Review
Pharmacology & Pharmacy
Yong Yu, Qingzhu Nie, Ziyi Wang, Yu Di, Xiaolong Chen, Kaiming Ren
Summary: Metabolic adaptation in tumors is heavily influenced by fatty acid synthesis, with acetyl-CoA carboxylase 1 playing a crucial role. This enzyme is involved in the production of fatty acids and has potential therapeutic implications for metabolic diseases and anti-tumor therapy.
FRONTIERS IN PHARMACOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Yulseung Sung, Ya Chun Yu, Jung Min Han
Summary: The macronutrients glucose, lipids, and amino acids are crucial for maintaining life and their fluctuations are sensed by molecular sensors, triggering signaling cascades to regulate cellular processes for energy and metabolic homeostasis. Perturbations in these nutrient-sensing pathways are associated with various pathologies, especially metabolic diseases. Understanding the networks connecting nutrient sensors can provide insights into nutrient supply in health and disease, and potentially lead to treatments for metabolic disorders.
EXPERIMENTAL AND MOLECULAR MEDICINE
(2023)
Article
Oncology
Stepan Novak, Michal Kolar, Arpad Szabo, Zdena Vernerova, Lukas Lacina, Hynek Strnad, Jana Sachova, Miluse Hradilova, Jan Havranek, Michal Spanko, Matus Coma, Lukas Urban, Miriam Kanuchova, Nikola Melegova, Robert Gurlich, Josef Dvorak, Karel Smetana, Peter Gal, Pavol Szabo
Summary: PDAC cell lines exhibit various responses to conditioned media derived from CAFs, with Panc-1 cells showing the most aggressive behavior and PaTu-8902 cells being inhibited. The heterogeneity in response highlights the complex tumor-stromal interactions that contribute to the aggressive behavior of PDAC.
CANCER GENOMICS & PROTEOMICS
(2021)
Article
Pharmacology & Pharmacy
Gangadharan Leela Shyni, Kaithathara Francis Sajin, Sivasankaran Nair Mangalam, Kozhiparambil Gopalan Raghu
Summary: TM from Myristica fragrans has shown anti-obesity effects in 3T3-L1 adipocytes by reducing lipid accumulation, promoting lipolysis, and regulating genes and proteins involved in lipid metabolism. It also enhances glucose uptake and increases carnitine palmitoyltransferase levels, suggesting its potential as an anti-obesity therapeutic.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Ozge Rencuzogullari, Pinar Obakan Yerlikaya, Ajda Coker Gurkan, Elif Damla Arisan, Dilek Telci
Summary: The study reveals that palbociclib can regulate AMPK/mTOR signaling through modulation of intracellular miR-33a levels, effectively inhibiting fatty acid metabolism in MiaPaCa-2 cells. Additionally, there is a higher increase of miR-33a in MiaPaCa-2 cells compared to Panc-1 cells when treated with palbociclib.
BIOTECHNOLOGY AND APPLIED BIOCHEMISTRY
(2022)
Article
Cell Biology
Katyayanee Neopane, Natalie Kozlov, Florentina Negoita, Lisa Murray-Segal, Robert Brink, Ashfaqul Hoque, Ashley J. Ovens, Gavin Tjin, Luke M. McAloon, Dingyi Yu, Naomi X. Y. Ling, Matthew J. Sanders, Jonathan S. Oakhill, John W. Scott, Gregory R. Steinberg, Kim Loh, Bruce E. Kemp, Kei Sakamoto, Sandra Galic
Summary: This study demonstrates the relevance of AMPK myristoylation for cellular metabolic signaling. Non-myristoylated AMPK shows increased kinase activity and has an improved metabolic health under conditions of high-fat diet-induced obesity.
Review
Biochemistry & Molecular Biology
Ze Yun, Zhiying Zou, Shanfeng Sun, Huilian Che
Summary: This study found that chlorogenic acid improved food allergy by regulating the AMPK/ACC/CPT-1 signaling pathway in the spleen.
JOURNAL OF FOOD BIOCHEMISTRY
(2022)
Article
Medical Laboratory Technology
Jingjing Jiang, Shifeng Meng, Linlin Li, Xinfei Duan, Haifa Xu, Shurui Li
Summary: The study revealed that the overexpression of circulating ACC1 in AIS patients is associated with increased Th17 and Th1 cells, NIHSS score, and shortened recurrence-free survival.
