pages 27692-27701
出版商
American Society for Biochemistry & Molecular Biology (ASBMB)
发表日期
2014-08-21
DOI
10.1074/jbc.m114.592576
参考文献
相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。- Mechanism of Action of Phenethylisothiocyanate and Other Reactive Oxygen Species-Inducing Anticancer Agents
- (2014) I. Jutooru et al. MOLECULAR AND CELLULAR BIOLOGY
- Metformin-mediated growth inhibition involves suppression of the IGF-I receptor signalling pathway in human pancreatic cancer cells
- (2013) Emelie Karnevi et al. BMC CANCER
- Metformin inhibits growth and enhances radiation response of non-small cell lung cancer (NSCLC) through ATM and AMPK
- (2013) Y Storozhuk et al. BRITISH JOURNAL OF CANCER
- A Cohort Study of Metformin Exposure and Survival in Patients with Stage I-III Colorectal Cancer
- (2013) S. Spillane et al. CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
- Metformin inhibits pancreatic cancer cell and tumor growth and downregulates Sp transcription factors
- (2013) V. Nair et al. CARCINOGENESIS
- The Cannabinoid WIN 55,212-2 Decreases Specificity Protein Transcription Factors and the Oncogenic Cap Protein eIF4E in Colon Cancer Cells
- (2013) Sandeep Sreevalsan et al. MOLECULAR CANCER THERAPEUTICS
- Metformin Blocks Melanoma Invasion and Metastasis Development in AMPK/p53-Dependent Manner
- (2013) M. Cerezo et al. MOLECULAR CANCER THERAPEUTICS
- Different Patterns of Akt and ERK Feedback Activation in Response to Rapamycin, Active-Site mTOR Inhibitors and Metformin in Pancreatic Cancer Cells
- (2013) Heloisa P. Soares et al. PLoS One
- Low Concentrations of Metformin Selectively Inhibit CD133+ Cell Proliferation in Pancreatic Cancer and Have Anticancer Action
- (2013) Shanmiao Gou et al. PLoS One
- Metformin inhibition of mTORC1 activation, DNA synthesis and proliferation in pancreatic cancer cells: Dependence on glucose concentration and role of AMPK
- (2012) James Sinnett-Smith et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Survival advantage observed with the use of metformin in patients with type II diabetes and colorectal cancer
- (2012) C R Garrett et al. BRITISH JOURNAL OF CANCER
- EGF Receptor Signaling Is Essential for K-Ras Oncogene-Driven Pancreatic Ductal Adenocarcinoma
- (2012) Carolina Navas et al. CANCER CELL
- EGF Receptor Is Required for KRAS-Induced Pancreatic Tumorigenesis
- (2012) Christine M. Ardito et al. CANCER CELL
- Metformin Use Is Associated with Better Survival of Diabetic Patients with Pancreatic Cancer
- (2012) N. Sadeghi et al. CLINICAL CANCER RESEARCH
- Metformin in cancer: translational challenges
- (2012) Ryan J O Dowling et al. JOURNAL OF MOLECULAR ENDOCRINOLOGY
- Insulin stimulation of SREBP-1c processing in transgenic rat hepatocytes requires p70 S6-kinase
- (2012) J. L. Owen et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Metformin, Independent of AMPK, Induces mTOR Inhibition and Cell-Cycle Arrest through REDD1
- (2011) I. Ben Sahra et al. CANCER RESEARCH
- Induction of apoptosis by metformin in epithelial ovarian cancer: Involvement of the Bcl-2 family proteins
- (2011) Amber Yasmeen et al. GYNECOLOGIC ONCOLOGY
- Metformin Induces Both Caspase-Dependent and Poly(ADP-ribose) Polymerase-Dependent Cell Death in Breast Cancer Cells
- (2011) Y. Zhuang et al. MOLECULAR CANCER RESEARCH
- Metformin inhibits P-glycoprotein expression via the NF-κB pathway and CRE transcriptional activity through AMPK activation
- (2010) Hyung Gyun Kim et al. BRITISH JOURNAL OF PHARMACOLOGY