JOURNAL OF CLINICAL LABORATORY ANALYSIS
(2022)
Article
Biochemistry & Molecular Biology
Jie Gao, Kangjie Ma, Li Zhang, Tao Li, Baodong Zhao, Yaping Jiang
Summary: This study reveals that paired related homeobox 1 (PRRX1) triggers autophagy through regulating free fatty acid (FFA) metabolism in salivary adenoid cystic carcinoma (SACC), leading to enhanced invasion and metastasis.
Article
Biology
Ozge Rencuzogullari, Elif Damla Arisan
Summary: This study demonstrates that combining CSC molecular regulators with palbociclib can improve the success rate of inhibiting pancreatic cancer cell proliferation.
TURKISH JOURNAL OF BIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Jin Young Huh, Alan R. Saltiel
Summary: This review focuses on the mechanisms of fatty acid metabolism in nonalcoholic fatty liver disease (NAFLD) and the dysregulation of lipid metabolism in obesity and NAFLD, with an emphasis on the roles of I kappa B kinase (IKK) and TANK-binding kinase 1 (TBK1) in hepatic inflammatory responses.
EXPERIMENTAL AND MOLECULAR MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
D. Grahame Hardie
Summary: This article reflects on the author's personal research journey, focusing on the early stages of defining AMPK and developing related tools, the exciting period of identifying upstream kinases in the late 1990s and early 2000s, and recent research on the complex role of AMPK in cancer.
BIOCHEMICAL JOURNAL
(2022)
Article
Biochemistry & Molecular Biology
Antonio Gnoni, Benedetta Di Chiara Stanca, Laura Giannotti, Gabriele Vincenzo Gnoni, Luisa Siculella, Fabrizio Damiano
Summary: The dysregulation of de novo lipogenesis (DNL) is considered a critical factor in the assessment of non-alcoholic fatty liver disease (NAFLD). Our study found that high glucose and free fatty acid conditions resulted in the highest cellular lipid accumulation. Quercetin exhibited an anti-lipogenic effect by inhibiting the DNL pathway.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Soojung Hahn, Gyuri Kim, Sang-Man Jin, Jae Hyeon Kim
Summary: This study utilized three-dimensional intestinal organoids to investigate the effects of metformin on inflammatory bowel disease (IBD) and found that metformin can enhance intestinal barrier function and reduce levels of inflammatory cytokines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
V. V. Sudarev, M. S. Gette, S. V. Bazhenov, O. M. Tilinova, E. V. Zinovev, I. V. Manukhov, A. I. Kuklin, Yu. L. Ryzhykau, A. V. Vlasov
Summary: This study investigated the self-assembly processes of ferritin-based protein complexes and obtained structurally characterized oligomeric states. These results provide new potential and opportunities for the application of ferritin in various fields.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Yalda Sabaghi, Farnaz Pourfarzad, Leila Zolghadr, Azita Bahrami, Tahereh Shojazadeh, Alireza Farasat, Nematollah Gheibi
Summary: p-Coumaric acid (p-CA) is a plant compound with anti-cancer activities. This study designed a nano-liposomal carrier containing p-CA to enhance its effectiveness against melanoma cells. The findings showed that the liposomal form of p-CA had a greater impact on the cells. Kinetic modeling indicated that the best fitting model was zero-order.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
M. D. Nazmul Hasan, Md Mahfuzur Rahman, Al Asmaul Husna, Nobuhiro Nozaki, Osamu Yamato, Naoki Miura
Summary: This study investigated the expression of ncRNAs other than miRNAs in different histologic subtypes of canine mammary gland tumors (MGT). Three aberrantly expressed ncRNAs were identified as potential biomarkers for differentiating MGT subtypes. YRNA and tRFs expression levels were found to be decreased in metastatic compared to primary MGT cell lines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Seine A. Shintani
Summary: In this study, the researchers used signal analysis to study the instantaneous amplitude and phase of sarcomeric oscillations in skeletal muscle. They identified two types of oscillations, sarcomeric oscillations and sarcosynced oscillations, and visualized their behavior during propagating waves. The researchers discovered the presence of sarcomeric defect holes and sarcomeric collision holes, which are important indicators for understanding the oscillation properties of sarcomeres. This finding has important implications for improving our understanding of muscle function and its regulatory mechanisms.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Shuanglin Zhang, Yuzhong Jia, Guolan Ma, Yanyan Yang, Zhenzhen Cao, Antao Luo, Zefu Zhang, Shihan Li, Jie Wen, Hanfeng Liu, Jihua Ma