- Chemoprevention Meets Glucose Control
- (2010) J. A. Engelman et al. Cancer Prevention Research
- Metformin and Other Biguanides in Oncology: Advancing the Research Agenda
- (2010) M. Pollak Cancer Prevention Research
- Crosstalk between Insulin/Insulin-like Growth Factor-1 Receptors and G Protein-Coupled Receptor Signaling Systems: A Novel Target for the Antidiabetic Drug Metformin in Pancreatic Cancer
- (2010) E. Rozengurt et al. CLINICAL CANCER RESEARCH
- Inhibition of NFκB and Pancreatic Cancer Cell and Tumor Growth by Curcumin Is Dependent on Specificity Protein Down-regulation
- (2010) Indira Jutooru et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Metformin Treatment Exerts Antiinvasive and Antimetastatic Effects in Human Endometrial Carcinoma Cells
- (2010) Bee K. Tan et al. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
- Drugs that Target Specificity Proteins Downregulate Epidermal Growth Factor Receptor in Bladder Cancer Cells
- (2010) Gayathri Chadalapaka et al. MOLECULAR CANCER RESEARCH
- Metformin in Cancer Therapy: A New Perspective for an Old Antidiabetic Drug?
- (2010) I. Ben Sahra et al. MOLECULAR CANCER THERAPEUTICS
- Methyl 2-Cyano-3,12-dioxooleana-1,9-dien-28-oate Decreases Specificity Protein Transcription Factors and Inhibits Pancreatic Tumor Growth: Role of MicroRNA-27a
- (2010) I. Jutooru et al. MOLECULAR PHARMACOLOGY
- Metformin use and prostate cancer in Caucasian men: results from a population-based case–control study
- (2009) Jonathan L. Wright et al. CANCER CAUSES & CONTROL
- Metformin Disrupts Crosstalk between G Protein-Coupled Receptor and Insulin Receptor Signaling Systems and Inhibits Pancreatic Cancer Growth
- (2009) K. Kisfalvi et al. CANCER RESEARCH
- New Users of Metformin Are at Low Risk of Incident Cancer: A cohort study among people with type 2 diabetes
- (2009) G. Libby et al. DIABETES CARE
- Sp1 coordinately regulatesde novolipogenesis and proliferation in cancer cells
- (2009) Suying Lu et al. INTERNATIONAL JOURNAL OF CANCER
- Metformin and Pathologic Complete Responses to Neoadjuvant Chemotherapy in Diabetic Patients With Breast Cancer
- (2009) Sao Jiralerspong et al. JOURNAL OF CLINICAL ONCOLOGY
- Antidiabetic Medication and Prostate Cancer Risk: A Population-based Case-Control Study
- (2008) T. J. Murtola et al. AMERICAN JOURNAL OF EPIDEMIOLOGY
- Sp1, a New Biomarker That Identifies a Subset of Aggressive Pancreatic Ductal Adenocarcinoma
- (2008) N. Y. Jiang et al. CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
- Fatty Acid Synthase Gene Is Up-regulated by Hypoxia via Activation of Akt and Sterol Regulatory Element Binding Protein-1
- (2008) E. Furuta et al. CANCER RESEARCH
- SREBP Activity Is Regulated by mTORC1 and Contributes to Akt-Dependent Cell Growth
- (2008) Thomas Porstmann et al. Cell Metabolism
- In vitro metformin anti-neoplastic activity in epithelial ovarian cancer
- (2008) Walter H. Gotlieb et al. GYNECOLOGIC ONCOLOGY
- The antidiabetic drug metformin exerts an antitumoral effect in vitro and in vivo through a decrease of cyclin D1 level
- (2008) I Ben Sahra et al. ONCOGENE
- Metformin induces apoptosis of pancreatic cancer cells
- (2008) Luo-Wei Wang et al. WORLD JOURNAL OF GASTROENTEROLOGY
Add your recorded webinar
Do you already have a recorded webinar? Grow your audience and get more views by easily listing your recording on Peeref.
Upload NowAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started