Summary: Bupleurum is an antiarrhythmic agent that may exert its effects by inhibiting L-type calcium channels.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Tomotaka Ohkubo, Yasuhiko Matsumoto, Hiroaki Sasaki, Kaoru Kinoshita, Yuki Ogasawara, Takashi Sugita
Summary: This study found that Citrobacter koseri inhibits the growth of Staphylococcus epidermidis, disrupting the balance between S. epidermidis and Staphylococcus aureus, and exacerbating inflammation in atopic dermatitis.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Toshifumi Asano, Philipp Sasse, Takao Nakata
Summary: A Cre recombination-based fluorescent reporter system was developed to monitor cell-cell fusion. The system successfully detected the formation of multinuclear myotubes and placental syncytiotrophoblast. This tool could facilitate the study of cell-to-cell fusion.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Ke Shi, Yunlong Shan, Xiao Sun, Kuida Chen, Qiong Luo, Qiang Xu
Summary: This study found that low expression of TP53INP2 is associated with poor survival in colorectal cancer (CRC) patients. As the malignancy of CRC progresses, TP53INP2 expression gradually decreases. Knockdown of TP53INP2 promotes CRC cell proliferation and tumor growth. Mechanistically, TP53INP2 deficiency decreases phosphorylation of beta-catenin, leading to increased accumulation and enhanced nuclear translocation and transcriptional activity. Additionally, TP53INP2 sequesters TIM50, inhibiting its activation of beta-catenin. In conclusion, downregulation of TP53INP2 promotes CRC progression by activating beta-catenin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Martina Rossi, Fabio Tomaselli, Alejandro Hochkoeppler
Summary: Oligomeric enzymes are known for their higher catalytic rates compared to monomeric enzymes, but the extent of additivity in their activity is still not well understood. This study used tetrameric rabbit lactate dehydrogenase as a model to examine the kinetics of its catalytic action. Surprisingly, when the concentration of the limiting reactant exceeded that of a single subunit, there was a significant slowdown in the enzyme's conformational rearrangements.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Amin Sahraei, Mohammad Javad Shamsoddini, Fakhrossadat Mohammadi, Leila Hassani
Summary: This study explored the inhibitory effects of gallium curcumin, indium curcumin, and vanadyl curcumin on the amyloid fibrillation of hen egg white lysozyme, as well as the binding interactions of these metal complexes with the enzyme. The results showed that indium curcumin and vanadyl curcumin exhibited higher binding affinities and stronger inhibitory effects on amyloid fibrillation compared to gallium curcumin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Takahiro Sasaki, Yoshiki Kuse, Shinsuke Nakamura, Masamitsu Shimazawa
Summary: PGRN deficiency plays a significant role in cardiac remodeling and arrhythmias post-myocardial infarction (MI), potentially by promoting metabolic abnormalities in macrophages.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Hongwei Zhao, Yiqiang Li, Yibo Zhang, Chi Zhang
Summary: Electrical brain stimulation technology is commonly used to treat brain neurological disorders, but it can cause side effects. This study investigated the impact of electric fields on nerve fibers and revealed the possible origin of side effects. The findings provide guidance for selecting electrical parameters in clinical stimulation therapy.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Julia S. Scott, Lake-Ee Quek, Andrew J. Hoy, Johannes V. Swinnen, Zeyad D. Nassar, Lisa M. Butler
Summary: The fatty acid elongation enzyme ELOVL5 plays a critical role in promoting metastasis in prostate cancer. Knocking down ELOVL5 leads to the accumulation of malonyl-CoA, which inhibits fatty acid oxidation in mitochondria. This study highlights the importance of fatty acid elongation in regulating cell viability and provides a potential target for prostate cancer treatment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Zan Zhou, Wen-jun Jiang, Li Li, Jun-qiang Si
Summary: This study investigates the effect of noise exposure on cognitive function in mice and explores the underlying molecular mechanisms. The findings suggest that noise exposure leads to increased inflammation, increased phosphorylation of Tau protein, and decreased levels of postsynaptic density protein, resulting in cognitive impairment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)